Journal of Pathology and Translational Medicine

Original Articles

Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects: Natalia Hyriavenko, Mykola Lyndin, Kateryna Sikora, Artem Piddubnyi, Ludmila Karpenko, Olha Kravtsova, Dmytrii Hyriavenko, Olena Diachenko, Vladyslav Sikora, Anatolii Romaniuk; J Pathol Transl Med. 2019;53(4):236-243. Published online April 11, 2019; DOI: https://doi.org/10.4132/jptm.2019.03.21

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Background
Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype.
Methods
The study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (estrogen receptor [ER], progesterone receptor [PR]), human epidermal growth factor receptor (HER2)/neu expression, proliferative potential (Ki-67), apoptosis (p53, Bcl-2), and pro-angiogenic (vascular endothelial growth factor) quality of serous tumors were studied in comparison with clinical and morphological characteristics.
Results
ER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (p < .001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (p < .05) and is associated with lymphogenic metastasis (p < .01). p53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (p < .001), and negative Bcl-2 status (p < .05). Positive Bcl-2 status is positively correlated with ER and PR expression and low grade malignancy.
Conclusions
Complex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.

Citations

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Rare non-serous fallopian tube cancers: institutional experience and literature review
Dmitrii Sumtsov, Georgyi Sumtsov, Nataliia Hyriavenko, Mykola Lyndin, Kateryna Sikora, Nataliia Kalashnik, Svitlana Smiian, Igor Gladchuk
Wiener Medizinische Wochenschrift.2024; 174(9-10): 199. CrossRef
UŞAQLIQ BORULARININ BİRİNCİLİ XƏRÇƏNGİ: DİAQNOSTİKASI VƏ MÜALİCƏSİNİN NƏTİCƏLƏRİ
D.G. Sumtsov, G.O. Sumtsov, N.I. Hyriavenko, S.A. Smiian, N.V. Kalashnyk, K.O. Sikora, N.M. Rozhkovska, I.Z. Gladchuk
Azerbaijan Medical Journal.2023; (4): 75. CrossRef
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M. Lytvynenko
Inter Collegas.2021; 8(1): 52. CrossRef
Concurrent Clostridial Enteritis and Oviductal Adenocarcinoma with Carcinomatosis in an Adult Alpaca (Vicugna pacos)
Mandy Womble, Megan E. Schreeg, Allison Hoch, Enoch B. de Souza Meira, Derek Foster, Christopher Premanandan, Tatiane T. Negrão Watanabe
Journal of Comparative Pathology.2021; 189: 52. CrossRef
Problems of primary fallopian tube cancer diagnostics during and after surgery
D.G. Sumtsov, I.Z. Gladchuk, G.O. Sumtsov, N.I. Hyriavenko, M.S. Lyndin, V.V. Sikora, V.M. Zaporozhan
REPRODUCTIVE ENDOCRINOLOGY.2021; (59): 66. CrossRef

Comparison of the Classical Method and SEE-FIM Protocol in Detecting Microscopic Lesions in Fallopian Tubes with Gynecological Lesions: Nermin Koc, Selçuk Ayas, Sevcan Arzu Arinkan; J Pathol Transl Med. 2018;52(1):21-27. Published online August 19, 2016; DOI: https://doi.org/10.4132/jptm.2016.06.17

