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Case Study
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Mucocele of the rectal stump: mucinous cystic neoplasm with low-grade dysplasia simulating low-grade appendiceal mucinous neoplasm
Hasan Basri Aydin, Maria Faraz, A. David Chismark, Haiyan Qiu, Hwajeong Lee
J Pathol Transl Med. 2025;59(2):139-146.   Published online February 26, 2025
DOI: https://doi.org/10.4132/jptm.2024.12.27
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  • 164 Download
AbstractAbstract PDF
Mucoceles, commonly observed in the appendix, are mucin-filled, dilated structures arising from a range of etiologies. Cases associated with dysplastic or neoplastic epithelium can rupture and disseminate within the abdominopelvic cavity. Similar lesions in other parts of the colon are exceedingly rare, with only 16 colonic mucoceles having been reported. The first case of a colonic mucinous neoplasm with dysplasia resembling a low-grade appendiceal mucinous neoplasm involving rectal stump was described in 2016. Here, we present the second such case arising in the rectal stump, identified in a 44-year-old male with extensive surgical history. Microscopic examination revealed low-grade dysplastic epithelium lining the cyst and mucin dissecting into the stroma, without evidence of rupture or extramural mucin. The patient was followed for 16 months without recurrence or peritoneal disease. The exact etiology and outcome of these rare lesions remain unknown, requiring close follow-up.
Original Article
Article image
TRPS1 expression in non-melanocytic cutaneous neoplasms: an immunohistochemical analysis of 200 cases
Yi A. Liu, Phyu P. Aung, Yunyi Wang, Jing Ning, Priyadharsini Nagarajan, Jonathan L. Curry, Carlos A. Torres-Cabala, Doina Ivan, Victor G. Prieto, Qingqing Ding, Woo Cheal Cho
J Pathol Transl Med. 2024;58(2):72-80.   Published online February 26, 2024
DOI: https://doi.org/10.4132/jptm.2024.01.23
  • 6,808 View
  • 386 Download
  • 13 Web of Science
  • 13 Crossref
AbstractAbstract PDFSupplementary Material
Background
Although trichorhinophalangeal syndrome type 1 (TRPS1) was initially thought to be highly sensitive and specific for carcinomas and mesenchymal tumors of mammary origin, more recent data suggest its expression is not limited to breast neoplasms but also can be seen in other cutaneous neoplasms, such as extramammary Paget disease and squamous cell carcinoma (SCC) in situ.
Methods
Two-hundred cases of non-melanocytic cutaneous neoplasm, including basal cell carcinomas (BCCs) (n = 41), SCCs (n = 35), Merkel cell carcinomas (MCCs) (n = 25), and adnexal neoplasms (n = 99), were tested for TRPS1 expression using a monoclonal anti- TRPS1 rabbit anti-human antibody.
Results
TRPS1 expression was present in almost all cases of SCC (94%), with a median H-score of 200, while it was either absent or only focally present in most BCCs (90%), with a median H-score of 5. The difference between BCCs and SCCs in H-score was significant (p < .001). All MCCs (100%) lacked TRPS1 expression. TRPS1 expression was frequently seen in most adnexal neoplasms, benign and malignant, in variable intensity and proportion but was consistently absent in apocrine carcinomas. All endocrine mucin-producing sweat gland carcinomas (EMPSGCs) (100%, 6/6) showed diffuse and strong TRPS1 immunoreactivity, with a median H-score of 300, which was significantly different (p < .001) than that of BCCs.
Conclusions
Our study shows that TRPS1 may be an effective discriminatory marker for BCCs and SCCs. It also has a role in distinguishing BCCs from EMPSGCs.

Citations

Citations to this article as recorded by  
  • Metastatic Vulvar Paget's Disease Presenting in a Supraclavicular Lymph Node: A Diagnostic Challenge on Fine Needle Aspiration Cytology
    Thiri Htoo Aung, Neha Seth, Anam Khan, Kasturi Das
    Diagnostic Cytopathology.2026;[Epub]     CrossRef
  • Trichorhinophalangeal syndrome type 1 (TRPS1) in breast pathology: diagnostic utility and pitfalls
    Atif Ali Hashmi, Edi Brogi, Hannah Y. Wen
    Diagnostic Pathology.2025;[Epub]     CrossRef
  • Refining NTRK Fusion Detection in Papillary Thyroid Carcinoma Through Pan-TRK Immunohistochemistry and Histopathologic Features
    Hyun Lee, Sue Youn Kim, Ji Min Park, Seung-Hyun Jung, Ozgur Mete, Chan Kwon Jung
    Endocrine Pathology.2025;[Epub]     CrossRef
  • Endocrine mucin-producing sweat gland carcinoma: Case report and literature review
    Nan Guo, Zhenlin Fan, Yitong Chen, Qian Li, Limin Guo
    European Journal of Ophthalmology.2025;[Epub]     CrossRef
  • Updates on utility of immunohistochemistry in diagnosis of metastatic breast cancer
    Hongxia Sun, Aysegul A. Sahin, Qingqing Ding
    Human Pathology.2025; 162: 105821.     CrossRef
  • Primary Cutaneous NUT Adnexal Carcinoma With BRD4::NUTM1 Fusion: A 19-Year Follow-Up
    Elsayed Ibrahim, Richard K. Yang, Maria A. Gubbiotti, Victor G. Prieto, Woo Cheal Cho
    The American Journal of Dermatopathology.2025; 47(9): 731.     CrossRef
  • Primary mucinous carcinoma of the skin with co-expression of TRPS1 and GATA3: a case report
    Liling Song, Ning Zhu, Lei Jiang, Dong Gao, Guohua Yu
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Diagnostic Algorithm for Secondary Extramammary Paget Disease from Institutional Cases and Literature Review
    Salin Kiratikanon, Ayaka Fukui, Masahiro Hirata, Jakob M. T. Moran, Masakazu Fujimoto, Mai P. Hoang
    Cancers.2025; 17(24): 4014.     CrossRef
  • TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall
    Moon Joo Kim, Yi A. Liu, Yunyi Wang, Jing Ning, Woo Cheal Cho
    Dermatopathology.2024; 11(3): 200.     CrossRef
  • TRPS1 expression in MPNST is correlated with PRC2 inactivation and loss of H3K27me3
    Rossana Lazcano, Davis R. Ingram, Gauri Panse, Alexander J. Lazar, Wei-Lien Wang, Jeffrey M. Cloutier
    Human Pathology.2024; 151: 105632.     CrossRef
  • Syringocystadenoma Papilliferum-Like Features in Poroma: An Unusual Morphologic Pattern of Poroma or True Synchronous Occurrence of 2 Distinct Neoplasms?
    Mouaz Alsawas, Fiorinda F. Muhaj, Phyu P. Aung, Priyadharsini Nagarajan, Woo Cheal Cho
    The American Journal of Dermatopathology.2024; 46(12): 871.     CrossRef
  • A Comprehensive Review of TRPS1 as a Diagnostic Immunohistochemical Marker for Primary Breast Carcinoma: Latest Insights and Diagnostic Pitfalls
    Antonia-Carmen Georgescu, Tiberiu-Augustin Georgescu, Simona-Alina Duca-Barbu, Lucian Gheorghe Pop, Daniela Oana Toader, Nicolae Suciu, Dragos Cretoiu
    Cancers.2024; 16(21): 3568.     CrossRef
  • Expression of TRPS1 in Metastatic Tumors of the Skin: An Immunohistochemical Study of 72 Cases
    Kassiani Boulogeorgou, Christos Topalidis, Triantafyllia Koletsa, Georgia Karayannopoulou, Jean Kanitakis
    Dermatopathology.2024; 11(4): 293.     CrossRef
Review
Article image
Standardization of the pathologic diagnosis of appendiceal mucinous neoplasms
Dong-Wook Kang, Baek-hui Kim, Joon Mee Kim, Jihun Kim, Hee Jin Chang, Mee Soo Chang, Jin-Hee Sohn, Mee-Yon Cho, So-Young Jin, Hee Kyung Chang, Hye Seung Han, Jung Yeon Kim, Hee Sung Kim, Do Youn Park, Ha Young Park, So Jeong Lee, Wonae Lee, Hye Seung Lee, Yoo Na Kang, Younghee Choi
J Pathol Transl Med. 2021;55(4):247-264.   Published online July 8, 2021
DOI: https://doi.org/10.4132/jptm.2021.05.28
  • 20,468 View
  • 1,101 Download
  • 18 Web of Science
  • 17 Crossref
AbstractAbstract PDFSupplementary Material
Although the understanding of appendiceal mucinous neoplasms (AMNs) and their relationship with disseminated peritoneal mucinous disease have advanced, the diagnosis, classification, and treatment of AMNs are still confusing for pathologists and clinicians. The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists (GPSG-KSP) proposed a multicenter study and held a workshop for the “Standardization of the Pathologic Diagnosis of the Appendiceal Mucinous Neoplasm” to overcome the controversy and potential conflicts. The present article is focused on the diagnostic criteria, terminologies, tumor grading, pathologic staging, biologic behavior, treatment, and prognosis of AMNs and disseminated peritoneal mucinous disease. In addition, GPSG-KSP proposes a checklist of standard data elements of appendiceal epithelial neoplasms to standardize pathologic diagnosis. We hope the present article will provide pathologists with updated knowledge on how to handle and diagnose AMNs and disseminated peritoneal mucinous disease.

Citations

Citations to this article as recorded by  
  • Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature
    P. Meister, J. Rawitzer, M. Reschke, H.A. Baba, U. Neumann, M. Kaths
    Current Problems in Cancer: Case Reports.2025; 18: 100364.     CrossRef
  • Complete laparoscopic resection of giant appendiceal mucinous neoplasm, case report, and literature review
    Shatha Awad Althobaiti, Rayan Z. Makeen, Abrar J. Filfilan, Ahmed Abdulaziz Hawsawi
    Saudi Surgical Journal.2025; 13(1): 35.     CrossRef
  • Survival Outcomes and Prognostic Factors in Metastatic Unresectable Appendiceal Adenocarcinoma Treated with Palliative Systemic Chemotherapy: A 10-Year Retrospective Analysis from Australia
    Jirapat Wonglhow, Hui-Li Wong, Michael Michael, Alexander Heriot, Glen Guerra, Catherine Mitchell, Jeanne Tie
    Cancers.2025; 17(20): 3297.     CrossRef
  • Lower Gastrointestinal Bleeding Secondary to Appendiceal Mucinous Neoplasm: A Report of Two Cases and a Review of the Literature
    Jesús Omar Soto Llanes, Samanta Kin Dosal Limón, Ana Jimena Iberri Jaime, Mario Zambrano Lara, Billy Jiménez Bobadilla
    Cureus.2024;[Epub]     CrossRef
  • Predicting Survival in Mucinous Adenocarcinoma of the Appendix: Demographics, Disease Presentation, and Treatment Methodology
    Paul H. McClelland, Stephanie N. Gregory, Shirley K. Nah, Jonathan M. Hernandez, Jeremy L. Davis, Andrew M. Blakely
    Annals of Surgical Oncology.2024; 31(9): 6237.     CrossRef
  • Histoséminaire biopsies péritonéales tumorales. Néoplasies mucineuses appendiculaires
    Peggy Dartigues
    Annales de Pathologie.2024; 44(4): 274.     CrossRef
  • Histoséminaire biopsies péritonéales tumorales. Cas no 2
    Peggy Dartigues
    Annales de Pathologie.2024; 44(4): 245.     CrossRef
  • A Case of Low-Grade Appendiceal Mucinous Neoplasm: The Role of Preoperative Imaging and Surgical Technique in Achieving Favorable Outcomes
    Daniel A Meza-Martinez, Yeudiel Suro Santos, Samantha J Andrade-Ordoñez, Julio A Palomino-Payan, Brando J Fematt-Rodriguez
    Cureus.2024;[Epub]     CrossRef
  • Incidental Appendiceal Mucinous Neoplasm Found During Appendectomy in a 15-Year-Old Patient: A Case Report
    Fernando Aguilar-Ruiz, Kevin Joseph Fuentes-Calvo, Sara Fernanda Arechavala-Lopez, Irving Fuentes-Calvo, Luis F Arias-Ruiz
    Cureus.2024;[Epub]     CrossRef
  • Uncovering the Hidden Threat: Ileocolic Intussusception in an Adult With Appendicular Tumor
    Mrunal Panchal, Shishir Kumar, Khushboo Jha, Kaushik Saha, Abhijit Kundu
    Cureus.2024;[Epub]     CrossRef
  • Low-Grade Appendiceal Mucinous Neoplasm vs. Appendiceal Diverticulum: Distinction with Histomorphologic Features
    Cevriye Cansiz Ersöz, Siyar Ersöz, Berna Savas, Arzu Ensari
    Gastrointestinal Disorders.2024; 6(4): 905.     CrossRef
  • Appendiceal perforation secondary to endometriosis with intestinal metaplasia: A case report
    Minghua Wang, Jing Liu, Boxin Hu, Simin Wang, Ping Xie, Ping Li
    Experimental and Therapeutic Medicine.2023;[Epub]     CrossRef
  • Primary and secondary tumors of the peritoneum: key imaging features and differential diagnosis with surgical and pathological correlation
    Javier Miguez González, Francesc Calaf Forn, Laura Pelegrí Martínez, Pilar Lozano Arranz, Rafael Oliveira Caiafa, Jordi Català Forteza, Lina Maria Palacio Arteaga, Ferrán Losa Gaspà, Isabel Ramos Bernadó, Pedro Barrios Sánchez, Juan Ramón Ayuso Colella
    Insights into Imaging.2023;[Epub]     CrossRef
  • Muzinöse Tumoren des Peritoneums
    Anne Kristin Fischer, Andrea Tannapfel, Alexander Quaas
    Die Chirurgie.2023; 94(10): 823.     CrossRef
  • Landscape of Genetic Mutations in Appendiceal Cancers
    Marian Constantin, Cristina Mătanie, Livia Petrescu, Alexandra Bolocan, Octavian Andronic, Coralia Bleotu, Mihaela Magdalena Mitache, Sorin Tudorache, Corneliu Ovidiu Vrancianu
    Cancers.2023; 15(14): 3591.     CrossRef
  • Delivery of an Incidental Appendiceal Mucinous Neoplasm
    Madison Bowles, Jessica Y Ng, Hajir Nabi
    Cureus.2022;[Epub]     CrossRef
  • Unearthing novel fusions as therapeutic targets in solid tumors using targeted RNA sequencing
    Sungbin An, Hyun Hee Koh, Eun Sol Chang, Juyoung Choi, Ji-Young Song, Mi-Sook Lee, Yoon-La Choi
    Frontiers in Oncology.2022;[Epub]     CrossRef
Original Article
Article image
Clinicopathologic characteristics of HER2-positive pure mucinous carcinoma of the breast
Yunjeong Jang, Hera Jung, Han-Na Kim, Youjeong Seo, Emad Alsharif, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Yeon Hee Park, Eun Yoon Cho, Soo Youn Cho
J Pathol Transl Med. 2020;54(1):95-102.   Published online November 13, 2019
DOI: https://doi.org/10.4132/jptm.2019.10.24
  • 10,573 View
  • 293 Download
  • 22 Web of Science
  • 18 Crossref
AbstractAbstract PDF
Background
Pure mucinous carcinoma (PMC) is a rare type of breast cancer, estimated to represent 2% of invasive breast cancer. PMC is typically positive for estrogen receptors (ER) and progesterone receptors (PR) and negative for human epidermal growth factor receptor 2 (HER2). The clinicopathologic characteristics of HER2-positive PMC have not been investigated.
Methods
Pathology archives were searched for PMC diagnosed from January 1999 to April 2018. Clinicopathologic data and microscopic findings were reviewed and compared between HER2-positive PMC and HER2-negative PMC. We also analyzed the differences in disease-free survival (DFS) and overall survival according to clinicopathologic parameters including HER2 status in overall PMC cases.
Results
There were 21 HER2-positive cases (4.8%) in 438 PMCs. The average tumor size of HER2-positive PMC was 32.21 mm (± 26.55). Lymph node metastasis was present in seven cases. Compared to HER2-negative PMC, HER2-positive PMC presented with a more advanced T category (p < .001), more frequent lymph node metastasis (p = .009), and a higher nuclear and histologic grade (p < .001). Microscopically, signet ring cells were frequently observed in HER2-positive PMC (p < .001), whereas a micropapillary pattern was more frequent in HER2-negative PMC (p = .012). HER2-positive PMC was more frequently negative for ER (33.3% vs. 1.2%) and PR (28.6% vs. 7.2%) than HER2-negative PMC and showed a high Ki-67 labeling index. During follow-up, distant metastasis and recurrence developed in three HER2-positive PMC patients. Multivariate analysis revealed that only HER2-positivity and lymph node status were significantly associated with DFS.
Conclusions
Our results suggest that HER2-positive PMC is a more aggressive subgroup of PMC. HER2 positivity should be considered for adequate management of PMC.

