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Case Report
- Metallic implant-associated lymphoma: ALK-negative anaplastic large cell lymphoma associated with total knee replacement arthroplasty
- Jai-Hyang Go
- J Pathol Transl Med. 2023;57(1):75-78. Published online January 10, 2023
- DOI: https://doi.org/10.4132/jptm.2022.10.30
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- 3 Web of Science
- 5 Crossref
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Abstract
PDF - Metallic implant-associated lymphomas are extremely rare. Only seven cases have been reported in association with knee joint arthroplasty, and all tumors were large B-cell lymphomas. This report is the first case of anaplastic large cell lymphoma occurring after total knee replacement arthroplasty. An 80‑year‑old female patient was admitted because of right knee pain for 2 years. She had undergone total knee replacement arthroplasty 10 years prior. Computed tomography showed an irregular osteolytic lesion in the right lateral femoral condyle, adjacent to the metallic prosthesis. Histologic findings reveal sheets of anaplastic tumor cells that were positive for CD2, CD4, CD5, CD43, and CD30 but negative for CD3, CD20, CD15, and anaplastic lymphoma kinase. Epstein-Barr encoding region in situ hybridization was negative. Analysis of T-cell receptor γ gene rearrangement studies using BIOMED-2–based multiplex polymerase chain reaction confirmed monoclonal T cell proliferation. The woman was finally diagnosed with ALK-negative anaplastic large cell lymphoma.
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Citations
Citations to this article as recorded by
- Implant-Associated Diffuse Large B-Cell Lymphoma following Total Knee Replacement Arthroplasty: Case Report of a Non-EBV-Related Case with Review of Literature
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Indian Journal of Medical and Paediatric Oncology.2026;[Epub] CrossRef - Clinical and microscopic evidence of biofilm formation on titanium miniplates applied in maxillofacial surgery: a case series analysis
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International Journal of Dermatology and Clinical Research.2025; 11(1): 022. CrossRef - Primary bone diffuse large B‐cell lymphoma (PB‐DLBCL): a distinct extranodal lymphoma of germinal centre origin, with a common EZB‐like mutational profile and good prognosis
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JBJS Case Connector.2024;[Epub] CrossRef
- Implant-Associated Diffuse Large B-Cell Lymphoma following Total Knee Replacement Arthroplasty: Case Report of a Non-EBV-Related Case with Review of Literature
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