Journal of Pathology and Translational Medicine

Extraskeletal Mesenchymal Chondrosarcoma in the Axillary Region: Reports of Two Cases: Chang-Young Seo, Sung-Taek Jung, Jae-Wook Byun; Korean J Pathol. 2012;46(5):483-488. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.483

8,190 View
43 Download
5 Crossref

Extraskeletal mesenchymal chondrosarcomas (EMCs) are relatively uncommon, and a location in the upper extremity, especially in the shoulder or axillary region, is rare. Furthermore, the radiographic findings of EMCs do not show any features that distinguish them from other neoplasms, and therefore, definitive diagnoses are made based on histological features. EMC is an aggressive tumor with a poor prognosis, and requires wide surgical excision. However, its treatment may involve peculiarities such as a difficulty in obtaining a proper surgical margin in the axillary region or shoulder. In this report, the authors present two rare cases of EMCs in the axillary region.

Citations

Citations to this article as recorded by

Complete surgical excision of a high‐grade extraskeletal mesenchymal chondrosarcoma, resulting in a longer survival than previously reported
Hannah Reeves, Tesh Smalle
Veterinary Record Case Reports.2022;[Epub] CrossRef
Locally recurrent extraskeletal myxoid chondrosarcoma of the shoulder: a case of complete neoadjuvant radiotherapy response
Luca Improta, Sergio Valeri, Rossana Alloni, Chiara Pagnoni, Francesco Mallozzi Santa Maria, Beniamino Brunetti, Carlo Greco, Irene Aprile, Mirella Maselli, Bruno Vincenzi, Alessandro Gronchi
Clinical Sarcoma Research.2020;[Epub] CrossRef
Primary extraskeletal chondrosarcoma in the axillary region of a dog with review of the literature
Catrina Pennington, Josep Monne Rodriguez, Marlene Finck, Ben Walton
Veterinary Record Case Reports.2018;[Epub] CrossRef
Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years
Jie Xu, Dasen Li, Lu Xie, Shun Tang, Wei Guo, David M Loeb
PLOS ONE.2015; 10(4): e0122216. CrossRef
Management of renal extraskeletal mesenchymal chondrosarcoma
Vitalie Gherman, Ciprian Tomuleasa, Catalina Bungardean, Nicolae Crisan, Victor-Dan Ona, Bogdan Feciche, Alexandru Irimie, Ioan Coman
BMC Surgery.2014;[Epub] CrossRef

Dedifferentiated Extraskeletal Myxoid Chondrosarcoma of the Masticator Space: A Case Report.: Geunyoung Jung, Kyung Ja Cho, Seung Ho Choi, Mi Jung Kim; Korean J Pathol. 2011;45:S101-S105.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S101

4,094 View
32 Download
3 Crossref

Abstract PDF

We describe a 69-year-old woman who presented with a dedifferentiated extraskeletal myxoid chondrosarcoma arising in the left masticator space. Computed tomography and magnetic resonance imaging revealed a 5 cm sized mass in the left masticator space. Histologically, the tumor consisted of two distinct areas. The less cellular area was a low-grade extraskeletal myxoid chondrosarcoma, composed of strands or cords of uniform spindle cells and abundant myxoid stroma. The more cellular, dedifferentiated area corresponded to a high grade myxofibrosarcoma, consisting of anaplastic tumor cells in myxoid stroma and geographic necrosis. The tumor cells of the former area were positive for S-100 protein, microtubule-associated protein-2 (MAP-2) and class III beta-tubulin, but negative for cytokeratin, smooth muscle actin, and desmin. The tumor cells in the latter, pleomorphic area showed MAP-2 and beta-tubulin immunoreactivity with a high Ki-67 labeling index. Based on its histologic and immunohistochemical features, the tumor was considered a dedifferentiated extraskeletal myxoid chondrosarcoma.

