Journal of Pathology and Translational Medicine

Review

Ménétrier’s Disease: Its Mimickers and Pathogenesis: Won Jae Huh, Robert J. Coffey, Mary Kay Washington; J Pathol Transl Med. 2016;50(1):10-16. Published online December 18, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.15

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Ménétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier’s disease and the role of EGFR signaling in Ménétrier’s disease.

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Case Report

Multiple Localized Hyperplastic Gastropathy: Report of A Case with A Special Reference to its Growth Pattern.: Jung Ran Kim, Yong Il Kim; Korean J Pathol. 1989;23(1):154-159.

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Abstract PDF: We present a case of localized mucosal hyperplasia of the stomach. The resected stomach contained four large, short stalked polyps, three of which were located in the anterior wall of body and the other in the posterior wall. In addition, numerous small sessile polyps were also scattered in the anterior and posterior fundic walls. Microscopically, the abnormally thick mucosa, carrying with it the muscularis mucosae and a thin core of loose fibrous tissue comprised the polyps by intraluminal infolding of widening of mucosal area. Abundant vasculature of the rugal pattern was prominent in the submucosa. The above findings suggest that the histogenesis of the polyps is related to both hyperplastic thickening and widening of mucosal areas in rugal pattern in the background of inverted distribution pattern of intestinal metaplasia.

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