Journal of Pathology and Translational Medicine

Case Studies

Mediastinal Glomus Tumor: A Case Report and Literature Review: Si-Hyong Jang, Hyun Deuk Cho, Ji-Hye Lee, Hyun Ju Lee, Hae Yoen Jung, Kyung-Ju Kim, Sung Sik Cho, Mee-Hye Oh; J Pathol Transl Med. 2015;49(6):520-524. Published online August 4, 2015; DOI: https://doi.org/10.4132/jptm.2015.07.02

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A glomus tumor in the mediastinum is very uncommon, and only five cases have been reported in the English literature. We recently encountered a 21-year-old woman with an asymptomatic mediastinal mass that measured 5.3 × 4.0 cm. Surgical excision was performed, and the tumor was finally diagnosed as mediastinal glomus tumor with an uncertain malignant potential. After reviewing this case and previous reports, we analyzed the clinicopathologic features associated with progression of such a tumor.

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Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta)
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Advances in Anatomic Pathology.2021; 28(5): 351. CrossRef
La glomangiomatose médiastinale postérieure : localisation exceptionnelle d’une tumeur rare. À propos d’un cas
A. Machboua, S. Hamraoui, S. Zarouki, I. Kamaoui, I. Alloubi
Revue des Maladies Respiratoires.2021; 38(8): 848. CrossRef
An unusual case of chest wall glomus tumor presenting with axillary pain: a case report and literature review
Leila Oryadi Zanjani, Bahman Shafiee Nia, Farzad Vosoughi, Elham Mirzaian, Leila Aghaghazvini, Aidin Arabzadeh
European Journal of Medical Research.2021;[Epub] CrossRef
Clinical Implications of 18F-FDG PET/CT in Malignant Glomus Tumors of the Esophagus
Romain-David Seban, Laurence Bozec, Laurence Champion
Clinical Nuclear Medicine.2020; 45(6): e301. CrossRef
Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review
Franco Palmisano, Franco Gadda, Matteo G. Spinelli, Marco Maggioni, Bernardo Rocco, Emanuele Montanari
Urologia Journal.2018; 85(3): 130. CrossRef
Thoracoscopic Surgery for Glomus Tumor: An Uncommon Mediastinal Neoplasm and Iatrogenic Tracheal Rupture
Zhongjie Fang, Dehua Ma, Baofu Chen, Huarong Luo
Case Reports in Surgery.2017; 2017: 1. CrossRef
Asymptomatic Glomus Tumor of the Mediastinum
Meletios Kanakis, Nikoletta Rapti, Maria Chorti, Achilleas Lioulias
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A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature: Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh; J Pathol Transl Med. 2015;49(4):331-334. Published online June 1, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.16

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Abstract PDF

Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor revealed tubular morphology with expression of cytokeratin 20 and caudal-type homeobox 2 according to immunohistochemistry, suggesting enteric features. Extensive clinical and radiological studies excluded the possibility of an extrathymic primary tumor. A review of the literature revealed only two global cases of primary tubular adenocarcinomas of the thymus with enteric immunophenotype.

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Clinical characteristics and prognosis of primary thymic adenocarcinoma: A single‐center retrospective analysis
Qian Hong, Rui Han, Chen Chen, Fuquan Wang, Sining Zhang, Chenguang Zhao, Fang Li, Juwei Mu, Jiagen Li
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Jonathan Willner, Osvaldo Hernandez, Lea Azour, Andre L. Moreira
Diagnostic Cytopathology.2023;[Epub] CrossRef
Enteric-type thymic adenocarcinoma: a case report and literature review focusing on prognosis based on histological subtypes
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Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
Man Li, Xiao-Yu Pu, Li-Hua Dong, Peng-Yu Chang
World Journal of Clinical Cases.2021; 9(7): 1676. CrossRef
A case report: primary thymic adenocarcinoma with enteric differentiation
Yuuki Kou, Hirokazu Tanaka, Nobuhisa Yamazaki, Hiroyoshi Watanabe, Makoto Sonobe
The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 107. CrossRef
Thymic enteric type adenocarcinoma: A case report with cytological features
Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta
Diagnostic Cytopathology.2018; 46(1): 92. CrossRef
Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Pathology - Research and Practice.2017; 213(2): 106. CrossRef
Characterization of genetic aberrations in a single case of metastatic thymic adenocarcinoma
Yeonghun Lee, Sehhoon Park, Se-Hoon Lee, Hyunju Lee
BMC Cancer.2017;[Epub] CrossRef
Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
Journal of Pathology and Translational Medicine.2017; 51(5): 509. CrossRef
Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano
Pathology International.2016; 66(1): 29. CrossRef
Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
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International Cancer Conference Journal.2016; 5(2): 113. CrossRef
Metastatic Thymic Adenocarcinoma from Colorectal Cancer
Mina Lee, Suk Jin Choi, Yong Han Yoon, Joung-Taek Kim, Wan Ki Baek, Young Sam Kim
The Korean Journal of Thoracic and Cardiovascular Surgery.2015; 48(6): 447. CrossRef