Citations

Citations to this article as recorded by  
  • Clinicopathological characteristics of mucinous breast cancer: a retrospective analysis of a 6-years study from national cancer center in Vietnam
    Thi Huyen Phung, Thanh Tung Pham, Huu Thang Nguyen, Dinh Thach Nguyen, Thanh Long Nguyen, Thi Hoai Hoang
    Breast Cancer Research and Treatment.2025; 209(3): 667.     CrossRef
  • Poor response of HER2-positive mucinous carcinomas of breast to neoadjuvant HER2-targeted therapy: A study of four cases
    Min Han, Daniel Schmolze, Javier A. Arias-Stella, Christina H. Wei, Joanne Mortimer, Fang Fan
    Annals of Diagnostic Pathology.2025; 74: 152396.     CrossRef
  • Comprehensive Immunohistochemical Analysis of Mesonephric Marker Expression in Low-grade Endometrial Endometrioid Carcinoma
    Yurimi Lee, Sangjoon Choi, Hyun-Soo Kim
    International Journal of Gynecological Pathology.2024; 43(3): 221.     CrossRef
  • Clinicopathological features and prognosis of mucinous breast carcinoma with a micropapillary structure
    Beibei Yang, Menglu Shen, Bo Sun, Jing Zhao, Meng Wang
    Thoracic Cancer.2024; 15(36): 2530.     CrossRef
  • Pure Mucinous Carcinoma of the Breast: Radiologic-Pathologic Correlation
    Cherie M Kuzmiak, Benjamin C Calhoun
    Journal of Breast Imaging.2023;[Epub]     CrossRef
  • Role of circ-FOXO3 and miR-23a in radiosensitivity of breast cancer
    Elahe Abdollahi, Hossein Mozdarani, Behrooz Z. Alizadeh
    Breast Cancer.2023; 30(5): 714.     CrossRef
  • On Ultrasonographic Features of Mucinous Carcinoma with Micropapillary Pattern
    Wei-Sen Yang, Yang Li, Ya Gao
    Breast Cancer: Targets and Therapy.2023; Volume 15: 473.     CrossRef
  • Spectrum of Mucin-containing Lesions of the Breast: Multimodality Imaging Review with Pathologic Correlation
    Janice N. Thai, Melinda F. Lerwill, Shinn-Huey S. Chou
    RadioGraphics.2023;[Epub]     CrossRef
  • Mesonephric-like Adenocarcinoma of the Ovary: Clinicopathological and Molecular Characteristics
    Hyun Hee Koh, Eunhyang Park, Hyun-Soo Kim
    Diagnostics.2022; 12(2): 326.     CrossRef
  • Alveolar Soft Part Sarcoma of the Uterus: Clinicopathological and Molecular Characteristics
    Yurimi Lee, Kiyong Na, Ha Young Woo, Hyun-Soo Kim
    Diagnostics.2022; 12(5): 1102.     CrossRef
  • Metastasis of the Mucionous adenocarcinoma of breast to the mandibular gingiva: Rare case report
    Ivana Mijatov, Aleksandra Fejsa Levakov, Aleksandar Spasić, Jelena Nikolić, Saša Mijatov
    Medicine.2022; 101(38): e30732.     CrossRef
  • Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses
    Jihee Sohn, Yurimi Lee, Hyun-Soo Kim
    Diagnostics.2022; 12(10): 2339.     CrossRef
  • Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation
    Sangjoon Choi, Yoon Yang Jung, Hyun-Soo Kim
    Diagnostics.2021; 11(4): 717.     CrossRef
  • HER2 positive mucinous carcinoma of breast with micropapillary features: Report of a case and review of literature
    Dinesh Chandra Doval, Rupal Tripathi, Sunil Pasricha, Pankaj Goyal, Chaturbhuj Agrawal, Anurag Mehta
    Human Pathology: Case Reports.2021; 25: 200531.     CrossRef
  • Carcinoma mucosecretor de mama HER2-positivo, un caso clínico
    A.M. González Aranda, E. Martínez Gómez, A. Santana Costa, F. Arnanz Velasco, M.H. González de Diego, A. Zapico Goñi
    Clínica e Investigación en Ginecología y Obstetricia.2021; 48(4): 100685.     CrossRef
  • Clinicopathologic features of unexpectedly HER2 positive breast carcinomas: An institutional experience
    Carissa LaBoy, Kalliopi P. Siziopikou, Lauren Rosen, Luis Z. Blanco, Jennifer L. Pincus
    Pathology - Research and Practice.2021; 222: 153441.     CrossRef
  • Mesonephric-like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-like Adenocarcinoma
    Sujin Park, Go Eun Bae, Jiyoung Kim, Hyun-Soo Kim
    Diagnostics.2021; 11(8): 1450.     CrossRef
  • Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Immunohistochemical Analyses Using Markers for Mesonephric, Endometrioid and Serous Tumors
    Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim
    Diagnostics.2021; 11(11): 2042.     CrossRef
Case Studies
Coexisting Mucinous Cystic Neoplasm of the Pancreas and Type 1 Autoimmune Pancreatitis
Mee-Jeong Kim, Tae Jun Song, Hyoung Jung Kim, Song-Cheol Kim, Myung-Hwan Kim, Seung-Mo Hong
J Pathol Transl Med. 2019;53(2):125-128.   Published online November 14, 2018
DOI: https://doi.org/10.4132/jptm.2018.10.25
  • 10,111 View
  • 122 Download
  • 3 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Type 1 autoimmune pancreatitis (AIP1) is an IgG4-related systemic disease that mimics tumors. We report a rare case of AIP1 accompanied by mucinous cystic neoplasm (MCN). A pancreatic lesion was incidentally detected in a woman in her 60s. After 6 years of follow-up, the lesion abruptly increased in size. Computed tomography showed a 3.5 cm unilocular cyst in the tail of the pancreas and distal pancreatectomy was performed. On microscopic examination, the cyst was lined by mucinous and non-mucinous epithelial cells with mild cytologic atypia. The surrounding stroma comprised ovarian-type spindle cells with progesterone receptor positivity. The pericystic pancreas exhibited multifocal lymphoid follicles, lymphoplasmacytic infiltrations, obliterative phlebitis, and storiform fibrosis. IgG4-positive plasma cell infiltration (215 cells high-power field) and the IgG4/IgG ratio (57%) were increased. Cases of MCN coexisting with AIP1 are extremely rare; only two such cases have been reported in the English-language literature. This third case featured low-grade MCN with AIP1.

Citations

Citations to this article as recorded by  
  • Utilizing Immunoglobulin G4 Immunohistochemistry for Risk Stratification in Patients with Papillary Thyroid Carcinoma Associated with Hashimoto Thyroiditis
    Faridul Haq, Gyeongsin Park, Sora Jeon, Mitsuyoshi Hirokawa, Chan Kwon Jung
    Endocrinology and Metabolism.2024; 39(3): 468.     CrossRef
  • Histological features of autoimmune pancreatitis and IgG4-related sclerosing cholangitis with a correlation with imaging findings
    Kenji NOTOHARA
    Choonpa Igaku.2023; 50(1): 55.     CrossRef
  • Imaging Features and Risk Factors of Pancreatic Cystic Lesions Complicating Autoimmune Pancreatitis: A Retrospective Study
    Bin-Bin Zhang, Xin-Meng Hou, Yu-Qi Chen, Jian-Wei Huo, Er-Hu Jin
    Current Medical Imaging Reviews.2023;[Epub]     CrossRef
  • Histological features of autoimmune pancreatitis and IgG4-related sclerosing cholangitis with a correlation with imaging findings
    Kenji Notohara
    Journal of Medical Ultrasonics.2021; 48(4): 581.     CrossRef
  • 自己免疫性膵炎診療ガイドライン2020

    Suizo.2020; 35(6): 465.     CrossRef
  • Mucinous cystic neoplasm of the pancreas with type-1 autoimmune pancreatitis-like lesion
    Kevin Gowing, David F. Schaeffer, Hui-Min Yang
    Human Pathology: Case Reports.2019; 18: 200339.     CrossRef
Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?
Sun-Ju Oh, Young-Ok Kim
J Pathol Transl Med. 2018;52(4):238-242.   Published online January 25, 2018
DOI: https://doi.org/10.4132/jptm.2017.11.21
  • 9,600 View
  • 146 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.

Citations

Citations to this article as recorded by  
  • Primary cutaneous mucinous carcinoma of the scalp masquerading as a benign dermatological mass – A case report
    Fadi Alnehlaoui, Nafad Mohamed Lotfy Elhadidi, Shafik Fwakhrji, Shekhar V. Shikare, Majid Hassan Alhammadi, Salman Yousuf Guraya
    International Journal of Surgery Case Reports.2024; 114: 109175.     CrossRef
  • Primary cutaneous mucinous carcinoma in a periorbital lesion: two case reports and literature review
    Jun Woo Kim, Sung Eun Kim
    Archives of Craniofacial Surgery.2024; 25(2): 90.     CrossRef
  • Primary Cutaneous Mucinous Carcinoma: A Review of the Literature
    Timothy Freeman, Aaron J. Russell, M. Laurin Council
    Dermatologic Surgery.2023; 49(12): 1091.     CrossRef
  • A Case of Eccrine Mucinous Carcinoma Involving Scalp
    Ramsha Saleem, Sachin Vaidya
    Cureus.2021;[Epub]     CrossRef
Original Article
Prognostic Significance of a Micropapillary Pattern in Pure Mucinous Carcinoma of the Breast: Comparative Analysis with Micropapillary Carcinoma
Hyun-Jung Kim, Kyeongmee Park, Jung Yeon Kim, Guhyun Kang, Geumhee Gwak, Inseok Park
J Pathol Transl Med. 2017;51(4):403-409.   Published online June 9, 2017
DOI: https://doi.org/10.4132/jptm.2017.03.18
  • 9,112 View
  • 201 Download
  • 17 Web of Science
  • 18 Crossref
AbstractAbstract PDF
Background
Mucinous carcinoma of the breast is an indolent tumors with a favorable prognosis; however, micropapillary features tend to lead to aggressive behavior. Thus, mucinous carcinoma and micropapillary carcinoma exhibit contrasting biologic behaviors. Here, we review invasive mucinous carcinoma with a focus on micropapillary features and correlations with clinicopathological factors.
Methods
A total of 64 patients with invasive breast cancer with mucinous or micropapillary features were enrolled in the study. Of 36 pure mucinous carcinomas, 17 (47.2%) had micropapillary features and were termed mucinous carcinoma with micropapillary features (MUMPC), and 19 (52.8%) had no micropapillary features and were termed mucinous carcinoma without micropapillary features. MUMPC were compared with 15 invasive micropapillary carcinomas (IMPC) and 13 invasive ductal and micropapillary carcinomas (IDMPC).
Results
The clinicopathological factors of pure mucinous carcinoma and MUMPC were not significantly different. In contrast to IMPC and IDMPC, MUMPC had a low nuclear grade, lower mitotic rate, higher expression of hormone receptors, negative human epidermal growth factor receptor 2 (HER2) status, lower Ki-67 proliferating index, and less frequent lymph node metastasis (p < .05). According to univariate analyses, progesterone receptor, HER2, T-stage, and lymph node metastasis were significant risk factors for overall survival; however, only T-stage remained significant in a multivariate analysis (p < .05).
Conclusions
In contrast to IMPC and IDMPC, the micropapillary pattern in mucinous carcinoma does not contribute to aggressive behavior. However, further analysis of a larger series of patients is required to clarify the prognostic significance of micropapillary patterns in mucinous carcinoma of the breast.

Citations

Citations to this article as recorded by  
  • Pure mucinous adenocarcinoma of the breast with the rare lymphoplasmacytic infiltration: A case report with review of literature
    Yash Hasmukhbhai Prajapati, Vishal Bhabhor, Kahan Samirkumar Mehta, Mithoon Barot, Husen Boriwala, Mohamed Omar
    Clinical Case Reports.2024;[Epub]     CrossRef
  • Clinicopathological features and prognosis of mucinous breast carcinoma with a micropapillary structure
    Beibei Yang, Menglu Shen, Bo Sun, Jing Zhao, Meng Wang
    Thoracic Cancer.2024; 15(36): 2530.     CrossRef
  • Expression of autocrine motility factor receptor (AMFR) in human breast and lung invasive micropapillary carcinomas
    Jing Xu, Hongfei Ma, Qi Wang, Hui Zhang
    International Journal of Experimental Pathology.2023; 104(1): 43.     CrossRef
  • The Spectrum of Mucinous Lesions of the Breast
    Upasana Joneja, Juan Palazzo
    Archives of Pathology & Laboratory Medicine.2023; 147(1): 19.     CrossRef
  • Pure Mucinous Carcinoma of the Breast: Radiologic-Pathologic Correlation
    Cherie M Kuzmiak, Benjamin C Calhoun
    Journal of Breast Imaging.2023; 5(2): 180.     CrossRef
  • On Ultrasonographic Features of Mucinous Carcinoma with Micropapillary Pattern
    Wei-Sen Yang, Yang Li, Ya Gao
    Breast Cancer: Targets and Therapy.2023; Volume 15: 473.     CrossRef
  • Micropapillary Breast Carcinoma: From Molecular Pathogenesis to Prognosis
    Georgios-Ioannis Verras, Levan Tchabashvili, Francesk Mulita, Ioanna Maria Grypari, Sofia Sourouni, Evangelia Panagodimou, Maria-Ioanna Argentou
    Breast Cancer: Targets and Therapy.2022; Volume 14: 41.     CrossRef
  • Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
    Minjung Jung
    Kosin Medical Journal.2022; 37(3): 176.     CrossRef
  • Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy
    Jennifer Zeng, Marcia Edelweiss, Dara S. Ross, Bin Xu, Tracy-Ann Moo, Edi Brogi, Timothy M. D'Alfonso
    Archives of Pathology & Laboratory Medicine.2021; 145(6): 728.     CrossRef
  • HER2 positive mucinous carcinoma of breast with micropapillary features: Report of a case and review of literature
    Dinesh Chandra Doval, Rupal Tripathi, Sunil Pasricha, Pankaj Goyal, Chaturbhuj Agrawal, Anurag Mehta
    Human Pathology: Case Reports.2021; 25: 200531.     CrossRef
  • Sonographic Features of Pure Mucinous Breast Carcinoma With Micropapillary Pattern
    Wu Zhou, Yong-Zhong Li, Li-Min Gao, Di-Ming Cai
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Clinicopathologic characteristics of HER2-positive pure mucinous carcinoma of the breast
    Yunjeong Jang, Hera Jung, Han-Na Kim, Youjeong Seo, Emad Alsharif, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Yeon Hee Park, Eun Yoon Cho, Soo Youn Cho
    Journal of Pathology and Translational Medicine.2020; 54(1): 95.     CrossRef
  • Mucinous carcinoma with micropapillary features is morphologically, clinically and genetically distinct from pure mucinous carcinoma of breast
    Peng Sun, Zaixuan Zhong, Qianyi Lu, Mei Li, Xue Chao, Dan Chen, Wenyan Hu, Rongzhen Luo, Jiehua He
    Modern Pathology.2020; 33(10): 1945.     CrossRef
  • Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?
    Xiaoli Xu, Rui Bi, Ruohong Shui, Baohua Yu, Yufan Cheng, Xiaoyu Tu, Wentao Yang
    Histopathology.2019; 74(2): 248.     CrossRef
  • An Update of Mucinous Lesions of the Breast
    Beth T. Harrison, Deborah A. Dillon
    Surgical Pathology Clinics.2018; 11(1): 61.     CrossRef
  • The clinicopathological significance of micropapillary pattern in colorectal cancers
    Jung-Soo Pyo, Mee Ja Park, Dong-Wook Kang
    Human Pathology.2018; 77: 159.     CrossRef
  • The sonographic findings of micropapillary pattern in pure mucinous carcinoma of the breast
    Heqing Zhang, Li Qiu, Yulan Peng
    World Journal of Surgical Oncology.2018;[Epub]     CrossRef
  • Diagnostic dilemma of micropapillary variant of mucinous breast cancer
    Geok Hoon Lim, Zhiyan Yan, Mihir Gudi
    BMJ Case Reports.2018; 2018: bcr-2018-225775.     CrossRef
Case Studies
Mucinous Cystadenoma of the Testis: A Case Report with Immunohistochemical Findings
Gilhyang Kim, Dohee Kwon, Hee Young Na, Sehui Kim, Kyung Chul Moon
J Pathol Transl Med. 2017;51(2):180-184.   Published online February 13, 2017
DOI: https://doi.org/10.4132/jptm.2016.08.30
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AbstractAbstract PDF
Mucinous cystadenoma of the testis is a very rare tumor. Herein, we report a case of mucinous cystadenoma arising in the testis of a 61-year-old man, along with a literature review. Computed tomography showed a 2.5-cm-sized poorly enhancing cystic mass. Grossly, the tumor was a unilocular cystic mass filled with mucinous material and confined to the testicular parenchyma. Histologically, the cyst had a fibrotic wall lined by mucinous columnar epithelium without atypia. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, as well as focally positive for cytokeratin 7. The pathologic diagnosis was mucinous cystadenoma.

