Journal of Pathology and Translational Medicine

Original Articles

Paricalcitol prevents MAPK pathway activation and inflammation in adriamycin-induced kidney injury in rats: Amanda Lima Deluque, Lucas Ferreira de Almeida, Beatriz Magalhães Oliveira, Cláudia Silva Souza, Ana Lívia Dias Maciel, Heloísa Della Coletta Francescato, Cleonice Giovanini, Roberto Silva Costa, Terezila Machado Coimbra; J Pathol Transl Med. 2024;58(5):219-228. Published online August 27, 2024; DOI: https://doi.org/10.4132/jptm.2024.07.12

1,026 View
183 Download

Abstract PDF: Background
Activation of the mitogen-activated protein kinase (MAPK) pathway induces uncontrolled cell proliferation in response to inflammatory stimuli. Adriamycin (ADR)-induced nephropathy (ADRN) in rats triggers MAPK activation and pro-inflammatory mechanisms by increasing cytokine secretion, similar to chronic kidney disease (CKD). Activation of the vitamin D receptor (VDR) plays a crucial role in suppressing the expression of inflammatory markers in the kidney and may contribute to reducing cellular proliferation. This study evaluated the effect of pre-treatment with paricalcitol on ADRN in renal inflammation mechanisms.
Methods
Male Sprague-Dawley rats were implanted with an osmotic minipump containing activated vitamin D (paricalcitol, Zemplar, 6 ng/day) or vehicle (NaCl 0.9%). Two days after implantation, ADR (Fauldoxo, 3.5 mg/kg) or vehicle (NaCl 0.9%) was injected. The rats were divided into four experimental groups: control, n = 6; paricalcitol, n = 6; ADR, n = 7 and, ADR + paricalcitol, n = 7.
Results
VDR activation was demonstrated by increased CYP24A1 in renal tissue. Paricalcitol prevented macrophage infiltration in the glomeruli, cortex, and outer medulla, prevented secretion of tumor necrosis factor-α, and interleukin-1β, increased arginase I and decreased arginase II tissue expressions, effects associated with attenuation of MAPK pathways, increased zonula occludens-1, and reduced cell proliferation associated with proliferating cell nuclear antigen expression. Paricalcitol treatment decreased the stromal cell-derived factor 1α/chemokine C-X-C receptor type 4/β-catenin pathway.
Conclusions
Paricalcitol plays a renoprotective role by modulating renal inflammation and cell proliferation. These results highlight potential targets for treating CKD.

Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma: Jae Won Joung, Hoon Kyu Oh, Sun Jae Lee, Young Ah Kim, Hyun Jin Jung; J Pathol Transl Med. 2018;52(5):323-330. Published online August 19, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.21

6,503 View
162 Download
16 Web of Science
15 Crossref

Background
Intratumoral fibrosis (ITF) is a frequent histologic finding in solid organ tumors. Renal cell carcinoma (RCC) is a highly vascularized tumor with different shapes and degrees of ITF and inflammation. ITF is a poor prognostic factor, especially in breast cancer, and is related to intratumoral necrosis (ITN) and intratumoral inflammation (ITI). However, the significance of ITF in RCC has not been fully studied. In this study, we evaluate the relationships between ITF and other clinicopathologic parameters associated with RCC prognosis.
Methods
ITF was evaluated in 204 clear cell renal cell carcinoma (CCRCC) specimens according to presence and grade of fibrosis, degree of ITI, and presence of ITN. Lysyl oxidase (LOX) expression in tumor cells was also evaluated with clinicopathologic parameters.
Results
Among 204 CCRCC cases, 167 (81.7%) showed ITF, 71 (34.8%) showed ITI, 35 (17.2%) showed ITN, and 111 (54.4%) showed LOX expression. ITF correlated with Fuhrman nuclear grade (p = .046), lymphovascular invasion (LVI) (p = .027), and ITN (p = .036). Patients with ITF had a poor five-year overall survival rate (p = .104).
Conclusions
ITF is related to other poor prognostic factors in CCRCC, such as Fuhrman nuclear grade, ITN, and LVI, but ITF itself had no significant correlation with prognosis of CCRCC.

