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Original Article
Ultrastructural Changes in Rat Kidney after Lead Acetate Administration.
Hyun Chul Kim, Seung Pil Kim, Kwan Kyu Park
Korean J Pathol. 1996;30(2):73-88.
  • 1,588 View
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AbstractAbstract PDF
This study was carried out to investigate the ultrastructural findings of rats after administration of 0.5% lead acetate with drinking water. The Sprague-Dawley rats were divided into control and experimental groups. The control group was composed of 12 rats and was orally administered with 0.5% sodium acetate. The experimental group was composed of 36 rats and orally administered with 0.5% lead acetate. Two rats in the control group and four rats in the experimental group were sacrificed on day 2, and week 1, 2, 4, 6 and 8 after administration. The kidney was extirpated and examined by electron microscopy. The results obtained were as follows: The blood lead concentration in the experimental group began to increase from the second day after administration and it increased gradually until the 6th week and it decreased at the 8 week. The urinary excretion of delta-ALA also increased from the secondary and gradually increased up to the 8th week. On electron microscopic examination, the proximal tubular cells showed fat droplets, dilatation of the endoplasmic reticulum, mitochondrial swelling, increased numbers of secondary lysosomes and myelin figure-like residual bodies and intranuclear inclusion bodies. All these findings peaked at the eighth week after administration. Ultrastructural findings after Timm sulphide silver reaction revealed the lead granules in the proximal tubular lumen and between the microvilli of the proximal tubular cells without membrane-bounded. It can be concluded that most of the changes of micro-organelles are compatible with degenerative changes of lead exposure and passive diffusion of lead granules are involved in the proximal tubular cells.
Case Report
Hybrid Cyst Coexisting with Glomus Coccygeum.
Hyun Soo Kim, Gou Young Kim, Sung Jig Lim, Youn Wha Kim
Korean J Pathol. 2008;42(5):323-326.
  • 1,570 View
  • 13 Download
AbstractAbstract PDF
A 36-year-old female patient with a mass in the coccygeal region underwent surgical removal of the mass, and this revealed a hybrid cyst in coexistence with a glomus coccygeum. This unusual cutaneous cyst had an epithelial lining composed of keratinizing, stratified squamous epithelium with an intact granular layer immediately adjacent to apocrine cells, and the apocrine cells showed the characteristic features of "decapitation secretion". The glomus coccygeum, which is a minor finding in specimens from the sacral area and it may represent a diagnostic challenge to the unaware observer, was incidentally identified in the dermis. The glomus coccygeum was located beneath the epithelial transition area of the hybrid cyst. Immunohistochemical analysis revealed that the cytoplasm of the epithelioid glomus cells was positive for smooth muscle actin, and these epithelioid glomus cells were arranged in concentric layers around blood vessels, and the cellular stroma surrounding the glomus bodies were positive for S-100 protein.
Original Article
Expression Patterns of Tumor Related Proteins for Differential Diagnoses of Intrahepatic Adenocarcinomas.
Ghil Suk Yoon, Mi Sung Kim, Young Hwa Li, Ji Hyun Uhm, Sun Ju Kim, Tae Sook Kim, In Su Suh, Han Ik Bae
Korean J Pathol. 2005;39(4):229-235.
  • 1,679 View
  • 15 Download
AbstractAbstract PDF
Background
: Differential diagnoses of intrahepatic adenocarcinomas (IHAC) play an important role in the detecting primary sites and the determining type of treatment and overall prognosis of the patient. However, histopathologic findings alone have limitations of differential diagnoses of IHAC. Methods : To clarify which tumor related proteins (TRP) are useful for differential diagnoses of IHAC, TRP expression were investigated immunohistochemically, using MUC5AC, MUC2, mAb 91.9H, MUC1, and pS2, and by high iron diamine (HID) staining in 61 clinically confirmed IHACs. Results : MUC5AC (9/18, p<0.05) and MUC1 (17/18, p>0.05) displayed the most frequent expression in cholangiocarcinomas, and MUC2 (11/18, p<0.05), mAb 91.9H (16/18, p<0.05), and HID (16/18, p<0.05) in colorectal adenocarcinomas. pS2 (3/11, p>0.05) was expressed more often in pancreatic adenocarcinomas than other IHAC, while MUC2 and 91.9H were not expressed at all in pancreatic adenocarcinomas. The positivity of several TRP did not correlate with tumor differentiation. Conclusions : MUC5AC, MUC2, mAb 91.9H, and HID may be useful in differentiating cholangiocarcinomas from colorectal adenocarcinomas.

J Pathol Transl Med : Journal of Pathology and Translational Medicine
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