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- Urinary Decoy Cell Grading and Its Clinical Implications
- Myoung Ju Koh, Beom Jin Lim, Songmi Noh, Yon Hee Kim, Hyeon Joo Jeong
- Korean J Pathol. 2012;46(3):233-236. Published online June 22, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.233
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- 6 Crossref
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Abstract
PDF Background Examination of urine for decoy cells (DCs) is a useful screening test for polyomavirus (PV) activation. We explored the significance of the amount of DCs in persistent shedding, PV nephropathy and acute rejection.
Methods A case-controlled study was performed in 88 renal allograft patients who had DCs detected at least once in four or more urine samples.
Results Fifty one patients were classified into the high-grade shedding group (HG) and 37 patients into the low-grade shedding group (LG) according to DC shedding (≥10 or <10 DCs/10 high power field [HPF]). DC shedding of more than three consecutive months was significantly more prevalent in the HG as compared with their LG counterparts (p<0.0001). Urinary DCs were present for more than one year in 29.4% of the HG and 8.1% of the LG. Real-time polymerase chain reaction for PV was higher in both urine (51.4% vs. 11.1%) and plasma (9.1% vs. 0%) of the HG than the LG. The prevalence of PV nephropathy was higher in the HG than the LG (p=0.019). However, there was no significant difference in the prevalence of acute rejection.
Conclusions Shedding of ≥10 DCs/10 HPF is associated with sustained shedding, polymerase chain reaction positivity and PV nephropathy, but not a predictor of acute rejection.
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Citations
Citations to this article as recorded by
- Polyomavirus nephropathy: diagnosis, histologic features, and differentiation from acute rejection
Cynthia C. Nast
Clinical Transplantation and Research.2024; 38(2): 71. CrossRef - Challenges and opportunities in research on BK virus infection after renal transplantation
Yukun Tang, Zipei Wang, Dunfeng Du
International Immunopharmacology.2024; 141: 112793. CrossRef - BK Virus-Associated Nephropathy after Renal Transplantation
Yasuhito Funahashi
Pathogens.2021; 10(2): 150. CrossRef - Diagnostic utility of urine cytology in detection of decoy cells in renal transplant patients: Report of five cases and review of literature
Santosh Tummidi, Kanchan Kothari, Mona Agnihotri, Leena Naik, Amey Rojekar
Diagnostic Cytopathology.2020; 48(3): 222. CrossRef - Association of Pretransplant BK Polyomavirus Antibody Status with BK Polyomavirus Infection After Kidney Transplantation: A Prospective Cohort Pilot Study of 47 Transplant Recipients
Yu Hisadome, Hiroshi Noguchi, Yuki Nakafusa, Kukiko Sakihama, Takanori Mei, Keizo Kaku, Yasuhiro Okabe, Kosuke Masutani, Yuki Ohara, Kazuyuki Ikeda, Yoshinao Oda, Masafumi Nakamura
Transplantation Proceedings.2020; 52(6): 1762. CrossRef - Association Between the Polyomaviruses Titers and Decoy Cell Positivity Rates After Renal Transplantation
Y. Funahashi, M. Kato, T. Fujita, S. Ishida, A. Mori, M. Gotoh
Transplantation Proceedings.2016; 48(3): 921. CrossRef
- Polyomavirus nephropathy: diagnosis, histologic features, and differentiation from acute rejection
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