Journal of Pathology and Translational Medicine

Case Study

Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features: Dong Ja Kim, SangHan Lee, Mee-seon Kim, Jeong-Hyun Hwang, Myong Hun Hahm; J Pathol Transl Med. 2021;55(3):225-229. Published online March 9, 2021; DOI: https://doi.org/10.4132/jptm.2021.01.27

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We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors.

Citations

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Treatment modalities and outcomes of granular cell tumors and spindle cell oncocytomas of the pituitary gland: an analysis of two national cancer databases
A. Yohan Alexander, Giorgos Michalopoulos, Panagiotis Kerezoudis, Jamie J. Van Gompel, Michael J. Link, Maria Peris-Celda
Acta Neurochirurgica.2024;[Epub] CrossRef
Spindle cell oncocytoma, a misdiagnosed rare entity of the pituitary – A case report with review of literature and special emphasis on the morphological differentials
Gittwa Vatsaraj Kottangal, Lilly Madhavan, Shalini Kuruvilla, Kavitha Kanjirakadu Parameswaran, Shehla Basheer Kollathodi
Indian Journal of Pathology and Oncology.2021; 8(4): 533. CrossRef

Brief Case Report

Gastric Mixed Adenoneuroendocrine Carcinoma with Squamous Differentiation: A Case Report: Han-Ik Bae, Chaeyoon Lee, Young-Min Jo, Ohkyung Kwon, Wansik Yu, Mee-Seon Kim, An Na Seo; J Pathol Transl Med. 2016;50(4):318-321. Published online January 11, 2016; DOI: https://doi.org/10.4132/jptm.2015.10.17

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Citations

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Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs
Hyung Kyu Park, Ghee Young Kwon
Journal of Korean Medical Science.2023;[Epub] CrossRef
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity
Christine Woischke, Peter Jung, Andreas Jung, Jörg Kumbrink, Sibylle Eisenlohr, Christoph Josef Auernhammer, Michael Vieth, Thomas Kirchner, Jens Neumann
The Journal of Pathology: Clinical Research.2021; 7(1): 75. CrossRef
Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation
Faheem Farooq, Kevin Zarrabi, Keith Sweeney, Joseph Kim, Jela Bandovic, Chiraag Patel, Minsig Choi
Journal of Gastric Cancer.2018; 18(2): 200. CrossRef

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