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- Melanotic Oncocytic Metaplasia of the Nasopharynx: A Report of Three Cases and Review of the Literature
- Joo Young Na, Yeong Hui Kim, Yoo Duk Choi, Ji Shin Lee
- Korean J Pathol. 2012;46(2):201-204. Published online April 25, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.201
- 8,180 View
- 46 Download
- 9 Crossref
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Abstract
PDF Melanotic oncocytic metaplasia of the nasopharynx is a rare condition which is characterized by the presence of usually a small, brown to black colored pigmented lesion around the Eustachian tube opening. Although it is a benign lesion, it may be clinically misdiagnosed as malignant melanoma. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. In our present study, we report three cases of melanotic oncocytic metaplasia of the nasopharynx. All the three cases occurred in men and were presented as multiple black pigmented lesions around the torus tubarius. Microscopically, mucous glands with diffuse oncocytic metaplasia and numerous black pigments were observed. No cellular atypia was observed. Immunohistochemically, the scattering of S-100 protein-positive, and human melanoma black 45-negative dendritic melanocytes was evident. This is the first report of cases of melanotic oncocytic metaplasia of the nasopharynx in Korea.
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Citations
Citations to this article as recorded by
- Lesions that mimic malignant tumors in nasopharyngeal biopsies: case series of 10 years
Mine Ozsen, Ozlem Saraydaroglu, Selin Yirmibes, H. Hakan Coskun
Tumori Journal.2022; 108(2): 119. CrossRef - Melanotic Oncocytic Metaplasia of the Nasopharynx Seen as a Rare Form
of Cystic Mass: A Case Report and Review of the Literature
Keun-Ik Yi, Yong-Wan Kim
Journal of Clinical Otolaryngology Head and Neck Surgery.2022; 33(1): 23. CrossRef - Melanotic Oncocytic Metaplasia of the Nasopharynx: A Case Report With Review of Literature
Hsing-Yu Chen, Mpendulo Felix Gule, I-Wei Chang
Ear, Nose & Throat Journal.2021; 100(5_suppl): 771S. CrossRef - Malignant Mucosal Melanoma of the Eustachian Tube With Extension Into the Ipsilateral External Ear Canal: A Case Report and Review of the Literature
Lifeng Li, Nyall R. London, Xiaohong Chen
Ear, Nose & Throat Journal.2021; 100(5_suppl): 730S. CrossRef - Melanotic oncocytic metaplasia of the nasopharynx: A case report discussing the pathogenesis of a lesion
Shina Sakaguchi, Hiromasa Takakura, Shin-ichi Hayashi, Akira Noguchi, Hirohiko Tachino, Hideo Shojaku, Johji Imura
Otolaryngology Case Reports.2021; 20: 100276. CrossRef - Oncocytic Cysts of the Nasopharynx: A Case Report
Joshua C. Hwang, Raj D. Dedhia, Joan E. Bernard, Toby O. Steele
Allergy & Rhinology.2020; 11: 215265672095659. CrossRef - Melanotic Oncocytic Metaplasia of the Nasopharynx in the Patient with Suspicious Hemoptysis: Case Report
Taek Yoon Cheong, Han Seong Kim, Ick Soo Choi
Journal of Rhinology.2020; 27(2): 140. CrossRef - Clinicopathological features of melanotic and non-melanotic oncocytic lesions of the nasopharynx
Joshua J.X. Li, Joanna K.M. Ng, Amy B.W. Chan
Pathology.2019; 51(6): 600. CrossRef - Melanotic oncocytic metaplasia of the nasopharynx
Keiichiro Uehara, Yu Usami, Yukihiro Imai, Michio Shimizu
Pathology International.2015; 65(3): 144. CrossRef
- Lesions that mimic malignant tumors in nasopharyngeal biopsies: case series of 10 years
- Pigmented Mediastinal Paraganglioma: A case report.
- Seong Ho Kim, Yoon Hee Jin, Eun Kyung Hong, Moon Hyang Park
- Korean J Pathol. 2000;34(8):597-600.
- 1,629 View
- 31 Download
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Abstract
PDF
- Pigmented extraadrenal paraganglioma is an unusual neoplasm that has rarely been reported in the literature. Based on histochemical staining or electron microscopy, pigment has been classified as lipofuscin, neuromelanin or true melanin. We report a case of pigmented extraadrenal paraganglioma in the posterior mediastinum of a 70-year-old woman. Histologically, the tumor had a characteristic organoid architecture of "zellballen" pattern with rich delicate microvasculature. Tumor cells contained numerous coarse brown-black pigment granules. Ultrastructurally, the tumor showed abundant large electron-dense pigment granules that vary in size and shape and smaller membrane-bound neurosecretory granules. The larger granules were consistent with neuromelanin or lipofuscin. Histochemically, the pigment is most likely neuromelanin, which is a waste product of catecholamine metabolism.
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