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Original Articles
- The Ultrastructural Study of Intermediate Filaments in Epithelial and Mesenchymal Tumors.
- Chae Hong Suh, Keun Hong Kee
- Korean J Pathol. 1993;27(4):328-338.
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Abstract
PDF - The immunohistochemical results are compared with ultrastructural features of neoplastic epithelial cells and mesenchymal cells to assess whether immunohistochemistry is useful in the differential diagnosis of epithelial tumors and mesenchymal tumors. Squamous cell carcinoma and transitional cell carcinoma exhibited positive reaction for keratin, but adenocarcinoma was weakly positive reaction for keratin. Ultrastructurally, heavy bundles of tonofilaments were more frequently encountered in squamous cell carcinoma. In adenocarcinomas, the intermediate filaments were arranged randomly as nonaggregated, short filaments spread throughout the cytoplasm. Fibroblastic and fibrohistiocytic tumors, schwannomas, and neurofibromas exhibited positive reaction for vimentin and alpha-smooth muscle actin. Vimentin consisted of large aggregates of gently curved filaments that often displace other cytoplasmic constituents was noted. Fibroblastic cells with features of smooth muscle differentiation were found in granulation tissue of healing wounds, hypertrophic scars, fibromatosis, fibroma, neurofibroma and malignant fibrous histiocytoma. Smooth muscle tumors showed abundant bundles of thin filaments with dense bodies, pinocytotic vesicles and dense attachment plaques along the cell membrane. Skeletal muscle tumors showed bundles of disorganized thick and thin filaments, remnants of sarcomeres and Z-bands. From the above result, ultrastructural and immunohistochemical studies on epithelial and mesenchymal tumors were useful in tumor diagnosis sand classification.
- Histochemical and Immunohistochemical Properties of Endometrial and Endocervical Adenocarcinoma.
- Kyu Rae Kim, In Joon Choi
- Korean J Pathol. 1988;22(3):259-267.
- 1,641 View
- 28 Download
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Abstract
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- The histologic differentiation of endometrial and endocervical adenocarcinomas is a common diagnostic problum of clinical importance, because the staging, treatment and prognosis of these lesions are quite different. First, we examined the distribution of acid mucin in endometrial and endocervical adenocarcinoma (23 cases and 25 cases repectively), but distinguishing differences between endometrial and endocervical adenocarcinoma, especially of endometrioid type, were not observed. Secondly, the distribution of low-molecular weight cytokeratin, vimentin and carcino-embryonic antigen (CEA) by immunohistochemistry were examined in formalin-fixed tissues. CEA was present in 88% of endocervical adenocarcinomas and 34.8% of endometrial adenocarcinoma. vimentin was found in 91.3% of endometrial adenocarcinomas, in contrast with only in 16% of endocervical adenocarcinomas. This study showed that the presence of vimentin in neoplastic glands, in which CEA is negative, may be helpful in the differential diagnosis of endometrial from endocervical adenocarcinomas.
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