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Original Article
- Prognostic Significance of a Micropapillary Pattern in Pure Mucinous Carcinoma of the Breast: Comparative Analysis with Micropapillary Carcinoma
- Hyun-Jung Kim, Kyeongmee Park, Jung Yeon Kim, Guhyun Kang, Geumhee Gwak, Inseok Park
- J Pathol Transl Med. 2017;51(4):403-409. Published online June 9, 2017
- DOI: https://doi.org/10.4132/jptm.2017.03.18
- 6,944 View
- 198 Download
- 17 Web of Science
- 18 Crossref
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Abstract
PDF - Background
Mucinous carcinoma of the breast is an indolent tumors with a favorable prognosis; however, micropapillary features tend to lead to aggressive behavior. Thus, mucinous carcinoma and micropapillary carcinoma exhibit contrasting biologic behaviors. Here, we review invasive mucinous carcinoma with a focus on micropapillary features and correlations with clinicopathological factors.
Methods
A total of 64 patients with invasive breast cancer with mucinous or micropapillary features were enrolled in the study. Of 36 pure mucinous carcinomas, 17 (47.2%) had micropapillary features and were termed mucinous carcinoma with micropapillary features (MUMPC), and 19 (52.8%) had no micropapillary features and were termed mucinous carcinoma without micropapillary features. MUMPC were compared with 15 invasive micropapillary carcinomas (IMPC) and 13 invasive ductal and micropapillary carcinomas (IDMPC).
Results
The clinicopathological factors of pure mucinous carcinoma and MUMPC were not significantly different. In contrast to IMPC and IDMPC, MUMPC had a low nuclear grade, lower mitotic rate, higher expression of hormone receptors, negative human epidermal growth factor receptor 2 (HER2) status, lower Ki-67 proliferating index, and less frequent lymph node metastasis (p < .05). According to univariate analyses, progesterone receptor, HER2, T-stage, and lymph node metastasis were significant risk factors for overall survival; however, only T-stage remained significant in a multivariate analysis (p < .05).
Conclusions
In contrast to IMPC and IDMPC, the micropapillary pattern in mucinous carcinoma does not contribute to aggressive behavior. However, further analysis of a larger series of patients is required to clarify the prognostic significance of micropapillary patterns in mucinous carcinoma of the breast. -
Citations
Citations to this article as recorded by
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Clinical Case Reports.2024;[Epub] CrossRef - Clinicopathological features and prognosis of mucinous breast carcinoma with a micropapillary structure
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Thoracic Cancer.2024;[Epub] CrossRef - Expression of autocrine motility factor receptor (AMFR) in human breast and lung invasive micropapillary carcinomas
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International Journal of Experimental Pathology.2023; 104(1): 43. CrossRef - The Spectrum of Mucinous Lesions of the Breast
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Breast Cancer: Targets and Therapy.2022; Volume 14: 41. CrossRef - Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
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Kosin Medical Journal.2022; 37(3): 176. CrossRef - Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy
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Archives of Pathology & Laboratory Medicine.2021; 145(6): 728. CrossRef - HER2 positive mucinous carcinoma of breast with micropapillary features: Report of a case and review of literature
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Human Pathology: Case Reports.2021; 25: 200531. CrossRef - Sonographic Features of Pure Mucinous Breast Carcinoma With Micropapillary Pattern
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Frontiers in Oncology.2021;[Epub] CrossRef - Clinicopathologic characteristics of HER2-positive pure mucinous carcinoma of the breast
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Journal of Pathology and Translational Medicine.2020; 54(1): 95. CrossRef - Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast
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Modern Pathology.2020; 33(10): 1945. CrossRef - Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?
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Histopathology.2019; 74(2): 248. CrossRef - An Update of Mucinous Lesions of the Breast
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Surgical Pathology Clinics.2018; 11(1): 61. CrossRef - The clinicopathological significance of micropapillary pattern in colorectal cancers
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Human Pathology.2018; 77: 159. CrossRef - The sonographic findings of micropapillary pattern in pure mucinous carcinoma of the breast
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World Journal of Surgical Oncology.2018;[Epub] CrossRef - Diagnostic dilemma of micropapillary variant of mucinous breast cancer
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BMJ Case Reports.2018; : bcr-2018-225775. CrossRef
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