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Case Report
- Primitive Neuroectodermal Tumor Associated with Mature Cystic Teratoma of the Ovary: A case report.
- Young Ju Kim, Mi Yeong Jeon, Mi Sun Kang, Chan Hwan Kim
- Korean J Pathol. 1996;30(12):1150-1154.
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Abstract
PDF - Malignant transformation of benign cystic teratomas of the ovary is rare, with an incidence rate of 1-3%. The most common malignancy associated with benign cystic teratoma of the ovary is squamous cell carcinoma, which represents 90% of malignant transformations, followed by adenocarcinoma and carcinoid. Primary malignant neuroectodermal tumor in a mature cystic teratoma is extremely rare and microscopically can be subclassified as differentiated, primitive, and anaplatic. We experienced a case of primitive neuroectodermal tumor (PNET) associated with mature cystic teratoma of the ovary in a 11-year-old girl. Grossly, the ovary was a unilocular cyst which contained sebum material and disclosed several large, yellow to gray-tan polypoid excresences attached to the inner cystic wall. Except a large, fish-flesh, soft mass, the other polypoid masses were covered with sebum and contained small pieces of cartilage and tooth, and microscopically represented as mature teratoma. The large, fish-flesh, soft mass disclosed sheets and lobules of closely packed small cells with thin fibrovascular septa, which frequently replacing and encroaching the mature cystic teratoma. The small tumor cells were uniform and made up of round to oval nuclei with coarse chromatin and prominent nucleoli, very similar to those of PNET of the central nervous system.
Original Articles
- Meningioma with Multiple Recurrences and Malignant Transformation Differences in expression of MIB1, p53 and progesterone receptor.
- Eun Joo Seo, Hi Jeong Kwon
- Korean J Pathol. 1997;31(12):1314-1316.
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Abstract
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- We describe herein a case of meningioma showing three recurrences and in the end malignant transformation. To compare the differences of MIB1, p53 and progesterone receptor expressions in benign, recurrent and malignant meningiomas of the same patient, we performed immunohistochemical stainings for those markers. MIB1 and p53 reactivities were increased in proportion to histologic aggressiveness. By contrast, the progesterone receptor expression was noted in benign meningioma but not in malignant meningioma.
- PDGF-R alpha Expression in Preneoplastic and Neoplastic Hepatocellular Lesions: A Rat Model N-nitrosomorpholine Stop Experiment.
- Su Jin Kim, Kyoung Tae Kim, Jin Sook Jeong
- Korean J Pathol. 2006;40(5):354-360.
- 1,561 View
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Abstract
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- BACKGROUND
N-nitrosomorpholine (NNM) is a genotoxic hepatocarcinogenic agent. Preneoplastic and neoplastic hepatocyte lesions were induced in rats by oral exposure to NNM (200 mg/L) in a stop model experiment. Platelet-derived growth factor receptor (PDGF-R) is a tyrosine kinase receptor that works with PDGF, stimulating cellular growth and proliferation. The present study was designed to determine the role of PDGF-R alpha expression in hepatocellular neoplasms and precursors.
METHODS
Seventeen rats out of a starting number of 30 died. From the fifth week until the 24th week one or two rats were evaluated. Preneoplastic single cells or foci, foci of altered hepatocytes (FAH) hepatocellular adenomas (HCA) and hepatocellular carcinomas (HCC) were studied histologically, and the expressions of GSTp and PDGF-R alpha by immunohistochemistry.
RESULTS
At the fifth week, GSTp +single cells showed PDGF-R alpha expression (20.8+/-5.8%). At the sixth week, GSTp +single cells, located at periportal areas, co-expressed PDGF-R alpha (43.4+/-9.6%). Over the next several weeks periportal hepatocytes showed weaker PDGF-R alpha expression but no GSTp. GSTp+FAH, and all HCA, demonstrated no PDGF-R alpha expression. However, nine out of 10 (90%) HCC showed PDGF-R alpha expression.
CONCLUSIONS
These data showed that there were two peaks of PDGF-R alpha expression, and suggest that the earlier expression is related with the response to NNM-induced hepatocyte toxicity, and that the later response is associated to malignant transformation.
- Schneiderian Papillomas A Clinicopathologic Study of 27 Cases.
- Chae Hong Suh, Ho Jong Chun
- Korean J Pathol. 1987;21(4):227-232.
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Abstract
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- Schneiderian papillomas are papillary lesions of the nasal cavity paranasal sinuses that arise from the Schneiderian membrane, a membrane of ectodermal origin embryologically derived from the nasal placodes. This membrane is characterized by transitional type epithelium, similar to bladder urothelium, with admixed microcysts or mucin droplets. It has a tendency to recur after removal and transform into malignancy even though rare. Total 27 cases of Schneiderian papillomas were examined in the Chosun University medical college, which were collected from 1978 to 1986. The results obtained were as follows: 1) There were 19 male and 8 female patients, and mean age at diagnosis was 50.5+/-12.0 (SD) year (27-74 years). 2) Nasal obstruction or perception of nasal mass was the most common presenting symptom; Mean duration of symptoms was 25.8+/-15.0 (SD) month (4-48 months). 3) Numbers of papillomas had predominantly endophytic (inverted, n=17) and predominantly exophytic (fungiofrom n=6) patients, and four had mixed pattern. 4) In 27 patients, recurrences developed in 9, local invasion in one (with an inverted papilloma), and epidermoid carcinoma in one (with an inverted papilloma).
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