Journal of Pathology and Translational Medicine

Case Reports

Ovarian and Pituitary Metastasis from Adenocarcinoma of the Lung: A Case Report.: Yun Kyung Kang; Korean J Pathol. 2006;40(6):452-455.

Abstract PDF: Ovarian metastasis as the first manifestation of a lung adenocarcinoma is an exceptionally rare condition and is often difficult to distinguish from primary ovarian carcinoma. Metastatic cancers of the pituitary gland are also very rarely recognized. This case concerns a 30-year-old woman who exhibited a unilateral ovarian mass that was initially diagnosed as a well- to moderately- differentiated mucinous adenocarcinoma. A month later, she was found to have a lung cancer. A year later, she developed a solitary pituitary mass. After immunohistochemical staining for thyroid transcription factor-1 (TTF-1), she was diagnosed with pulmonary adenocarcinoma with metastases to her right ovary and pituitary gland. This could be the first case of primary lung adenocarcinoma metastasis to two unusual secondary sites, the ovary and pituitary gland, without widespread systemic metastasis. In the differential diagnosis of an ovarian adenocarcinoma, metastatic carcinoma from the lung should be considered. Immunohistochemical staining for TTF-1 would be helpful as well.

Aspergillous Hypophysitis: A Case Report.: Jeana Kim, Leeso Maeng, Je Hoon Lee, Kyoung Mee Kim, Anhi Lee, Chang Suk Kang; Korean J Pathol. 2005;39(3):197-199.

Abstract PDF: Aspergillous hypophysitis is an unusual cause of sella turcica enlargement, and this malady has a clinical presentation as a pituitary tumor, and especially as a pituitary adenoma. We report here on a case of aspergillous hypophysitis that developed in a 37-year-old healthy woman. She first experienced a blurred vision with amenorrhea and galactorrhea. Three months later, the CT scan revealed an intrasellar mass. The patient underwent a transsphenoidal exploration of the sella turcica for a presumed pituitary tumor. Histologically, the pituitary displayed necrotizing granuloma with the acutely branching fungal hyphae of Aspergillus.

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