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Case Report
- Metaplastic Thymoma: Report of 4 Cases
- Guhyun Kang, Nara Yoon, Joungho Han, Young Eun Kim, Tae Sung Kim, Kwhanmien Kim
- Korean J Pathol. 2012;46(1):92-95. Published online February 23, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.92
- 8,317 View
- 63 Download
- 14 Crossref
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Abstract
PDF Metaplastic thymoma (MT), accepted in the World Health Organization 2004 scheme, is a circumscribed tumor of the thymus exhibiting biphasic morphology. We herein describe the clinicopathologic features of four MTs and the differential diagnoses of this unusual tumor. There were three women and one man with mean age of 49.5 years. The patients were found to have mediastinal masses, and underwent surgical excision. One exhibited symptoms of myasthenia gravis, and the serum titer for anti-acetylcholine receptor antibody was positive. Grossly, the tumors were encapsulated, and showed vaguely multinodular, solid, tan-white to yellow cut surfaces. Histologically, they comprised epithelial islands intertwining with bundles of delicate spindle cells. The patients remained well after surgical excision at 5-55 months. Because of the distinctive histological appearance and benign clinical course, MT should be distinguished from other more aggressive mediastinal neoplasms displaying biphasic feature.
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Citations
Citations to this article as recorded by
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Ilianne Vega Prado, John Shymansky, Anisha Apte, Keith Mortman, Henry J. Kaminski, Stephanie Barak
International Journal of Surgical Pathology.2024; 32(1): 155. CrossRef - Thymic epithelial tumours: histopathological classification and differential diagnosis
Jan von der Thüsen
Histopathology.2024; 84(1): 196. CrossRef - Epigenetics of Thymic Epithelial Tumors
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Annals of Medicine.2023;[Epub] CrossRef - Loss of YAP1 C‐terminus expression as an ancillary marker for metaplastic thymoma: a potential pitfall in detecting YAP1::MAML2 gene rearrangement
Xuan Wang, Lei‐lei Liu, Qing Li, Qiu‐yuan Xia, Rui Li, Sheng‐bing Ye, Ru‐song Zhang, Ru Fang, Hui Chen, Nan Wu, Qiu Rao
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(4): 538. CrossRef - Malignant Transformation of Metaplastic Thymoma into High-Grade Sarcomatoid Carcinoma: A Case Report
Zheng Hua Piao, Jin Ping Chen, Hai Ren Chen, Xin Cheng Zhou
International Journal of Surgical Pathology.2022; 30(5): 564. CrossRef - YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma
Jikai Zhao, Ruiying Zhao, Chan Xiang, Jinchen Shao, Lianying Guo, Yuchen Han
Frontiers in Oncology.2021;[Epub] CrossRef - Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions
Marina Vivero, Phani Davineni, Valentina Nardi, John K.C. Chan, Lynette M. Sholl
Modern Pathology.2020; 33(4): 560. CrossRef - Metaplastic thymoma: Report of two cases
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The Journal of the Japanese Association for Chest Surgery.2020; 34(7): 733. CrossRef - Type AB thymoma is not a mixed tumor of type A and type B thymomas, but a distinct type of thymoma
Yukari Miki, Kana Hamada, Tadashi Yoshino, Katsuya Miyatani, Kiyoshi Takahashi
Virchows Archiv.2014; 464(6): 725. CrossRef - Potential Role of Adjuvant Radiation Therapy in Cervical Thymic Neoplasm Involving Thyroid Gland or Neck
Jae Myoung Noh, Sang Yun Ha, Yong Chan Ahn, Dongryul Oh, Seung Won Seol, Young Lyun Oh, Joungho Han
Cancer Research and Treatment.2014; 47(3): 436. CrossRef - A Case of Metaplastic Thymoma
Eiji MIYAHARA, Tomoko ITAGAKI, Masaki KUWAHARA, Akira KAMEDA, Yoshihiro MIYATA, Kazuhiro SENTANI, Wataru YASUI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(2): 360. CrossRef
- A Rare Case of Metaplastic Thymoma Presenting With Myasthenia Gravis
Original Article
- Thymoma: A clinicopathologic analysis of 66 cases.
- Weon Seo Park, Seong Hoe Park, Yong Il Kim
- Korean J Pathol. 1992;26(4):372-380.
- 1,504 View
- 12 Download
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Abstract
PDF
- A total of 66 cases of thymoma(57 surgically resected cases and 9 incisional biopsy cases) were reviewed with an attempt to correlate pathomorphologic features and clinical presentations. Criteria of benign or invasive thymoma were primarily determined by operative clinical and pathologic findings. Of them, 21 cases were invasive thymomas. The mean age of patients at the time of surgery was 47 years and it occurred largely in the sixth decade. Myasthenia gravis was accompanied in 29 cases(43%). One patient died during folow-up period, and five of the remainder suffered from recurrence. Microscopically, mixed type was the most common one(33 cases), being followed by predominantly epithelial type(17 cases) and predominantly lymphocytic type(16 cases). Thirty four cases of thymomas were cortical type, 29 mixed type, and the remaining 3 medullary type. None of the histologic type were significantly correlated with tumor invasiveness, Myasthenia gravis was more frequently associated with mixed and cortical type, respectively.
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