Citations

Citations to this article as recorded by

Extraskeletal myxoid chondrosarcoma of the parotid gland
NyimiBushabu Fidele, Wu Tianfu, Bing Liu, Yanfang Sun, Zhao Yifang
Annals of Maxillofacial Surgery.2019; 9(2): 439. CrossRef
Myxoid chondrosarcoma of maxilla: A rare case report
Hiralal Ash, Ajoy Kumar Shahi, Kabita Chatterjee, Dipankar Samaddar
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(3): 273. CrossRef
Maxillo-facial Extraskeletal Myxoid Chondrosarcoma: A Case Report and Discussion
Ratnadeep Ganguly, Abhishek Mukherjee
The Korean Journal of Pathology.2011; 45(6): 639. CrossRef

Maxillo-facial Extraskeletal Myxoid Chondrosarcoma: A Case Report and Discussion.: Ratnadeep Ganguly, Abhishek Mukherjee; Korean J Pathol. 2011;45(6):639-643.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.639

3,487 View
24 Download
2 Crossref

Abstract PDF

In this report, we share our experience of a case of maxillo-facial extraskeletal myxoid chondrosarcoma, a very rare location for this neoplasm. In addition, a literature review is provided. The patient, a 61-year-old male, had a maxillary mass encroaching on the nasal cavity. After debulking, the tumor recurred, attaining its pre-surgical proportion in two months. The patient improved clinically with radiation and remained stable for about one year. However, he ultimately developed metastases in his lung which were treated with palliative chemotherapy with a good outcome lasting three months. We could find only eight reported cases of this tumor in the head region of which two are in the maxilla; hence, ruling out other primary sites is mandatory for a patient presenting with a primary head and neck mass. Surgical removal may be complicated because of the location. A combination of surgery and radiation is the management of choice, with palliative chemotherapy in metastasis.

Citations

Citations to this article as recorded by

Extraskeletal Myxoid Chondrosarcoma of Floor of Mouth—A Rare Case Report and Review of Literature
Surendra K Dabas, Nandini N Menon, Reetesh Ranjan, Bikas Gurung, Sukirti Tiwari, Bharat Bhushan Bassan, Himanshu Shukla, Sunil Pasricha, Ajit Sinha, Rahul Kapoor, Vinay Kumar Verma, Devesh Verma, Saurabh Arora, Ashwani Sharma, Sourabh Mukharjee, Rishu Sin
Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(1): 1290. CrossRef
Intracranial Metastasis of Extracranial Chondrosarcoma: Systematic Review With Illustrative Case
Charles E. Mackel, Harry Rosenberg, Hemant Varma, Erik J. Uhlmann, Rafael A. Vega, Ron L. Alterman
Brain Tumor Research and Treatment.2023; 11(2): 103. CrossRef

Imprint Cytologic Feature of Extraskeletal Osteosarcoma: A Case Report.: Mi Jin Gu, Young Kyung Bae, Mi Jin Kim, Joon Hyuk Choi, Won Hee Choi; Korean J Cytopathol. 2000;11(1):59-63.

1,801 View
18 Download

Abstract PDF: Extraskeletal osteosarcoma is an uncommon tumor originated from soft tissue without evidence of skeletal involvement. It usually affects adults and its common locations are extremity, buttock, and retroperitoneum. Although the histologic feature of this tumor is well known, there have been few reports on the fine needle aspiration cytologic findings. We report the imprint cytologic feature of extraskeletal osteosarcoma. The patient was a 49-year-old man with a mass of the left anterior chest for 2 years. On the imprint preparation, the smears showed malignant round, polygonal or spindle cells with coarsely clumped chromatin and occasionally prominent nucleoli. The malignant cells occur singly, in clusters, or associated with amorphous eosinophilic osteoid. Mitotic figures are also seen.

Extraskeletal Osteosarcoma of the Posterior Mediastinum: A Case Report.: Weon Cheol Han, Hyang Jung Cho, Jai Kyoo Lee, Hyung Bae Moon, Jae Y Ro; Korean J Pathol. 2004;38(5):350-352.

