Journal of Pathology and Translational Medicine

Original Article

Mesothelin Expression in Gastric Adenocarcinoma and Its Relation to Clinical Outcomes: Song-Hee Han, Mee Joo, Hanseong Kim, Sunhee Chang; J Pathol Transl Med. 2017;51(2):122-128. Published online February 15, 2017; DOI: https://doi.org/10.4132/jptm.2016.11.18

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Background
Although surgical resection with chemotherapy is considered effective for patients with advanced gastric cancer, it remains the third leading cause of cancer-related death in South Korea. Several studies have reported that mesothelial markers including mesothelin, calretinin, and Wilms tumor protein 1 (WT1) were positive in variable carcinomas, associated with prognosis, and were evaluated as potential markers for targeted therapy. The aim of this study was to assess the immunohistochemical expression of mesothelial markers (mesothelin, calretinin, and WT1) in gastric adenocarcinoma and their relations to clinocopathological features and prognosis. Methods: We evaluated calretinin, WT1, and mesothelin expression by immunohistochemical staining in 117 gastric adenocarcinomas. Results: Mesothelin was positively stained in 30 cases (25.6%). Mesothelin expression was related to increased depth of invasion (p = .002), lymph node metastasis (p = .013), and presence of lymphovascular (p = .015) and perineural invasion (p = .004). Patients with mesothelin expression had significantly worse disease-free survival rate compared with that of nonmesothelin expression group (p = .024). Univariate analysis showed that mesothelin expression is related to short-term survival. None of the 117 gastric adenocarcinomas stained for calretinin or WT1. Conclusions: Mesothelin expression was associated with poor prognosis. Our results suggest that mesothelin-targeted therapy should be considered as an important therapeutic alternative for gastric adenocarcinoma patients with mesothelin expression.

Citations

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Targeting Mesothelin in Solid Tumours: Anti-mesothelin Antibody and Drug Conjugates
Quincy Chu
Current Oncology Reports.2023; 25(4): 309. CrossRef
High expression of mesothelin in plasma and tissue is associated with poor prognosis and promotes invasion and metastasis in gastric cancer
Suryendu Saha, Chitranjan Mukherjee, Dipjit Basak, Prasun Panja, Pronoy Kanti Mondal, Ranajoy Ghosh, Aniket Halder, Abhijit Chowdhury, Gopal Krishna Dhali, Bitan Kumar Chattopadhyay, Saurabh Ghosh, Somsubhra Nath, Shalini Datta
Advances in Cancer Biology - Metastasis.2023; 7: 100098. CrossRef
Novel Anti-Mesothelin Nanobodies and Recombinant Immunotoxins with Pseudomonas Exotoxin Catalytic Domain for Cancer Therapeutics
Minh Quan Nguyen, Do Hyung Kim, Hye Ji Shim, Huynh Kim Khanh Ta, Thi Luong Vu, Thi Kieu Oanh Nguyen, Jung Chae Lim, Han Choe
Molecules and Cells.2023; 46(12): 764. CrossRef
