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Review
- Cervical intraepithelial neoplasia and cervical cytology in pregnancy
- Ji-Young Kim, Jeong Yun Shim
- J Pathol Transl Med. 2024;58(6):283-290. Published online November 7, 2024
- DOI: https://doi.org/10.4132/jptm.2024.10.17
- 1,784 View
- 256 Download
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Abstract
PDF - Cervical cancer screening during pregnancy presents unique challenges for cytologic interpretation. This review focuses on pregnancy-associated cytomorphological changes and their impact on diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Pregnancy-induced alterations include navicular cells, hyperplastic endocervical cells, immature metaplastic cells, and occasional decidual cells or trophoblasts. These changes can mimic abnormalities such as koilocytosis, adenocarcinoma in situ, and high-grade squamous intraepithelial lesions, potentially leading to misdiagnosis. Careful attention to nuclear features and awareness of pregnancy-related changes are crucial for correct interpretation. The natural history of CIN during pregnancy shows higher regression rates, particularly for CIN 2, with minimal risk of progression. Management of abnormal cytology follows modified risk-based guidelines to avoid invasive procedures, with treatment typically deferred until postpartum. The findings reported in this review emphasize the importance of considering pregnancy status in cytological interpretation, highlight potential problems, and provide guidance on differentiating benign pregnancy-related changes from true abnormalities. Understanding these nuances is essential for accurate diagnosis and proper management of cervical abnormalities in pregnant women.
Brief Case Report
- Multifocal Polypoid Endometriosis Mimicking Malignancy in a Young Woman with a History of Hormonal Treatment
- Ji-Young Kim, Tae-Jong Song, Hye-Kyung Choi, Jeong Yun Shim
- J Pathol Transl Med. 2015;49(5):418-420. Published online June 9, 2015
- DOI: https://doi.org/10.4132/jptm.2015.05.12
- 8,822 View
- 61 Download
- 4 Web of Science
- 3 Crossref
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Citations
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- Fertility preservation of polypoid endometriosis: Case series and literature review
Sayuri Miyoshi, Ken Yamaguchi, Yoshitsugu Chigusa, Masumi Sunada, Koji Yamanoi, Akihito Horie, Junzo Hamanishi, Eiji Kondoh, Masaki Mandai
Journal of Obstetrics and Gynaecology Research.2022; 48(2): 502. CrossRef - A case of polypoid endometriosis mimicking advanced ovarian carcinoma with rapid growth, invasion, and dissemination
Hiroyuki Yazawa, Riho Yazawa, Kaoru Fukuda, Miki Ohara
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE.2022; 68(3): 183. CrossRef - Polypoid endometriosis: a mimic of malignancy
Soleen Ghafoor, Yulia Lakhman, Kay J. Park, Iva Petkovska
Abdominal Radiology.2020; 45(6): 1776. CrossRef
- Fertility preservation of polypoid endometriosis: Case series and literature review
Original Article
- Angiogenensis and Overexpression of p53 Gene Produc in Brain Tumor.
- Jeong Yun Shim, Ho Guen Kim, Tai Seung Kim
- Korean J Pathol. 1997;31(1):23-33.
- 1,968 View
- 17 Download
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Abstract
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- Angiogenesis depends on the net balance between positive and negative angiogenic factors. Tumor cells are angiogenic resulting from increased production of positive factors and decreased production of negative factors. Among these, vascular endothelial growth factor and glioma- derived angiogenesis inhibiting factor are related to glioblastoma multiforme. The p53 gene is more frequently mutated than any other known oncogene or tumor suppressor gene in human tumors including glioblastoma multiforme. Angiogenesis is reported to be controlled by p53 regulation in recent studies. To examine the effect of p53 overexpression on angiogenesis in glioblastoma multiforme, we performed immunohistochemical staining in 51 cases of glioblastoma multiforme, using monoclonal antibodies to p53 protein and factor VIII. 20 cases of low grade astrocytoma were used as control. p53 overexpression was present in 15(75%) of 20 cases of low grade astrocytoma and the mean vessel count was 37.7+/-9.9 at x200 field and 17.5+/-5.8 at x400 field. p53 overexpression was present in 35(68%) of 51 cases of glioblastoma multiforme and the mean vessel count was 91.9 45.8 at x200 field and 40.7 19.1 at x400 field. Mean vessel count in low grade astrocytoma with p53 overexpression was 39.4 10.2 at x200 field and 18.9 5.7 at x400 field, while in cases without p53 overexpression it was 32.4+/-7.6 at x200 field and 13.2 3.5 at x400 field. Mean vessel count in glioblastoma multiforme with p53 overexpression was 94.5+/-51.8 at x200 field and 42.1+/-16.8 at x400 field, while in cases without p53 overexpression it was 86.1+/-29.5 at x200 field and 37.1+/-16.8 at x400 field. The mean survival time was 12.4 months in the 39 cases of glioblastoma multiforme in which follow-up studies were possible. Significant prognostic factors were age, p53 overexpression and adjuvant therapy. These results show that p53 gene mutation is one of the many contributing factors to angiogenesis in glioblastoma multiforme. In addition, other oncogenes and tumor suppressor genes, as well as growth factors may be involved. Age, p53 overexpression and adjuvant therapy proved to be significant prognostic factors, while microvessel density was not.
Case Report
- Enteric Cyst in the Tongue.
- Jeong Yun Shim, Ho Guen Kim
- Korean J Pathol. 1997;31(11):1237-1239.
- 1,614 View
- 10 Download
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Abstract
- A case of enteric cyst in the anterior two-thirds of the tongue is reported. The patient, a 42 day-old female infant, presented with a protruding tongue mass since birth. Under the impression of ectopic thyroid gland or leiomyoma, complete resection was performed. The mass proved to be an enteric cyst, lined by small intestinal mucosa with an underlying coat of smooth muscle. Enteric cysts arising in the tongue is rare and only 8 such cases have been reported in the literature.
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