1,820 View
18 Download

Abstract PDF: Extraskeletal osteosarcoma is a rare malignant tumor of soft tissue. In addition, there are only several cases of osteosarcoma of the mediastinum as a primary site in the world. We report a case of extraskeletal osteosarcoma arising in the posterior mediastinum. A 54-year-old man visited our hospital because of chest pain. Chest CT showed a 12 cm sized huge mediastinal mass. The mass revealed solid and ivory-colored cut surface with multifocally ovoid cystic spaces and hemorrhage. Microscopically, the tumor consisted of polygonal stromal cells, giant cells and varying amounts of neoplastic new bone, and mitotic figures were frequently observed. There were no distant metastasis and regional lymph node involvement.

Extraskeletal Chondroma Arising from Tongue and Tonsils: Three cases report.: Ki Ouk Min, Kyo Young Lee, Chang Suk Kang, Sang In Shim, Sun Moo Kim; Korean J Pathol. 1993;27(4):421-423.

1,709 View
25 Download

Abstract PDF: Three rare tumors of the oral cavity are presented. Lingual chondromas, approximately twenty to thirty cases appear to have been reported since the lesion was first described by Berry in 1892, which are usually seen on the lateral borders in the anterior two thirds of the tongue, while the ventral surface and the posterior third are rarely involved. Chondromas of the tonsil are of very rare occurrence, which are thought to arise as a result of metaplasia, rather than from embryonic rests, with chronic fibrosing inflammation being the inciting factor. Because of its rarity, the following cases of chondroma of the tongue and tonsil are being added to small list of such case reported in the literature.

Extraskeletal Osteosarcoma of the Sole: A case report.: Ki Ouk Min, Mi Kyung Jee, Seok Jin Kang, Byoung Kee Kim, Sun Moo Kim; Korean J Pathol. 1993;27(3):279-282.

1,611 View
12 Download

Abstract PDF: Compared with osteosarcoma of bone, primary osteosarcoma of the soft tissue is very rare. Extraskeletal osteosarcoma is also a highly malignant pleomorphic sarcoma composed of cells exhibiting primarily osteoblastic, and to a lesser extent, chondroblastic differentiation. A case of extraskeletal osteosarcoma in the right sole is presented in a 67 year old male. The patient had noticed a progressively enlarging soft tissue mass, during about 14 months. This sarcoma was located in the soft tissues without attachment to the skeleton, as determined by examination of the X-Ray findings. The mass of right plantar portion was simply excised and pathologically confirmed to be an extraskeletal osteosarcoma. The clinical and pathological features of this sarcoma are described, and brief review of the literature is made.

Extraskeletal Osteosarcoma: A case Report.: Gi Yeong Huh, Sun Kyung Lee; Korean J Pathol. 1988;22(4):489-494.

1,512 View
12 Download

Abstract PDF: We report a case of extraskeletal osteosarcoma in view of rarity, and a brief review of the literature related to this type of tumor is presented. The patient was a 31-year-old Korean woman, who had noticed a bean-sized hard mass in the right thigh progressively enlarged to become egg-size during about 7 months, followed by pain and tenderness. There was neither recognizable previous lesion nor causable agent about the mass on history taking. Physical examination revealed another palpable mass on the inguinal area. The right thigh and inguinal masses were simply excised and histologically confirmed to be an extraskeletal osteosarcoma and metastatic one, respectively.

Extraskeletal Ewing's Sarcoma.: Gui Ohk Yoon, Hae Kyung Ahn, Ill Hyang Ko; Korean J Pathol. 1988;22(2):195-198.

1,563 View
10 Download

Abstract PDF: A case of extrastkeletal Ewing's sarcoma on lower extremity in a 60-year-old male is reported. Extraskeletal Ewing's sarcoma is a rare malignant neoplasm that shows similar histologic and ultrastructural features to Ewing's sarcoma of bone. Histologically, the neoplasm was composed of small, round to oval cells with scant cytoplasm that were arranged in sheets with large area of necrosis. Electron microscopy of the neoplastic cells revaled scant cytopasm containing glycogen rosettes and a paucity of organelles. There is no ultrastructural evidence to indicate the origin of the cells.

Search