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Original Article
- Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma.
- Yeon Sook Kim, Sang Shin Lee, Ji Yong Song, Eun Cheol Kim, Suk Keun Lee
- Korean J Pathol. 2010;44(3):284-294.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.3.284
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Abstract
PDF - BACKGROUND
The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known.
METHODS
We examined a case of clear cell type MEC by immunohistochemical (IHC) array using 59 antibodies against oncoproteins, proliferation-related proteins, apoptosis-related proteins, growth factor-related proteins, angiogenesis-related proteins, and matrix proteins.
RESULTS
MEC tumor cells showed 40 to 60% more expression of BCL-2 and cyclin-dependent kinase 4 than normal gingival tissue, and 20-40% more expression of BCL-2-associated agonist of cell death, deleted in malignant brain tumors 1, E-cadherin, eIF5A, hypoxia-inducible factor, vimentin, and Wnt-1. Expression of other proteins, including p53, epidermal growth factor receptor, proliferating cell nuclear antigen, survivin, carcinoembryonic antigen, beta-catenin, poly-ADP ribose-polymerase, etc. were relatively weak in MEC tumor cells.
CONCLUSIONS
The IHC array for our MEC contained strong oncogenic signals involving Wnt-1/adenomatous polyposis coli, tumor necrosis factor a/signal transducer and activator of transcription 3/BCL-2, and pAKT pathways, signals that could result in the prolonged survival of clear tumor cells. -
Citations
Citations to this article as recorded by
- Adolescent tongue base tumour with diagnostic histopathological dilemma
Mousam Maiti, Ajay Mallick, Debangshu Ghosh, Indranil Chakrabarti
BMJ Case Reports.2024; 17(8): e259570. CrossRef - A review: Immunological markers for malignant salivary gland tumors
P.C. Anila Namboodiripad
Journal of Oral Biology and Craniofacial Research.2014; 4(2): 127. CrossRef - DISPLACEMENT OF MAXILLARY LATERAL INCISOR CAUSED BY IDIOPATHIC GINGIVAL FIBROMATOSIS
Ji-Sook Jung, Ho-Won Park, Ju-Hyun Lee, Hyun-Woo Seo, Suk-Keun Lee
THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2011; 38(3): 296. CrossRef
- Adolescent tongue base tumour with diagnostic histopathological dilemma
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