Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.

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• Mucinous cystadenocarcinoma of the breast harbours TRPS1 expressions and PIK3CA alterations
  Wei‐Yu Chen, Yu‐Hsuan Hu, Yu‐Hsin Tsai, Jen‐Fan Hang, Puay Hoon Tan, Chih‐Jung Chen
  Histopathology.2024; 84(3): 550.     CrossRef
• Pure mucinous adenocarcinoma of the breast with the rare lymphoplasmacytic infiltration: A case report with review of literature
  Yash Hasmukhbhai Prajapati, Vishal Bhabhor, Kahan Samirkumar Mehta, Mithoon Barot, Husen Boriwala, Mohamed Omar
  Clinical Case Reports.2024;[Epub]     CrossRef
• HER2‐positive mucinous cystadenocarcinoma of the breast coexisting with invasive lobular carcinoma: A case report and review of the literature
  Ismail Guzelis, Betul Bolat Kucukzeybek, Mehmet Ali Uyaroglu, Melek Bekler Gokova, Gulten Sezgin, Yuksel Kucukzeybek
  Diagnostic Cytopathology.2024;[Epub]     CrossRef
• Mammary mucinous cystadenocarcinoma with long-term follow-up: molecular information and literature review
  Ting Lei, Yong Qiang Shi, Tong Bing Chen
  Diagnostic Pathology.2023;[Epub]     CrossRef
• Primary Mucinous Cystadenocarcinoma of the Breast Intermixed with Pleomorphic Invasive Lobular Carcinoma: The First Report of This Rare Association
  Federica Vegni, Nicoletta D’Alessandris, Angela Santoro, Giuseppe Angelico, Giulia Scaglione, Angela Carlino, Damiano Arciuolo, Michele Valente, Stefania Sfregola, Maria Natale, Alejandro Martin Sanchez, Valeria Masciullo, Gian Franco Zannoni, Antonino Mu
  Journal of Personalized Medicine.2023; 13(6): 948.     CrossRef
• Special Histologic Type and Rare Breast Tumors – Diagnostic Review and Clinico-Pathological Implications
  Benjamin Yongcheng Tan, Elaine Hsuen Lim, Puay Hoon Tan
  Surgical Pathology Clinics.2022; 15(1): 29.     CrossRef
• Mucinous cystadenocarcinoma of the breast: a new entity with broad differentials—a case report
  Kanwalpreet Kaur, Ashini Shah, Jahnvi Gandhi, Priti Trivedi
  Journal of the Egyptian National Cancer Institute.2022;[Epub]     CrossRef
• Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
  Minjung Jung
  Kosin Medical Journal.2022; 37(3): 176.     CrossRef
• Primary Mucinous Cystadenocarcinoma of the Breast: A Rare Case Report With Review of Literature
  Ekta Jain, Abhishek Kumar, Raajul Jain, Shivani Sharma
  International Journal of Surgical Pathology.2021; 29(7): 740.     CrossRef
• Mucinous Cystadenocarcinoma of the Breast: Report of 2 Cases Including One With Long-Term Local Recurrence
  Anupma Nayak, Ira J. Bleiweiss, Kimberly Dumoff, Tawfiqul A. Bhuiya
  International Journal of Surgical Pathology.2018; 26(8): 749.     CrossRef
• Mucinous breast carcinoma with tall columnar cells
  N Tsoukalas, M Kiakou, M Tolia, ID Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
  The Annals of The Royal College of Surgeons of England.2018; 100(5): e132.     CrossRef
• Radiologic Findings of Primary Mucinous Cystadenocarcinoma of the Breast: A Report of Two Cases and a Literature Review
  Minjung Seong, Eun Young Ko, Boo-Kyung Han, Soo Youn Cho, Eun Yoon Cho, Se Kyung Lee, Jeong Eon Lee
  Journal of Breast Cancer.2016; 19(3): 330.     CrossRef
• Primary Mucinous Cystadenocarcinoma of the Breast with Endocervical-Like Mucinous Epithelium
  Dong-Liang Lin, Ji-Lin Hu, Shi-Hong Shao, Dong-Mei Sun, Ji-Gang Wang
  Breast Care.2013; 8(6): 445.     CrossRef