Journal of Pathology and Translational Medicine

Case Study

Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features: Miguel Fdo. Salazar, María del Rocío Estrada Hernández, Erick Gómez Apo, Laura G. Chávez Macías, Carlos Alfonso Rodríguez Álvarez; J Pathol Transl Med. 2015;49(5):403-408. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.05.28

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We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described.

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Reticulohistiocytoses: a revision of the full spectrum
A. Bonometti, E. Berti
Journal of the European Academy of Dermatology and Venereology.2020; 34(8): 1684. CrossRef

Case Report

Solitary Cutaneous Reticulohistiocytoma On the Upper Lip: A Case Report.: Jae Wang Kim, Hyun Wook Kang; Korean J Pathol. 2006;40(5):373-376.

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Abstract PDF: Reticulohistiocytosis represents a rare spectrum of non-Langerhans cell histiocytosis: the solitary cutaneous form (reticulohistiocytoma), the diffuse or multiple cutaneous form without systemic involvement, and multicentric reticulohistiocytosis with systemic involvement. To the best of our knowledge, there have been relatively few reports in the literature of solitary cutaneous reticulohistiocytoma found on the lip. We report here on a case of solitary cutaneous reticulohistiocytoma in a 58-year-old male, who presented with an asymptomatic dome-shaped nodule adjacent to the upper lip. The histopathologic examination revealed a dense dermal infiltrate, that was composed predominantly of large oncocytic histiocytes and multinucleated giant cells with abundant granular eosinophilic cytoplasms, which had a "ground-glass" appearance.

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