Immunotherapy for lung cancer: Focusing on chimeric antigen receptor (CAR)-T cell therapy
Tongqing Xue, Xiang Zhao, Kun Zhao, Yan Lu, Juan Yao, Xianguo Ji
Current Problems in Cancer.2022; 46(1): 100791. CrossRef
Cellular Immunotherapy in Gastric Cancer: Adoptive Cell Therapy and Dendritic Cell-Based Vaccination
Elnaz Faghfuri, Mahdi Abdoli Shadbad, Amir Hossein Faghfouri, Narges Soozangar
Immunotherapy.2022; 14(6): 475. CrossRef
Mesothelin Expression in Human Tumors: A Tissue Microarray Study on 12,679 Tumors
Sören Weidemann, Pauline Gagelmann, Natalia Gorbokon, Maximilian Lennartz, Anne Menz, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Niclas C. Blessin, Christoph Fraune, Katharina Möller, Christian Bernreuther, Patrick Lebok, Till S. Clauditz, Frank
Biomedicines.2021; 9(4): 397. CrossRef
Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment
Tyvette S. Hilliard, Brooke Kowalski, Kyle Iwamoto, Elizabeth A. Agadi, Yueying Liu, Jing Yang, Marwa Asem, Yuliya Klymenko, Jeff Johnson, Zonggao Shi, Gifty Marfowaa, Madeleine G. Yemc, Phillip Petrasko, M. Sharon Stack
International Journal of Molecular Sciences.2021; 22(22): 12443. CrossRef
CAR-T Cell Therapy—An Overview of Targets in Gastric Cancer
Dominika Bębnowska, Ewelina Grywalska, Paulina Niedźwiedzka-Rystwej, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Marcin Pasiarski, Stanisław Góźdź, Jacek Roliński, Wojciech Polkowski
Journal of Clinical Medicine.2020; 9(6): 1894. CrossRef
Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors
Brendan L. Hagerty, Guillaume J. Pegna, Jian Xu, Chin-Hsien Tai, Christine Alewine
Biomolecules.2020; 10(7): 973. CrossRef
Phase I/II clinical trial of a Wilms’ tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer
Wen Zhang, Xu Lu, Peilin Cui, Chunmei Piao, Man Xiao, Xuesong Liu, Yue Wang, Xuan Wu, Jingwei Liu, Lin Yang
Cancer Immunology, Immunotherapy.2019; 68(1): 121. CrossRef
Mesothelin as a target for cervical cancer therapy
Korinna Jöhrens, Lea Lazzerini, Jana Barinoff, Jalid Sehouli, Guenter Cichon
Archives of Gynecology and Obstetrics.2019; 299(1): 211. CrossRef
A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer
Qiujin Shen, Karol Polom, Coralie Williams, Felipe Marques Souza de Oliveira, Mariana Guergova-Kuras, Frederique Lisacek, Niclas G. Karlsson, Franco Roviello, Masood Kamali-Moghaddam
eBioMedicine.2019; 44: 322. CrossRef
Mesothelin as a biomarker for targeted therapy
Jiang Lv, Peng Li
Biomarker Research.2019;[Epub] CrossRef
Antibody drug conjugates under investigation in phase I and phase II clinical trials for gastrointestinal cancer
Alexis D. Leal, Anuradha Krishnamurthy, Lia Head, Wells A. Messersmith
Expert Opinion on Investigational Drugs.2018; 27(11): 901. CrossRef
Mesothelin‑targeted second generation CAR‑T cells inhibit growth of mesothelin‑expressing tumors in�vivo
Lin Ye, Yuqing Lou, Liming Lu, Xiaohong Fan
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef

