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Case Study
Aggressive Supratentorial Ependymoma, RELA Fusion-Positive with Extracranial Metastasis: A Case Report
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park
J Pathol Transl Med. 2017;51(6):588-593.   Published online November 15, 2017
DOI: https://doi.org/10.4132/jptm.2017.08.10
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  • 13 Web of Science
  • 17 Crossref
AbstractAbstract PDF
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome. For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of intra-axial neuroepithelial tumors are extremely rare. In this paper, we report a case of aggressive anaplastic ependymoma arising in the right frontoparietal lobe, which had genetically 1q25 gain, CDKN2A homozygous deletion, and L1CAM overexpression. The patient was a 10-year-old boy who underwent four times of tumor removal and seven times of gamma knife surgery. Metastatic loci were scalp and temporalis muscle overlying primary operation site, lung, liver, buttock, bone, and mediastinal lymph nodes. He had the malignancy for 10 years and died. This tumor is a representative case of RELA fusion-positive ST ependymoma, showing aggressive behavior.

Citations

Citations to this article as recorded by  
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    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Changes to pediatric brain tumors in 2021 World Health Organization classification of tumors of the central nervous system
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    Pediatric Radiology.2022; 53(3): 523.     CrossRef
  • Delineation of molecular characteristics in pediatric PFA ependymoma involving rare osseous and pulmonary metastases: A case report and literature review
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    Frontiers in Oncology.2022;[Epub]     CrossRef
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    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Cytology of Extraneural Metastases of Nonhematolymphoid Primary Central Nervous System Tumors: Six Cases with Histopathological Correlation and Literature Update
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    Acta Cytologica.2021; 65(6): 529.     CrossRef
  • Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing
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    F1000Research.2020; 8: 613.     CrossRef
  • Cortically based cystic supratentorial RELA fusion-positive ependymoma: a case report with unusual presentation and appearance and review of literature
    Yasmine T. Sallam, Qi Zhang, Sachin K. Pandey
    Radiology Case Reports.2020; 15(12): 2495.     CrossRef
  • Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing
    Muhammad Butt, Sabra Alyami, Tahani Nageeti, Muhammad Saeed, Khalid AlQuthami, Abdellatif Bouazzaoui, Mohammad Athar, Zainularifeen Abduljaleel, Faisal Al-Allaf, Mohiuddin Taher
    F1000Research.2019; 8: 613.     CrossRef
  • Extraneural metastatic anaplastic ependymoma: a systematic review and a report of metastases to bilateral parotid glands
    Gray Umbach, Tarek Y El Ahmadieh, Aaron R Plitt, Salah G Aoun, Om J Neeley, Kristopher A Lyon, Ekokobe Fonkem, Jack M Raisanen, Justin A Bishop, Zabi Wardak, Toral R Patel, Larry Myers, Bruce E Mickey
    Neuro-Oncology Practice.2019;[Epub]     CrossRef
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