Original Articles

Clinicopathologic Implication of Ezrin Expression in Non-small Cell Lung Cancer: Ho Won Lee, Eui Han Kim, Mee-Hye Oh; Korean J Pathol. 2012;46(5):470-477. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.470

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Abstract PDF

Background

Ezrin, a member of the ezrin-radixin-moesin family, is implicated in tumor progression, metastatic dissemination, and adverse outcomes, in several cancer types. In this study, we explored the clinicopathological significance of ezrin expression in non-small cell lung carcinomas (NSCLCs).

Methods

Immunohistochemical analysis of tissue microarray with 112 surgically resected NSCLC specimens, was performed to examine the ezrin expression. We also correlated ezrin expression with other clinicopathological features and prognosis.

Results

The ezrin-positive group revealed significantly higher correlation with pleural invasion (p=0.016) and pathologic stage (p=0.050). Univariate survival analysis showed that ezrin-positive group had a significantly shorter cancer-specific survival than ezrin-negative group (p=0.016). Meanwhile, female (p=0.030), no pleural invasion (p=0.023), no lymphatic invasion (p=0.026), and early pathologic stage (p=0.008) significantly correlated with longer survival. Multivariate survival analysis showed that variables such as ezrin positivity (p=0.032), female (p=0.035), and early pathologic stage (p=0.001) were independent prognostic factors for NSCLC.

Conclusions

Ezrin might be a molecular marker to predict poor prognosis of NSCLC.

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Perspectives for Targeting Ezrin in Cancer Development and Progression
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José Miguel Pardo-Sánchez, Nuria Mancheño, José Cerón, Carlos Jordá, Emilio Ansotegui, Óscar Juan, Sarai Palanca, Antonio Cremades, Carolina Gandía, Rosa Farràs
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Loss of ARID1A expression is associated with poor prognosis in non-small cell lung cancer
Si-Hyong Jang, Ji-Hye Lee, Hyun Ju Lee, Hyundeuk Cho, Hyein Ahn, In Hag Song, Mee-Hye Oh
Pathology - Research and Practice.2020; 216(11): 153156. CrossRef
Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review
Yanan Song, Xiaokun Ma, Miao Zhang, Menghan Wang, Guoyu Wang, Ying Ye, Wei Xia
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma
Thomas Cash, Hong Yin, Courtney McCracken, Zhi Geng, Steven G. DuBois, Bahig M. Shehata, Thomas A. Olson, Howard M. Katzenstein, Cynthia Wetmore
Sarcoma.2017; 2017: 1. CrossRef
Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer
Ji-Hye Lee, Myoung-Won Son, Kyung-Ju Kim, Mee-Hye Oh, Hyundeuk Cho, Hyun Ju Lee, Si-Hyong Jang, Moon Soo Lee
Journal of Gastric Cancer.2016; 16(1): 21. CrossRef
Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma
XIN LIU, DONGDONG QI, JUJIE QI, ZESHU MAO, XIANGDAN LI, JINHUI ZHANG, JINZI LI, WENBIN GAO
Oncology Reports.2016; 35(1): 155. CrossRef
Silencing of high‐mobility group box 2 (HMGB2) modulates cisplatin and 5‐fluorouracil sensitivity in head and neck squamous cell carcinoma
Nazia Syed, Sandip Chavan, Nandini A. Sahasrabuddhe, Santosh Renuse, Gajanan Sathe, Vishalakshi Nanjappa, Aneesha Radhakrishnan, Remya Raja, Sneha M. Pinto, Anand Srinivasan, T. S. Keshava Prasad, Kotteazeth Srikumar, Harsha Gowda, Vani Santosh, David Sid
PROTEOMICS.2015; 15(2-3): 383. CrossRef
Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis
Jianwei Li, Kuanhai Wei, Hailang Yu, Dan Jin, Gang Wang, Bin Yu
Scientific Reports.2015;[Epub] CrossRef
Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway
Qi-Hong Jiang, Ai-Xiang Wang, Yan Chen
The Scientific World Journal.2014; 2014: 1. CrossRef
Clinical significance of microRNA-183/Ezrin axis in judging the prognosis of patients with osteosarcoma
Yisila Mu, Haoshaqiang Zhang, Lixin Che, Kun Li
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Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer
Tiefeng Jin, Jingchun Jin, Xiangyu Li, Songnan Zhang, Yun Ho Choi, Yingshi Piao, Xionghu Shen, Zhenhua Lin
BMC Cancer.2014;[Epub] CrossRef
Prognostic Value of Ezrin in Solid Tumors: A Meta-Analysis of the Literature
Kun Han, WeiXiang Qi, ZhiHua Gan, Zan Shen, Yang Yao, DaLiu Min, Yves St-Pierre
PLoS ONE.2013; 8(7): e68527. CrossRef