Case Reports

Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report: Sunhee Chang, Mee Joo, Hanseong Kim; Korean J Pathol. 2012;46(3):302-305. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.302

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Abstract PDF

Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear : cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE.

Citations

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Coexistence of intrathyroid thymic carcinoma and papillary thyroid carcinoma: a case report and literature review
Maryam Vajihinejad, Ali Ataei, Mohammad Pashmchi, Ali Aledavoud, Vahid Zand, Mohammad Ali Broomand, Mohammad Mohammadi, Niloofar Zare Reshkuiyeh
Frontiers in Oncology.2024;[Epub] CrossRef
Intrathyroidal Thymic Carcinoma: A Retrospective Case Series Study
Jinhui Liang, Mei Huang, Helang Huang, Li Li, Hailin Luo, Weidong Mao, Shan Gao, Haoxiang Xu
Ear, Nose & Throat Journal.2023; 102(9): 584. CrossRef
Carcinoma showing thymus‐like differentiation of the parotid gland: The brief report of cytomorphology and review of the literature
Tomoko Uchiyama, Chiyoko Terada, Yuma Tachibana, Hirokazu Nishiura, Maiko Takeda, Tomomi Fujii, Takahiro Kimura, Masahiro Tsutsumi, Chiho Ohbayashi
Diagnostic Cytopathology.2023;[Epub] CrossRef
A case of concurrent occurrence of carcinoma showing thymus-like differentiation and follicular variant of papillary thyroid cancer in the same thyroid
Takahito Kimura, Keisuke Enomoto, Masamitsu Kono, Masanobu Hiraoka, Saori Takeda, Naoko Kumashiro, Shun Hirayama, Eri Kimura, Shunji Tamagawa, Makiko Ohtani, Shin-Ichi Murata, Muneki Hotomi
Journal of Surgical Case Reports.2022;[Epub] CrossRef
Ultrasonographic Features of Intrathyroidal Thymic Carcinoma: Review and Analysis of 10 Cases
Wang, MD Yanhai, Yang, MD Hua, Liu, MD Hanqing, Luo, MD Xiaoli, Liu, BS Luying, Zhou, BS Pingting
ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY.2022; 6(2): 58. CrossRef
Thyroid carcinoma with thymus-like differentiation (CASTLE) tumor: а сase report
A. A. Ilyin, V. V. Polkin, P. A. Isaev, F. E. Sevrukov, N. Yu. Dvinskych, M. I. Ryzhenkova, S. A. Ivanov, A. D. Kaprin
Head and Neck Tumors (HNT).2021; 11(2): 64. CrossRef
Metastatic Renal Cell Neoplasm Within a Papillary Thyroid Carcinoma as Incidental Finding in an Asymptomatic Patient: a Case Report
Maria-Rosa Bella-Cueto, Mireia Pascua-Solé, Albert Cano-Palomares, M. Àngels Cabezuelo-Hernandez, Maria-Rosa Escoda-Giralt, Santiago Barcons-Vilaplana, Paula Serret-Miralles, Carmen Caral-Vanaclocha, Xavier Guirao-Garriga, Joan Prats-Lopez, Meritxell Meda
SN Comprehensive Clinical Medicine.2020; 2(7): 978. CrossRef
Intrathyroidal thymic carcinoma exhibiting neuroendocrine differentiation: Case report with cytomorphology, immunocytochemistry, and review of the literature focusing on cytology
Wen‐hao Ren, Kun Dong, Xiao‐zheng Huang, Yan‐li Zhu
Diagnostic Cytopathology.2019; 47(11): 1197. CrossRef
Management and Prognostic Factors for Thyroid Carcinoma Showing Thymus-Like Elements (CASTLE): A Case Series Study
Rui Gao, Xi Jia, Ting Ji, Jinteng Feng, Aimin Yang, Guangjian Zhang
Frontiers in Oncology.2018;[Epub] CrossRef
Multiple squamous cells in thyroid fine needle aspiration: Friends or foes?
Heather Gage, Elizabeth Hubbard, Laurentia Nodit
Diagnostic Cytopathology.2016; 44(8): 676. CrossRef
Clinical analysis of 82 cases of carcinoma showing thymus-like differentiation of the thyroid
WEI GE, YONG-ZHONG YAO, GANG CHEN, YI-TAO DING
Oncology Letters.2016; 11(2): 1321. CrossRef
Carcinoma Showing Thymus-Like Differentiation (CASTLE): Cytopathological Features and Differential Diagnosis
Jennifer A. Collins, Bo Ping, Justin A. Bishop, Syed Z. Ali
Acta Cytologica.2016; 60(5): 421. CrossRef
Carcinoma Showing Thymus-Like Elements of the Thyroid Gland: Report of Three Cases Including One Case with Breast Cancer History
Guanjun Zhang, Xi Liu, Wei Huang, Xiaofeng Li, Marianne Johnstone, Yuan Deng, Yongqiang Ke, Quentin M. Nunes, Hongyan Wang, Yili Wang, Xuebin Zhang
Pathology & Oncology Research.2015; 21(1): 45. CrossRef
Potential Role of Adjuvant Radiation Therapy in Cervical Thymic Neoplasm Involving Thyroid Gland or Neck
Jae Myoung Noh, Sang Yun Ha, Yong Chan Ahn, Dongryul Oh, Seung Won Seol, Young Lyun Oh, Joungho Han
Cancer Research and Treatment.2014; 47(3): 436. CrossRef

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma: A Case Report.: Sunhee Chang, Sang Hwa Shim, Mee Joo, Hanseong Kim, Yong Kyu Kim; Korean J Pathol. 2010;44(1):97-100.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.97

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9 Crossref

Abstract PDF

An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analogous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We describe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partially filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.

