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Case Report
- Aspiration Cytology of the Osteoclastic Variant of Anaplastic Thyroid Carcinoma: with Special Emphasis on the Undifferentiated Mononuclear Cells.
- Kang Min Han, Dong Hoon Kim, Wonae Lee
- Korean J Pathol. 2010;44(6):682-686.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.682
- 2,974 View
- 19 Download
- 5 Crossref
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Abstract
PDF - Anaplastic thyroid carcinoma (ATC) is an uncommon aggressive malignant tumor, and the osteoclastic variant of ATC is extremely rare. We report here on the fine needle aspiration cytology of the osteoclastic variant of ATC in an 83-year-old woman. The smear was composed of many oval to slightly elongated undifferentiated mononuclear cells admixed with multinucleated osteoclast-like giant cells. The mononuclear tumor cells revealed inconspicuous nuclear pleomorphism and the nuclei were characterized by vesicular chromatin and an indented or lobulated nuclear membrane with conspicuous nuclear grooves. A few epithelial clusters suggestive of a papillary carcinoma component were also observed. Making the proper cytological diagnosis of the osteoclastic variant of ATC is helpful to determine the proper treatment modality for these patients.
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Citations
Citations to this article as recorded by
- Anaplastic carcinoma of thyroid with giant cells –Cytodiagnosis of category VI high grade thyroid tumor
Dhiraj B Nikumbh
IP Archives of Cytology and Histopathology Research.2024; 9(4): 176. CrossRef - A case of osteoclastic variant of anaplastic thyroid carcinoma: Diagnostic and prognostic marker studies by cytology
Surekha Bantumilli, Lee‐Ching Zhu, Muthukumar Sakthivel, Leslie Dodd
Diagnostic Cytopathology.2022;[Epub] CrossRef - Cytodiagnosis of anaplastic thyroid carcinoma with osteoclast-like giant cells − A case report with a review of the literature
Padmanaban Krishnan Govindaraman, Selvaraj Balakumar, Anthuvan Jeyarani Lawrence
Thyroid Research and Practice.2021; 18(1): 40. CrossRef - Role of cytology in differentiating anaplastic thyroid carcinoma with osteoclast like giant cells from giant cell variant of medullary thyroid carcinoma
GP S Gahlot, Tathagata Chatterjee, Rohit Tewari, Vijendra Singh, Ankur Ahuja, Kanwaljeet Singh, Beenu Singh
Journal of Marine Medical Society.2020; 22(2): 255. CrossRef - Osteoclastic variant of anaplastic thyroid carcinoma
Divya Shelly, Divya Gupta, Shashank Mishra, Reena Bharadwaj
Journal of Cancer Research and Therapeutics.2019; 15(3): 704. CrossRef
- Anaplastic carcinoma of thyroid with giant cells –Cytodiagnosis of category VI high grade thyroid tumor
Original Article
- Fine Needle Aspiration Cytology of Osteoclastic Giant Cell Tumor of the Pancreas.
- Sun Hee Sung, Woon Sup Han
- Korean J Cytopathol. 1998;9(1):89-94.
- 1,526 View
- 16 Download
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Abstract
PDF
- A case of fine needle aspiration cytology of an osteoclastic giant cell tumor of pancreas, which is an uncommon variant of ductal adenocarcinoma, is described. Aspirated tumor cells were characterized by three populations: (1) bland osteoclast like giant cells with multiple small, round nuclei with distinct nucleoli, and abundant cytoplasm, (2) individually scattered or loosely clustered medium sized mononuclear tumor cells, having fine chromatin, smooth nuclear membrane, often prominent nucleoli, and high N/C ratio, (3) bland or atypical spindle shaped cells. Osteoid like lacy material was also seen on cell block section. The immunohistochemical studies using paraffin embedded cell block section showed positivities for vimentin and lysozyme in both giant and mononuclear tumor cells. However, they were negative for cytokeratin, epithelial membrane antigen, S-100 protein, carcinoembryonic antigen, and p53.
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