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Case Report
- Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report.
- Ga Eon Kim, Young Kim, Eun Hui Jeong, Jo Heon Kim, Min Ho Park, Ji Shin Lee
- Korean J Pathol. 2010;44(4):431-434.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.431
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- 3 Crossref
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Abstract
PDF - Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-beta, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-alpha, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.
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Citations
Citations to this article as recorded by
- Whole slide phase imaging by space-time digital holography for stain-free characterization of breast cancer and fibroadenoma in histological tissues
Zhe Wang, Vittorio Bianco, Lisa Miccio, Valentina Brancato, Giovanni Smaldone, Massimiliano D’ Aiuto, Gennaro Mossetti, Pier Luca Maffettone, Marco Salvatore, Pietro Ferraro
Journal of Physics: Photonics.2026; 8(1): 015074. CrossRef - Fibroadenomatoid Hyperplasia of the Breast with Prominent Smooth Muscle Component: An Uncommon Histopathological Encounter
Seetu Palo, Divya Donepudi, Shrinivas Bheemrao Somalwar
Journal of Mid-life Health.2025; 16(2): 226. CrossRef - Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour
Barbara Brunetti, Luisa Vera Muscatello, Louis J. DeTolla, Giancarlo Avallone, Isabel Pires
Case Reports in Veterinary Medicine.2021; 2021: 1. CrossRef
- Whole slide phase imaging by space-time digital holography for stain-free characterization of breast cancer and fibroadenoma in histological tissues
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