Citations

Citations to this article as recorded by

New insights into fibrotic signaling in renal cell carcinoma
Jiao-Yi Chen, Wai-Han Yiu, Patrick Ming-Kuen Tang, Sydney Chi-Wai Tang
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Tumor-associated fibrosis impairs the response to immunotherapy
Angha Naik, Andrew Leask
Matrix Biology.2023; 119: 125. CrossRef
Decreased renal expression of PAQR5 is associated with the absence of a nephroprotective effect of progesterone in a rat UUO model
P. A. Abramicheva, D. S. Semenovich, L. D. Zorova, I. B. Pevzner, I. A. Sokolov, V. A. Popkov, E. P. Kazakov, D. B. Zorov, E. Y. Plotnikov
Scientific Reports.2023;[Epub] CrossRef
Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma
Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin, Tao Xu
BMC Cancer.2022;[Epub] CrossRef
Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis
Seungwon Ryu, Jae Woo Shin, Soie Kwon, Jiwon Lee, Yong Chul Kim, Yoe-Sik Bae, Yong-Soo Bae, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Hye Young Kim
Journal of Clinical Investigation.2022;[Epub] CrossRef
The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma
Melanie Glueck, Alexander Koch, Robert Brunkhorst, Nerea Ferreiros Bouzas, Sandra Trautmann, Liliana Schaefer, Waltraud Pfeilschifter, Josef Pfeilschifter, Rajkumar Vutukuri
The FEBS Journal.2022; 289(18): 5670. CrossRef
The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
Pramod Mallikarjuna, Yang Zhou, Maréne Landström
Biomolecules.2022; 12(5): 635. CrossRef
In Vitro Characterization of Renal Drug Transporter Activity in Kidney Cancer
Pedro Caetano-Pinto, Nathanil Justian, Maria Dib, Jana Fischer, Maryna Somova, Martin Burchardt, Ingmar Wolff
International Journal of Molecular Sciences.2022; 23(17): 10177. CrossRef
PD-1 immunobiology in glomerulonephritis and renal cell carcinoma
Colleen S. Curran, Jeffrey B. Kopp
BMC Nephrology.2021;[Epub] CrossRef
Intratumoral Fibrosis in Facilitating Renal Cancer Aggressiveness: Underlying Mechanisms and Promising Targets
Chao Hu, Yufeng Zhao, Xuanchuan Wang, Tongyu Zhu
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
What Mediates Fibrosis in the Tumor Microenvironment of Clear Renal Cell Carcinoma
Wenbo Yang, Caipeng Qin, Jingli Han, Songchen Han, Wenjun Bai, Yiqing Du, Tao Xu
Frontiers in Genetics.2021;[Epub] CrossRef
Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort
Pedro Caetano Pinto, Cindy Rönnau, Martin Burchardt, Ingmar Wolff
Biomedicines.2021; 9(12): 1761. CrossRef
The Significance of Fibrosis Quantification as a Marker in Assessing Pseudo-Capsule Status and Clear Cell Renal Cell Carcinoma Prognosis
Caipeng Qin, Huaqi Yin, Huixin Liu, Feng Liu, Yiqing Du, Tao Xu
Diagnostics.2020; 10(11): 895. CrossRef
The challenges of adoptive cell transfer in the treatment of human renal cell carcinoma
Zuzana Strizova, Jirina Bartunkova, Daniel Smrz
Cancer Immunology, Immunotherapy.2019; 68(11): 1831. CrossRef
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma
Wen-Hao Xu, Yue Xu, Jun Wang, Xi Tian, Junlong Wu, Fang-Ning Wan, Hong-Kai Wang, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye
Aging.2019; 11(16): 6503. CrossRef

Chronic Placental Inflammation in Twin Pregnancies: Heejin Bang, Go Eun Bae, Ha Young Park, Yeon Mee Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh, Jung-Sun Kim; J Pathol Transl Med. 2015;49(6):489-496. Published online October 13, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.09

9,362 View
90 Download
11 Web of Science
11 Crossref

Abstract PDF

Background
Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate its frequency in twin pregnancies compared to singleton pregnancies. Methods: Three hundred twin placentas and 1,270 singleton placentas were consecutively collected at a tertiary medical center in Seoul, Republic of Korea from 2009 to 2012. Hematoxylin and eosin sections of tissue samples (full-thickness placental disc and chorioamniotic membranes) were reviewed. Results: Non-basal VUE was more frequent in twin placentas than in singleton placentas (6.0% vs 3.2%, p < .05). In preterm birth, CCA was found less frequently in twin placentas than in singleton placentas (9.6% vs 14.8%, p < .05), reaching its peak at an earlier gestational age in twin placentas (29–32 weeks) than in singleton placentas (33–36 weeks). CCA was more frequent in twin pregnancies with babies of a different sex than with those with the same sex (13.8% vs 6.9%, p = .052). Separate dichorionic diamniotic twin placentas were affected by chronic deciduitis more frequently than singleton placentas (16.9% vs 9.7%, p < .05). Conclusions: The higher frequency of non-basal VUE in twin placentas and of CCA in twin placentas with different fetal sex supports the hypothesis that the underlying pathophysiological mechanism is maternal anti-fetal rejection related to increased fetal antigens in twin pregnancies. The peak of CCA at an earlier gestational age in twin placentas than in singleton placentas suggests that CCA is influenced by placental maturation.