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  • Review of Paratesticular Appendageal Tumors, Morphology, Immunohistochemistry, and Recent Molecular Advances
    Mathew Vega, Muhammad T. Idrees
    Surgical Pathology Clinics.2025; 18(1): 119.     CrossRef
  • Cistoadenoma Mucinoso Paratesticular: Caso Interesante en el Instituto Guatemalteco de Seguridad Social
    Edgar Estuardo González López, Carlos Gonzalo Estrada Pazos
    Revista Guatemalteca de Urología.2023; 10(2): 16.     CrossRef
  • Primary borderline mucinous tumor of the testis with postoperative metastasis: A rare case report
    Yingyu Shi, Ling Song, Yan Luo
    Radiology Case Reports.2023; 18(9): 3203.     CrossRef
  • Case report: Misdiagnosis of primary mucinous cystadenoma of the testicle by ultrasound
    Linlin Zhang, Jianyuan Xuan, Manxi Li, Mei Zhang, Yu Song, Ziang Pan, Bo Fan, Lin Lu, Hongyan Zhou, Yang Li
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Primary Borderline Mucinous Testicular Tumor: A Case Report and Literature Review
    Changjuan Hao, Chunsong Kang, Xiaoyan Kang, Zhuanzhuan Yu, Tingting Li, Jiping Xue
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances
    Michelle S Lin, Alberto G Ayala, Jae Y Ro
    annals of urologic oncology.2019; : 1.     CrossRef
  • Borderline Mucinous Testicular Tumour: Diagnostic and Management difficulties
    Krishan Pratap, Marlon Perera, Frances Malczewski, Rachel Esler
    BMJ Case Reports.2018; 2018: bcr-2017-223787.     CrossRef
  • Mucinous tumor arising in a giant sacrococcygeal teratoma
    Fengtian Zhang, Xiaolong Yu, Jin Zeng, Min Dai
    Medicine.2017; 96(47): e8759.     CrossRef
Mucinous Carcinoma with Extensive Signet Ring Cell Differentiation: A Case Report
Hye Min Kim, Eun Kyung Kim, Ja Seung Koo
J Pathol Transl Med. 2017;51(2):176-179.   Published online December 5, 2016
DOI: https://doi.org/10.4132/jptm.2016.08.17
  • 11,484 View
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  • 4 Web of Science
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AbstractAbstract PDF
Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin. In a case with signet ring cell differentiation, differential diagnosis with metastatic signet ring cell carcinoma of the stomach and colon is essential. In this case, the presence of accompanied ductal carcinoma in situ component and mammaglobin and gross cystic disease fluid protein-15 positivity were findings that suggested the breast as the origin.

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  • Signet ring cell carcinoma of the urachus: survival and pathologic outcomes from the national cancer database
    Deerush Kannan Sakthivel, Pushan Prabhakar, Mohamed Javid Raja Iyub, Rohan Garje, Murugesan Manoharan
    International Urology and Nephrology.2025;[Epub]     CrossRef
  • Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
    Nian-Long Meng, Yang-kun Wang, Hai-Li Wang, Jun-Ling Zhou, Su-nan Wang
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Clinicopathologic characteristics of HER2-positive pure mucinous carcinoma of the breast
    Yunjeong Jang, Hera Jung, Han-Na Kim, Youjeong Seo, Emad Alsharif, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Yeon Hee Park, Eun Yoon Cho, Soo Youn Cho
    Journal of Pathology and Translational Medicine.2020; 54(1): 95.     CrossRef
  • Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy
    Yunjeong Jang, Eun Yoon Cho, Soo Youn Cho
    Journal of Breast Cancer.2019; 22(2): 336.     CrossRef
Original Article
Size of Non-lepidic Invasive Pattern Predicts Recurrence in Pulmonary Mucinous Adenocarcinoma: Morphologic Analysis of 188 Resected Cases with Reappraisal of Invasion Criteria
Soohyun Hwang, Joungho Han, Misun Choi, Myung-Ju Ahn, Yong Soo Choi
J Pathol Transl Med. 2017;51(1):56-68.   Published online October 16, 2016
DOI: https://doi.org/10.4132/jptm.2016.09.17
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AbstractAbstract PDF
Background
We reviewed a series of 188 resected pulmonary mucinous adenocarcinomas (MAs) to clarify the prognostic significance of lepidic and non-lepidic patterns.
Methods
Non-lepidic patterns were divided into bland, non-distorted acini with uncertain invasiveness (pattern 1), unequivocal invasion into stroma (pattern 2), or invasion into alveolar spaces (pattern 3).
Results
The mean proportion of invasive patterns (patterns 2 and 3) was lowest in small (≤ 3 cm) tumors, and gradually increased in intermediate (> 3 cm and ≤ 7 cm) and large (> 7 cm) tumors (8.4%, 34.3%, and 50.1%, respectively). Adjusted T (aT) stage, as determined by the size of invasive patterns, was positively correlated with adverse histologic and clinical features including older age, male sex, and ever smokers. aTis tumors, which were exclusively composed of lepidic pattern (n = 9), or a mixture of lepidic and pattern 1 (n = 40) without any invasive patterns, showed 100% disease- free survival (DFS). The aT1mi tumors, with minimal (≤ 5 mm) invasive patterns (n = 63), showed a 95.2% 5-year DFS, with recurrences (n = 2) limited to tumors greater than 3 cm in total size (n = 23). Both T and aT stage were significantly associated with DFS; however, survival within the separate T-stage subgroups was stratified according to the aT stage, most notably in the intermediatestage subgroups. In multivariate analysis, the size of invasive patterns (p = .020), pleural invasion (p < .001), and vascular invasion (p = .048) were independent predictors of recurrence, whereas total size failed to achieve statistical significance (p = .121).
Conclusions
This study provides a rationale for histologic risk stratification in pulmonary MA based on the extent of invasive growth patterns with refined criteria for invasion.

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  • Distinct Recurrence Pattern and Survival Outcomes of Invasive Mucinous Adenocarcinoma of the Lung: The Potential Role of Local Therapy in Intrapulmonary Spread
    Dong Woog Yoon, Soohyun Hwang, Tae Hee Hong, Yoon-La Choi, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Jong Ho Cho
    Annals of Surgical Oncology.2024; 31(1): 201.     CrossRef
  • Pulmonary invasive mucinous adenocarcinoma
    Wei‐Chin Chang, Yu Zhi Zhang, Andrew G Nicholson
    Histopathology.2024; 84(1): 18.     CrossRef
  • Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison With Invasive Non-Mucinous Adenocarcinoma
    Hui He, Lue Li, Yuan-yuan Wen, Li-yong Qian, Zhi-qiang Yang
    International Journal of Surgical Pathology.2024; 32(5): 926.     CrossRef
  • Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma
    Dae Hyeon Kim, So Young Bae, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim
    Interactive CardioVascular and Thoracic Surgery.2022; 34(2): 229.     CrossRef
  • Micropapillary Pattern in Invasive Mucinous Adenocarcinoma of the Lung: Comparison with Invasive Non-Mucinous Adenocarcinoma
    Hui He, Yuanyuan Wen, Liyong Qian, Zhiqiang Yang
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung
    Tomonari Oki, Keiju Aokage, Shogo Nomura, Kenta Tane, Tomohiro Miyoshi, Norihiko Shiiya, Kazuhito Funai, Masahiro Tsuboi, Genichiro Ishii
    Journal of Cancer Research and Clinical Oncology.2020; 146(5): 1291.     CrossRef
  • Prognostic Impact of Histopathologic Features in Pulmonary Invasive Mucinous Adenocarcinomas
    Wei-Chin Chang, Yu Zhi Zhang, Eric Lim, Andrew G Nicholson
    American Journal of Clinical Pathology.2020; 154(1): 88.     CrossRef
Case Studies
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome
Eun Na Kim, Gu-Hwan Kim, Jiyoon Kim, In Ah Park, Jin Ho Shin, Yun Chai, Kyu-Rae Kim
J Pathol Transl Med. 2017;51(2):159-164.   Published online August 22, 2016
DOI: https://doi.org/10.4132/jptm.2016.07.01
  • 9,932 View
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AbstractAbstract PDF
We describe an ovarian mucinous neoplasm that histologically resembles lobular endocervical glandular hyperplasia (LEGH) containing pyloric gland type mucin in a patient with Peutz-Jeghers syndrome (PJS). Although ovarian mucinous tumors rarely occur in PJS patients, their pyloric gland phenotype has not been clearly determined. The histopathologic features of the ovarian mucinous tumor were reminiscent of LEGH. The cytoplasmic mucin was stained with periodic acid-Schiff reaction after diastase treatment but was negative for Alcian blue pH 2.5, suggesting the presence of neutral mucin. Immunohistochemically, the epithelium expressed various gastric markers, including MUC6, HIK1083, and carbonic anhydrase-IX. Multiple ligation-dependent probe amplification detected a germline heterozygous deletion mutation at exons 1–7 of the STK11 gene (c.1-?_920+?del) in peripheral blood leukocytes and mosaic loss of heterozygosity in ovarian tumor tissue. Considering that LEGH and/or gastric-type cervical adenocarcinoma can be found in patients with PJS carrying germline and/or somatic STK11 mutations, our case indicates that STK11 mutations have an important role in the proliferation of pyloric-phenotype mucinous epithelium at various anatomical locations.

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  • Molecular evidence of a clonal relationship of synchronous/multifocal gastric‐type lesions of the female genital tract
    Min Shi, Hong Yang, Fang Zhang, Ting Hou, Huageng Huang, Yi Lu, Yehan Zhou, Ting Lan, Juan Ji, Jun Hou, Chengmin Zhou, Zhou Zhang, Sheng Qin, Zongyao Huang, Yang Liu
    The Journal of Pathology.2026; 268(1): 27.     CrossRef
  • Serine/threonine kinase 11 (STK11) associated adnexal tumors: from biology to therapeutic impact
    Guanxiang Huang, Wenyu Lin, Tingting Jiang, Yuanjun Cai, Chengbin Lin, Pengming Sun
    Human Genomics.2025;[Epub]     CrossRef
  • Novel ultrasound features and diagnostic clues of gastric-type endocervical adenocarcinoma: a case series
    Liwen Yang, Yangyang Wang, Jian Cai, Ying Xiong, Juan Li, Qi Zhou, Nan Ye, Hua Lai, Tianjiao Liu, Liuying Zhou
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report
    Hiroshi Yoshida, Kengo Hiranuma, Mariko Nakahara, Mayumi Kobayashi-Kato, Yasuhito Tanase, Masaya Uno, Kouya Shiraishi, Mitsuya Ishikawa, Tomoyasu Kato
    International Journal of Surgical Pathology.2024; 32(2): 394.     CrossRef
  • Preoperative multimodal ultrasonic imaging in a case of Peutz-Jeghers syndrome complicated by atypical lobular endocervical glandular hyperplasia: a case report and literature review
    Liwen Yang, Duan Duan, Ying Xiong, Tianjiao Liu, Lijun Zhao, Fan Lai, Dingxian Gu, Liuying Zhou
    Hereditary Cancer in Clinical Practice.2024;[Epub]     CrossRef
  • Gastric‐type glandular lesions of the female genital tract excluding the cervix: emerging pathological entities
    Richard W‐C Wong, Karen L Talia, W Glenn McCluggage
    Histopathology.2024; 85(1): 20.     CrossRef
  • Gastric-phenotype Mucinous Carcinoma of the Fallopian Tube with Secondary Ovarian Involvement in a Woman with Peutz-Jeghers Syndrome: A Case Report
    Mónica Bronte Anaut, Javier Arredondo Montero, Maria Pilar Fernández Seara, Rosa Guarch Troyas
    International Journal of Surgical Pathology.2023; 31(1): 92.     CrossRef
  • Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing
    Swati Garg, Teddy S. Nagaria, Blaise Clarke, Orit Freedman, Zanobia Khan, Joerg Schwock, Marcus Q. Bernardini, Amit M. Oza, Kathy Han, Adam C. Smith, Tracy L. Stockley, Marjan Rouzbahman
    Modern Pathology.2019; 32(12): 1823.     CrossRef
  • The developing spectrum of gastric-type cervical glandular lesions
    Karen L. Talia, W. Glenn McCluggage
    Pathology.2018; 50(2): 122.     CrossRef
ThinPrep Cytological Findings of Desmoplastic Small Round Cell Tumor with Extensive Glandular Differentiation: A Case Study
Hyun-Jung Kim, Byeong Seok Sohn, Ji-Eun Kwon, Jeong Yeon Kim, Kyeongmee Park
Korean J Pathol. 2013;47(2):182-187.   Published online April 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.182
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AbstractAbstract PDF

Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of this tumor has only been reported in a few cases. In most of these cases, the diagnosis was made using fine-needle aspiration cytology. Most DSRCTs resemble disseminated carcinomatoses in their clinical manifestation as well as cytomorphologically, even in young-adult patients. These authors report a case of using peritoneal-washing and pleural-effusion ThinPrep cytology to diagnose DSRCT, with extensive glandular differentiation and mucin vacuoles. We found that fibrillary stromal fragment, clinical setting, and adjunctive immunocytochemical staining were most helpful for avoiding misdiagnosis.

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  • Desmoplastic Small Round Cell Tumor: Study of Cytomorphologic and Immunophenotypical Features in Seven Cases, One With Unusual Rhabdoid Morphology
    Sameer Chhetri Aryal, Khalid Shittu, Mohamed Mustafa, Fatimah I. Alruwaii, Kyle D. Perry, Lisi Yuan
    Diagnostic Cytopathology.2026;[Epub]     CrossRef
  • A Rare and Aggressive Abdominopelvic Tumor: A Case of Desmoplastic Small Round Cell Tumor in a Young Male
    Yağmur Sena Tosun, Aytan Babazade, Emine Sena Sözen, Betül Erişmiş, Enes Seyda Şahiner
    Caucasian Medical Journal.2025; 3(1): 4.     CrossRef
  • Desmoplastic Small Round Cell Tumor Involving Serous Fluid: Cytologic Features and Diagnostic Pitfalls: A Series of 8 Cases
    Nibras L Fakhri, Qiong Gan
    American Journal of Clinical Pathology.2023; 160(4): 417.     CrossRef
  • A Review of Effusion Cytomorphology of Small Round Cell Tumors
    Lucy M. Han, Christopher J. VandenBussche, Mads Abildtrup, Ashish Chandra, Poonam Vohra
    Acta Cytologica.2022; 66(4): 336.     CrossRef
  • Intra-abdominal desmoplastic small blue round cell tumor: A case report
    Tareq Hamed Al Taei, Hasan Al Fardan, Sarah Ali Al Mail
    Radiology Case Reports.2022; 17(12): 4502.     CrossRef
  • Desmoplastic Small Round Cell Tumor of the Kidney: Report of a Case, Literature Review, and Comprehensive Discussion of the Distinctive Morphologic, Immunohistochemical, and Molecular Features in the Differential Diagnosis of Small Round Cell Tumors Affec
    Carlos A. Galliani, Michele Bisceglia, Antonio Del Giudice, Giuseppe Cretì
    Advances in Anatomic Pathology.2020; 27(6): 408.     CrossRef
  • Intra-abdominal desmoplastic small round cell tumors: CT and FDG-PET/CT findings with histopathological association
    JINGJING CHEN, ZENGJIE WU, BINBIN SUN, DACHENG LI, ZHENGUANG WANG, FANGJUN LIU, HUI HUA
    Oncology Letters.2016; 11(5): 3298.     CrossRef
  • Desmoplastic small round cell tumor with sphere‐like clusters mimicking adenocarcinoma
    Yukinori Hattori, Akihiko Yoshida, Naoshi Sasaki, Yasuo Shibuki, Kenji Tamura, Koji Tsuta
    Diagnostic Cytopathology.2015; 43(3): 214.     CrossRef
  • Tumor intraabdominal desmoplásico de células pequeñas y redondas
    Andrés Alejandro Briseño-Hernández, Deissy Roxana Quezada-López, Lilia Edith Corona-Cobián, Agar Castañeda-Chávez, Alfonso Tonatiuh Duarte-Ojeda, Michel Dassaejv Macías-Amezcua
    Cirugía y Cirujanos.2015; 83(3): 243.     CrossRef
  • Intra-abdominal desmoplastic small round cell tumour
    Andrés Alejandro Briseño-Hernández, Deissy Roxana Quezada-López, Lilia Edith Corona-Cobián, Agar Castañeda-Chávez, Alfonso Tonatiuh Duarte-Ojeda, Michel Dassaejv Macías-Amezcua
    Cirugía y Cirujanos (English Edition).2015; 83(3): 243.     CrossRef
  • Diagnostic Pitfalls of Differentiating Desmoplastic Small Round Cell Tumor (DSRCT) From Wilms Tumor (WT)
    Michael A. Arnold, Lynn Schoenfield, Berkeley N. Limketkai, Christina A. Arnold
    American Journal of Surgical Pathology.2014; 38(9): 1220.     CrossRef
Original Article
Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
Korean J Pathol. 2013;47(1):28-35.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.28
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AbstractAbstract PDF
Background

Gastric cancers with microsatellite instabilities (MSI) have been reported to be associated with favorable prognosis. However, the significance of the effect of MSI on the clinicopathological features, as well as its association with mucin phenotype, remains unclear.

Methods

MSI status was assessed in 414 cases of gastric cancer using polymerase chain reaction analysis of five microsatellite loci, as recommended by National Cancer Institution criteria. The expression of mucins (MUC5AC, MUC6, MUC2, and CD10) was assessed.

Results

Out of 414 total cases of gastric cancer, 380 (91.7%), 11 (2.7%), and 23 (5.6%) were microsatellite stable (MSS), low-level MSI (MSI-L), and high-level MSI (MSI-H), respectively. Compared to MSS/MSI-L, MSI-H gastric cancers were associated with older age (p=0.010), tumor size (p=0.014), excavated gross (p=0.042), intestinal type (p=0.028), aggressive behaviors (increase of T stage [p=0.009]), perineural invasion [p=0.022], and lymphovascular emboli [p=0.027]). MSI-H gastric cancers were associated with tumor necrosis (p=0.041), tumor-infiltrating lymphocytes (≥2/high power field, p<0.001), expanding growth patterns (p=0.038), gastric predominant mucin phenotypes (p=0.028), and MUC6 expression (p=0.016). Tumor necrosis (≥10% of mass, p=0.031), tumor-infiltrating lymphocytes (p<0.001), intestinal type (p=0.014), and gastric mucin phenotypes (p=0.020) could represent independent features associated with MSI-H gastric cancers. MSI-H intestinal type gastric cancers had a tendency for poor prognosis in univariate analysis (p=0.054) but no association in Cox multivariate analysis (p=0.197).

