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Original Article
- Expression of Minichromosome Maintenance Protein 7 and Smad 4 in Squamous Cell Carcinoma of the Esophagus.
- Ji Hyun Ahn, Hee Kyung Chang
- Korean J Pathol. 2010;44(4):346-353.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.346
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- 4 Crossref
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Abstract
PDF - BACKGROUND
Minichromosome maintenance protein 7 (MCM 7) performs a direct role in the initiation of DNA replication, which suggests that it may prove useful as a marker of cell proliferation. Smad 4 is a tumor suppressor gene that mediates the transforming growth factor beta pathway. The principal objective of this study was to characterize the expression of MCM 7 and Smad 4 and to analyze their relationship to clinicopathological parameters in patients with esophageal squamous cell carcinoma.
METHODS
Expression levels of MCM 7 and Smad 4 were evaluated via immunohistochemistry on formalin-fixed and paraffin-embedded tissues from 67 cases of esophageal squamous cell carcinoma.
RESULTS
High levels of MCM 7 expression were detected in 53 cases (74.6%), and were associated with higher T stages (p = 0.030). Kaplan-Meier survival curves demonstrated that patients with higher levels of MCM 7 expression had poorer prognoses, although this association was not significant (p = 0.086). Loss of Smad 4 expression was noted in 18 cases (23.4%), and was not associated with clinicopathological characteristics, including MCM 7 expression, or prognosis.
CONCLUSIONS
MCM 7 expression is associated with the invasiveness of esophageal squamous cell carcinoma. Altered expression of Smad 4 does not appear to have pathobiological significance in esophageal carcinoma. -
Citations
Citations to this article as recorded by
- Immunohistochemical analysis of proliferating cell nuclear antigen and minichromosome maintenance complex component 7 in benign and malignant salivary gland tumors
Nafiseh Shamloo, Nasim Taghavi, Samane Ahmadi, Soudeh Shalpoush
Dental Research Journal.2022; 19(1): 17. CrossRef - Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma
Jelena Stojkovic-Filipovic, Dimitrije Brasanac, Martina Bosic, Novica Boricic, Branislav Lekic
Applied Immunohistochemistry & Molecular Morphology.2018; 26(3): 165. CrossRef - Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study
Verena Karla Monteiro LOPES, Adriana Souza de JESUS, Lucas Lacerda de SOUZA, Ligia Akiko Ninokata MIYAHARA, Douglas Magno GUIMARÃES, Helder Antônio Rebelo PONTES, Flavia Sirotheau Correa PONTES, Pedro Luiz de CARVALHO
Brazilian Oral Research.2017;[Epub] CrossRef - Immunohistochemical Expression of MCM2 in Nonmelanoma Epithelial Skin Cancers
Asmaa Gaber Abdou, Mohammed Gaber Abd Elwahed, Marwa Mohammed Serag El-dien, Dina Sharaf Eldien
The American Journal of Dermatopathology.2014; 36(12): 959. CrossRef
- Immunohistochemical analysis of proliferating cell nuclear antigen and minichromosome maintenance complex component 7 in benign and malignant salivary gland tumors
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