Citations

Citations to this article as recorded by

Villitis of unknown etiology, chronic deciduitis, chronic chorioamnionitis and chronic histiocytic intervillositis in monozygotic and dizygotic twin pregnancies. A retrospective analysis of 16 cases
Henning Feist, Ulrich Lehmann, Simin Bajwa, Corinna Brüschke, Nora Schaumann
Placenta.2023; 133: 32. CrossRef
Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta
Evelina Silvestri, Francesca Servadei, Ione Tamagnini, Laura Moretti, Maria Paola Bonasoni
International Journal of Molecular Sciences.2023; 24(11): 9207. CrossRef
Histopathologic evaluation of dichorionic twin placentas in unassisted and in vitro fertilized pregnancies affected by preeclampsia
Evelina Manvelyan, Karmaine A. Millington, Baruch S. Abittan, Matthew J. Blitz, Brittany Kwait, Weiwei Shan, Randi H. Goldman
The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(26): 10262. CrossRef
Microbiological safety of the Dr. Arabin cervical pessary in pregnant women with short cervix
Gabriel S. Sargsyan, Olesya N. Bespalova, Alevtina M. Savicheva, Tatyana A. Khusnutdinova, Olga V. Budilovskaya, Anna A. Krysanova, Kira V. Shalepo
Journal of obstetrics and women's diseases.2022; 71(5): 65. CrossRef
Disorders of placental villous maturation in fetal death
Sunil Jaiman, Roberto Romero, Percy Pacora, Eunjung Jung, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Bomi Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Offer Erez, Nardhy Gomez-Lopez, Chaur-Dong Hsu
Journal of Perinatal Medicine.2020;[Epub] CrossRef
Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies
Shemoon Marleen, Chamalika Dias, Rebecca MacGregor, John Allotey, Joseph Aquilina, Asma Khalil, Shakila Thangaratinam
European Journal of Obstetrics & Gynecology and Reproductive Biology.2020; 250: 130. CrossRef
Serratia marcescens as a cause of unfavorable outcome in the twin pregnancy
Duško Kljakić, Miloš Z. Milosavljević, Milan Jovanović, Vesna Čolaković Popović, Saša Raičević
Open Medicine.2020; 16(1): 81. CrossRef
The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes
Kyung Joon Oh, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon
The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(4): 527. CrossRef
Discordance of Twin Placentas for Multifocal Eosinophilic/T-cell Chorionic Vasculitis
Erik W Nohr, James R Wright
Pediatric and Developmental Pathology.2019; 22(1): 40. CrossRef
Differential immunophenotype of macrophages in acute and chronic chorioamnionitis
Go-Eun Bae, Joon-Seok Hong, Jung-Sun Kim, Ha Young Park, Ja Yun Jang, Yi Seul Kim, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh
Journal of Perinatal Medicine.2017; 45(4): 483. CrossRef
Fetal death: an extreme manifestation of maternal anti-fetal rejection
Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim, Offer Erez
Journal of Perinatal Medicine.2017; 45(7): 851. CrossRef

Case Report

Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation Manifested as a Soft Tissue Mass: Incidental Discovery on Histological Examination.: Sang Yun Ha, Yoon La Choi, Sung Joo Kim, Young Hye Ko; Korean J Pathol. 2011;45(4):417-422.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.417

4,006 View
35 Download
5 Crossref

Abstract PDF

We report an extraordinary case of diffuse large B-cell lymphoma arising in a cystic necrotic mass in a 35-year-old man who presented with a soft tissue mass at the site of previous surgery. A benign mass was surgically removed 17 years ago, after which a cystic lesion gradually developed at the same site. The resected mass appeared as a thick-walled cyst filled with brown necrotic and hemorrhagic material. On microscopic examination, the cyst wall was primarily necrotic tissue with some aggregates of large atypical lymphoid cells. These atypical cells were diffusely positive for CD20 and showed a high proliferation index, Epstein-Barr virus positivity, and clonal rearrangement of the immunoglobulin gene. His present condition was diagnosed as Epstein-Barr virus-associated diffuse large B-cell lymphoma arising from chronic inflammation. It is important to be aware of the clinical manifestations and histological features of this rare disease in light of diagnosis and treatment.

