Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Orna Staretz-Chacham"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review
Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia
Nandor Gabor Than, Roberto Romero, Andrea Balogh, Eva Karpati, Salvatore Andrea Mastrolia, Orna Staretz-Chacham, Sinuhe Hahn, Offer Erez, Zoltan Papp, Chong Jai Kim
J Pathol Transl Med. 2015;49(3):181-208.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.02.25
  • 26,701 View
  • 279 Download
  • 49 Web of Science
  • 47 Crossref
AbstractAbstract PDF
Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis, signal transduction, and pre-mRNA splicing, as well as homo- and heterotypic cell-cell and cell-extracellular matrix interactions. Galectins are also pivotal in immune responses since they regulate host-pathogen interactions, innate and adaptive immune responses, acute and chronic inflammation, and immune tolerance. Some galectins are also central to the regulation of angiogenesis, cell migration and invasion. Expression and functional data provide convincing evidence that, due to these functions, galectins play key roles in shared and unique pathways of normal embryonic and placental development as well as oncodevelopmental processes in tumorigenesis. Therefore, galectins may sometimes act as double-edged swords since they have beneficial but also harmful effects for the organism. Recent advances facilitate the use of galectins as biomarkers in obstetrical syndromes and in various malignancies, and their therapeutic applications are also under investigation. This review provides a general overview of galectins and a focused review of this lectin subfamily in the context of inflammation, infection and tumors of the female reproductive tract as well as in normal pregnancies and those complicated by the great obstetrical syndromes.

Citations

Citations to this article as recorded by  
  • The functional roles of protein glycosylation in human maternal–fetal crosstalk
    Jiangming Zhong, Jianlin Li, Graham J Burton, Hannu Koistinen, Ka Wang Cheung, Ernest H Y Ng, Yuanqing Yao, William S B Yeung, Cheuk-Lun Lee, Philip C N Chiu
    Human Reproduction Update.2024; 30(1): 81.     CrossRef
  • Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value
    Eszter Tóth, Dániel Györffy, Máté Posta, Petronella Hupuczi, Andrea Balogh, Gábor Szalai, Gergő Orosz, László Orosz, András Szilágyi, Orsolya Oravecz, Lajos Veress, Sándor Nagy, Olga Török, Padma Murthi, Offer Erez, Zoltán Papp, Nándor Ács, Nándor Gábor T
    International Journal of Molecular Sciences.2024; 25(3): 1865.     CrossRef
  • Surface-Conjugated Galactose on Electrospun Polycaprolactone Nanofibers: An Innovative Scaffold for Uterine Tissue Engineering
    Srividya Hanuman, Harish Kumar B, K. Sreedhara Ranganath Pai, Manasa Nune
    ACS Omega.2024; 9(32): 34314.     CrossRef
  • Is human labor at term an inflammatory condition?
    Chandrashekara Kyathanahalli, Madeline Snedden, Emmet Hirsch
    Biology of Reproduction.2023; 108(1): 23.     CrossRef
  • Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology
    Zhengyuan Huang, Pei F. Lai, Alexander T. H. Cocker, Stuart M. Haslam, Anne Dell, Hugh J. M. Brady, Mark R. Johnson
    Biochemical Society Transactions.2023; 51(2): 639.     CrossRef
  • Placental galectins regulate innate and adaptive immune responses in pregnancy
    Orsolya Oravecz, Roberto Romero, Eszter Tóth, Judit Kapitány, Máté Posta, Dahiana M. Gallo, Simona W. Rossi, Adi L. Tarca, Offer Erez, Zoltán Papp, János Matkó, Nándor Gábor Than, Andrea Balogh
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas
    Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Tha
    International Journal of Molecular Sciences.2022; 23(10): 5798.     CrossRef
  • Evolution of Placental Hormones: Implications for Animal Models
    Anthony M. Carter
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Possible important roles of galectins in the healing of human fetal membranes
    Jia-Le Chen, Yu Chen, De-Xiang Xu, Dao-Zhen Chen
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Melatonin-Primed MSCs Alleviate Intrauterine Adhesions by Affecting MSC-Expressed Galectin-3 on Macrophage Polarization
    Qi Jiang, Jingman Li, Yuchen Pan, Jiali Wang, Jingjing Yang, Sunan Shen, Yayi Hou
    Stem Cells.2022; 40(10): 919.     CrossRef
  • Galectin-1 and Galectin-9 Concentration in Maternal Serum: Implications in Pregnancies Complicated with Preterm Prelabor Rupture of Membranes