Conclusions

Our data suggest that MSI-H gastric cancers exhibit distinct aggressive biologic behaviors and a gastric mucin phenotype. This contradicts previous reports that describe MSI-H gastric cancer as being associated with favorable prognosis.

Citations

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  • Intestinal Subtype as a Biomarker of Response to Neoadjuvant Immunochemotherapy in Locally Advanced Gastric Adenocarcinoma: Insights from a Prospective Phase II Trial
    Lei Wang, Mengting Sun, Jinyang Li, Linghong Wan, Yuting Tan, Shuoran Tian, Yongying Hou, Linyu Wu, Ziyi Peng, Xiao Hu, Qihua Zhang, Zening Huang, Mengyi Han, Shiyin Peng, Yuwei Pan, Yuanfeng Ren, Mengsi Zhang, Dongfeng Chen, Qin Liu, Xianfeng Li, Zhong-y
    Clinical Cancer Research.2025; 31(1): 74.     CrossRef
  • How do I treat dMMR/MSI gastro-oesophageal adenocarcinoma in 2025? A position paper from the EORTC-GITCG gastro-esophageal task force
    Christelle de la Fouchardière, Antonella Cammarota, Magali Svrcek, Maria Alsina, Tania Fleitas-Kanonnikoff, Radka Lordick Obermannová, Anna Dorothea Wagner, Dominic Yap Wei Ting, Diana Enea, Angelica Petrillo, Elizabeth C. Smyth
    Cancer Treatment Reviews.2025; 134: 102890.     CrossRef
  • T-bet+CD8+ T cells govern anti-PD-1 responses in microsatellite-stable gastric cancers
    Shiying Tang, Xiaofang Che, Jinyan Wang, Ce Li, Xin He, Kezuo Hou, Xiaojie Zhang, Jia Guo, Bowen Yang, Danni Li, Lili Cao, Xiujuan Qu, Zhenning Wang, Yunpeng Liu
    Nature Communications.2025;[Epub]     CrossRef
  • Prediction of a Panel of Programmed Cell Death Protein-1 (PD-1) Inhibitor–Sensitive Biomarkers Using Multiphase Computed Tomography Imaging Textural Features: Retrospective Cohort Analysis
    Shiqi Wang, Na Chai, Jingji Xu, Pengfei Yu, Luguang Huang, Quan Wang, Zhifeng Zhao, Bin Yang, Jiangpeng Wei, Xiangjie Wang, Gang Ji, Minwen Zheng
    JMIR Cancer.2025; 11: e67379.     CrossRef
  • Isolated tumor cell clusters (ITC) in lymph nodes and PD-L1 expression on tumor-associated immune cells are prognostic factors for microsatellite instable-high gastric cancers
    Menghan Cui, Yangli Zhou, Yin Han, Nannan Chen, Min Zhao, Yan Wang, Fengxia He
    Translational Oncology.2025; 59: 102465.     CrossRef
  • Microsatellite Instability and BAT-26 Marker Expression in a Mexican Prostate Cancer Population with Different Gleason Scores
    Ana K. Flores-Islas, Manuel A. Rico-Méndez, Marisol Godínez-Rubí, Martha Arisbeth Villanueva-Pérez, Erick Sierra-Díaz, Ana Laura Pereira-Suárez, Saul A. Beltrán-Ontiveros, Perla Y. Gutiérrez-Arzapalo, José M. Moreno-Ortiz, Adrián Ramírez-de-Arellano
    Diseases.2025; 13(7): 202.     CrossRef
  • Prognostic implications of ERBB2 amplification and mismatch repair in gastric adenocarcinoma: a single-center study
    Han Xia, Zekang Li, Minyi Wang, Dachuan Zhang, Xiao Zheng, Jun Wu, Chen Wu
    Gastrointestinal Tumors.2025;[Epub]     CrossRef
  • Microsatellite Instability in Chronic Gastritis Associated with Gastric Cancer
    A. V. Kononov, V. A. Rubtsov, E. V. Demidova, M. N. Parygina, A. G. Shimanskaya, S. I. Mozgovoi, E. G. Pomorgailo, М. V. Markelova
    Russian Journal of Gastroenterology, Hepatology, Coloproctology.2025; 35(4): 48.     CrossRef
  • Non–Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Nonampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study
    Ryotaro Uema, Yoshito Hayashi, Masato Komori, Narihiro Shibukawa, Noriko Hayashi, Masayoshi Horimoto, Takuya Yamada, Masashi Yamamoto, Satoshi Hiyama, Kazuo Kinoshita, Hideharu Ogiyama, Shinjiro Yamaguchi, Satoshi Egawa, Takashi Kanesaka, Minoru Kato, Shu
    Clinical and Translational Gastroenterology.2024; 15(1): e00649.     CrossRef
  • Intratumoral and peritumoral CT-based radiomics for predicting the microsatellite instability in gastric cancer
    Xingchi Chen, Zijian Zhuang, Lin Pen, Jing Xue, Haitao Zhu, Lirong Zhang, Dongqing Wang
    Abdominal Radiology.2024; 49(5): 1363.     CrossRef
  • The tumor immune composition of mismatch repair deficient and Epstein-Barr virus-positive gastric cancer: A systematic review
    J. Bos, T.S. Groen-van Schooten, C.P. Brugman, F.S. Jamaludin, H.W.M. van Laarhoven, S. Derks
    Cancer Treatment Reviews.2024; 127: 102737.     CrossRef
  • Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair
    Akira Ooki, Hiroki Osumi, Koichiro Yoshino, Kensei Yamaguchi
    Gastric Cancer.2024; 27(5): 907.     CrossRef
  • The mechanism of RGS5 regulating gastric cancer mismatch repair protein
    Zhenwei Yang, Ranran Zhang, Jialong Liu, Sufang Tian, Hailin Zhang, Lingxiu Zeng, Yangyang Zhang, Liping Gao, Meng Wang, Wenqing Shan, Jing Liu
    Molecular Carcinogenesis.2024; 63(9): 1750.     CrossRef
  • Prognostic significance of microsatellite instability in patients with resectable gastric cancer
    Marina Alessandra Pereira, Marcus Fernando Kodama Pertille Ramos, Leonardo Cardili, André Roncon Dias, Venancio Avancini Ferreira Alves, Evandro Sobroza de Mello, Ulysses Ribeiro
    Journal of Gastrointestinal Surgery.2024; 28(10): 1687.     CrossRef
  • Access to radiotherapy in improving gastric cancer care quality and equality
    Minmin Wang, Kepei Huang, Xiaohan Fan, Jia Wang, Yinzi Jin, Zhi-Jie Zheng
    Communications Medicine.2024;[Epub]     CrossRef
  • Deep learning captures selective features for discrimination of microsatellite instability from pathologic tissue slides of gastric cancer
    Sung Hak Lee, Yujin Lee, Hyun‐Jong Jang
    International Journal of Cancer.2023; 152(2): 298.     CrossRef
  • Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives
    Yasushi Sato, Koichi Okamoto, Yutaka Kawano, Akinari Kasai, Tomoyuki Kawaguchi, Tamotsu Sagawa, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
    Journal of Clinical Medicine.2023; 12(14): 4646.     CrossRef
  • The results of treatment for resectable gastric cancer with microsatellite instability
    H. Sun, S. N. Nered, A. A. Tryakin, E. V. Artamonova, A. E. Kalinin, V. E. Bugaev, A. M. Stroganova, N. S. Besova, P. P. Arkhiri, V. I. Marshall, R. Sh. Abdulaeva, I. S. Stilidi
    Pelvic Surgery and Oncology.2023; 13(2): 17.     CrossRef
  • Heterogeneity and Adjuvant Therapeutic Approaches in MSI-H/dMMR Resectable Gastric Cancer: Emerging Trends in Immunotherapy
    Hui Wu, Wenyuan Ma, Congfa Jiang, Ning Li, Xin Xu, Yongfeng Ding, Haiping Jiang
    Annals of Surgical Oncology.2023; 30(13): 8572.     CrossRef
  • Dual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer
    Yongjian Zhu, Peng Wang, Bingzhi Wang, Zhichao Jiang, Ying Li, Jun Jiang, Yuxin Zhong, Liyan Xue, Liming Jiang
    Insights into Imaging.2023;[Epub]     CrossRef
  • Concordance between microsatellite instability testing and immunohistochemistry for mismatch repair proteins and efficient screening of mismatch repair deficient gastric cancer
    Gou Yamamoto, Tetsuya Ito, Okihide Suzuki, Nao Kamae, Miho Kakuta, Akemi Takahashi, Katsuya Iuchi, Tomio Arai, Hideyuki Ishida, Kiwamu Akagi
    Oncology Letters.2023;[Epub]     CrossRef
  • Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study
    Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei
    Scientific Reports.2023;[Epub]     CrossRef
  • Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer
    He-Li Liu, Huan Peng, Chang-Hao Huang, Hai-Yan Zhou, Jie Ge
    World Journal of Gastrointestinal Surgery.2023; 15(12): 2855.     CrossRef
  • Genomic and Immunologic Markers of Intrinsic Resistance to Pembrolizumab Monotherapy in Microsatellite Instability-High Gastric Cancer: Observations from a Prospective Phase II Study
    Haibo Qiu
    Global Medical Genetics.2022; 09(02): 060.     CrossRef
  • Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan
    Tsutomu Yoshida, Go Ogura, Mikiko Tanabe, Takuo Hayashi, Chiho Ohbayashi, Mizutomo Azuma, Chikara Kunisaki, Yoichi Akazawa, Soji Ozawa, Sohei Matsumoto, Takayoshi Suzuki, Akira Mitoro, Tetsu Fukunaga, Akiko Shimizu, Go Fujimoto, Takashi Yao
    Cancer Biology & Therapy.2022; 23(1): 191.     CrossRef
  • Development of Tissue-Agnostic Treatments for Patients with Cancer
    Steven Lemery, Lola Fashoyin-Aje, Leigh Marcus, Sandra Casak, Julie Schneider, Marc Theoret, Paul Kluetz, Richard Pazdur, Julia A. Beaver
    Annual Review of Cancer Biology.2022; 6(1): 147.     CrossRef
  • A multicenter study on the preoperative prediction of gastric cancer microsatellite instability status based on computed tomography radiomics
    Xiuqun Liang, Yinbo Wu, Ying Liu, Danping Yu, Chencui Huang, Zhi Li
    Abdominal Radiology.2022; 47(6): 2036.     CrossRef
  • Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
    Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong, Zhi Peng, Xiaotian Zhang, Jinping Cai, Shiqing Chen, Xiaochen Zhao, Lin Shen, Jian Li
    Journal for ImmunoTherapy of Cancer.2022; 10(6): e004703.     CrossRef
  • Eldest gastric cancer patient with high microsatellite instability responding to pembrolizumab
    Akinobu Wakasugi, Akinori Sasaki, Risa Okamoto, Yasuaki Motomura
    International Cancer Conference Journal.2022; 12(1): 59.     CrossRef
  • Baseline lesion number as an efficacy predictive and independent prognostic factor and its joint utility with TMB for PD-1 inhibitor treatment in advanced gastric cancer
    Xiao-Li Wei, Jian-Ying Xu, De-Shen Wang, Dong-Liang Chen, Chao Ren, Jia-Ning Li, Feng Wang, Feng-Hua Wang, Rui-Hua Xu
    Therapeutic Advances in Medical Oncology.2021;[Epub]     CrossRef
  • Clinical and morphological portrait of tumors with microsatellite instability
    A. A. Musaelyan, V. D. Nazarov, A. S. Budnikova, S. V. Lapin, S. L. Vorobyev, V. L. Emanuel, A. A. Zakharenko, S. V. Orlov
    Advances in Molecular Oncology.2021; 8(2): 52.     CrossRef
  • How to Best Exploit Immunotherapeutics in Advanced Gastric Cancer: Between Biomarkers and Novel Cell-Based Approaches
    Michele Ghidini, Angelica Petrillo, Andrea Botticelli, Dario Trapani, Alessandro Parisi, Anna La Salvia, Elham Sajjadi, Roberto Piciotti, Nicola Fusco, Shelize Khakoo
    Journal of Clinical Medicine.2021; 10(7): 1412.     CrossRef
  • Microsatellite instability in Gastric Cancer: Between lights and shadows
    Elisabetta Puliga, Simona Corso, Filippo Pietrantonio, Silvia Giordano
    Cancer Treatment Reviews.2021; 95: 102175.     CrossRef
  • Impact of microsatellite status on negative lymph node count and prognostic relevance after curative gastrectomy
    Zhenghao Cai, Junjun Ma, Shuchun Li, Abe Fingerhut, Jing Sun, Lu Zang, Chao Yan, Wentao Liu, Zhenggang Zhu, Minhua Zheng
    Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer
    Zhenghao Cai, Haiqin Song, Abe Fingerhut, Jing Sun, Junjun Ma, Luyang Zhang, Shuchun Li, Chaoran Yu, Minhua Zheng, Lu Zang
    BMC Cancer.2021;[Epub]     CrossRef
  • Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer
    Minsuk Kwon, Minae An, Samuel J. Klempner, Hyuk Lee, Kyoung-Mee Kim, Jason K. Sa, Hee Jin Cho, Jung Yong Hong, Taehyang Lee, Yang Won Min, Tae Jun Kim, Byung-Hoon Min, Woong-Yang Park, Won Ki Kang, Kyu-Tae Kim, Seung Tae Kim, Jeeyun Lee
    Cancer Discovery.2021; 11(9): 2168.     CrossRef
  • Advanced Gastric Cancer: Current Treatment Landscape and a Future Outlook for Sequential and Personalized Guide: Swiss Expert Statement Article
    Alexander R. Siebenhüner, Sara De Dosso, Daniel Helbling, Christoforos Astaras, Petr Szturz, Peter Moosmann, Stefanie Pederiva, Thomas Winder, Philippe Von Burg, Markus Borner
    Oncology Research and Treatment.2021; 44(9): 485.     CrossRef
  • High homogeneity of mismatch repair deficiency in advanced prostate cancer
    Christoph Fraune, Ronald Simon, Doris Höflmayer, Katharina Möller, David Dum, Franziska Büscheck, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Andrea Hinsch, Eike Burandt, Till Sebastian Clauditz, Waldemar Wilczak, Guido Sauter, Stefan Steu
    Virchows Archiv.2020; 476(5): 745.     CrossRef
  • High homogeneity of MMR deficiency in ovarian cancer
    Christoph Fraune, Janina Rosebrock, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Barbara Schmalfeldt, Volkmar Müller, Linn Wölber, Isabell Witzel, Peter Paluchowski, Christian Wilke, Uwe He
    Gynecologic Oncology.2020; 156(3): 669.     CrossRef
  • Molecular Classification of Gastric Cancer among Alaska Native People
    Holly Martinson, Dominic Mallari, Christine Richter, Tsung-Teh Wu, James Tiesinga, Steven Alberts, Matthew Olnes
    Cancers.2020; 12(1): 198.     CrossRef
  • Tumor immune response and immunotherapy in gastric cancer
    Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee
    Journal of Pathology and Translational Medicine.2020; 54(1): 20.     CrossRef
  • MMR deficiency in urothelial carcinoma of the bladder presents with temporal and spatial homogeneity throughout the tumor mass
    Christoph Fraune, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Christian Kähler, Martina Kluth, Doris Höflmayer, Franziska Büscheck, David Dum, Andreas M. Luebke, Eike Burandt, Till Sebastian Clauditz, Waldemar Wilczak, Guido Sauter, Stefan
    Urologic Oncology: Seminars and Original Investigations.2020; 38(5): 488.     CrossRef
  • MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
    Christoph Fraune, Eike Burandt, Ronald Simon, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Martina Kluth, Franziska Büscheck, Doris Höflmayer, Niclas Ch. Blessin, Tim Mandelkow, Wenchao Li, Daniel Perez, Jakob R. Izbicki, Waldemar Wilczak, Guido Sauter, J
    Annals of Surgical Oncology.2020; 27(10): 3997.     CrossRef
  • CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers
    Jerry B. Harvey, Luan H. Phan, Oscar E. Villarreal, Jessica L. Bowser
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer
    Zhihao Lu, Huan Chen, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Lihong Wu, Jianing Yu, Wenbo Han, Huaibo Sun, Xi Jiao, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
    Journal for ImmunoTherapy of Cancer.2020; 8(2): e000374.     CrossRef
  • Protein expression-based classification of gastric cancer by immunohistochemistry of tissue microarray
    Chong Zhao, Zhiqiang Feng, Hongzhen He, Dan Zang, Hong Du, Hongli Huang, Yanlei Du, Jie He, Yongjian Zhou, Yuqiang Nie, Girijesh Kumar Patel
    PLOS ONE.2020; 15(10): e0238836.     CrossRef
  • Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects
    Jooyoung Lee, Su Jin Chung, Ji Min Choi, Yoo Min Han, Joo Sung Kim, Greger Lindberg
    Gastroenterology Research and Practice.2020; 2020: 1.     CrossRef
  • Implication of expression of MMR proteins and clinicopathological characteristics in gastric cancer
    Renu Verma, Puja Sakhuja, Ritu Srivastava, Prakash Chand Sharma
    Asia-Pacific Journal of Oncology.2020; : 1.     CrossRef
  • Prognostic significance of microsatellite‐instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy
    Georg Martin Haag, Elena Czink, Aysel Ahadova, Thomas Schmidt, Leila Sisic, Susanne Blank, Ulrike Heger, Leonidas Apostolidis, Anne Katrin Berger, Christoph Springfeld, Felix Lasitschka, Dirk Jäger, Magnus von Knebel Doeberitz, Matthias Kloor
    International Journal of Cancer.2019; 144(7): 1697.     CrossRef
  • Serological Markers Associated With Response to Immune Checkpoint Blockade in Metastatic Gastrointestinal Tract Cancer
    Zhihao Lu, Jianling Zou, Ying Hu, Shuang Li, Tao Zhou, Jifang Gong, Jian Li, Xiaotian Zhang, Jun Zhou, Ming Lu, Xicheng Wang, Zhi Peng, Changsong Qi, Yanyan Li, Jie Li, Yan Li, Jianyin Zou, Xiao Du, Henghui Zhang, Lin Shen
    JAMA Network Open.2019; 2(7): e197621.     CrossRef
  • Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications
    Carolina Martinez-Ciarpaglini, Tania Fleitas-Kanonnikoff, Valentina Gambardella, Marta Llorca, Cristina Mongort, Regina Mengual, Gema Nieto, Lara Navarro, Marisol Huerta, Susana Rosello, Desamparados Roda, Noelia Tarazona, Samuel Navarro, Gloria Ribas, An
    ESMO Open.2019; 4(3): e000470.     CrossRef
  • The role of pembrolizumab in the treatment of PD-L1 expressing gastric and gastroesophageal junction adenocarcinoma
    Gagandeep Brar, Manish A. Shah
    Therapeutic Advances in Gastroenterology.2019;[Epub]     CrossRef
  • Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer
    Alessandro Cavaliere, Valeria Merz, Simona Casalino, Camilla Zecchetto, Francesca Simionato, Hayley Louise Salt, Serena Contarelli, Raffaela Santoro, Davide Melisi
    Journal of Gastric Cancer.2019; 19(4): 375.     CrossRef
  • MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE
    D. L. Rotin, O. V. Paklina, I. O. Tin’kova, D. N. Grekov
    Russian Journal of Biotherapy.2019; 18(4): 17.     CrossRef
  • Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer
    K Polom, L Marano, D Marrelli, R De Luca, G Roviello, V Savelli, P Tan, F Roviello
    Journal of British Surgery.2018; 105(3): 159.     CrossRef
  • Gastric poorly cohesive carcinoma: a correlative study of mutational signatures and prognostic significance based on histopathological subtypes
    Chae H Kwon, Young K Kim, Sojeong Lee, Ahrong Kim, Hye J Park, Yuri Choi, Yeo J Won, Do Y Park, Gregory Y Lauwers
    Histopathology.2018; 72(4): 556.     CrossRef
  • Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches
    Margherita Ratti, Andrea Lampis, Jens C. Hahne, Rodolfo Passalacqua, Nicola Valeri
    Cellular and Molecular Life Sciences.2018; 75(22): 4151.     CrossRef
  • High-throughput Protein and mRNA Expression–based Classification of Gastric Cancers Can Identify Clinically Distinct Subtypes, Concordant With Recent Molecular Classifications
    Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y. Lauwers, Do Youn Park
    American Journal of Surgical Pathology.2017; 41(1): 106.     CrossRef
  • Molecular Testing for Gastrointestinal Cancer
    Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
    Journal of Pathology and Translational Medicine.2017; 51(2): 103.     CrossRef
  • Molecular testing of gastrointestinal tumours
    Matthew Evans, Matthew Smith, Brendan O'Sullivan, Philippe Taniere
    Diagnostic Histopathology.2017; 23(10): 442.     CrossRef
  • Gastric Carcinomas With Lymphoid Stroma
    Raul S Gonzalez, Justin M M Cates, Frank Revetta, Loralee A McMahon, Kay Washington
    American Journal of Clinical Pathology.2017; 148(6): 477.     CrossRef
  • Meta-Analysis of Prognostic Role of Ki-67 Labeling Index in Gastric Carcinoma
    Jung-Soo Pyo, Nae Yu Kim
    The International Journal of Biological Markers.2017; 32(4): 447.     CrossRef
  • Tissue-Agnostic Drug Development
    Keith T. Flaherty, Dung T. Le, Steven Lemery
    American Society of Clinical Oncology Educational Book.2017; (37): 222.     CrossRef
  • Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection
    Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang, Kyueng-Whan Min
    Oncotarget.2017; 8(47): 82399.     CrossRef
  • Hypermutation and microsatellite instability in gastrointestinal cancers
    Kizuki Yuza, Masayuki Nagahashi, Satoshi Watanabe, Kazuaki Takabe, Toshifumi Wakai
    Oncotarget.2017; 8(67): 112103.     CrossRef
  • The Emerging Role of Immunotherapy in Gastric and Esophageal Adenocarcinoma
    Bruno Bockorny, Eirini Pectasides
    Future Oncology.2016; 12(15): 1833.     CrossRef
  • Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland
    Katarzyna Karpińska-Kaczmarczyk, Magdalena Lewandowska, Małgorzata Ławniczak, Andrzej Białek, Elżbieta Urasińska
    Medical Science Monitor.2016; 22: 2886.     CrossRef
  • Immunotherapy for Gastroesophageal Cancer
    Emily Goode, Elizabeth Smyth
    Journal of Clinical Medicine.2016; 5(10): 84.     CrossRef
  • Lauren classification and individualized chemotherapy in gastric cancer
    JUNLI MA, HONG SHEN, LINDA KAPESA, SHAN ZENG
    Oncology Letters.2016; 11(5): 2959.     CrossRef
  • High-risk and low-risk gastric cancer areas in Italy and its association with microsatellite instability
    Karol Polom, Daniele Marrelli, Valeria Pascale, Giandomenico Roviello, Costantino Voglino, Henry Rho, Carla Vindigni, Mario Marini, Raffaele Macchiarelli, Franco Roviello
    Journal of Cancer Research and Clinical Oncology.2016; 142(8): 1817.     CrossRef
  • MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang, Dong-Hoon Kim, Kyungeun Kim, In-Gu Do, Dong Hyun Kim
    Journal of Pathology and Translational Medicine.2015; 49(3): 249.     CrossRef
  • Correlation between microsatellite instability-high phenotype and occult lymph node metastasis in gastric carcinoma
    Jiwoon Choi, Soo Kyung Nam, Do Joong Park, Hwal Woong Kim, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    APMIS.2015; 123(3): 215.     CrossRef
  • Clinicopathologic and molecular features associated with patient age in gastric cancer
    Ji Yeon Seo, Eun Hyo Jin, Hyun Jin Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Hyun Chae Jung, Dong Ho Lee
    World Journal of Gastroenterology.2015; 21(22): 6905.     CrossRef
  • Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy
    Ismael Riquelme, Kathleen Saavedra, Jaime A. Espinoza, Helga Weber, Patricia García, Bruno Nervi, Marcelo Garrido, Alejandro H. Corvalán, Juan Carlos Roa, Carolina Bizama
    Oncotarget.2015; 6(28): 24750.     CrossRef
  • A phylogenetic model for understanding the effect of gene duplication on cancer progression
    Qin Ma, Jaxk H. Reeves, David A. Liberles, Lili Yu, Zheng Chang, Jing Zhao, Juan Cui, Ying Xu, Liang Liu
    Nucleic Acids Research.2014; 42(5): 2870.     CrossRef
  • The analysis of microsatellite instability in extracolonic gastrointestinal malignancy
    Andrew S. Williams, Weei-Yuarn Huang
    Pathology.2013; 45(6): 540.     CrossRef
Case Reports
Primary Mucinous Cystadenocarcinoma of the Breast: Cytologic Finding and Expression of MUC5 Are Different from Mucinous Carcinoma
Sung Eun Kim, Ji Hye Park, SoonWon Hong, Ja Seung Koo, Joon Jeong, Woo-Hee Jung
Korean J Pathol. 2012;46(6):611-616.   Published online December 26, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.611
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AbstractAbstract PDF

Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.

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  • BMP2 alterations in mucinous cystadenocarcinoma of the breast: insights from whole-exome sequencing
    Zhenyu Li, Yi Gong, Guangxin Li, Qingming Jiang, Juanhui Dong, Rui Chen
    PeerJ.2025; 13: e19948.     CrossRef
  • Primary mucinous cystadenocarcinoma of the breast commonly harbours TP53 mutations and PI3K/AKT pathway alterations
    Cheng Xu, Jing Wu, Ying Ding, Zhihong Zhang, Cong Wang
    Virchows Archiv.2025; 487(6): 1235.     CrossRef
  • Mucinous cystadenocarcinoma of the breast harbours TRPS1 expressions and PIK3CA alterations
    Wei‐Yu Chen, Yu‐Hsuan Hu, Yu‐Hsin Tsai, Jen‐Fan Hang, Puay Hoon Tan, Chih‐Jung Chen
    Histopathology.2024; 84(3): 550.     CrossRef
  • Pure mucinous adenocarcinoma of the breast with the rare lymphoplasmacytic infiltration: A case report with review of literature
    Yash Hasmukhbhai Prajapati, Vishal Bhabhor, Kahan Samirkumar Mehta, Mithoon Barot, Husen Boriwala, Mohamed Omar
    Clinical Case Reports.2024;[Epub]     CrossRef
  • HER2‐positive mucinous cystadenocarcinoma of the breast coexisting with invasive lobular carcinoma: A case report and review of the literature
    Ismail Guzelis, Betul Bolat Kucukzeybek, Mehmet Ali Uyaroglu, Melek Bekler Gokova, Gulten Sezgin, Yuksel Kucukzeybek
    Diagnostic Cytopathology.2024;[Epub]     CrossRef
  • Primary mucinous cystadenocarcinoma of the breast: A case report and literature review
    Xi Cao, Yongchao Luo, Songjie Shen, Xinyu Ren
    Oncology Letters.2024;[Epub]     CrossRef
  • Mammary mucinous cystadenocarcinoma with long-term follow-up: molecular information and literature review
    Ting Lei, Yong Qiang Shi, Tong Bing Chen
    Diagnostic Pathology.2023;[Epub]     CrossRef
  • Primary Mucinous Cystadenocarcinoma of the Breast Intermixed with Pleomorphic Invasive Lobular Carcinoma: The First Report of This Rare Association
    Federica Vegni, Nicoletta D’Alessandris, Angela Santoro, Giuseppe Angelico, Giulia Scaglione, Angela Carlino, Damiano Arciuolo, Michele Valente, Stefania Sfregola, Maria Natale, Alejandro Martin Sanchez, Valeria Masciullo, Gian Franco Zannoni, Antonino Mu
    Journal of Personalized Medicine.2023; 13(6): 948.     CrossRef
  • Special Histologic Type and Rare Breast Tumors – Diagnostic Review and Clinico-Pathological Implications
    Benjamin Yongcheng Tan, Elaine Hsuen Lim, Puay Hoon Tan
    Surgical Pathology Clinics.2022; 15(1): 29.     CrossRef
  • Mucinous cystadenocarcinoma of the breast: a new entity with broad differentials—a case report
    Kanwalpreet Kaur, Ashini Shah, Jahnvi Gandhi, Priti Trivedi
    Journal of the Egyptian National Cancer Institute.2022;[Epub]     CrossRef
  • Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
    Minjung Jung
    Kosin Medical Journal.2022; 37(3): 176.     CrossRef
  • Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature
    Ekta Jain, Abhishek Kumar, Raajul Jain, Shivani Sharma
    International Journal of Surgical Pathology.2021; 29(7): 740.     CrossRef
  • Mucinous Cystadenocarcinoma of the Breast: Report of 2 Cases Including One With Long-Term Local Recurrence
    Anupma Nayak, Ira J. Bleiweiss, Kimberly Dumoff, Tawfiqul A. Bhuiya
    International Journal of Surgical Pathology.2018; 26(8): 749.     CrossRef
  • Mucinous breast carcinoma with tall columnar cells
    N Tsoukalas, M Kiakou, M Tolia, ID Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
    The Annals of The Royal College of Surgeons of England.2018; 100(5): e132.     CrossRef
  • Radiologic Findings of Primary Mucinous Cystadenocarcinoma of the Breast: A Report of Two Cases and a Literature Review
    Minjung Seong, Eun Young Ko, Boo-Kyung Han, Soo Youn Cho, Eun Yoon Cho, Se Kyung Lee, Jeong Eon Lee
    Journal of Breast Cancer.2016; 19(3): 330.     CrossRef
  • Primary Mucinous Cystadenocarcinoma of the Breast with Endocervical-Like Mucinous Epithelium
    Dong-Liang Lin, Ji-Lin Hu, Shi-Hong Shao, Dong-Mei Sun, Ji-Gang Wang
    Breast Care.2013; 8(6): 445.     CrossRef
Primary Thymic Mucinous Adenocarcinoma: A Case Report
Jamshid Abdul-Ghafar, Suk-Joong Yong, Woocheol Kwon, Il Hwan Park, Soon-Hee Jung
Korean J Pathol. 2012;46(4):377-381.   Published online August 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.377
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AbstractAbstract PDF

Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.

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  • Unresectable Primary Enteric‐Type Thymic Adenocarcinoma Treated With FOLFOX Chemotherapy: A Case Report
    Carl He, Georgia Bentick, Patrick Hosking, Andrew Mant
    Cancer Reports.2025;[Epub]     CrossRef
  • Enteric thymic adenocarcinoma: Understanding a unique pathology in the mediastinum
    Raja Chhabra, Kartik Mittal, Anmol Tufchi, Sajjan Rajpurohit, Deepak Kumar Mittal, Aditya Vidushi, Swati Saxena, Md Ali Osama
    Indian Journal of Pathology and Microbiology.2025; 68(4): 820.     CrossRef
  • Primary mucinous adenocarcinoma of the thymus
    Kohei Soejima, Hidehito Matsuoka
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  • Stage IV thymic mucinous adenocarcinoma under long-term disease control after primary tumor resection: A case report
    Chihaya Maeda, Tomoyuki Hishida, Kyohei Masai, Keisuke Asakura, Katsura Emoto, Hisao Asamura
    The Journal of the Japanese Association for Chest Surgery.2022; 36(2): 156.     CrossRef
  • Lenvatinib-refractory thymic mucinous carcinoma with PIK3CA mutation
    Akihiro Tsukaguchi, Shoichi Ihara, Hironao Yasuoka, Seigo Minami
    International Cancer Conference Journal.2022; 12(1): 36.     CrossRef
  • Thymic mucinous adenocarcinoma: A case report
    Hideki Tsubouchi, Naoki Ozeki, Yuka Suzuki, Koji Kawaguchi, Takayuki Fukui, Toyofumi F. Chen-Yoshikawa
    The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 547.     CrossRef
  • Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
    Man Li, Xiao-Yu Pu, Li-Hua Dong, Peng-Yu Chang
    World Journal of Clinical Cases.2021; 9(7): 1676.     CrossRef
  • Primary Mucinous Adenocarcinoma of the Thymus: a Rare Type of Thymic Carcinoma—Case Report
    Koichi Tomoshige, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Ryusuke Machino, Satoshi Mizoguchi, Takamune Matumoto, Yutaka Maeda, Takeshi Nagayasu
    SN Comprehensive Clinical Medicine.2021; 3(5): 1233.     CrossRef
  • Primary mucinous adenocarcinoma of the thymus: A case report
    Tomoka Hamahiro, Ryo Maeda, Takanori Ayabe, Yuichiro Sato, Masaki Tomita
    Respiratory Medicine Case Reports.2021; 34: 101497.     CrossRef
  • Primary Thymic Mucinous Adenocarcinoma: A Case Report Focusing on Radiological Findings and Review of the Literature
    Young Hoon Koo, Jae Wook Lee, Jai Soung Park, Kyung Eun Shin, Heon Lee, Susie Chin
    Iranian Journal of Radiology.2020;[Epub]     CrossRef
  • Mucinous adenocarcinoma of the thymus: report of a case
    Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara
    General Thoracic and Cardiovascular Surgery.2018; 66(2): 111.     CrossRef
  • Thymic enteric type adenocarcinoma: A case report with cytological features
    Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta
    Diagnostic Cytopathology.2018; 46(1): 92.     CrossRef
  • Primary thymic adenocarcinomas: a clinicopathological and immunohistochemical study of 16 cases with emphasis on the morphological spectrum of differentiation
    Neda Kalhor, Cesar A. Moran
    Human Pathology.2018; 74: 73.     CrossRef
  • Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
    Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
    Pathology - Research and Practice.2017; 213(2): 106.     CrossRef
  • Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
    Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
    Journal of Pathology and Translational Medicine.2017; 51(5): 509.     CrossRef
  • Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
    Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano
    Pathology International.2016; 66(1): 29.     CrossRef
  • Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
    Akihiko Sawaki, Mikiya Ishihara, Yuji Kozuka, Hiroyasu Oda, Satoshi Tamaru, Yumiko Sugawara, Yoshiki Yamashita, Toshiro Mizuno, Taizo Shiraishi, Naoyuki Katayama
    International Cancer Conference Journal.2016; 5(2): 113.     CrossRef
  • Adenocarcinoma of the Thymus, Enteric Type
    Bernhard Moser, Ana Iris Schiefer, Stefan Janik, Alexander Marx, Helmut Prosch, Wolfgang Pohl, Barbara Neudert, Anke Scharrer, Walter Klepetko, Leonhard Müllauer
    American Journal of Surgical Pathology.2015; 39(4): 541.     CrossRef
  • A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer
    Eun Na Cho, Hye Sung Park, Tae Hoon Kim, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang
    Tuberculosis and Respiratory Diseases.2015; 78(2): 112.     CrossRef
  • A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature
    Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh
    Journal of Pathology and Translational Medicine.2015; 49(4): 331.     CrossRef
  • Primary mucinous adenocarcinoma of the thymus: a case report
    Tadashi Sakane, Kotaro Mizuno, Risa Oda, Takuya Matsui, Makoto Ito, Takeshi Yamada
    The Journal of the Japanese Association for Chest Surgery.2014; 28(7): 904.     CrossRef
Urachal Mucinous Tumor of Uncertain Malignant Potential: A Case Report
Jung-Woo Choi, Ju-Han Lee, Young-Sik Kim
Korean J Pathol. 2012;46(1):83-86.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.83
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AbstractAbstract PDF

Urachal mucinous tumor of uncertain malignant potential is very rare and is characterized by a multilocular cyst showing the proliferation of atypical mucin-secreting cells without stromal invasion. As in ovarian and appendiceal borderline tumors, it represents a transitional stage of mucinous carcinogenesis in the urachus. In addition, this tumor may recur locally and develop into pseudomyxoma peritonei. Due to its scarcity and diagnostic challenges, we report a mucinous tumor of uncertain malignant potential arising in the urachus.