Citations

Citations to this article as recorded by

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid
Ji Eon Kang, Sung Eun Kim, Suk-Woo Yang
Journal of the Korean Ophthalmological Society.2023; 64(2): 149. CrossRef
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis
Michael H. Froehlich, Keith R. Conti, Ivy I. Norris, Jordan J. Allensworth, Nicole A. Ufkes, Shaun A. Nguyen, Evelyn T. Bruner, Joel Cook, Terry A. Day
Journal of Dermatological Treatment.2022; 33(4): 2182. CrossRef
Next-generation sequencing analysis suggests varied multistep mutational pathogenesis for endocrine mucin-producing sweat gland carcinoma with comments on INSM1 and MUC2 suggesting a conjunctival origin
Joseph G. Mathew, Anita S. Bowman, Jad Saab, Klaus J. Busam, Kishwer Nehal, Melissa Pulitzer
Journal of the American Academy of Dermatology.2022; 86(5): 1072. CrossRef
Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature
Rebecca Tian Mei Au, Manish M. Bundele
Journal of Cutaneous Pathology.2021; 48(9): 1156. CrossRef
An Update on Endocrine Mucin-producing Sweat Gland Carcinoma
Meghana Agni, Meisha L. Raven, Randy C. Bowen, Nora V. Laver, Patricia Chevez-Barrios, Tatyana Milman, Charles G. Eberhart, Steven Couch, Daniel D. Bennett, Daniel M. Albert, R. Nick Hogan, Paul O. Phelps, Hillary Stiefel, Norberto Mancera, Martin Hyrcza,
American Journal of Surgical Pathology.2020; 44(8): 1005. CrossRef
A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma: Is it Still an Under-Recognized Entity?
Khaled A. Murshed, Mohamed Ben-Gashir
Case Reports in Dermatology.2020; 12(3): 255. CrossRef
Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge
Mary Anne Brett, Samih Salama, Gabriella Gohla, Salem Alowami
Case Reports in Pathology.2017; 2017: 1. CrossRef
Endocrine mucin‐producing sweat gland carcinoma occurring on extra‐facial site: a case report
Jia‐Huei Tsai, Tzu‐Lin Hsiao, Yi‐Ying Chen, Cheng‐Hsiang Hsiao, Jau‐Yu Liau
Journal of Cutaneous Pathology.2014; 41(6): 544. CrossRef
Endocrine Mucin-Producing Sweat Gland Carcinoma
Catharine A. Dhaliwal, Antonia Torgersen, Jonathan J. Ross, James W. Ironside, Asok Biswas
The American Journal of Dermatopathology.2013; 35(1): 117. CrossRef

Original Article

Cytologic Findings of Fine Needle Aspiration Biopsy of 23 Schwannomas.: Sunhee Chang, Mee Joo, Hanseong Kim; Korean J Cytopathol. 2008;19(1):41-46.; DOI: https://doi.org/10.3338/kjc.2008.19.1.41

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Abstract PDF

In an attempt to better define the cytologic characteristics of schwannomas, we have reviewed aspirates and corresponding histologic sections from 23 schwannomas. Of this number, the original cytologic diagnoses were: schwannoma in 14 cases (61%), benign soft tissue tumor in 2 cases (9%), and insufficient specimen in 7 cases (30%). The cytologic findings common to all cases of schwannoma included fragments of tightly cohesive fascicles with variable cellularity and corresponding Antoni type A area. The Antoni type B area, consisting of scattered spindle cells and some histiocytes and lymphocytes against a myxoid background, was seen in 14 cases. Fibrillary stroma was seen in 12 cases. The tumor cells had spindle- or oval-shaped nuclei, with pointed ends and indistinct cell borders. Nuclear palisading was seen in 10 cases, and distinctive Verocay bodies were seen in 5 cases. In ancient schwannomas, there were no Verocay bodies. Most schwannomas have distinct cytomorphologic features that allow correct diagnosis. The major problem with fine needle aspiration cytology of these tumors is the high frequency of poor cellularity, particularly in lesions with cystic degeneration. Of 7 cases with insufficient specimen, 4 showed marked cystic changes and 1 showed marked hyaline changes on histologic sections. In conclusion, we believe that if cytopathologist reminds the situation such as cystic degeneration or hyaline degeneration, the correct diagnosis of the schwannoma will be easily made.

Citations

Citations to this article as recorded by

Multiple Cervical Schwannomas Mimicking Metastatic Lymph Nodes from Papillary Thyroid Cancer
Ji-Sun Kim, Chang-Young Yoo, Rae-Hyung Kim, Jung-Hae Cho
Journal of Korean Thyroid Association.2014; 7(1): 102. CrossRef

Case Reports

A Diagnostically Challenging Case of an Infarcted Adenomatoid Tumor of the Epididymis.: Sunhee Chang, Sang Hwa Shim, Ji Eun Kwak, Mee Joo, Hanseong Kim, Je G Chi, Keon cheol Lee; Korean J Pathol. 2008;42(4):229-231.