    Dorota Grażyna Boroń, Aleksy Świetlicki, Michał Potograbski, Grażyna Kurzawińska, Przemysław Wirstlein, Daniel Boroń, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
    Journal of Clinical Medicine.2022; 11(21): 6330.     CrossRef
  • Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia
    Ellen Menkhorst, Wei Zhou, Leilani Santos, Jian-Guo Zhang, Yves St-Pierre, Morag J. Young, Evdokia Dimitriadis
    Pregnancy Hypertension.2022; 30: 130.     CrossRef
  • A természetes ölősejtek szerepe az anyai-magzati immunhomeostasis fenntartásában
    Kornél Lakatos, Kevin M. Elias, Ross S. Berkowitz, Kathleen Hasselblatt, György Végh, Vilmos Fülöp
    Orvosi Hetilap.2022; 163(19): 734.     CrossRef
  • Galectin-1 expression in the serum and placenta of pregnant women with fetal growth restriction and its significance
    Xiao-Xiao Jin, Xiang Ying, Min-Yue Dong
    BMC Pregnancy and Childbirth.2021;[Epub]     CrossRef
  • Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation
    Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes
    Başak Kaya, Uğur Turhan, Salim Sezer, Serdar Kaya, İsmail Dağ, Ahmet Tayyar
    The Journal of Maternal-Fetal & Neonatal Medicine.2020; 33(5): 861.     CrossRef
  • Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice
    Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Hui-Hui Yang, Chen-Yu Zhang, Si-Yuan Tang
    Free Radical Biology and Medicine.2020; 146: 222.     CrossRef
  • Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood
    Masashi Mizuno, Kana Sakaguchi, Iwao Sakane
    Biomolecules.2020; 10(2): 258.     CrossRef
  • Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis
    Matyas Meggyes, Laszlo Szereday, Noemi Bohonyi, Miklos Koppan, Sarolta Szegedi, Anna Marics-Kutas, Mirjam Marton, Anett Totsimon, Beata Polgar
    International Journal of Molecular Sciences.2020; 21(7): 2343.     CrossRef
  • Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand
    Mirian Mendoza, Dongli Lu, Angela Ballesteros, Sandra M Blois, Kelsey Abernathy, Chiguang Feng, Charles J Dimitroff, Jonathan Zmuda, Maria Panico, Anne Dell, Gerardo R Vasta, Stuart M Haslam, Gabriela Dveksler
    Glycobiology.2020; 30(11): 895.     CrossRef
  • Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions
    Franziska Krautter, Carlota Recio, Mohammed T. Hussain, Danielle R. Lezama, Francesco Maione, Myriam Chimen, Asif J. Iqbal
    Biomedicine & Pharmacotherapy.2020; 130: 110595.     CrossRef
  • Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
    Sandra M. Blois, Stefan Verlohren, Gang Wu, Gary Clark, Anne Dell, Stuart M. Haslam, Gabriela Barrientos
    Seminars in Immunopathology.2020; 42(4): 469.     CrossRef
  • Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
    Ellen Menkhorst, Wei Zhou, Leilani L. Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J. Young, Kypros H. Nicolaides, Yves St-Pierre, Evdokia Dimitriadis
    Hypertension.2020; 76(4): 1185.     CrossRef
  • Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?
    Katalin Karaszi, Szilvia Szabo, Kata Juhasz, Peter Kiraly, Barbara Kocsis-Deak, Beata Hargitai, Tibor Krenacs, Petronella Hupuczi, Offer Erez, Zoltan Papp, Ilona Kovalszky, Nandor Gabor Than
    Placenta.2019; 76: 30.     CrossRef
  • Tacrolimus treatment for infertility related to maternal‐fetal immune interactions
    Koushi Yamaguchi
    American Journal of Reproductive Immunology.2019;[Epub]     CrossRef
  • Human trophoblast requires galectin-3 for cell migration and invasion
    Ž. Bojić-Trbojević, M. Jovanović Krivokuća, A. Vilotić, N. Kolundžić, I. Stefanoska, F. Zetterberg, U. J. Nilsson, H. Leffler, Lj. Vićovac
    Scientific Reports.2019;[Epub]     CrossRef
  • Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
    Sandra M. Blois, Gabriela Dveksler, Gerardo R. Vasta, Nancy Freitag, Véronique Blanchard, Gabriela Barrientos
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response
    Andrea Balogh, Eszter Toth, Roberto Romero, Katalin Parej, Diana Csala, Nikolett L. Szenasi, Istvan Hajdu, Kata Juhasz, Arpad F. Kovacs, Hamutal Meiri, Petronella Hupuczi, Adi L. Tarca, Sonia S. Hassan, Offer Erez, Peter Zavodszky, Janos Matko, Zoltan Pap
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy
    Marei Sammar, Tijana Drobnjak, Maurizio Mandala, Sveinbjörn Gizurarson, Berthold Huppertz, Hamutal Meiri
    International Journal of Molecular Sciences.2019; 20(13): 3192.     CrossRef
  • Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions