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  • Exploring the Enigma of a Urachal Mucinous Cystic Tumor of Low Malignant Potential (MCTLMP): A Case Report and Literature Review
    Klaas De Corte, Ali Ramadhan
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  • Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms
    Diping Wang, Norbert Sule
    Archives of Pathology & Laboratory Medicine.2019; 143(2): 258.     CrossRef
  • Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma
    Kelly Brennan, Paul Johnson, Heather Curtis, Thomas Arnason
    Case Reports in Gastrointestinal Medicine.2019; 2019: 1.     CrossRef
  • Pseudomyxoma Peritonei Arising from Mucinous Cystadenoma of the Urachus with Postoperative Disease-Free Survival over 15 Years
    Tomoki Kobayashi, Shinichi Mizuno, Hideki Matsuba, Min Kanamori, Toshio Tamauchi, Makoto Urano
    The Japanese Journal of Gastroenterological Surgery.2019; 52(6): 307.     CrossRef
  • Urachal borderline mucinous cystadenoma
    Jingjun Wu, Ailian Liu, Anliang Chen, Pengxin Zhang
    Medicine.2017; 96(47): e8740.     CrossRef
  • Incidental Finding of a Rare Urachal Pathology: Urachal Mucinous Cystic Tumour of Low Malignant Potential
    Luke L. Wang, Heath Liddell, Sharman Tan Tanny, Briony Norris, Sree Appu, David Pan
    Case Reports in Urology.2016; 2016: 1.     CrossRef
  • A Case of Borderline Mucinous Cystadenoma Thought to be of Urachal Origin
    Kiichiro YAGUCHI, Yoshihito GOMYO, Hiroyasu SAITO, Tatsuo IKENO, Hiromi SAKAGUCHI, Hideo MIYAMOTO
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(5): 1418.     CrossRef
  • An unexpected mass of the urachus: a case report
    Monica C. Pasternak, Jonathan D. Black, Natalia Buza, Masoud Azodi, Aileen Gariepy
    American Journal of Obstetrics and Gynecology.2014; 211(4): e1.     CrossRef
Simultaneous Pancreatic Serous Microcystic Adenoma and Intraductal Papillary Mucinous Tumor of the Pancreas: A Case Report.
Hyoung Jong Kwak, Young Kon Kim, Baik Hwan Cho, Woo Sung Moon
Korean J Pathol. 2011;45:S29-S31.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S29
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AbstractAbstract PDF
Serous cystadenomas of the pancreas account for approximately a third of pancreatic cystic neoplasms. Their coexistence with a second tumor is extremely rare. We now report a case of a serous microcystic adenoma combined with an intraductal papillary mucinous tumor of the pancreas in a 69-year-old man. Abdominal computed tomography scans demonstrated an incidental cystic mass in the body with cystic dilatation of the duct in the head of the pancreas. Central pancreatectomy with pancreatico-jejunostomy, and cyst excision of the pancreatic head were performed. Histologic examination demonstrated a serous microcystic cystadenoma in the body coexisting with an intraductal papillary mucinous adenoma in the head of the pancreas. This case study highlights the importance of careful intra-operative and pathologic examination for synchronous pancreatic tumors.
Ovarian Large Cell Neuroendocrine Carcinoma Associated with Endocervical-like Mucinous Borderline Tumor: A Case Report and Literature Review.
Jun Mo Kim, Hyeong Chan Shin, Mi Jin Kim
Korean J Pathol. 2011;45(5):523-528.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.523
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AbstractAbstract PDF
Ovarian large cell neuroendocrine carcinoma is a rare tumor that is usually associated with surface epithelial tumors. Mucinous tumors are most common surface epithelial component identified in reported cases. Ovarian mucinous tumor associated with large cell neuroendocrine carcinoma is almost always an intestinal type. However, large cell neuroendocrine carcinoma associated with pure mucinous borderline tumor of endocervical-like type has not been described previously. The present case report describes a large cell neuroendocrine carcinoma associated with endocervical-like mucinous borderline tumor of the ovary in a 35-year-old woman. The tumor was confirmed by histopathology and immunohistochemistry. A review of the pertinent literature is included.

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  • The puzzle of gynecologic neuroendocrine carcinomas: State of the art and future directions
    Giuseppe Caruso, Carolina Maria Sassu, Federica Tomao, Violante Di Donato, Giorgia Perniola, Margherita Fischetti, Pierluigi Benedetti Panici, Innocenza Palaia
    Critical Reviews in Oncology/Hematology.2021; 162: 103344.     CrossRef
  • Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature
    Xiaohang Yang, Junyu Chen, Ruiying Dong
    Journal of Ovarian Research.2019;[Epub]     CrossRef
  • Primary pure large cell neuroendocrine carcinoma of the ovary
    Chen-Hsien Lin, Yu-Chieh Lin, Mu-Hsien Yu, Her-Young Su
    Taiwanese Journal of Obstetrics and Gynecology.2014; 53(3): 413.     CrossRef
  • Pure Large Cell Neuroendocrine Carcinoma of Ovary: A Rare Clinical Entity and Review of Literature
    P. N. Shakuntala, K. Uma Devi, K. Shobha, U. D. Bafna, M. Geetashree
    Case Reports in Oncological Medicine.2012; 2012: 1.     CrossRef
Cytologic Distinctive Features of Brenner Tumor.
Jung Sik Jang, An Na Seo, Seon Jae Lee, Ji Young Park
Korean J Pathol. 2011;45(2):223-226.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.223
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AbstractAbstract PDF
Herein, we present two cases of Brenner tumor, a rarely occurring neoplasm in the ovaries, obtained via intraoperative fine needle aspiration. The borderline Brenner tumor exhibited marked squamous metaplasia, characterized by individually distributed atypical squamous cells. A benign Brenner tumor associated with mucinous cystadenoma evidenced typical mucinous metaplastic features and transitional foci. These distinctive features may prove helpful in differential diagnosis of varied ovarian tumors, and particularly for intraoperative consultation.

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  • Pre‐operative cytodiagnosis of an adult granulosa cell tumour: report of a case with its differential diagnosis
    S. R. Jinkala, S. E. Jacob, S. Neelaiah, B. A. Badhe
    Cytopathology.2014; 25(1): 63.     CrossRef
A Case of Ovarian Microinvasive Mucinous Carcinoma and Co-existent Angiosarcoma.
Jin Hyung Heo, Yoon Hee Lee, Gwang Il Kim, Tae Heon Kim, Haeyoun Kang, Hee Jung An, Bo Sung Yoon, Seok Ju Seong, Hyun Park, Ji Young Kim
Korean J Pathol. 2011;45(1):96-100.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.96
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AbstractAbstract PDF
Primary ovarian angiosarcoma is very rare with only 27 cases reported so far in the medical literature. We report here on a rare case of ovarian microinvasive mucinous carcinoma that was coexistent with angiosarcoma in a 54-year-old woman. The tumor was a 26x19x10 cm-sized multilocular cystic mass with a 4x3 cm-sized solid hematoma-like nodule in the center. Microscopically, it was composed mostly of mucinous tumor of various grades from borderline to microinvasive carcinoma. The hematoma-like area turned out to be an angiosarcoma, composed of pleomorphic cells that formed slit-like spaces, spindle cells that formed short fascicles and anastomosing vascular channels with atypical endothelial cells. All these cells were positive for CD31, CD34 and factor VIII-related antigen. The patient developed peritoneal and pleural metastases, which were angiosarcoma and mucinous carcinoma, respectively. We believe this case is only the fourth example of an ovarian collision tumor of angiosarcoma and surface epithelial tumor.

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  • Ovarian angiosarcoma: A systematic review of literature and survival analysis
    Shafi Rehman, Arya Harikrishna, Amisha Silwal, B.R. Sumie, Safdar Mohamed, Nisha Kolhe, Meghana Maddi, Linh Huynh, Jesus Gutierrez, Yoshita Rao Annepu, Ameer Mustafa Farrukh
    Annals of Diagnostic Pathology.2024; 73: 152331.     CrossRef
  • Tumor to Tumor Metastasis: A Case Report of Metastatic Angiosarcoma to an Ovarian Brenner Tumor and Review of the Literature
    Bilge Dundar, Audai Alrwashdeh, Laila Dahmoush
    International Journal of Gynecological Pathology.2023; 42(2): 176.     CrossRef
  • Collision Tumors in Ovary: Case Series and Literature Review
    Borges A, Loddo A, Martins A, Peiretti M, Fanni D, Djokovic D
    Journal of Surgical Oncology.2019; : 1.     CrossRef
  • Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis
    Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Tip Pongsuvareeyakul, Sumalee Siriaunkgul
    Case Reports in Pathology.2016; 2016: 1.     CrossRef
  • Impact of body burden of pesticide residues on the reproductive tract of buffalo
    KARANPREET KAUR, SARVPREET SINGH GHUMAN, OPINDER SINGH, JASBIR SINGH BEDI, JATINDER PAUL SINGH GILL
    The Indian Journal of Animal Sciences.2016;[Epub]     CrossRef
Original Articles
Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression.
Nari Shin, Hye Yeon Kim, Woo Kyung Kim, Min Gyung Park, Kyung Bin Kim, Dong Hoon Shin, Kyung Un Choi, Jee Yeon Kim, Chang Hun Lee, Gi Young Huh, Mee Young Sol, Do Youn Park
Korean J Pathol. 2011;45(1):69-78.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.69
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AbstractAbstract PDF
BACKGROUND
It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of mucin expression in gastric cancer.
METHODS
We analyzed various protein expressions and microsatellite instability (MSI) status based on mucin expression in 130 differentiated early gastric adenocarcinoma cases. Furthermore, we evaluated the genomic alternation in 10 selected differentiated early gastric adenocarcinoma cases using array based comparative genomic hybridization (aCGH).
RESULTS
Intestinal mucin predominant subtype showed significantly elevated p53 protein and caudal-related homeobox 2 expression, and delocalization of beta catenin expressions compared to the gastric mucin predominant subtype. On MSI status, the gastric mucin predominant subtype more frequently showed unstable status than the intestinal mucin predominant subtype. CGH study showed more frequent chromosomal gain and loss in the intestinal mucin predominant subtype than the gastric mucin predominant subtype, albeit without statistical significance. Interestingly, there were significant differences in chromosomal alternation between four mucin phenotypes.
CONCLUSIONS
Study results suggest possible different points of biologic behaviors in early differentiated gastric adenocarcinomas by mucin expression type.

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  • Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance
    Dae Hwan Kim, Nari Shin, Gwang Ha Kim, Geum Am Song, Tae-Yong Jeon, Dong-Heon Kim, Gregory Y. Lauwers, Do Youn Park
    Archives of Pathology & Laboratory Medicine.2013; 137(8): 1047.     CrossRef
  • Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
    Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
    Korean Journal of Pathology.2013; 47(1): 28.     CrossRef
Clinical Outcome of Surgically Resected Pancreatic Intraductal Papillary Mucinous Neoplasm According to the Marginal Status: A Single Center Experience.
Sun A Kim, Eunsil Yu, Song Cheol Kim, Jihun Kim
Korean J Pathol. 2010;44(4):410-419.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.410
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AbstractAbstract PDF
BACKGROUND
Surgical resection is the treatment of choice of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. However, the benefit of clearing resection margin is still controversial.
METHODS
We reviewed 281 surgically resected cases of IPMN. The recurrences were compared according to the histologic grade (benign or borderline IPMN, malignant noninvasive IPMN, invasive carcinoma) and size (pancreatic intraepithelial neoplasia, PanIN, less than 0.5 cm in the long axis; and IPMN, greater than or equal to 0.5 cm) of the residual lesions at the resection margin.
RESULTS
Sixty cases (21.4%) were invasive carcinoma, and 221 (78.6%) noninvasive cases included 87 (31.0%) benign, 107 (38.1%) borderline and 11 (3.9%) malignant noninvasive IPMN cases. In noninvasive IPMN, increased recurrence in patients with five or more years of follow-up was only related to the involvement of resection margin by severe dysplasia. The recurrence of invasive carcinoma was high (27.3%) even when the resection margin was clear, and was not related to the grade or size of residual tumors at the resection margin.
CONCLUSIONS
Invasiveness is a strong risk factor for recurrence in IPMN regardless of the status of the resection margin. However, in noninvasive IPMN, histologic grading of residual lesions at the resection margin predicts local recurrence.

Citations

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  • Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms
    Laura D. Wood, N. Volkan Adsay, Olca Basturk, Lodewijk A.A. Brosens, Noriyoshi Fukushima, Seung-Mo Hong, Sung-Joo Kim, Jae W. Lee, Claudio Luchini, Michaël Noë, Martha B. Pitman, Aldo Scarpa, Aatur D. Singhi, Mariko Tanaka, Toru Furukawa
    Pancreatology.2023; 23(7): 878.     CrossRef
  • The Use of Intraoperative Frozen Sections in Guiding the Extent of Pancreatic Resections for Intraductal Papillary Mucinous Neoplasms
    Zhikai Chi, Deepti Dhall, Richard Mertens
    Pancreas.2022; 51(1): 63.     CrossRef
  • Recurrence of non-invasive intraductal papillary municious neoplasm seven years following total pancreatectomy
    Nayima M. Clermont Dejean, Sinziana Dumitra, Jeffrey S. Barkun
    International Journal of Surgery Case Reports.2013; 4(9): 789.     CrossRef
Expression of MUC1 and MUC4 and Its Prognostic Significance in Non-Small Cell Lung Carcinoma.
Ji Min Jeon, Hye Won Lee, Ji Young Park, Hye Ra Jung, Ilseon Hwang, Sun Young Kwon, Mi Sun Choe, Yu Na Kang, Sang Pyo Kim, Sang Sook Lee, Won Il Choi, Kun Young Kwon
Korean J Pathol. 2010;44(4):397-403.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.397
  • 5,409 View
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AbstractAbstract PDF
BACKGROUND
Mucin (MUC)1 and MUC4 (MUC1, 4) are high molecular weight glycoproteins expressed in normal and malignant epithelial cells, and these expressions are related to the prognosis of some carcinomas. In non-small cell lung carcinoma (NSCLC), the relationship between MUC1, 4 expressions and their prognostic significance is not well known. We evaluated these relationships in a series of NSCLC: 1) between MUC1, 4 expression levels and histologic subtypes, and 2) between high expression of MUC1, 4 and their prognostic significance.
METHODS
We performed immunohistochemical staining for MUC1, 4 in paraffin-embedded tissues from 165 NSCLC cases arranged in a tissue microarray.
RESULTS
We found a significant correlation between MUC1, 4 expressions and NSCLC histologic subtypes (p < 0.05). High MUC1 expression was characteristic of adenocarcinoma. Low MUC1, 4 expressions were characteristic of squamous cell carcinoma. In adenocarcinoma, we found significant association between diffuse MUC1 expression and short patient survival (p = 0.005). In squamous cell carcinoma, diffuse MUC4 expression showed long patient survival trend (p = 0.128).
CONCLUSIONS
MUC1, 4 expression levels were significantly correlated with NSCLC histologic subtypes. Diffuse MUC1 expression was significantly associated with shortened survival in NSCLC patients, especially in adenocarcinoma.

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  • Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells
    Jeong-A Park, Sangkyu Park, Jun-Kyu Choi, Myung-Kwan Han, Younghee Lee
    International Journal of Stem Cells.2020;[Epub]     CrossRef
  • Assessing the prognostic significance of MUC4β in mucoepidermoid carcinoma of the salivary glands: An immunohistochemical study
    Poonam R. Sawant, Anita Spadigam, Anita Dhupar, Shaheen Syed, Karla Carvalho
    Heliyon.2019; 5(11): e02753.     CrossRef
  • Ultrasensitive cytosensing based on an aptamer modified nanobiosensor with a bioconjugate: Detection of human non-small-cell lung cancer cells
    Tanveer A. Mir, Jang-Hee Yoon, N.G. Gurudatt, Mi-Sook Won, Yoon-Bo Shim
    Biosensors and Bioelectronics.2015; 74: 594.     CrossRef
  • Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma
    Su-Mi Kim, Sun-Ju Oh, Bang Hur
    Korean Journal of Pathology.2012; 46(5): 429.     CrossRef
  • MUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer
    Yukihiro Tamura, Michiyo Higashi, Sho Kitamoto, Seiya Yokoyama, Masahiko Osako, Michiko Horinouchi, Takeshi Shimizu, Mineo Tabata, Surinder K. Batra, Masamichi Goto, Suguru Yonezawa, Fazlul H. Sarkar
    PLoS ONE.2012; 7(11): e49251.     CrossRef
  • Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma
    ILSEON HWANG, YU NA KANG, JIN YOUNG KIM, YOUNG ROK DO, HONG SUK SONG, KEON UK PARK
    Experimental and Therapeutic Medicine.2012; 4(2): 311.     CrossRef
Case Reports
A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma: A Case Report.
Sunhee Chang, Sang Hwa Shim, Mee Joo, Hanseong Kim, Yong Kyu Kim
Korean J Pathol. 2010;44(1):97-100.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.97
  • 5,467 View
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  • 9 Crossref
AbstractAbstract PDF
An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analogous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We describe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partially filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.