Citations

Citations to this article as recorded by

EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review
Tin Wai Ho, Wah Cheuk, John K.C. Chan
International Journal of Surgical Pathology.2023; 31(7): 1420. CrossRef
Diffuse Large B Cell Lymphoma in a Prosthetic Aortic Graft
David Bell, David Marshman
Heart, Lung and Circulation.2017; 26(2): e4. CrossRef
Fibrin-associated EBV-positive Large B-Cell Lymphoma
Daniel F. Boyer, Penelope A. McKelvie, Laurence de Leval, Kerstin L. Edlefsen, Young-Hyeh Ko, Zachary A. Aberman, Alexandra E. Kovach, Aneal Masih, Ha T. Nishino, Lawrence M. Weiss, Alan K. Meeker, Valentina Nardi, Maryknoll Palisoc, Lina Shao, Stefania P
American Journal of Surgical Pathology.2017; 41(3): 299. CrossRef
Malignant Lymphoma Mimicking an Infection After Shoulder Surgery
Jabari Ian Justin Martin, Jasmine Bauknight, Vincent Desiderio, Bahman Sadr
Journal of the American Academy of Orthopaedic Surgeons.2017; 25(4): 314. CrossRef
Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
Korean Journal of Pathology.2014; 48(2): 81. CrossRef

Original Articles

Incidence of Acute Placental Inflammation through Histopathological Analysis: One year experience in 1995 at Seoul National University Hospital.: Hyun Ju Yoo, Yun Kyung Kang, Chong Jai Kim, Jung Sun Kim, Tae Sook Kim, Kyung Cheun Jung, Kyo Hoon Park, Jong Kwan Jun, Bo Hyun Yoon; Korean J Pathol. 1996;30(12):1123-1128.

1,658 View
20 Download

Abstract PDF: The diagnosis of acute inflammation of the placenta, represented as acute chorioamnionitis, is important in that it is associated with a poor clinical outcome for both the mother and the fetus, including major perinatal morbidities such as sepsis, respiratory distress syndrome, and CNS damage. However, current medical trends in Korea seem to overlook the significance of a histopathological diagnosis of acute placental inflammation, mainly due to the indifferences of clinicians and pathologists. Since late 1993, histopathological examinations have been performed on preterm placentas at Seoul National University. These examinations have demonstrated acute placental inflammation in a significant number of cases. In the present study the incidence of acute placental inflammation was analyzed in 521 placentas which were submitted for pathological examinations in 1995. Examinations were performed to provide basic information on the incidence and profile of acute placental inflammation in this hospital and, thereby, to emphasize the significance of histopathological examinations of the placenta in the routine surgical pathology service. Among the 521 placentas, acute inflammation was found in 194 cases (37.2%). In preterm placentas acute inflammation was found in 39.6% of the cases (67/169), while 36.1% (127/352) of term placentas showed acute inflammation. Taking the delivery mode into account, 26.3% (49/186) of the placentas delivered by cesarean section showed acute inflammation, while 43.3% (145/335) of the transvaginally delivered placentas showed inflammation. The present analysis demonstrates the existence of acute inflammation in a significant proportion of placentas with different clinical settings. The importance of a histopathological examination in routine hospital practice should be emphasized.

Topographic Difference of Inflammatory Reactions in Gastric Mucosa in Various Helicobacter pylori-Associated Diseases.: Suk Jin Choi, Tae Jung Jang; Korean J Pathol. 2000;34(1):29-33.

1,628 View
20 Download

Abstract PDF: Gastric biopsy specimens from 140 patients (66 chronic gastritis, 33 gastric ulcers, 26 duodenal ulcers, 15 gastric cancers) were examined to investigate the topographic difference of inflammation, glandular atrophy, intestinal metaplasia, and Helicobacter pylori (H. pylori) colonization by the updated Sydney system. Density of H. pylori of the antrum was significantly higher in duodenal ulcers than in chronic gastritis, gastric ulcers, and gastric cancers. Inflammation of duodenal ulcers was predominantly antral and glandular atrophy and intestinal metaplasia of duodenal ulcer were significantly less than those of gastric ulcers and gastric cancers. Chronic inflammation of gastric ulcers and gastric cancers was higher in antrum than in corpus. Increasing atrophy of the antrum was associated with decreasing density of H. pylori of antrum itself, but increasing colonization of the corpus. This study reveals the inflammatory reactions of gastric mucosa differ in chronic gastritis, gastric ulcers, gastric cancers, and duodenal ulcers and suggests that antral atrophy fosters the colonization of oxyntic mucosa by H. pylori.

Case Report

Combined Xanthogranulomatous Urachitis and Bullous Cystitis: A Case Report.: Ji Eun Kwak, Han Seong Kim, Mee Joo, Sun Hee Chang, Sang Hwa Shim, Je G Chi, In Rae Cho; Korean J Pathol. 2008;42(1):41-44.

1,821 View
27 Download

Abstract PDF: Xanthogranulomatous inflammation of the urachus is a very rare benign chronic inflammatory disease of an unknown etiology. Herein we report a case of a 31-year-old woman who complained of lower abdominal pain and dysuria. Cystoscopy revealed a bullous change at the dome of the urinary bladder. MRI revealed a cystic mass above the bladder dome that extended to the umbilicus. A partial cystectomy with urachal resection was performed. Pathological examination revealed xanthogranulomatous urachitis combined with bullous cystitis.

First
Prev
Page of 1
Next
Last

Search