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Abstract PDF: We describe a case of an infarcted adenomatoid tumor of the epididymis that was challenging to diagnose. A 20-year-old man presented with acute left scrotal pain. He was found to have a 2x1.5x1 cm tumor that was relatively well circumscribed on gross examination. There was a central necrotic area that exhibited gaping spaces and ghost outlines of epithelial cells. The periphery of the necrotic lesion showed focally viable adenomatoid tumor. The majority of the tissue adjacent to the necrosis consisted of granulation tissue, fibroblastic and myofibroblastic proliferation, and neutrophils. The fibroblasts and myofibroblasts showed plump nuclei, often with small nucleoli. No mitotic activity was present. The differential diagnosis for an infarcted adenomatoid tumor includes malignant mesothelioma, inflammatory myofibroblastic tumor, and inflammatory conditions. The key to diagnosing an infarcted adenomatoid tumor is to consider it in the differential diagnosis of any spindle cell tumor with necrosis occurring in the genital tract.

Fibrovascular Polyp of the Hypopharynx: A Case Report.: Sunhee Chang, Sang Hwa Shim, Ji Eun Kwak, Mee Joo, Hanseong Kim, Bum Jo Jung, Joong Wook Shin, See Young Park, Kyung Ja Cho, Je G Chi; Korean J Pathol. 2008;42(4):226-228.

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Abstract PDF: We report here on a case of fibrovascular polyp arising in the hypopharynx of a 62-year-old man. Laryngomicroscopic surgery with laser ablation was performed to excise the mass. Histopathologically, the surface of the polyp was covered with mature squamous epithelium. The polyp showed a characteristic lobular proliferation of mature adipose tissue that was separated by myxoid or collagenous connective tissue. Some scattered skeletal muscle bundles were seen in the central portions of the polyp and these bundles were surrounded by a concentric proliferation of the spindle cells; this was reminiscent of Pacinian corpuscles. Regarding their location and the intermingled pattern of proliferating tissues, it is more plausible that the skeletal muscle is a hamartomatous component rather than entrapped, preexisting tissue.

A Case Report of Cutaneous Coccidioidomycosis.: Sunhee Chang, Sang Hwa Shim, Ji Eun Kwak, Mee Joo, Hanseong Kim, Hai Jin Park, Yee Gyung Kwak, Je G Chi; Korean J Pathol. 2008;42(4):223-225.

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Abstract PDF: Coccidioidomycosis, which results from inhaling the spores of Coccidioides species, is endemic in the southwestern United States. The primary infection site is the lung, and dissemination of the disease can occur. We report a case of cutaneous coccidioidomycosis in a 79-year-old Korean woman who presented with purpura on both lower extremities, but no pulmonary symptoms and no history of visiting an endemic area. Microscopically, skin biopsy showed multiple aggregates of granulomas in the dermis. Numerous multinucleated giant cells were associated with the granulomas. Mature and immature fungal spherules, which were 20 to 30 micrometer in diameter, were present inside and outside the multinucleated giant cells.

Synchronous Development of Gastrointestinal Stromal Tumor and Arteriovenous Malformation in the Jejunum: A Case Report.: Sang Hwa Shim, Yoon Hee Han, Ji Eun Kwak, Sun Hee Chang, Hanseong Kim, Je G Chi, Mee Joo; Korean J Pathol. 2008;42(3):185-188.

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Abstract PDF: Vascular malformations associated with neoplasms are extremely rare. Herein we report an extraordinary coincidence of arteriovenous malformation (AVM) and gastrointestinal stromal tumor (GIST) in the jejunum. A 44-year-old woman presented with melena and anemia. Abdominal computed tomography revealed a highly vascularized, strong early arterial enhancing soft tissue mass in the jejunum, which was confirmed by angiography to be an AVM supplied by the distal jejunal branch of the superior mesenteric artery. An emergency operation was performed due to active gastrointestinal (GI) bleeding. The resected jejunum showed a protruding, mostly solid subserosal mass. The mass was confirmed to be a spindle cell type GIST and was intermingled with the AVM located in the overlying submucosa and muscularis propria. To our knowledge, this is the first reported case of an AVM associated with a GIST. This case masqueraded radiologically as an AVM alone and presented clinically with GI bleeding.

Original Article

Expression of c-kit and Cell Cycle Regulators in Non-small Cell Lung Carcinoma.: Sun Hee Chang, Mee Joo, Hanseong Kim; Korean J Pathol. 2006;40(6):427-431.