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  • A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid
    Ji Eon Kang, Sung Eun Kim, Suk-Woo Yang
    Journal of the Korean Ophthalmological Society.2023; 64(2): 149.     CrossRef
  • Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis
    Michael H. Froehlich, Keith R. Conti, Ivy I. Norris, Jordan J. Allensworth, Nicole A. Ufkes, Shaun A. Nguyen, Evelyn T. Bruner, Joel Cook, Terry A. Day
    Journal of Dermatological Treatment.2022; 33(4): 2182.     CrossRef
  • Next-generation sequencing analysis suggests varied multistep mutational pathogenesis for endocrine mucin-producing sweat gland carcinoma with comments on INSM1 and MUC2 suggesting a conjunctival origin
    Joseph G. Mathew, Anita S. Bowman, Jad Saab, Klaus J. Busam, Kishwer Nehal, Melissa Pulitzer
    Journal of the American Academy of Dermatology.2022; 86(5): 1072.     CrossRef
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Intraductal Papillary Mucinous Tumor Simultaneously Involving the Liver and Pancreas: A Case Report.
Bong Hee Park, Jae Hee Suh, Hee Jeong Cha, Young Min Kim, Hye Jeong Choi
Korean J Pathol. 2010;44(1):83-86.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.83
  • 4,091 View
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  • 6 Crossref
AbstractAbstract PDF
We describe here a 67-year-old man who was diagnosed with a rare case of intraductal papillary mucinous tumors that occurred simultaneously in the liver and pancreas. Abdominal computed tomography showed a tubular and cystic dilatation of the pancreatic duct in the pancreas tail, which suggested an intraductal papillary mucinous tumor (IPMT), and multiple intrahepatic duct stones. The patient underwent a distal pancreatectomy with splenectomy and a lateral segmentectomy of the liver. Microscopic examination showed an intraductal papillary mucinous neoplasms of borderline malignancy in the pancreas and a non-invasive intraductal papillary mucinous tumor with moderate dysplasia of the bile duct. Although several cases of intraductal papillary mucinous neoplasm of the liver (IPNL) without any pancreatic association have been described, the simultaneous presentation of both IPMT of the pancreas and IPNL is very rare. The patient has been doing well for 10 months postoperatively.

