Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.
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Clinical characteristics and prognosis of primary thymic adenocarcinoma: A singleācenter retrospective analysis Qian Hong, Rui Han, Chen Chen, Fuquan Wang, Sining Zhang, Chenguang Zhao, Fang Li, Juwei Mu, Jiagen Li Thoracic Cancer.2024; 15(24): 1815. CrossRef
Case report: Primary adenocarcinoma NOS of the thymus and cytological features Jonathan Willner, Osvaldo Hernandez, Lea Azour, Andre L. Moreira Diagnostic Cytopathology.2023;[Epub] CrossRef
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