Histologic alterations of lymph nodes following fine-needle aspiration have not been well described. Only two cases of lymph node infarction following fine-needle aspiration have currently been reported. We report here on a case of near total infarction of a lymph node that was detected 16 days after fine-needle aspiration in a 74-year old man. A fine-needle aspiration smear of the right inguinal lymph node showed scattered and clustered cells including lymphocytes, plasma cells, neutrophils that were seen as a reactive nodal hyperplasia in the clean background. There were no malignant cells, granulomas or necrotic debris. In the incisional biopsy of the same lymph node, the sections revealed a thin rim of viable lymphocytes, granular tissue was noted peripherally and extensive necrosis associated with vascular thrombi was noted centrally. There was no evidence of malignancy or granulomatous inflammation.