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Abstract PDF

Background
The objective of this study was to compare the classical method and Sectioning and Extensively Examining the Fimbriated End Protocol (SEE-FIM) in detecting microscopic lesions in fallopian tubes with gynecological lesions. Methods: From a total of 1,118 cases, 582 with various parts of both fallopian tubes sampled in three-ring-shape sections and 536 sampled with the SEE-FIM protocol were included in this study. Pathological findings of cases with endometrial carcinoma, non-uterine pelvic malignant tumor, ovarian borderline tumors, premalignancy, and benign lesions were compared. Results: We detected two tubal infiltrative carcinomas among 40 uterine endometrioid adenocarcinomas, 15 serous tubal intraepithelial carcinomas in 39 non-uterine pelvic serous high-grade carcinoma cases, seven papillary tubal hyperplasias in 13 serous borderline tumor cases, and 11 endometriotic foci and four adenomatoid tumors among all cases sampled with the SEE-FIM protocol. Using the classical method, we detected only one serous tubal intraepithelial carcinoma in 113 non-uterine pelvic serous high-grade carcinoma cases and two papillary tubal hyperplasia cases in 31 serous borderline tumors. We did not identify additional findings in 185 uterine endometrioid carcinoma cases, and neither endometriotic focus nor adenomatoid tumor was shown in other lesions by the classical method. Conclusions: Benign, premalignant, and malignant lesions can possibly be missed using the classical method. The SEE-FIM protocol should be considered especially in cases of endometrial carcinoma, nonuterine pelvic serous cancers, or serous borderline ovarian tumors. For other lesions, at least a detailed examination of the fimbrial end should be undertaken.

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WFUMB Ultrasound Open.2024; 2(1): 100031. CrossRef
ESGO–ESMO–ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease
J.A. Ledermann, X. Matias-Guiu, F. Amant, N. Concin, B. Davidson, C. Fotopoulou, A. González-Martin, C. Gourley, A. Leary, D. Lorusso, S. Banerjee, L. Chiva, D. Cibula, N. Colombo, S. Croce, A.G. Eriksson, C. Falandry, D. Fischerova, P. Harter, F. Joly, C
Annals of Oncology.2024; 35(3): 248. CrossRef
Incidental Serous Tubal Intraepithelial Carcinoma Finding in a Nepalese Patient Undergoing Opportunistic Salpingectomy and the Discovery of a BRCA1 Pathogenic Variant
Kristin M. Tischer, Siddhartha Yadav, Debra Bell, Kathleen Hansen, Larissa N. Veres, Brandon Maddy, Jamie N. Bakkum-Gamez
O&G Open.2024; : 009. CrossRef
Prevention of Ovarian Cancer: Where are We Now and Where are We Going?
Isabel V. Rodriguez, Talayeh Ghezelayagh, Kathryn P. Pennington, Barbara M. Norquist
Current Oncology Reports.2024; 26(11): 1355. CrossRef
Prophylactic Radical Fimbriectomy with Delayed Oophorectomy in Women with a High Risk of Developing an Ovarian Carcinoma: Results of a Prospective National Pilot Study
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Cancers.2023; 15(4): 1141. CrossRef
Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study
Joep M A Bogaerts, Majke H D van Bommel, Rosella P M G Hermens, Miranda P Steenbeek, Joanne A de Hullu, Jeroen A W M van der Laak, Michiel Simons
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Quality of life after risk-reducing surgery for breast and ovarian cancer prevention: a systematic review and meta-analysis
Xia Wei, Samuel Oxley, Michail Sideris, Ashwin Kalra, Adam Brentnall, Li Sun, Li Yang, Rosa Legood, Ranjit Manchanda
American Journal of Obstetrics and Gynecology.2023; 229(4): 388. CrossRef
Adherence to risk-reducing salpingo-oophorectomy guidelines among gynecologic oncologists compared to general gynecologists
Pegah Blustein, Sarah R. Werner, Pooja Uppalapati, Tung Ming Leung, Gregg A. Husk, Elena B. Pereira, Jill S. Whyte, Jeannine A. Villella
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Intraluminal tumor cells and prognostic accuracy of endometrial cancer stage criteria: A multi-institution study
Ashley S. Felix, Jennifer A. Sinnott, David E. Cohn, Máire A. Duggan, Laura J. Havrilesky, Alexander B. Olawaiye, Andrea Mariani, Monica Rodriquez, Mary Anne Brett, Giorgia Dinoi, Caitlin E. Meade, Bobbie Hall, Ester Goldfeld, Esther Elishaev, Mark E. She
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Joep M. A. Bogaerts, Miranda P. Steenbeek, Majke H. D. van Bommel, Johan Bulten, Jeroen A. W. M. van der Laak, Joanne A. de Hullu, Michiel Simons
Virchows Archiv.2022; 480(4): 725. CrossRef
Magnetic resonance imaging findings of extrauterine high-grade serous carcinoma based on new pathologic criteria for primary site assignment
Masaya Kawaguchi, Hiroki Kato, Yuichiro Hatano, Hiroyuki Tomita, Akira Hara, Tatsuhiko Miyazaki, Masayuki Matsuo
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Histomorphological Spectrum of Incidentally Detected Fallopian Tube Lesions in Patients Operated for Various Clinical Conditions and Detection of Precursor Lesion by Applying Sectioning and Extensively Examining the Fimbriated End Sampling Protocol
Neha Singh, Ipsita Dhal, Aneesha Mohanpuria, Swati Saxena
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Case Study

