Journal of Pathology and Translational Medicine

Clear Cell Renal Cell Carcinoma with Intratumoral Granulomatous Reaction: A Case Report and Review of the Literature: Hayeon Kim, Jong Wook Kim, Aeree Kim, Hyeyoon Chang; J Pathol Transl Med. 2017;51(3):325-328. Published online March 14, 2017; DOI: https://doi.org/10.4132/jptm.2016.09.08

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Abstract PDF: Granulomatous reaction associated with clear cell renal cell carcinoma (CCRCC) is a rare finding, and only a few cases have been described in the literature. It is postulated to occur due to cancer- related antigenic factors such as cancer cells themselves or soluble tumor antigens shed into the blood. Herein, we describe a case of a 56-year-old male patient diagnosed with CCRCC with intratumoral granulomatous inflammation.

Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Aggressive Behavior: An Unusual Renal Epithelial Neoplasm: A Case Report.: Ji Hye Lee, Mee Hye Oh, Hyun Deuk Cho, Young Sik Kim; Korean J Pathol. 2010;44(2):211-215.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.211

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Mucinous tubular and spindle cell carcinoma is a rare low-grade renal cell carcinoma, which was first described as a new entity in the World Health Organization 2004 classification. We report here on a case of this tumor with very unusual aggressive behavior. A 73-year-old man presented with gross hematuria. A computed tomography scan demonstrated a 5 cm sized low density mass in the left kidney. The radical nephrectomy specimen grossly showed a well demarcated tumor confined to the renal parenchyma. Histologically, the tumor consisted of elongated tubules or trabeculae of oval to cuboidal cells with a low nuclear grade, and these tubules/trabeculae were separated by abundant acidic mucinous stroma. In some areas, spindle cell components were mixed with parallel tubules. Neither significant atypia nor mitosis was seen. The patient developed multiple metastatic pulmonary nodules 2 months later. Four months after the surgery, the left supraclavicular, right hilar and right subcarinal lymph nodes were also enlarged by metastasis. The patient died of respiratory failure 13 months after the operation.

Citations

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Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma
Kvetoslava Peckova, Petr Martinek, Maris Sperga, Delia Perez Montiel, Ondrej Daum, Pavla Rotterova, Kristýna Kalusová, Milan Hora, Kristýna Pivovarcikova, Boris Rychly, Semir Vranic, Whitney Davidson, Josef Vodicka, Magdaléna Dubová, Michal Michal, Ondrej
Annals of Diagnostic Pathology.2015; 19(4): 226. CrossRef

Teratoid Wilms' Tumor: A Case Report.: Seong Rim Kim, Sang Yong Song, Yeon Lim Suh, Ki Woong Sung, Suk Koo Lee; Korean J Pathol. 2002;36(3):187-190.

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Abstract PDF: Teratoid Wilms' tumor is a rare renal tumor. Fourteen cases have been reported. A 14-month-old girl was presented to us. She had a right renal mass which was diagnosed as a Wilms' tumor in another hospital. She had been treated with chemotherapy but failed to respond to it. The nephrectomy specimen revealed an encapsulated mass of which the cut surface was solid, firm, gray to yellow tan. Microscopically, the stromal elements were predominant, especially comparing with few blastemal element, but the degree of heterologous differentiation was sufficient to warrant the diagnosis of teratoid Wilms' tumor.

Renal Angiomyolipoma with Vascular Leiomyomatous Features: A Case Report.: Na Rae Kim, Yeon Lim Suh; Korean J Pathol. 2002;36(5):353-356.

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Abstract PDF: Angiomyolipoma is the most common mesenchymal tumor of the kidney. It occurs sporadically and is associated with tuberous sclerosis. It can appear in any organs, but most commonly in the kidney, and it appears slightly more in females. Angiomyolipoma is pathologically composed of three heterogeneous components of blood vessels, smooth muscle cells and fat cells of varying proportion, which occasionally make several unusual histologic variants. We describe a variant of renal angiomyolipoma simulating vascular leiomyoma on routine hematoxylin-eosin stain; prominent thick-walled blood vessels interspersed with proliferation of smooth muscle cells and total absence of fat cells. Perivascular spindle-shaped smooth muscle cells were reactive for smooth muscle actin, desmin and HMB-45 immunostains. This case illustrates vascular leiomyoma-like angiomyolipoma, which was finally diagnosed on the basis of HMB-45 immunostain, and also raises a question about the real existence of renal vascular leiomyoma.

Ipsilateral Synchronous Renal Cell Carcinoma and Transitional Cell Carcinoma: A Case Report.: Ji Young Park, Eun Kyung Kwak, Tae In Park; Korean J Pathol. 2002;36(6):429-432.

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Abstract PDF: We report a synchronous renal cell carcinoma (RCC) and renal pelvic transitional cell carcinoma (TCC) in the kidney of a 74-year-old man. The kidney was without hydronephrosis. The patient was admitted to the hospital because he had intermittent gross hematuria for three years. Histologically, a section of the specimen revealed a conventional (clear cell) RCC in renal parenchyma just beneath the renal pelvis and a papillary urothelial carcinoma arising from the renal pelvis at the upper pole; the two are completely separated from one another. The tumor cells of the TCC showed an overexpression of c-MET immunohistochemical staining and more intense positive reactivity for p53 immunohistochemical staining than those of the RCC. These findings suggest that c-Met and p53 may be associated with the development of papillary TCC.

Mucinous Tubular and Spindle Cell Carcinoma of Kidney Occurring in a Patient with Pulmonary Adenocarcinoma.: Seog Yun Park, Gyeong Hoon Kang, Jae Y Ro, Jennifer Black, Jinsoo Chung, Kang Hyun Lee, Eun Kyung Hong, Weon Seo Park; Korean J Pathol. 2008;42(1):54-59.

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Abstract PDF: Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of kidney tumor that has only been recently described. Furthermore, a case of MTSCC associated with a simultaneous lung cancer in the same patient has never been reported in the literature. In this paper, we describe a kidney tumor that was detected during staging work-up in a 72-year-old lung cancer patient. The kidney tumor was removed and shown to exhibit histological and immunophenotypic features of MTSCC, completely distinct from the pulmonary adenocarcinoma. In addition, this case was unique because it was characterized by neuroendocrine differentiation as well as p53 and Ki-67 overexpression in tumor cells. Therefore, we report a case of MTSCC diagnosed in a patient with pulmonary adenocarcinoma and describe the detailed histologic and immunohistochemical features of MTSCC.

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