Citations

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  • Surgical resection for simultaneous intraductal papillary mucinous neoplasm of the bile duct and pancreatic duct: A case report
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    World Journal of Gastrointestinal Surgery.2025;[Epub]     CrossRef
  • Reoperation for heterochronic intraductal papillary mucinous neoplasm of the pancreas after bile duct neoplasm resection: A case report
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    World Journal of Gastrointestinal Surgery.2023; 15(7): 1542.     CrossRef
  • Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology
    Federico Mocchegiani, Paolo Vincenzi, Grazia Conte, Daniele Nicolini, Roberta Rossi, Andrea Benedetti Cacciaguerra, Marco Vivarelli
    World Journal of Gastroenterology.2023; 29(38): 5361.     CrossRef
  • Multicentric recurrence of intraductal papillary neoplasm of bile duct after spontaneous detachment of primary tumor: A case report
    Hiroki Fukuya, Akifumi Kuwano, Shigehiro Nagasawa, Yusuke Morita, Kosuke Tanaka, Masayoshi Yada, Akihide Masumoto, Kenta Motomura
    World Journal of Clinical Cases.2022; 10(3): 1000.     CrossRef
  • Co-occurrence of IPMN and malignant IPNB complicated by a pancreatobiliary fistula: A case report and review of the literature
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    World Journal of Clinical Cases.2019; 7(1): 102.     CrossRef
  • Synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma arising in the context of intraductal papillary neoplasms
    Anmol Bansal, Swan N. Thung, Hongfa Zhu, Myron Schwartz, Sara Lewis
    Clinical Imaging.2016; 40(5): 897.     CrossRef
Original Article
Ultrastructural Changes in Human Gallbladder Epithelium in Acalculous and Calculous Cholecystitis.
Sung Chul Lim, Chae Hong Suh
Korean J Pathol. 1995;29(6):714-726.
  • 1,989 View
  • 15 Download
AbstractAbstract PDF
Cholelithiasis is defined as the presence of stones within the lumen of the gallbladder or in the extrahepatic biliary tree. Cholecystitis, secondary to gallstones, is a common surgical disorder in Korea. Detailed microscopic descriptions, particularly the ultrastructural changes, of these diseases were not available. The goal of this study was to identify the ultrastructural alterations of gallbladder epithelium in cholecystitis with and without a stone, according to the degree of severity of inflammation, and the nature of the stone. The gallbladders of the control group, and cholecystitis cases without stone and with stone were fixed and examined with routine stain, special stain, immunohistochemical stain and trans-mission electron microscopy. The number and the volume density of the mucin containing secretary granules were not significantly increased in the calculous cholecystitis cases compared with those of the acalculous cholecystitis cases. Major findings were that the calculous cholecystitis cases showed a markedly reduced total lysosome area and volume density of the lysosome compared with those of the acalculous chole-cystitis cases. The differences between the mucin secretary granules and lysosomes, according to the degree of severity of cholecystitis and the natures of gallstones, were statistically not significant.
Case Reports
Intraductal Papillary-Mucinous Neoplasm of the Pancreas: A case report.
Ji Eun Kim, Young Hyeh Ko, Howe Jung Ree, Yong Il Kim, Poong Ryul Lee
Korean J Pathol. 1996;30(8):726-732.
  • 2,363 View
  • 24 Download
AbstractAbstract PDF
Intraductal papillary mucinous neoplasm (IPMN) is a recently recognized clinicopathologic entity characterized by dilatation of pancreatic duct filled with copious mucin and papillary ductal epithelial proliferation ranging from simple hyperplasia to invasive carcinoma. The exact clinicopathologic identification of this tumor is important because of favorable prognosis contrast to that of conventional ductal adenocarcinoma. Herein we report a case of surgically resected typical IPMN. A 59-year-old man had a long history of diabetes mellitus with epigastric pain of 4 months duration. Ultrasonography and computed tomographic examination revealed cystic dilatations of main pancreatic duct in the head. The patient underwent total pancreatectomy. The gross appearance showed diffuse dilatation of main pancreatic duct associated with cystic dilatation of subbranches in the uncinate process. Histologic examination revealed diffuse papillary proliferations lined by mucinous epithelium with mild atypism within ectatic ducts. No invasive carcinoma was noted. Histochemically, the papillary epithelium contained mostly neutral and acid sialomucin.
Goblet Cell Carcinoid of the Appendix: A case report.
Joo Heon Kim, Ho Lee, So Young Oh, Myoung Jae Kang, Ho Yeul Choi, Dong Geun Lee
Korean J Pathol. 1996;30(9):839-842.
  • 2,209 View
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AbstractAbstract PDF
Carcinoid tumors of the appendix are common incidental findings, but appendiceal tumors with histologic features of both carcinoids and adenocarcinomas are rare, and their biologic behavior and histogenesis are still unclear. We report a case of goblet cell carcinoid of the appendix in a 54-year-old male, who exhibited pain in the right lower abdomen. Microscopically, the tumor contained smooth-bordered, widely separated nests composed of tumor cells with abundant mucin. The principal tumor cell type had a close resemblance to the normal goblet cell. Histochemically, the tumor cells revealed positive reaction for PAS and alcian blue stain. Immunohistochemically, the tumor showed strong reactivity for carcinoembryonic antigen, chromogranin and, neuron specific enolase but none for cytokeratin and epithelial membrane antigen.
Original Article
Mucinous Adenocarcinoma of Anal Ducts.
Young Ha Oh, Wan Seop Kim, Eun Kyung Hong, Moon Hyang Park, Jung Dal Lee
Korean J Pathol. 1996;30(9):843-850.
  • 2,390 View
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AbstractAbstract PDF
Anal duct carcinoma is a rare tumor, and accounts for less than 5 percent of all anal cancers, which typically present a long-standing perianal fistulas. Some authors suggest that the fistulous tracts are congenital duplications of the lower end of the hind gut lined by rectal mucosa which is prone to malignant change to mucinous adenocarcinoma. It is usually a well differentiated mucinous (colloid) adenocarcinoma. The prognosis after wide excision of the rectum is relatively good. Since 1985, we have had three cases of anal duct carcinoma with well differentiated mucinous adenocarcinoma involving the posterior wall of the anus. Two patients had a long history of perianal fistula with mucinous discharge. There was no spread to the regional lymph node except one patient who had regional lymph node metastasis, and post-operative chemotherapy and radiation therapy were then given. All patients have no evidence of any recurrent problem at 16 months to 3 years following the surgical treatment. Because of their rarity and the failure of recognition at an early stage, we are presenting three cases to emphasize the characteristic features of this insidious, slow-growing carcinoma.
Case Report
Sarcoma-like Mural Nodule in Ovarian Mucinous Cystadenocarcinoma: A case report.
Suk Hee Lee, Min Hee Jung, Byung Yuk Lee, Jong Min Chae
Korean J Pathol. 1996;30(9):854-857.
  • 2,080 View
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AbstractAbstract PDF
We describe an ovarian mucinous cystadenocarcinoma with a sarcoma-like mural nodule. In the literature, rare cases of ovarian mucinous tumors have been described which contain foci of undifferentiated carcinoma, sarcoma, and sarcoma-like nodules. The distinction between these lesions is important because of poorer prognosis of true sarcoma and anaplastic carcinoma than sarcoma-like mural nodules. This case shows different results of immunohistochemical stain for anaplastic carcinoma.
Original Article
Mucinous Tumors of the Appendix Associated with Mucinous Tumors of the Ovary and Pseudomyxoma Peritonei: A Clinicopathologic Analysis of 5 Cases Supporting an Appendiceal Origin.
Eung Seok Lee, Han Kyeom Kim, In Sun Kim
Korean J Pathol. 1998;32(2):131-137.
  • 2,711 View
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AbstractAbstract PDF
Pseudomyxoma peritonei often have synchronous appendiceal and ovarian mucinous tumors. There has been considerable debate as to whether the ovarian tumors are secondary to the appendiceal tumor or they are independent primary ovarian tumors. It is important to reveal the primary site for treatment and prognosis of a patient. Five cases of synchronous mucinous tumors of the ovary and appendix were studied. Four cases had pseudomyxoma peritonei and pseudomyxoma ovarii. The ovarian tumors were bilateral in two cases, right in two, and left in one. The ovarian tumors were four mucinous cystadenoma of borderine malignancy and one mucinous cystadenocarcinoma, and the appendiceal tumors consisted of four mucinous tumors of borderline malignancy and one mucinous adenocarcinoma. The histology of the ovarian and appendiceal tumors was similar. Rupture of the tumor was seen in all appendiceal tumors and two ovarian tumors. It has been reported that cytokeratin 7 is a useful marker for distinguishing primary ovarian neoplasms from metastases of intestinal origin. All ovarian and appendiceal tumors showed positive reaction for broad-spectrum cytokeratin, but negative for cytokeratin 7. Based on the clinicopathologic and immunohistochemical features, it should be considered that the appendiceal tumors are primary and ovarian tumors are secondary in the synchronous presentation of the ovarian and appendiceal mucinous tumors.
Case Reports
Metastatic Adenocarcinoma with Mucin Emboli in the Lung: A case report.
Chung Yeul Kim, Kwang Il Kim, Sung Hwan Park, Eung Suk Lee, Han Kygum Kim
Korean J Pathol. 1999;33(6):450-452.
  • 1,999 View
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AbstractAbstract PDF
Lung is known as a vulnerable organ to metastatic tumors. Metastasis occurs mainly through lymphatics but seldom via blood vessels. Adenocarcinoma with mucin emboli is very rare. Primary foci reported in the literature were breast, lung, ovary and pancreas. A lung biopsy from a 60-year-old male patient showed floating mucin associated with metastatic adenocarcinoma to the lung in the blood vessels. The tumor cells spreaded along the vascular endothelium as if they were vascular endothelial cells. The tumor cells and mucin in the vessel were strong positive for PAS staining. Elastic and immunohistochemical staining for smooth muscle actin highlighted the vascular wall in the mucin containing structure with infarction of the lung. The primary focus was identified in the pancreatic head through the abdominal ultra-sonographic and computer-tomographic examination.
Combined Mucinous Tumor and Carcinoid of Appendix Associated with Mucinous Tumor of Ovary and Pseudomyxoma Peritonei: A case report .
Hye Jeong Choi, Mi Jin Kim
Korean J Pathol. 1999;33(11):1094-1096.
  • 2,176 View
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AbstractAbstract PDF
We report a case of mucinous cystadenoma of uncertain malignant potential and carcinoid of appendix associated with bilateral mucinous cystadenoma of ovary and pseudomyxoma peritonei. The patient was a 46-year-old female. She suffered from dyspnea and lower abdominal palpable masses for several months. Ultrasonogram showed multilocular huge ovarian cysts. Appendectomy, transabdominal hysterectomy, bilateral salphingo-oophorectomy and biopsy of omentum were performed. The bilateral ovaries measured 16 11 cm and 7X5 cm in size, respectively. The both ovaries showed multilocular cysts filled with thick mucus material. The ovarian cysts were covered by a single layer of columnar epithelium with focal proliferation. Mucus materials dissected through the ovarian stroma (pseudomyxoma ovarii). The tip of appendix was dilated and covered by mucus material. The cut surface showed a cyst and a yellowish solid mass proximal to the cyst. Microscopically, the appendiceal cyst was lined by stratified columnar epithelium with moderate cytologic atypia. Mucus material dissected through the wall. In the proximal portion of the appendix, a classic carcinoid with focal tubular form was present in submucosa and muscle layer. The omentum was covered by thick mucus material. Microscopically, the omentum showed mucinous epithelium and mucus material (pseudomyxoma peritonei).
Original Article
Aberrant Crypt Foci: Histopathologic Classification and Profiles of Mucin Secretion.
Aeree Kim, Jong Sang Choi, Won Jun Choi, Hong Young Moon
Korean J Pathol. 2000;34(1):50-55.
  • 2,285 View
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AbstractAbstract PDF
Aberrant crypt foci (ACF) are grossly unidentifiable lesions of the colon and visible only with low-power microscopic examinations after methylene blue stain. To establish the role of ACF in colorectal carcinogenesis, we evaluated the distribution, frequency, histopathological classification, and patterns of mucin secretion of ACF in the colon. A total of 142 aberrant crypt foci were found in 41 colectomy specimen for adenocarcinoma (36 cases) and benign diseases of colon (5 cases). Ten of 142 ACFs were in the ascending and transverse colon, 39 in the descending and sigmoid colon, and 93 in the rectum. The mean number of ACFs in the rectum (0.13 0.11/cm2) was higher than in the ascending and transverse colons (0.019 0.018/ cm2) and descending and sigmoid colon (0.10 0.14/cm2). ACFs were found only in cancer patients. One hundred and twenty ACFs among 142 ACFs identified by topology, were identified on histological examination. We classified ACFs into simple (48.3%), hyperplastic (42.5%), and dysplastic (9.2%) types. All ACFs were infiltrated by the lymphocytes in the stroma and 18 of these accompanied the lymphoid follicles. ACFs have variable histopathologic features and mucin profiles. Some variants of ACFs are at the early stage of the spectrum between benign and malignant.
Case Report
Heterotopic Enchondral Ossification in Metastatic Colonic Adenocarcinoma: A case report .
So Yeon Park, Yong Il Kim, Woo Ho Kim
Korean J Pathol. 2000;34(7):531-533.
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AbstractAbstract PDF
Calcification and ossification of colon cancer is frequently encountered, especially in the mucinous carcinoma. However, cartilage formation or enchondral ossification has rarely been described in human colon cancer. This report describes a case of a 59-year-old man with retroperitoneal metastasis of mucinous adenocarcinoma of colon, which showed a widespread heterotopic ossification through membranous or enchondral ossification. The ossification appeared in apposition to tumor cell nests and in the organized mucin pool. In our knowledge, this is the first case showing enchondral ossification in gastrointestinal carcinoma in Korea.
Original Article
Value of Fine Needle Aspiration Cytology of Mucinous Carcinoma of the Breast.
Yoon Jung Kim, Gyung Yub Gong, Joo Ryung Huh, Jeong Mi Park, Sei Hyun Ahn, On Ja Kim
J Pathol Transl Med. 1996;7(2):157-162.
  • 2,110 View
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AbstractAbstract PDF
Fine needle aspiration(FNA) is an effective tool in diagnosing mammary carcinoma, We experienced 7 cases of histologically confirmed mammary mucinous carcinoma among 3,052 aspirated cases of breast from 1992 to 1996 in Asan Medical Center" The average age of the patient was 48(33-64) years. The mean size of the lesions was 1.6(0.7-3) cm, and they were palpated as well-defined, firm to hard masses. The cytologic features that may be useful in making a FNA diagnosis of mucinous carcinoma of the breast were analysed. Mucinous background and tumor cell, clusters with occasional single cells were observed in all cases. Among them, two, cases showed abundant scattered single cells, whereas only few single cells were seen in the other two cases. Tumor cells exhibited mild pleomorphism in four cases, and moderate pleomorphism in three cases. Nucleoli tended to be not prominen and are observed in three cases, rarely noted in other three cases and not seen in one. There was microcalcification in four cases(57%). In conclusion, mucinous background and clustered tumor cells showing mild td moderate pleomorphism with characteristic clinical findings allow us to diagnose, mucinous carcinoma of the breast.
Case Report
Primary Signet Ring Cell Carcinoma of the Lung: Report of Two Cases .
Dong Ja Kim, Sook Hee Lee, Yoon Kyung Sohn
J Pathol Transl Med. 1997;8(1):83-86.
  • 1,931 View
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AbstractAbstract PDF
Signet ring cell carcinoma is a variant of adenocarcinoma and has been rarely reported in the lung as a primary site. Recently, we experienced two cases of primary signet ring cell carcinoma in the lung without any other extrapulmonary lesion. Sputum cytology was performed and the tumor cells which have eccentrically located nuclei and abundnat mucinous cytoplasm were dispersed in diffuse sheets. On resected specimen, the signet ring cells occupied about 50~80% of all tumor cell nests. HIstochemical staining revealed that the mucin produced by tumor cells was mostly carboxylated acid mucins. Ultrastructurally, the tumor cells contained variable sized membrane-bound mucin granules with weak central osmiophilic density and showed numerous surface microvilli, which represented that tumor cells arose from bronchial epithelial cells. In general, this tumor has diffusely infiltrative nature and the prognosis is fatal due to widespread metastasis before clinical discovery.
Original Articles
Distinction between Reactive Mesothelial and Carcinoma Cells in Serous Effusions by Mucin- and Immuno-cytochemical Panel .
Byung Heon Kim
J Pathol Transl Med. 1998;9(1):1-14.
  • 3,596 View
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AbstractAbstract PDF
The cytologic distinction of carcinoma cells from reactive mesothelial cells can be difficult, especially in specimens containing abundant reactive mesothelial cells and inflammatory cells with scant carcinoma cells. This study evaluates the usefulness of mucin and immunocytochemistry for discrimination between reactive mesothelial cells and carcinoma cells, and sensitivity and specificity of these stains for the detection of metastatic carcinoma in serous effusions. Immunocytochemical panel including mucin cytochemistry with the periodic acid-Schiff(PAS) reaction after or without diastase digestion was undertaken on 127 serous effusion specimens with histologically confirmed diagnoses. The specimens including cell smears and cell blocks were stained with PAS and antibodies to carcinoembryonic antigen(CEA), epithelial membrane antigen(EMA), cytokeratin(CK), and vimentin. The sensitivities of these stains for metastatic carcinoma(127 cases) were 49%(46/94) in PAS, 48%(60/124) in CEA, 89%(97/109) in EMA, 88%(93/106) in CK, and 25%(20/81) in vimentin. The sensitivities of stains for reactive mesothelial cells(36 cases) were 19%(7/36) in EMA, 78%(28/36) in CK, and 75%(27/36) in vimentin. The PAS and CEA stains were not reacted with all cases of benign reactive serous effusions containing abundant reactive mesothelial cells. The specificities of stains for metastatic carcinoma(127 cases) were 100% in PAS, 100% in CEA, 81% in EMA, 22% in CK, and 25% in vimentin. The optimal combination of stains for use in a panel was PAS and CEA. Combined results from these two stains yielded an advanced sensitivity of 8% in PAS and 4% in CEA for metastatic carcinoma. EMA wasalso cosiderably useful for identification of carcinoma cells. CK and vimentin were not suitable for distinguishing between reactive mesothelial cells and carcinoma cells.
Differential Diagnosis of Ovarian Mucinous, Serous, and Endometrioid Adenocarcinoma in Peritoneal Washing Cytology .
Shi Nae Lee, In Ae Park
J Pathol Transl Med. 2000;11(2):83-88.
  • 2,947 View
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AbstractAbstract PDF
This study presents the cytologic features of peritoneal washings, with particular emphasis on the cytologic discrimination among serous, mucinous, and endometrioid adenocarcinoma of the ovary. We selected histologically confirmed 27 cases of peritoneal washing : 8 cases of serous cystadenocarcinomas, 5 cases of mucinous cystadenocarcinomas, and 14 cases of endometrioid adenocarcinomas. The most frequent cytologic pattern of three tumors was clusters. Ball pattern was found in serous cystadenocarcinoma(36%) and acinar pattern in endometrioid adenocarcinoma (36%). Mucinous adenocarcinoma showed mucoid background(100%) and endometrioid adenocarcinoma revealed inflammatory background(43%). The cytoplasmic vacuoles were noted in 80%, 13%, and 43% of mucinous, serous, and endometrioid adenocarcinoma, respectively. The endometrioid adenocarcinoma showed prominent nucleoli(64%). In conclusion, the cytologic findings of mucinous cystadenocarcinoma were different from that of serous and endometrioid carcinomas, such as mucoid background, abundant cytoplasm with vacuolated cytoplasm, and peripherally located cytoplasm. Although endometrioid carcinoma showed acinar pattern and prominent nucleoli, the differential diagnosis between serous cystadenocarcinoma and endometrioid adenocarcinoma in peritoneal washing cytology was not always possible.
Case Reports
Fine Needle Aspiration Cytology of the Intraductal Papillary Mucinous Tumor of the Pancreas: A Case Report.
In Gu Do, Jae Hoon Park, Youn Wha Kim, Ju Hie Lee, Moon Ho Yang, Sung Wha Hong, Yong Koo Park
J Pathol Transl Med. 2003;14(2):91-95.
  • 1,891 View
  • 17 Download
AbstractAbstract PDF
Intraductal papillary mucinous tumor of the pancreas is characterized by intraductal papillary proliferation of mucin-producing epithelial cells with or without excessive mucin secretion. According to the degree of epithelial dysplasia, intraductal papillary mucinous tumor is classified into adenoma, borderline tumor, and carcinoma. We recently experienced a case of fine needle aspiration cytology of the intraductal papillary mucinous adenoma in a 69-year-old male. The fine needle aspiration cytology yielded flat sheets of columnar, mucin containing epithelial cells in the background of dense mucin containing degenerated cellular material and histiocytes.
Fine Needle Aspiration Cytology of Mucinous Cystic Carcinoma of the Pancreas: A Case Report.
Kyungji Lee, Ahwon Lee, Kyo Young Lee, Chang Suk Kang, Sang In Shim
J Pathol Transl Med. 2005;16(2):88-92.
  • 1,910 View
  • 15 Download
AbstractAbstract PDF
Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.
Fine Needle Aspiration Cytology of Chronic Sclerosing Sialadenitis with Mucinous Metaplasia in Parotid Gland: A Case Report.
Jae Yeon Seok, Woo Hee Jung, Xu Xiang Fan, Jin Kim, Soon Won Hong
J Pathol Transl Med. 2005;16(2):102-105.
  • 2,826 View
  • 72 Download
AbstractAbstract PDF
Chronic sclerosing sialadenitis, also known as Kuttner tumor, is a benign chronic inflammatory lesion of the salivary gland. Here, we describe a case of chronic sclerosing sialadenitis with mucinous ductal metaplasia in a parotid gland, which was confused with low-grade mucoepidermoid carcinoma on aspiration cytology.
Salivary Duct Carcinoma with Mucin Containing Cells: Report of a Case Misdiagnosed as Mucoepidermoid Carcinoma on Fine Needle Aspiration Cytology.
Haeryoung Kim, Hyunki Kim, Hoguen Kim, Jin Kim, Soon Won Hong, Se Hoon Kim
J Pathol Transl Med. 2006;17(1):56-62.
  • 2,296 View
  • 25 Download
AbstractAbstract PDF
Salivary duct carcinoma (SDC) is a rare primary salivary gland malignancy characterized by histological features similar to those of ductal carcinomas of the breast. It is regarded as a high-grade malignancy associated with frequent local recurrences and early distant metastases that require aggressive treatment. The typical fine needle aspiration cytology (FNAC) findings in SDC include cellular smears showing tumor cells with eccentric pleomorphic nuclei and a granular cytoplasm arranged in flat sheets or cribriform patterns against a necrotic background. However, the presence of mucin-containing cells in SDC has been rarely described. We report the FNAC findings in a patient with histologically confirmed SDC that demonstrated numerous mucin-containing cells and was subsequently misdiagnosed as a high-grade mucoepidermoid carcinoma. Here we discuss the problems involved in distinguishing SDC from high-grade mucoepidermoid carcinoma on the basis of cytologic findings alone.
Oncocytic Type Intraductal Papillary Mucinous Neoplasm Mimicking Mucinous Cystic Neoplasm of the Pancreas: A Case Report.
Tae Jung Jang, Jong Im Lee
Korean J Pathol. 2008;42(3):172-174.
  • 2,272 View
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AbstractAbstract PDF
Oncocytic type intraductal papillary mucinous neoplasm is a newly defined subgroup of intraductal papillary mucinous neoplasms. A 35-year-old woman presented complaining of epigastric pain for one month. Enhanced computed tomography revealed a multilocular cystic mass in the distal body and tail of the pancreas. Endoscopic retrograde cholangiopancreatography showed no communication between the mass and the main pancreatic duct. The patient underwent a distal pancreatectomy and splenectomy. Microscopical examination showed a fibrous cyst wall; polypoid tumors exhibiting thin stalks, with extensive arborizing papillary growths from these stalks; and a focally cribriform pattern, lined by plump cells with abundant eosinophilic and granular cytoplasm. Red granules were detected in the cytoplasm of tumor cells on modified Gomori trichrome stain. Ultrastructurally, the tumor cells contained abundant cytoplasm packed with numerous mitochondria and intracellular and intercellular lumina. We describe an oncocytic type intraductal papillary mucinous neoplasm having the clinical characteristics of a mucinous cystic neoplasm.
Mucinous Adenocarcinoma in a Horseshoe Kidney.
Man Hoon Han, Sang Chul Nam, Bup Wan Kim, Ghil Suk Yoon
Korean J Pathol. 2008;42(1):60-62.
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AbstractAbstract PDF
We report here on a case of mucinous adenocarcinoma that probably originated in the renal pelvis of a horseshoe kidney. A 61-year-old woman presented with a palpable mass in the left upper quadrant of the abdomen, and this mass had been present for several months. Computed tomography (CT) revealed a left renal pelvic tumor in the horseshoe kidney. Grossly, a 10x9x8 cm unilocular cystic mass filled with chocolate colored mucinous fluid was seen. A connection between the cystic mass and the renal pelvis was demonstrated on retrograde pyelography. Microscopically, the cyst contained anaplastic columnar mucosecretory epithelial cells. Some atypical cell clusters were freely floating in the mucinous lakes. The histopathological findings were consistent with mucinous adenocarcinoma. In addition, glandular metaplasia was noted in the cystic wall. Immunohistochemical assessment of the pelvic adenocarcinoma revealed the positive expressions of carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) and a weak positive expression of cytokeratin 7 (CK7).
Original Articles
Genetic Expression Pattern of Gastric Carcinomas According to Cellular Mucin Phenotypes.
Won Ae Lee, In Soo Suh, Ying Hua Li, Ji Hyun Eum, Wan Sik Yu, Han Ik Bae
Korean J Pathol. 2007;41(5):307-315.
  • 2,125 View
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AbstractAbstract PDF
BACKGROUND
Gastric carcinomas (GCs) have recently been reclassified according to the mucin phenotypes. We aimed to characterize the relationship between the mucin phenotypes and the genetic alterations or the clinicopathologic parameters of GCs.
METHODS
Immunohistochemistry was performed for MUC1, MUC5AC, MUC6, MUC2, CD10, p53, hMLH1, CerbB2 and E-cadherin in 150 GCs. The mucin phenotypes of the GCs were classified as 4 phenotypes: gastric, intestinal, mixed and unclassified.
RESULTS
MUC1, MUC5AC, MUC6, MUC2 and CD10 were expressed in 63.3%, 42.7%, 14.0%, 24.7% and 14.0% of the GCs, respectively. The mucin phenotypes of the GCs corresponded to the gastric type in 31.3%, the intestinal type in 20.0%, the mixed type in 15.3% and the unclassified type in 33.3%. The incidence of a p53 overexpression was higher in the gastric or mixed phenotype than in the intestinal or unclassified phenotype. MUC5AC expression, p53 overexpression and the gastric or mixed phenotype were associated with poor patient survival by multivariate analysis.
CONCLUSION
This study suggests the gastric or mixed mucin phenotype may more likely go through the p53 pathway in carcinogenesis and the mucin phenotype may be considered as a prognostic indicator.
Mucin Phenotype and CDX2 Expression as Prognostic Factors in Gastric Carcinomas.
Chan Kwon Jung, Kyo Young Song, Gyeongsin Park, Cho Hyun Park, Myeong Gyu Choi, Young Seon Hong, Kyo Young Lee
Korean J Pathol. 2007;41(3):139-148.
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AbstractAbstract PDF
Background
: Mucin phenotypic markers and CDX2 are widely expressed in gastric carcinomas, however, recent studies have produced conflicting results regarding whether the expression patterns of these markers have clinicopathologic significance.
Methods
: We examined samples from 217 gastric carcinoma patients immunohistochemically to determine if the expression of mucin phenotypic markers and CDX2 was correlated with postoperative survival and other clinicopathologic factors.
Results
: All tumors were phenotypically classified as gastric (type G, 81 cases), gastric and intestinal mixed (type GI, 55 cases), intestinal (type I, 43 cases), or unclassified (type U, 38 cases). The occurrence of type G and GI tumors was positively correlated with tumor progression whereas that of type U tumors was negatively correlated with tumor progression. CDX2 expression was correlated with type I tumors. Tumors that expressed MUC5AC or MUC6 had a better prognosis than those that did not. When the relationship between phenotype and prognosis was considered, type GI had the best prognosis, followed by type G, then type U.
Conclusions
: The mucin phenotypic markers may be useful for predicting tumor progression and survival in patients with gastric carcinomas. Additionally, CDX2 may play an important role in gastric carcinogenesis of type I tumors.
Clinicopathological Analysis of Growth Patterns of Malignant Intraductal Papillary Mucinous Tumors of the Pancreas: Unusual Growth Pattern of Fistulous Extension.
Kee Taek Jang, Ghee Young Kwon, Geunghwan Ahn
Korean J Pathol. 2007;41(1):38-43.
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BACKGROUND
Usually, a malignant intraductal papillary mucinous tumor (IPMT) of the pancreas shows invasive carcinoma. Recently, IPMT with an unusual growth pattern of a fistulous extension was reported. However, little is known about malignant IPMTs with a different growth pattern of invasion and fistulous extension.
METHODS
Malignant IPMTs were classified into invasive (colloid or tubular type) carcinomas and the fistulous extension type according to their growth patterns. Their clinicopathological characteristics were compared.
RESULTS
Among a total of 68 cases of IPMT, there were 16 cases with malignant IPMT; eight, six and two of the colloid, tubular, and fistulous extension types, respectively. The immunohistochemical (IHC) expression of MUC1 was found in seven out of eight colloid and five out of six tubular types, but there was no IHC expression of MUC1 in the fistulous extension type. The IHC expression of MUC2 was noted in one of the eight colloid, one of the six tubular and in both cases with the fistulous extension type. There was no difference in the tumor recurrence rates bet- ween the different growth patterns.
CONCLUSIONS
IPMT with the fistulous extension type has a peculiar extension pattern consisting of multiple fistulous tracts without a mass. Although most of the epithelium in the fistulous tract show moderate to severe dysplasia, only the fistulous extension should be considered to be an unusual growth pattern of malignant IPMT. The clinical significance of this unusual type of IPMT remains to be determined.
Ovarian Borderline Epithelial Tumors.
Geunghwan Ahn
Korean J Pathol. 2005;39(5):291-300.
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Ovarian borderline epithelial tumors are abnormal proliferative epithelial lesions without obvious invasion of the stroma of the ovary, a finding distinguishing between borderline tumors and carcinoma. There have been controversies regarding the terminology and diagnostic feature of the tumors, even though these tumors have been accepted as a distinct entity in WHO classification of ovarian epithelial tumors. This review is limited to serous and mucinous borderline tumors which are the most common and about which many clinicopathological studies have been undertaken. It has been agreed that "micropapillary carcinoma" espoused by a group of pathologists is a micropapillary variant of serous borderline tumor in the borderline ovarian tumor workshop. Diagnostic criteria of invasive implants needs further study but invasion of underlying normal tissue was reported to be correlated well with prognosis. Other issues such as diagnostic criteria of microinvasion and multiplicity of serous borderline tumors have been presented. The sole diagnostic criteria agreed upon for the diagnosis of intraepithelial carcinoma in the mucinous borderline tumor was the presence of severe cytological atypia. It was also agreed that the ovarian tumors associated with pseudomyxoma peritonei are almost invariably from gastrointestinal tract, usually appendix. Stratification and complex intracystic growth without severe cytological atypia are considered to be characteristics of mucinous borderline tumors. Diagnostic criteria of microinvasion and two types of invasion, expansile and infiltrative invasion, have also been discussed.
Case Report
Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix: Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae.
Eundeok Chang, Eunjung Lee, Kyoungmee Kim, Okran Shin, Youngmi Ku, Heejung An, Changsuk Kang
Korean J Pathol. 2004;38(2):121-125.
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Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.
J Pathol Transl Med : Journal of Pathology and Translational Medicine
© The Korean Society of Pathologists and the Korean Society for Cytopathology.
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