    Yongzhi Guo, Tom van Schaik, Naveed Jhamat, Adnan Niazi, Metasu Chanrot, Gilles Charpigny, Jean Francois Valarcher, Erik Bongcam-Rudloff, Göran Andersson, Patrice Humblot, Peter J. Hansen
    PLOS ONE.2019; 14(9): e0222081.     CrossRef
  • The Impact of Natural Selection on the Evolution and Function of Placentally Expressed Galectins
    Zackery A Ely, Jiyun M Moon, Gregory R Sliwoski, Amandeep K Sangha, Xing-Xing Shen, Abigail L Labella, Jens Meiler, John A Capra, Antonis Rokas, Soojin Yi
    Genome Biology and Evolution.2019; 11(9): 2574.     CrossRef
  • Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles
    Jennifer R. King, Melissa L. Wilson, Szabolcs Hetey, Peter Kiraly, Koji Matsuo, Antonio V. Castaneda, Eszter Toth, Tibor Krenacs, Petronella Hupuczi, Paulette Mhawech-Fauceglia, Andrea Balogh, Andras Szilagyi, Janos Matko, Zoltan Papp, Lynda D. Roman, Vic
    International Journal of Molecular Sciences.2019; 20(20): 4999.     CrossRef
  • The emerging role of galectins in high-fatality cancers
    Cherylane Dubé-Delarosbil, Yves St-Pierre
    Cellular and Molecular Life Sciences.2018; 75(7): 1215.     CrossRef
  • Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
    Yi-Chen Chan, Hsien-Ya Lin, Zhijay Tu, Yen-Hsi Kuo, Shang-Te Hsu, Chun-Hung Lin
    International Journal of Molecular Sciences.2018; 19(2): 392.     CrossRef
  • The link between immunity, autoimmunity and endometriosis: a literature update
    Tao Zhang, Caterina De Carolis, Gene Chi Wai Man, Chi Chiu Wang
    Autoimmunity Reviews.2018; 17(10): 945.     CrossRef
  • Systemic expression of galectin genes in periparturient goats
    Kingsley Ekwemalor, Sarah Adjei-Fremah, Emmanuel Asiamah, Egbogoye Eluka-Okoludoh, Bertha Osei, Mulumebet Worku
    Small Ruminant Research.2018; 168: 60.     CrossRef
  • Body Mass Index Impact and Predictability on Preeclamptic Toxemia
    AbdAllah Khaled M
    Journal of Gynecological Research and Obstetrics.2018; : 009.     CrossRef
  • The association between oxidative stress-induced galectins and differentiation of human promyelocytic HL-60 cells
    James R. Vinnai, Robert C. Cumming, Graham J. Thompson, Alexander V. Timoshenko
    Experimental Cell Research.2017; 355(2): 113.     CrossRef
  • Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition
    Haidy El-Azzamy, Andrea Balogh, Roberto Romero, Yi Xu, Christopher LaJeunesse, Olesya Plazyo, Zhonghui Xu, Theodore G. Price, Zhong Dong, Adi L. Tarca, Zoltan Papp, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Chong Jai Kim, Nardhy Gomez-Lopez, Nandor Gabor
    Journal of Pathology and Translational Medicine.2017; 51(3): 264.     CrossRef
  • Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function
    Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
    Computational and Structural Biotechnology Journal.2017; 15: 433.     CrossRef
  • Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7
    Nathalie Bibens-Laulan, Yves St-Pierre, Ivan R Nabi
    PLOS ONE.2017; 12(11): e0187194.     CrossRef
  • Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders
    Reka Brubel, Attila Bokor, Akos Pohl, Gabriella Krisztina Schilli, Laszlo Szereday, Reka Bacher-Szamuel, Janos Rigo, Beata Polgar
    Fertility and Sterility.2017; 108(6): 1016.     CrossRef
  • The relationship between cervical precancerous lesion galectin-3 and p27 protein expression and clinical prognosis
    Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
    Oncology Letters.2017;[Epub]     CrossRef
  • Development and Applications of Lectins as Biological Tools in Biomedical Research
    Xiuli Dan, Wenlong Liu, Tzi Bun Ng
    Medicinal Research Reviews.2016; 36(2): 221.     CrossRef
  • The human fetoembryonic defense system hypothesis: Twenty years on
    Poh-Choo Pang, Stuart M. Haslam, Anne Dell, Gary F. Clark
    Molecular Aspects of Medicine.2016; 51: 71.     CrossRef
  • A Human Lectin Microarray for Sperm Surface Glycosylation Analysis
    Yangyang Sun, Li Cheng, Yihua Gu, Aijie Xin, Bin Wu, Shumin Zhou, Shujuan Guo, Yin Liu, Hua Diao, Huijuan Shi, Guangyu Wang, Sheng-ce Tao
    Molecular & Cellular Proteomics.2016; 15(9): 2839.     CrossRef
  • Fetal gender specific expression of tandem-repeat galectins in placental tissue from normally progressed human pregnancies and intrauterine growth restriction (IUGR)
    Stefan Hutter, Julia Knabl, Ulrich Andergassen, Doris Mayr, Simone Hofmann, Christina Kuhn, Sven Mahner, Petra Arck, Udo Jeschke
    Placenta.2015; 36(12): 1352.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP