E-submission
Search
- Page Path
- HOME > Search
Original Article
- Diagnostic value of cytology in detecting human papillomavirus–independent cervical malignancies: a nation-wide study in Korea
- Hye-Ra Jung, Junyoung Shin, Chong Woo Yoo, Eun Na Kim, Cheol Lee, Kyeongmin Kim, Ho-chang Lee, Yonghee Lee, Ji Hye Kim, Soo Jin Jung, Yumin Chung, Joo Yeon Kim, Hye Eun Park, Tae Hoen Kim, Wonae Lee, Min-Sun Cho, Ran Hong, Yoon Jung Choi, Younghee Choi, Young Sub Lee, Sang-Ryung Lee, Myunghee Kang, Young Jin Seo, Seung-Sook Lee, Yoon-Jung Hwang, Hyun-Jung Kim
- J Pathol Transl Med. 2025;59(6):444-452. Published online November 11, 2025
- DOI: https://doi.org/10.4132/jptm.2025.10.21
- 4,225 View
- 140 Download
-
Abstract
PDF - Background
Human papillomavirus (HPV) independent cervical malignancies (HPV-IDCMs) have recently been classified by the World Health Organization (WHO) 5th edition. These malignancies have historically received limited attention due to their rarity and the potential for evasion of HPV-based screening.
Methods
We retrospectively reviewed 5,854 biopsy-confirmed cervical malignancies from 22 institutions over 3 years (July 2020–June 2023). Histologic classification followed the WHO guidelines. HPV independence was confirmed by dual negativity for p16 and HPV; discordant cases (p16-positive/HPV-negative) underwent additional HPV testing using paraffin-embedded tissue. Cytological results were matched sequentially to histological confirmation.
Results
The prevalence of HPV-IDCM was 4.4% (257/5,854) overall and was 3.6% (208/5,805 cases) among primary cervical malignancy. Patient age of HPV-IDCM was 29 to 89 years (median, 57.79). Its histologic subtypes included primary adenocarcinoma (n = 116), endometrial adenocarcinoma (n = 35), squamous cell carcinoma (n = 72), metastatic carcinoma (n = 14), carcinoma, not otherwise specified (n = 10), neuroendocrine carcinoma (n = 3), and others (n = 7). Among 155 cytology-histological matched cases, the overall and primary Pap test detection rates were 85.2% (132/155) and 83.2% (104/125), respectively. The interval between cytology and histologic confirmation extended up to 38 months.
Conclusions
HPV-IDCMs comprised 3.6% of primary cervical malignancies with a high detection rate via cytology (83.2%). These findings affirm the value of cytological screening, particularly in patients with limited screening history or at risk for HPV-independent lesions, and may guide future screening protocols.
Brief Case Report
- Primary Gastric Histiocytic Sarcoma Reminiscent of Inflammatory Pseudotumor: A Case Report with Review of the Literature
- Dakeun Lee, Young-Bae Kim, Sook Hee Chung, Sang-Ryung Lee, Cheul Su Byun, Sang-Uk Han, Jae Ho Han
- Korean J Pathol. 2014;48(3):258-262. Published online June 26, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.258
- 8,570 View
- 41 Download
- 6 Crossref
-
PDF
-
Citations
Citations to this article as recorded by
- Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature
Li-Wei Liu, Jang-Shian Liang, Chien-Chin Chen, Hao-Wen Chuang
International Journal of Surgical Pathology.2026; 34(1): 255. CrossRef - NF1 mutation and TUBB3 amplification in gastric histiocytic sarcoma: a case report and literature review
Yi Yang, Wei Fan, Xiaoping Liu, Qiongrong Chen
Medical Molecular Morphology.2024; 57(3): 244. CrossRef - Histiocytic sarcoma of the thigh: A diagnostic dilemma
Sana Ahuja, Meetu Agrawal
Journal of Dr. NTR University of Health Sciences.2023; 12(3): 294. CrossRef - Small bowel and lung histiocytic sarcoma revealed by acute peritonitis: A case report with review of literature
Ahlem Bellalah, Ibtissem korbi, Seifeddine Ben Hammouda, Asma Achour, Nouha Ben Abdeljelil, Manel Njima, Amira Daldoul, Rim Hadhri, Leila Njim, Abdelfatteh Zakhama
Annals of Medicine and Surgery.2021; 68: 102638. CrossRef - An unexpected diagnosis of histiocytic sarcoma
Joshua T. Byers, Samuel W. French
Experimental and Molecular Pathology.2019; 106: 60. CrossRef - NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling
Sheryl Coutermarsh-Ott, Alysha Simmons, Vittoria Capria, Tanya LeRoith, Justin E. Wilson, Bettina Heid, Casandra W. Philipson, Qizhi Qin, Raquel Hontecillas-Magarzo, Josep Bassaganya-Riera, Jenny P-Y Ting, Nikolaos Dervisis, Irving C. Allen
Oncotarget.2016; 7(22): 33096. CrossRef
- Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature
First
Prev
