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2 "Prematurity"
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Original Article
Chronic Placental Inflammation as a Risk Factor of Severe Retinopathy of Prematurity
Chae Young Kim, Euiseok Jung, Eun Na Kim, Chong Jai Kim, Joo Yong Lee, Ji Hye Hwang, Woo Sun Song, Byong Sop Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim
J Pathol Transl Med. 2018;52(5):290-297.   Published online July 16, 2018
DOI: https://doi.org/10.4132/jptm.2018.07.09
  • 11,228 View
  • 126 Download
  • 16 Web of Science
  • 16 Crossref
AbstractAbstract PDF
Background
Chronic placental inflammation (CPI) has been implicated in the pathogenesis of diseases in premature infants, whereas retinopathy of prematurity (ROP) is a major complication primarily affecting preterm and very low-birth-weight (VLBW) infants. This study aims to investigate the association between CPI and ROP in VLBW infants.
Methods
We performed a retrospective review of clinical records of VLBW infants born between 2013 and 2016. Placental pathology findings including CPI cases were analyzed using logistic regression to study infants’ morbidities and other clinical characteristics.
Results
A total of 402 infants with a mean (standard deviation) gestational age of 28.5 (2.8) weeks and birth weight of 1,027.2 (304.4) g were included. The incidence of ROP was 24.1%. CPI was found in 90 infants (22.4%), among which 28.9% (26 of 90) developed ROP, and 21.1% (19 of 90) underwent laser photocoagulation. Lower gestational age, lower birth weight, longer duration of oxygen supply, and presence of CPI were associated with the development of ROP. After adjustment for gestational age, birth weight, sex, duration of oxygen supply, and other overlapping placental pathology, CPI was associated with the odds for type 1 ROP that required laser photocoagulation (adjusted odds ratio, 2.739; 95% confidence interval, 1.112 to 6.749; p = .029).
Conclusions
CPI was associated with severe ROP requiring treatment with laser photocoagulation in VLBW infants.

Citations

Citations to this article as recorded by  
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Review
Article image
White Matter Injury of Prematurity: Its Mechanisms and Clinical Features
Young Ah Lee
J Pathol Transl Med. 2017;51(5):449-455.   Published online August 11, 2017
DOI: https://doi.org/10.4132/jptm.2017.07.25
  • 13,262 View
  • 403 Download
  • 28 Web of Science
  • 26 Crossref
AbstractAbstract PDF
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.

Citations

Citations to this article as recorded by  
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