The rib is an unusual location for osteosarcoma and is reported in only 2% of all cases. The major histological variants of osteosarcoma are osteoblastic, chondroblastic, and fibroblastic, with a few rare variants including one epithelioid type. This report describes a 44-year-old male with an osteolytic mass in the right seventh rib. Histological examination revealed osteosarcoma with unique features of epithelioid appearance and rosette structures. To the best of our knowledge, this is the first reported case of a rosette-forming osteosarcoma of the rib that showed epithelioid morphology. Despite successful surgery, the patient’s prognosis was poor because this malignancy had an unusual location within the axial skeleton and was a rare histological variant.
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Clinicopathological correlations and prognostic insights in osteosarcoma: a retrospective analysis Ştefan Adrian Niculescu, Alexandru Florian Grecu , Alex Emilian Stepan , Mădălina Iuliana Muşat , Aritina-Elvira Moroşanu , Tudor Adrian Bălşeanu , Michael Hadjiargyrou , Dan Cristian Grecu Romanian Journal of Morphology and Embryology.2025; 65(4): 723. CrossRef
Eccrine spiradenoma is a rare adnexal tumor of the skin and its cytomorphology has seldom been described in literature.
To evaluate the cytologic features and diagnostic pitfalls of eccrine spiradenoma, we report a case of 33-year-old male whose clinical presentation was a painful subcutaneous mass at the right preauricular area. Fine needle aspirates revealed tight clusters of multilayered, uniform, cuboidal cells arranged around hyalinized perivascular spaces. Some epithelial cells showed tubules or rosette formations. The background showed scattered, naked nuclei. The histologic findings confirmed the eccrine spiradenoma. The recognition of peculiar cytologic features and clinical correlation could be helpful in the diagnosis of skin adnexal tumors.