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- Primary leiomyosarcoma of the bone: a case report
- Ala Abu-Dayeh, Samir Alhyassat
- J Pathol Transl Med. 2024;58(1):35-39. Published online January 10, 2024
- DOI: https://doi.org/10.4132/jptm.2023.11.14
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- 3 Web of Science
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Abstract
PDF - Primary leiomyosarcoma of the bone is rare. Histologically, it resembles leiomyosarcoma of soft tissue. Given the rarity of this entity, its diagnosis should be made only after clinical studies and workup have excluded metastasis from other sites. Herein, we describe an additional case of primary bone leiomyosarcoma. We report a 32-year-old female patient, who presented with right knee pain and was found to have a right distal femur mass by imaging studies. Biopsy showed a neoplasm composed of fascicles of spindle cells, arranged in different patterns, with significant pleomorphism. The tumor cells were positive for smooth muscle actin, focally positive for desmin and H-caldesmon. No other masses in the body were detected by imaging studies. The diagnosis of leiomyosarcoma of the bone was rendered. Given the broad diagnostic differential of primary bone leiomyosarcoma, it is important to be aware of this rare bone tumor phenotype and of its histomorphologic and immunohistochemical features for an accurate diagnosis.
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Citations
Citations to this article as recorded by
- Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature
Jitin Goyal, Bineeta Parihar, Nitin Agarwal, Sulagna Manna, Anila Sharma, Sunil Kumar Puri
Indian Journal of Medical and Paediatric Oncology.2025;[Epub] CrossRef - Primary Limb Leiomyosarcoma With Multifocal Musculoskeletal Soft Tissue Metastasis: A Case Report and Literature Review
Milad Haji Agha Bozorgi, Hoda Borooghani, Taghi Aghajanlou
Clinical Case Reports.2025;[Epub] CrossRef - Chronic Ethanol Exposure Induces Early Epithelial-to-Mesenchymal Transition (EMT) and Premalignant Changes in Gingival Keratinocytes: An In Vitro Model of Very Early Oral Carcinogenesis
Martin Philipp Dieterle, Thorsten Steinberg, Ayman Husari, Pascal Tomakidi
Cells.2025; 14(23): 1887. CrossRef
- Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature
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