Fallopian Metaplastic Papillary Tumour: An Atypical Transdifferentiation of the Tubal Epithelium?: Miguel Fdo. Salazar, Isaías Estrada Moscoso, Lorena Troncoso Vázquez, Nubia Leticia López García, Paola Andrea Escalante Abril; J Pathol Transl Med. 2015;49(2):148-155. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.15

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Abstract PDF

A metaplastic papillary tumor of the Fallopian tube is an extremely uncommon condition, with odd and confusing features that make it difficult to categorize as benign or borderline. Here, we summarize all the published cases to date and document the case of a 41-year-old woman diagnosed with this alteration after her last childbirth and ensuing tubal ligation. One of the tubes was bulky and filled with a caramel-like substance encircling a blurry spot. Light microscopy detailed a slender stalk covered by eosinophilic, columnar plump cells, showing atypical nuclei and focal budding. Mitotic figures were absent. The immunohistochemistry panel was positive for pan-cytokeratin, epithelial membrane antigen, cyclin D1, and hormone receptors. Additionally, a proliferation index of less than 5% was rated using Ki-67. The true nature of this tumor (reactive vs neoplastic) is uncertain. Nonetheless, its association with pregnancy suggests an adaptive change, likely similar to the atypical transdifferentiation proposed for Arias-Stella reaction.

Citations

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Ungewöhnliche Proliferation des Eileiters
Angelina Vlaški, Vanessa Neukunft, Andrea Maria Gassel, Frederick Klauschen, Doris Mayr
Die Pathologie.2024;[Epub] CrossRef
Fallopian tube papilloma
Shashank Mishra, Prerna Guleria
Indian Journal of Pathology and Microbiology.2021; 64(3): 608. CrossRef
Metaplastic papillary tumour of the fallopian tube, a rare entity, analysed by next‐generation sequencing
Sandra Sunitsch, Julia Reisinger, Luca Abete, Karl Kashofer, Peter Regitnig
Histopathology.2020; 76(6): 923. CrossRef

Case Reports

Mature Cystic Teratoma of the Fallopian Tube: A Brief Case Report.: Woo Jung Sung, Jun Mo Kim, Mi Jin Kim; Korean J Pathol. 2011;45(3):303-305.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.303

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Abstract PDF

Mature cystic teratomas of the fallopian tube are unusual, being almost incidentally identified. Here we describe a case of mature cystic teratoma arising in the fallopian tube, in a 44-year-old female. The mass was found during a regular checkup without complication. Microscopically, components from each germ layer were identified.

Citations

Citations to this article as recorded by

Mature Cystic Teratoma of the Fallopian Tube in a Postmenopausal Woman: A Case Report and Review of the Literature
Mustafa Erkan Sari, Ozhan Ozdemir, Pinar Kadirogullari, Funda Arpaci Ertugrul, Cemal Resat Atalay
Case Reports in Obstetrics and Gynecology.2015; 2015: 1. CrossRef

Mature Cystic Teratoma of the Fallopian Tube: A case report.: Kye Weon Kwon, Jong Yup Bae, Hee Jung Ahn, Yoon Jung Ahn, Bok Soo Kim; Korean J Pathol. 1996;30(10):951-953.

