Journal of Pathology and Translational Medicine

Brief Case Report

Malignant Perivascular Epithelioid Cell Tumor of the Uterus with Lung Metastasis: Jeong Bae Kang, Jin Won Seo, Young-Han Park, Pong Rheem Jang; Korean J Pathol. 2014;48(6):454-457. Published online December 31, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.454

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Citations

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A Retrospective Case Study of 13 Uterine Perivascular Epithelioid Cell Neoplasm (PEComa) Patients
Jiahui Gu, Wantong Wang, Shizhuo Wang
OncoTargets and Therapy.2021; Volume 14: 1783. CrossRef
Predicting the Behavior of Perivascular Epithelioid Cell Tumors of the Uterine Corpus
Andres Martin Acosta, Brian P. Adley
Archives of Pathology & Laboratory Medicine.2017; 141(3): 463. CrossRef

Case Report

Pulmonary Calciphylaxis Associated with Acute Respiratory and Renal Failure Due to Cryptogenic Hypercalcemia: An Autopsy Case Report: Na Rae Kim, Jin Won Seo, Young Hwan Lim, Hyoung Suk Ham, Wooseong Huh, Joungho Han; Korean J Pathol. 2012;46(6):601-605. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.601

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Abstract PDF

Metastatic calcification is rare; it is found during autopsy in patients who underwent hemodialysis. Diffuse calcium precipitation of small and medium-sized cutaneous vessels, known as calciphylaxis, can result in progressive tissue necrosis secondary to vascular calcification. This condition most commonly involves the skin; however, a rare occurrence of visceral calciphylaxis has been reported. Here we report on an autopsy case. Despite a thorough evaluation, and even performing an autopsy, the underlying cause of acute-onset hypercalcemia, resulting in the production of pulmonary calciphylaxis and metastatic renal calcification associated with acute respiratory and renal failure, could not be determined. Metastatic calcification often lacks specific symptoms, and the degree of calcification is a marker of the severity and chronicity of the disease. This unusual autopsy case emphasizes the importance of rapidly progressing visceral calciphylaxis, as well as its early detection.

Citations

Citations to this article as recorded by

Acute Respiratory Distress Syndrome Induced by Parathyroid Storm
Georgios Zagkotsis, Maria Markou, Panagiota Papanikolaou, Nikolaos Sabanis
Cureus.2021;[Epub] CrossRef
Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19
D. Pamart, M. Otekpo, M. Asfar, G. Duval, J. Gautier, Cédric Annweiler
The Journal of nutrition, health and aging.2021; 25(10): 1140. CrossRef
A rare case report of multiple myeloma presenting with paralytic ileus and type II respiratory failure due to hypercalcemic crisis
Yuchen Guo, Liang He, Yiming Liu, Xueyuan Cao
Medicine.2017; 96(52): e9215. CrossRef
Development of multiorganic calciphylaxis during teriparatide, vitamin D, and calcium treatment
A. Monegal, P. Peris, M. Alsina, J. Colmenero, N. Guañabens
Osteoporosis International.2016; 27(8): 2631. CrossRef
Calciphylaxis: from the disease to the diseased
Tiago M. Oliveira, João M. Frazão
Journal of Nephrology.2015; 28(5): 531. CrossRef

Original Article

Expression of the Thyroid Transcription Factor-1 in Carcinomas of Salivary Gland Type and Pulmonary Adenocarcinomas.: Jong Sun Choi, Jeong Wook Seo, Jin Won Seo, Joungho Han; Korean J Pathol. 2003;37(3):180-185.

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Abstract PDF: BACKGROUND
Carcinomas of salivary gland type (CSGT) in the low respiratory tract are rare and often difficult to differentiate from pulmonary adenocarcinomas, which are more common and more aggressive than CSGT, especially in the biopsy specimens. Thyroid transcription factor-1 (TTF-1) is a tissue-specific transcription factor expressed in the thyroid gland and the lung. The purpose of this study is to elucidate the diagnostic utility of TTF-1 in discerning CSGT from adenocarcinomas in the low respiratory tract.
METHODS
Immunohistochemical expression of TTF-1 was investigated in 14 CSGT (9 mucoepidermoid carcinomas and 5 adenoid cystic carcinomas) and 19 adenocarcinomas (5 well differentiated, 12 moderately differentiated and 2 poorly differentiated).
RESULTS
Normal alveolar cells as well as bronchial epithelial cells showed the immunoreactivity for TTF-1, but not in the bronchial glands. In tumors, immunoreactivity for TTF-1 was identified in 17 out of 19 cases of adenocarcinomas (89%), but in none of 14 cases of CSGT. In adenocarcinomas, the immunoreactivity for TTF-1 was strongly correlated with the degree of differentiation (p<0.001).
CONCLUSIONS
These results suggest that TTF-1 can be a valuable marker in distinguishing CSGT from adenocarcinomas of the low respiratory tract.

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