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Abstract PDF: BACKGROUND
The abnormal expression of c-kit is implicated in the pathogenesis of a variety of solid tumors. The Rb pathway and p53 act as cell cycle regulators. The purpose of this study was to assess the expression of c-kit, Rb, p53, p16 and cyclin D1 and their relationship to clinical and pathological parameters in patients with non-small cell lung carcinomas (NSCLC(s)).
METHODS
Tissue microarrays consisting of 2 mm cores from the corresponding blocks were constructed from 54 NSCLC(s). Immunohistochemical staining for c-kit, Rb, p53, p16 and cyclin D1 was performed. C-kit immunostaining was considered positive if > or =10% of tumor cells were immunoreactive along the membrane and/or in cytoplasm. For Rb, p53, p16 and cyclin D1, tumor cells showing a nuclear staining pattern were interpreted as positive.
RESULTS
We found that c-kit was expressed in 13 (24%) cases, Rb was lost in 39 (72%) cases, p53 was expressed in 28 (52%) cases, p16 was lost in 42 (78%) cases and cyclin D1 was expressed in 33 (61%) cases. The c-kit expression was significantly higher in adenocarcinoma (39%) than in squamous cell carcinoma (8%). We did not find any correlation between c-kit, Rb, p53, p16 and cyclin D1 expression and clinicopathological parameters such as: age, tumor size, lymph node involvement, disease stage and distant metastasis. There was a direct correlation between p53 expression and Rb loss.
CONCLUSIONS
These results suggest that c-kit may be a useful therapeutic target for patients with c-kit positive tumors, and that the disruption of Rb and p53 pathways may play an important role in the development and progression of NSCLC(s).

Case Report

Urachal Adenocarcinoma with a Concomitant Urachal Remnant: A Case Report.: Tae Hoon Kim, Mee Joo, Min Kyung Kim, Hanseong Kim, Je G Chi, Jae Y Ro; Korean J Pathol. 2004;38(4):280-283.

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Abstract PDF: Urachal adenocarcinoma is a rare tumor, and it has similarities with nonurachal adenocarcinoma; therefore, it is sometimes difficult to make a diagnosis. We present a typical case of urachal adenocarcinoma that had all the diagnostic criteria including the presence of an urachal remnant. A 65-year-old woman presented with complaints of a painless gross hematuria. Pelvic CT and cystoscopy showed an intraluminal protruding mass centered in the bladder wall. When diagnosed as adenocarcinoma with a signet ring cell component being noted by frozen biopsy, partial cystectomy with resection of the median umbilical ligament and peritoneum was carried out for a suspected urachal adenocarcinoma. The tumor morphology showed as typical mucinous adenocarcinoma. Characteristic tubular structures showing the typical histology of an urachal remnant was found in the perivesical fat. On immunohistochemical staining, the urachal adenocarcinoma showed a pattern similar to colonic adenocarcinoma, while the urachal remnant showed strong positivity for CK7 and Chromogranin A.

Original Article

Genomic Imbalances in Ependymoma by Degenerate Oligonucleotide Primed PCR-Comparative Genomic Hybridization.: Sung Hye Park, Gi Jin Kim, Min Kyung Kim, Hanseong Kim, Yoen Lim Suh, Sun Hwa Park; Korean J Pathol. 2004;38(3):133-137.

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Abstract PDF: BACKGROUND
The most consistent chromosomal abnormality in ependymomas, is loss of 22q (17-75%) and gain of 1q (0-50%). However, significance of this abnormality is uncertain.
METHODS
Genomic imbalances in 27 Korean ependymomas, including 21 low grade ependymomas, 4 anaplastic and 2 myxopapillary ependymomas, were analyzed by degenerate oligonucleotide primed-PCR-comparative genomic hybridization.
RESULTS
Common gains were found in 17 (63%), 20q (59%), 9q34 (41%), 15q24-qter (33%), 11q13 (30%), 12q23 (26%), 7q23-qter (26%), 16q23-qter (30%), 19 (26%), and 1q32-qter (22%). DNA amplification was identified in 12 tumors (44%). Chromosomal loss was a less common occurrence in our study, but was found in 13q (26%), 6q (19%), and 3 (11%).
CONCLUSION
The recurrent gains or losses of the chromosomal regions which were identified in this study provide candidate regions that may be involved in the development and progression of ependymomas.

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