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Original Article
- Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
- Myunghee Kang, Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Seung Yeon Ha, Sangho Lee, Jungsuk An, Jae Yeon Seok, Gie-Taek Yie, Chan Jong Yoo, Sang Gu Lee, Eun Young Kim, Woo Kyung Kim, Seong Son, Sun Jin Sym, Dong Bok Shin, Hee Young Hwang, Eung Yeop Kim, Kyu Chan Lee
- J Pathol Transl Med. 2019;53(2):104-111. Published online January 14, 2019
- DOI: https://doi.org/10.4132/jptm.2018.11.10
- 10,100 View
- 648 Download
- 8 Web of Science
- 8 Crossref
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Abstract
PDF - Background
Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate the diagnostic value of cytology in frozen diagnoses of CNS neoplasms.
Methods
Cases were selected from patients undergoing both frozen cytology and frozen sections. Diagnostic accuracy was evaluated.
Results
Four hundred and fifty-four cases were included in this retrospective single-center review study covering a span of 10 years. Five discrepant cases (1.1%) were found after excluding 53 deferred cases (31 cases of tentative diagnosis, 22 cases of inadequate frozen sampling). A total of 346 cases of complete concordance and 50 cases of partial concordance were classified as not discordant cases in the present study. Diagnostic accuracy of intraoperative frozen diagnosis was 87.2%, and the accuracy was 98.8% after excluding deferred cases. Discrepancies between frozen and permanent diagnoses (n = 5, 1.1%) were found in cases of nonrepresentative sampling (n = 2) and misinterpretation (n = 3). High concordance was observed more frequently in meningeal tumors (97/98, 99%), metastatic brain tumors (51/52, 98.1%), pituitary adenomas (86/89, 96.6%), schwannomas (45/47, 95.8%), high-grade astrocytic tumors (47/58, 81%), low grade astrocytic tumors (10/13, 76.9%), non-neoplastic lesions (23/36, 63.9%), in decreasing frequency.
Conclusions
Using intraoperative cytology and frozen sections of CNS tumors is a highly accurate diagnostic ancillary method, providing subtyping of CNS neoplasms, especially in frequently encountered entities. -
Citations
Citations to this article as recorded by
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- Crush Cytology of Microcystic Meningioma with Extensive Sclerosis
- Jae Yeon Seok, Na Rae Kim, Hyun Yee Cho, Dong Hae Chung, Gi-Taek Yee, Eung Yeop Kim
- Korean J Pathol. 2014;48(1):77-80. Published online February 25, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.77
- 9,351 View
- 56 Download
- 6 Crossref
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Citations
Citations to this article as recorded by- Cytologic features of meningioma: An analysis of common and uncommon subtypes and diagnostic difficulties during intraoperative procedures
Ana M. Rodríguez‐García, Isabel Esteban‐Rodríguez, José A. Jiménez‐Heffernan, Carmen Bárcena, Samuel López‐Muñoz, Pilar López‐Ferrer
Cytopathology.2024; 35(5): 581. CrossRef - Exploring the role of epidermal growth factor receptor variant III in meningeal tumors
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PLOS ONE.2021; 16(9): e0255133. CrossRef - Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone
Na Rae Kim, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2020; 54(6): 508. CrossRef - Can amide proton transfer–weighted imaging differentiate tumor grade and predict Ki-67 proliferation status of meningioma?
Hao Yu, Xinrui Wen, Pingping Wu, Yueqin Chen, Tianyu Zou, Xianlong Wang, Shanshan Jiang, Jinyuan Zhou, Zhibo Wen
European Radiology.2019; 29(10): 5298. CrossRef - Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
Myunghee Kang, Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Seung Yeon Ha, Sangho Lee, Jungsuk An, Jae Yeon Seok, Gie-Taek Yie, Chan Jong Yoo, Sang Gu Lee, Eun Young Kim, Woo Kyung Kim, Seong Son, Sun Jin Sym, Dong Bok Shin, Hee Young Hwang, Eung Yeop Kim, K
Journal of Pathology and Translational Medicine.2019; 53(2): 104. CrossRef - Crush Cytology of Secretory Meningioma: A Case Report
Na Rae Kim, Gie-Taek Yee, Hyun Yee Cho
Brain Tumor Research and Treatment.2015; 3(2): 147. CrossRef
- Cytologic features of meningioma: An analysis of common and uncommon subtypes and diagnostic difficulties during intraoperative procedures
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