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Abstract PDF: Teratomas of the fallopian tube are extremely rare, and only about 50 cases have reported in the world literature. Most cases of mature cystic tubal teratoma are asymptomatic and are discovered as an incidental finding on physical or radiologic examination, or at the time of laparatomy. We report a case of mature cystic teratoma of the right fallopian tube which was discovered during pelvic ultrasonogram for antenatal care in a 28 year old woman. Right salpingectomy was performed during cesarean section for cephalo-pelvic distortion at IUP 39 weeks. Gross examination of the right fallopian tube reveals a distended fallopian tube, measuring 8cm in length and 2cm in diameter. On section, it is filled with several small pedunculated nodules and cysts containing sebaceous materials. Microscopically the tumor was seen in continuity with the lining epithelium of mucosal folds. The majority of the tumor was composed of well differentiated mature elements of three germ layers with skin and skin appendages, mature brain tissue, bone, breast tissue, intestinal mucosa and bronchial epithelium.

Prolapse of Fallopian Tube into Vaginal Vault after Hysterectomy: A case report.: Yi Kyeong Chun, Hy Sook Kim; Korean J Pathol. 1998;32(6):474-475.

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Abstract: The prolapse of a fallopian tube into the vagina is a rare complication of hysterectomy. We recently experienced a case of tubal prolapse after a laparoscopic hysterectomy in a 44-year-old woman. The vaginal examination showed a polypoid mass in the vaginal apex. Microscopically, the mass had the typical appearance of a fallopian tube with chronic inflammation. The cytologic finding of a vaginal vault smear was also described.

Malignant Mixed Mullerian Tumor of Fallopian Tube with Multiple Distinct Heterologous Components.: Beom Jin Lim, Jae Wook Kim, Woo Ick Yang, Nam Hoon Cho; Korean J Pathol. 2003;37(6):429-431.

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Abstract PDF: We experienced a case of primary malignant mixed mullerian tumors (MMMT) of the fallopian tube of FIGO stage I. In addition to endometrioid adenocarcinomas, multiple apparent heterologous elements encompassing myxoid chondrosarcoma, osteosarcoma, myxoid liposarcoma and well differentiated angiosarcoma were recognized as separate nodules. These findings have not been described previously in MMMTs of the female genital tract.

Benign Teratomas of the Fallopian Tubes: A report of two cases.: Hee Na Kim, Mi Kyung Jee, Ki Hwa Yang, Seok Jin Gang, Eun Joo Seo, Byung Kee Kim, Sun Moo Kim; Korean J Pathol. 1989;23(3):374-378.

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Abstract PDF: Teratomas of the fallopian tubes are very rarely encountered in the western literature, and not a single case has been documented in Korea. The authors experienced two cases of tubal teratomas. Both patients developed a teratoma in an ampullary portion of the right fallopian tubes. One case occured as an incidental finding, and the other case was presented with a tubal mass. The gross and light microscopic features of these teratomas were described, and a brief review of the literature on the tubal teratomas is made.

Malignant Mixed Mullerian Tumor of the Fallopian Tube: Report of a Case.: Eun Deok Chang, Young Hee Jee, Sun Moo Kim; Korean J Pathol. 1988;22(1):92-96.

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Abstract PDF: Malignant mixed mullerian tumor of the fallopian tube is an extremely rare neoplasm. To date, only 26 cases of primary malignant mixed mullerian tumor of the fallopian tube have been reported, and no report has been published in Korea. This is not surprising, since as a group these meoplasms are least likely to occur in the fallopian tube; the most common sites being the endometrium, vagina, cervix and ovary. We report a case of malignant mixed mullerian tumor of the fallopian tube ina 63-year-old woman with brief review of the literatures.

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