Meningioma is the most common primary intracranial tumor in adults. The grading of meningioma is based on World Health Organization criteria, which rely on histopathological features alone. This grading system is unable to conclusively predict the clinical behavior of these tumors (i.e., recurrence or prognosis in benign or atypical grades). Advances in molecular techniques over the last decade that include genomic and epigenomic data associated with meningiomas have been used to identify genetic biomarkers that can predict tumor behavior. This review summarizes the molecular characteristics of meningioma using genetic and epigenetic biomarkers. Molecular alterations that can predict meningioma behavior may be integrated into the upcoming World Health Organization grading system.
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The Natural History and Treatment of Meningiomas: An Update Arsene Daniel Nyalundja, Fabrice Mugisha, Claire Karekezi Seminars in Neurology.2024; 44(01): 001. CrossRef
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The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care S. Joy Trybula, Mark W. Youngblood, Constantine L. Karras, Nikhil K. Murthy, Amy B. Heimberger, Rimas V. Lukas, Sean Sachdev, John A. Kalapurakal, James P. Chandler, Daniel J. Brat, Craig M. Horbinski, Stephen T. Magill Cancers.2024; 16(9): 1753. CrossRef
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Related mechanisms, current treatments, and new perspectives in meningioma Gizem Inetas‐Yengin, Omer Faruk Bayrak Genes, Chromosomes and Cancer.2024;[Epub] CrossRef
Clinical application of intraoperative ultrasound superb microvascular imaging in brain tumors resections: contributing to the achievement of total tumoral resection Siman Cai, Hao Xing, Yuekun Wang, Yu Wang, Wenbin Ma, Yuxin Jiang, Jianchu Li, Hongyan Wang BMC Medical Imaging.2024;[Epub] CrossRef
WHO CNS 5 and meningiomas: What’s new? Indranil Chakrabarti, Sujaya Mazumder IP Archives of Cytology and Histopathology Research.2024; 9(2): 67. CrossRef
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Differential Expression of Proteins and Genes at the Tumor‐Brain Interface in Invasive Meningioma Kornwika Senglek, Chinachote Teerapakpinyo, Nutchawan Jittapiromsak, Pakrit Jittapiromsak, Irin Lertparinyaphorn, Paul Scott Thorner, Shanop Shuangshoti Genes, Chromosomes and Cancer.2024;[Epub] CrossRef
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Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J Drummond BMC Cancer.2023;[Epub] CrossRef
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Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas Liguo Ye, Shi’ao Tong, Yaning Wang, Yu Wang, Wenbin Ma Journal of Cancer Research and Clinical Oncology.2023; 149(12): 9857. CrossRef
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Meningioma: A Biography—Tumor Forever Tied to the Origins and “Soul of Neurosurgery” Nolan J. Brown, Zach Pennington, Cathleen C. Kuo, Julian Gendreau, Sachiv Chakravarti, Rohin Singh, Dontré M. Douse, Jamie J. Van Gompel World Neurosurgery.2023; 178: 191. CrossRef
Molecular genetic features of meningiomas E.S. Makashova, N.V. Lasunin, M.V. Galkin, S.V. Zolotova, K.O. Karandasheva, A.V. Golanov Voprosy neirokhirurgii imeni N.N. Burdenko.2023; 87(4): 101. CrossRef
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Molecular diagnosis and treatment of meningiomas: an expert consensus (2022) Jiaojiao Deng, Lingyang Hua, Liuguan Bian, Hong Chen, Ligang Chen, Hongwei Cheng, Changwu Dou, Dangmurenjiapu Geng, Tao Hong, Hongming Ji, Yugang Jiang, Qing Lan, Gang Li, Zhixiong Liu, Songtao Qi, Yan Qu, Songsheng Shi, Xiaochuan Sun, Haijun Wang, Yongpi Chinese Medical Journal.2022;[Epub] CrossRef
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The Prognostic Value of Methylation Signatures and NF2 Mutations in Atypical Meningiomas Rahmina Meta, Henning B. Boldt, Bjarne W. Kristensen, Felix Sahm, Wenche Sjursen, Sverre H. Torp Cancers.2021; 13(6): 1262. CrossRef
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An Overview of Managements in Meningiomas Lianhua Zhao, Wei Zhao, Yanwei Hou, Cuixia Wen, Jing Wang, Pei Wu, Zaiyu Guo Frontiers in Oncology.2020;[Epub] CrossRef
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Neues zur Einteilung und Therapie von Meningeomen Corinna Seliger, Wolfgang Wick Neurologie up2date.2020; 3(04): 343. CrossRef
The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the guidelines for using molecular genetic tests in routine pathological practice for an accurate diagnosis and appropriate management. While astrocytomas and IDH-mutant (secondary) glioblastomas are characterized by the mutational status of IDH, TP53, and ATRX, oligodendrogliomas have a 1p/19q codeletion and mutations in IDH, CIC, FUBP1, and the promoter region of telomerase reverse transcriptase (TERTp). IDH-wildtype (primary) glioblastomas typically lack mutations in IDH, but are characterized by copy number variations of EGFR, PTEN, CDKN2A/B, PDGFRA, and NF1 as well as mutations of TERTp. High-grade pediatric gliomas differ from those of adult gliomas, consisting of mutations in H3F3A, ATRX, and DAXX, but not in IDH genes. In contrast, well-circumscribed low-grade neuroepithelial tumors in children, such as pilocytic astrocytoma, pleomorphic xanthoastrocytoma, and ganglioglioma, often have mutations or activating rearrangements in the BRAF, FGFR1, and MYB genes. Other CNS tumors, such as ependymomas, neuronal and glioneuronal tumors, embryonal tumors, meningothelial, and other mesenchymal tumors have important genetic alterations, many of which are diagnostic, prognostic, and predictive markers and therapeutic targets. Therefore, the neuropathological evaluation of brain tumors is increasingly dependent on molecular genetic tests for proper classification, prediction of biological behavior and patient management. Identifying these gene abnormalities requires cost-effective and high-throughput testing, such as next-generation sequencing. Overall, this paper reviews the global guidelines and diagnostic algorithms for molecular genetic testing of brain tumors.
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PTEN regulates expression of its pseudogene in glioblastoma cells in DNA methylation-dependent manner Tatyana F. Kovalenko, Bhupender Yadav, Ksenia S. Anufrieva, Tatyana D. Larionova, Tatiana E. Aksinina, Yaroslav A. Latyshev, Soniya Bastola, Michail I. Shakhparonov, Amit Kumar Pandey, Marat S. Pavlyukov Biochimie.2024; 219: 74. CrossRef
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression Yeajina Lee, Tamrin Chowdhury, Sojin Kim, Hyeon Jong Yu, Kyung-Min Kim, Ho Kang, Min-Sung Kim, Jin Wook Kim, Yong-Hwy Kim, So Young Ji, Kihwan Hwang, Jung Ho Han, Jinha Hwang, Seong-Keun Yoo, Kyu Sang Lee, Gheeyoung Choe, Jae-Kyung Won, Sung-Hye Park, Yon Experimental & Molecular Medicine.2024; 56(4): 975. CrossRef
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BrainBase: a curated knowledgebase for brain diseases Lin Liu, Yang Zhang, Guangyi Niu, Qianpeng Li, Zhao Li, Tongtong Zhu, Changrui Feng, Xiaonan Liu, Yuansheng Zhang, Tianyi Xu, Ruru Chen, Xufei Teng, Rongqin Zhang, Dong Zou, Lina Ma, Zhang Zhang Nucleic Acids Research.2022; 50(D1): D1131. CrossRef
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