Detection of BRAF^V600E Mutations in Papillary Thyroid Carcinomas by Peptide Nucleic Acid Clamp Real-Time PCR: A Comparison with Direct Sequencing: Dongjun Jeong, Yujun Jeong, Sungche Lee, Hyeran Lee, Wanju Lee, Hyungjoo Kim, Doosan Park, Soyoung Park, Wenxia Mu, Hyun-Deuk Cho, Mee-Hye Oh, Sung Soo Lee, Seung-Ha Yang, Chang-Jin Kim; Korean J Pathol. 2012;46(1):61-67. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.61

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Abstract PDF

Background

Papillary thyroid carcinoma (PTC) of the thyroid is the most common endocrine malignancy. High prevalence of an activating point mutation of BRAF gene, BRAF^V600E, has been reported in PTC. We assessed the efficiency of peptide nucleic acid clamp real-time polymerase chain reaction (PNAcqPCR) for the detection of BRAF^V600E mutation in PTC in comparison with direct sequencing (DS).

Methods

A total of 265 thyroid lesions including 200 PTCs, 5 follicular carcinomas, 60 benign lesions and 10 normal thyroid tissues were tested for BRAF^V600E mutation by PNAcqPCR and DS.

Results

The sensitivity and accuracy of the PNAcqPCR method were both higher than those of DS for the detection of the BRAF^V600E mutation. In clinical samples, 89% of PTCs harbored the BRAF^V600E mutation, whereas 5 follicular carcinomas, 50 benign lesions and 10 normal thyroid tissues lacked the mutation. The mutation was associated with aggressive clinical behaviors as extrathyroid invasion (p=0.015), lymph node metastasis (p=0.002) and multiple tumor numbers (p=0.016) with statistical significance.

Conclusions

The PNAcqPCR method is efficiently applicable for the detection of the BRAF^V600E mutation in PTCs in a clinical setting.

