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- Aneurysmal bone cyst: a review
- Elham Nasri, John David Reith
- J Pathol Transl Med. 2023;57(2):81-87. Published online March 14, 2023
- DOI: https://doi.org/10.4132/jptm.2023.02.23
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- 524 Download
- 15 Web of Science
- 18 Crossref
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Abstract
PDF - Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABC-like changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.
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Citations
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