Cavernous hemangioma of the uterus is an uncommon mesenchymal tumor. Most cases have been reported in young, pregnant women and the condition is very rare in a postmenopausal patient. An 81-year-old woman presented with a huge pelvic mass. Abdominal computed tomography and magnetic resonance imaging results suggested a leiomyoma with degenerative change and hemorrhage. Microscopically, large, thick-walled and variable-sized vascular channels were evident in the majority part of myometrium; the lining cells were immunohistochemically reactive for CD31. Vascular tumors of the female genital tract should be cautiously excised due to the profuse intra-operative bleeding. The pathological examination of a hysterectomy specimen is the only method to confirm the diagnosis of this tumor.
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A rare case report of cervical hemangioma and a comprehensive literature review of 137 cases of cervical and uterine hemangiomas Maasomeh Farahani, Seyyed‐Ali Hashemi, Sogand Goodarzi, Bardia Hajikarimloo, Farzad Pour‐Ghazi, Shahrzad Noori, Saba Alijani, Armin Khavandegar International Journal of Gynecology & Obstetrics.2024; 164(2): 421. CrossRef
Cavernous hemangioma of corpus imitating endometrial polyp in a young non‐pregnant woman: A case report study Ali Emami, Ensiyeh Bahadoran, Fatemeh SamieeRad Clinical Case Reports.2024;[Epub] CrossRef
Diffuse cavernous hemangioma of the uterus mimicking adenomyosis- A rare case report Saloni Naresh Shah, N Geetha Indian Journal of Obstetrics and Gynecology Research.2020; 7(2): 283. CrossRef
Haemangioma- Common Neoplasm in an Unusual Location - A Case Report Dahlia Joseph, Elizabeth Joseph, Ajitha K Journal of Evidence Based Medicine and Healthcare.2019; 6(51): 3216. CrossRef
Estrogen receptor(ER) and progesterone receptor(PR) were studied immunohistochemically using specific antireceptor monoclonal antibodies in leiomyomas and myometrium from same patients from 38 women in various stages of the menstrual cycle, menopause and pregnancy. Two postpartum uteri are also included. Immunohistochemical localization was quantified as to intensity of staining and tissue distribution, and the results were compared with those of PCNA index. In all samples, ER and PR localized within the nuclei of target cells. The histochemical score of ER in leiomyoma was significantly greater than that found in myometrium. But ER in leiomyoma was expressed in cyclic fashion(r=0.45, P=0.006), like as in myometrium, throughout the menstrual cycle, paralleled by a concomitant, though delayed. In contrast, PR content constantly maintained in myometrium and leiomyoma throughout menstrual cycle, and there was no significant difference between them. However, leiomyoma and myometrium of pregnancy showed a significant reduction in the amount of ER and PR localized. PCNA index in leiomyoma(14.9+/-24.4) was also significantly higher than that found in myometrium(2.1+/-3.3). The index declined throughout the secretory phase. The leiomyoma had increased PCNA index during pregnancy, while the increasing rate in leiomyoma was lower than that of myometrium. The growth potential of leiomyomas is appearently higher than that of myometrium under the high progesterone level. The most of neoplasm with high PCNA index(10 above) contained absolute or relative abundant PR or ER content. Alteration of receptor content may be an important mechanism in steroid dependent growth of leiomyoma and may provide information useful in the clinical management of this neoplastic disorder.
Uterine adenomyoma is a neoplasm that is composed of endometrial glands and smooth muscle, and this is found in the uterine corpus; however, the glandular component is occasionally of mucin-secreting endocervical type. We describe here a case of uterine adenomyoma of the endocervical type, and this presented in a 38-year-old pregnant woman.