Citations

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Joonseon Park, Solji An, Kwangsoon Kim, Jeong Soo Kim, Chan Kwon Jung, Ja Seong Bae
Scientific Reports.2024;[Epub] CrossRef
BRAFV600E Positivity-Dependent Effect of Age on Papillary Thyroid Cancer Recurrence Risk
Joonseon Park, Solji An, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim
Cancers.2023; 15(22): 5395. CrossRef
TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae
Jae Yeon Seok, Xuemo Fan
Annals of Diagnostic Pathology.2022; 57: 151903. CrossRef
Null Association between BRAF V600E Mutation and Tumor Recurrence in Patients with Papillary Thyroid Microcarcinoma in South Korea
Ji Yoon Kim, Kyoung Jin Kim, Jae Hyun Bae, Joo Hyung Kim, Nam Hoon Kim, Hee Young Kim, Hoon Yub Kim, Seung-Kuk Baek, Sin Gon Kim, Kwang Yoon Jung, Kyeong Jin Kim
International Journal of Thyroidology.2021; 14(2): 135. CrossRef
Evaluation of the expression levels of BRAFV600E mRNA in primary tumors of thyroid cancer using an ultrasensitive mutation assay
Tien Viet Tran, Kien Xuan Dang, Quynh Huong Pham, Ung Dinh Nguyen, Nhung Thi Trang Trinh, Luong Van Hoang, Son Anh Ho, Ba Van Nguyen, Duc Trong Nguyen, Dung Tuan Trinh, Dung Ngoc Tran, Arto Orpana, Ulf-Håkan Stenman, Jakob Stenman, Tho Huu Ho
BMC Cancer.2020;[Epub] CrossRef
The Current State of Molecular Testing in the BRAF-Mutated Melanoma Landscape
Irene Vanni, Enrica Teresa Tanda, Francesco Spagnolo, Virginia Andreotti, William Bruno, Paola Ghiorzo
Frontiers in Molecular Biosciences.2020;[Epub] CrossRef
Highly prevalent BRAF V600E and low-frequency TERT promoter mutations underlie papillary thyroid carcinoma in Koreans
Sue Youn Kim, Taeeun Kim, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, Chan Kwon Jung
Journal of Pathology and Translational Medicine.2020; 54(4): 310. CrossRef
Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance
Giorgia Acquaviva, Michela Visani, Andrea Repaci, Kerry J Rhoden, Dario de Biase, Annalisa Pession, Tallini Giovanni
Histopathology.2018; 72(1): 6. CrossRef
Development of ultra-short PCR assay to reveal BRAF V600 mutation status in Thai colorectal cancer tissues
Nunthawut Chat-Uthai, Pichpisith Vejvisithsakul, Sutthirat Udommethaporn, Puttarakun Meesiri, Chetiya Danthanawanit, Yannawan Wongchai, Chinachote Teerapakpinyo, Shanop Shuangshoti, Naravat Poungvarin, John Souglakos
PLOS ONE.2018; 13(6): e0198795. CrossRef
T-blocker: a Simple and Robust Probe-Free Quantitative PCR Assay to Detect Somatic Mutations Down to 0.1% Frequency
Hanyoup Kim, Aaron E Ruby, Harini G Shandilya, Arvind K Virmani, Nandita Rahman, Christina M Strange, Jarkko Huuskonen
BioTechniques.2018; 65(4): 205. CrossRef
The usefulness of a novel fully automated PCR-based Idylla test for detection of the BRAF V600E mutation in thyroid tissue: comparison with PNA-clamping PCR, real-time PCR and pyrosequencing
Min-Kyung Yeo, Min-Kyu Jung, Su-Yel Lee, Yong-Moon Lee, Gang Min Hur, Jin-Man Kim
Journal of Clinical Pathology.2017; 70(3): 260. CrossRef
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Joo Kyung Park, Yoon Jung Lee, Jong Kyun Lee, Kyu Taek Lee, Yoon-La Choi, Kwang Hyuck Lee
Oncotarget.2017; 8(2): 3519. CrossRef
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Christopher S Hong, Chunzhang Yang, Zhengping Zhuang
Molecular Therapy - Nucleic Acids.2016; 5: e314. CrossRef
Prediction Table and Nomogram as Tools for Diagnosis of Papillary Thyroid Carcinoma
Seo Ki Kim, Jun Ho Lee, Jung-Woo Woo, Inhye Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
Medicine.2015; 94(21): e760. CrossRef
The association between BRAF V600E mutation and pathological features in PTC
Xin Liu, Kangkang Yan, Xuejun Lin, Longyu Zhao, Wenxiu An, Chunpeng Wang, Xiaodong Liu
European Archives of Oto-Rhino-Laryngology.2014; 271(11): 3041. CrossRef
Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review
Byeong-Joo Noh, Ji-Youn Sung, Youn-Wha Kim, Yong-Koo Park
Korean Journal of Pathology.2014; 48(4): 297. CrossRef
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Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
Korean Journal of Pathology.2014; 48(2): 100. CrossRef
VE1 immunohistochemistry in pituitary adenomas is not associated with BRAF V600E mutation
Jan Sperveslage, Midea Gierke, David Capper, Jürgen Honegger, Bence Sipos, Rudi Beschorner, Jens Schittenhelm
Acta Neuropathologica.2013; 125(6): 911. CrossRef
BRAF Mutations in Iranian Patients with Papillary Thyroid Carcinoma
Nastran Ranjbari, Sara Almasi, Javad Mohammadi-asl, Fakher Rahim
Asian Pacific Journal of Cancer Prevention.2013; 14(4): 2521. CrossRef

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