Journal of Pathology and Translational Medicine

Case Study

Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: A Case Study and Review of the Literature: Seyda Erdogan, Arbil Acikalin, Handan Zeren, Gulfılız Gonlusen, Suzan Zorludemir, Volkan Izol; Korean J Pathol. 2014;48(3):225-228. Published online June 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.225

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Well-differentiated papillary mesothelioma is an uncommon tumor of the testes that usually presents as a hydrocele. Here, we present the case of one patient who did not have a history of asbestos exposure. The tumor was localized in the tunica vaginalis and was composed of three pedunculated masses macroscopically. Microscopically, branching papillary structures with focal coagulative necrosis were present. In addition to immunohistochemistry, simian virus 40 DNA was also tested by polymerase chain reaction. This report presents one case of this rare entity, its clinical and macroscopic features, and follow-up results.

Citations

Citations to this article as recorded by

Testicular/paratesticular mesothelial tumours: Uncommon histopathologic entities in a very complex anatomical site
Francesca Pagliuca, Stefano Lucà, Marco De Sio, Davide Arcaniolo, Gaetano Facchini, Marco De Martino, Francesco Esposito, Ferdinando DE Vita, Paolo Chieffi, Renato Franco
Pathology - Research and Practice.2024; 253: 155069. CrossRef
Well-differentiated Papillary Mesothelial Tumour of the Tunica Vaginalis Testis – A Rare Lesion, but one Pathologists Should Know About Two Patient Reports and a Review of the Literature
Johannes Kläger, Felicitas Oberndorfer, Cristophe Brunel, Julian Veser, Eva Compérat
International Journal of Surgical Pathology.2023; 31(6): 1126. CrossRef
A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
Rabia Zafar, Lacey J. Schrader, John C. Cheville, J. Kenneth Schoolmeester, Anja C. Roden, Marie-Christine Aubry, Eunhee S. Yi, Aditya Raghunathan, Loren Herrera-Hernandez, R. Houston Thompson, Stephen A. Boorjian, Bradley C. Leibovich, Gary L. Keeney, Ra
Human Pathology.2022; 128: 31. CrossRef
Mesothelioma subtypes of the tunica vaginalis: a rare case report and review of histological criteria
Cutts Rebecca, Martin J Connor, Luxi Sun, Thomas Johnston, Rachel Gooch, John McLoughlin
Journal of Surgical Case Reports.2019;[Epub] CrossRef
Well‐differentiated papillary mesothelioma of tunica vaginalis testis of unknown malignant potential: Sonographic appearance
K.W.S. Ko, K.S. Tse, K.W. Shek, M.N. Hau, S.H. Ting
Journal of Clinical Ultrasound.2018; 46(5): 364. CrossRef
Tunica Vaginalis Thickening, Hemorrhagic Infiltration and Inflammatory Changes in 8 Children with Primary Hydrocele; Reactive Mesothelial Hyperplasia? A Prospective Clinical Study
Ioannis Patoulias, Evangelia Rachmani, Maria Kalogirou, Kyriakos Chatzopoulos, Dimitrios Patoulias
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Two Case Reports of Benign Testicular Mesothelioma and Review of the Literature
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Well-differentiated Papillary Mesothelioma of the Tunica Vaginalis
Wei Keith Tan, Mae-Yen Tan, Hui Meng Tan, Rajadurai Pathmanathan, Wei Phin Tan
Urology.2016; 90: e7. CrossRef
Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature
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The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)
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Critical Reviews in Toxicology.2016; 46(8): 641. CrossRef
Malignant Mesothelioma of the Tunica Vaginalis: A Rare Neoplasm—Case Report and Literature Review
Manuel Segura-González, Jorge Urias-Rocha, Jorge Castelán-Pedraza
Clinical Genitourinary Cancer.2015; 13(6): e401. CrossRef
In vivo Optical Coherence Tomography Imaging of the Mesothelium Using Developed Window Models
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Journal of the Optical Society of Korea.2015; 19(1): 69. CrossRef

Original Articles

No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea: Minseob Eom, Jamshid Abdul-Ghafar, Sun-Mi Park, Joung Ho Han, Soon Won Hong, Kun Young Kwon, Eun Suk Ko, Lucia Kim, Wan Seop Kim, Seung Yeon Ha, Kyo Young Lee, Chang Hun Lee, Hye Kyoung Yoon, Yoo Duk Choi, Myoung Ja Chung, Soon-Hee Jung; Korean J Pathol. 2013;47(2):124-129. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.124

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Abstract PDF

Background

Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA.

Methods

We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA.

Results

Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls.

Conclusions

SV40 is not associated with the development of MM in Korea.

Citations

Citations to this article as recorded by

Association Study of Pleural Mesothelioma and Oncogenic Simian Virus 40 in the Crocidolite-Contaminated Area of Dayao County, Yunnan Province, Southwest China
Ru-ai Liu, Bo-yong Wang, Xin Chen, Yuan-qian Pu, Jia-ji Zi, Wen Mei, Ye-pin Zhang, Lu Qiu, Wei Xiong
Genetic Testing and Molecular Biomarkers.2024; 28(5): 189. CrossRef
Binding of SV40’s Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study
Raisa Kociurzynski, Sophie D. Beck, Jean-Baptiste Bouhon, Winfried Römer, Volker Knecht
Langmuir.2019; 35(9): 3534. CrossRef
Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033
Kyeong Min Kwak, Domyung Paek, Seung-sik Hwang, Young-Su Ju, Mark Allen Pershouse
PLOS ONE.2017; 12(8): e0183404. CrossRef
The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
Tumor Biology.2014; 35(2): 889. CrossRef
The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma
Leonardo Vinícius Monteiro de Assis, Jamille Locatelli, Mauro César Isoldi
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2014; 1845(2): 232. CrossRef
Pleural Mesothelioma: An Institutional Experience of 66 Cases
Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn
Korean Journal of Pathology.2014; 48(2): 91. CrossRef

Detection of SV40 Large T Antigen in Malignant Lymphomas.: Young A Kim, MeeSoo Chang, Jinho Paik, Sun Och Yoon, Yoon Kyung Jeon, Chul Woo Kim, Ji Eun Kim; Korean J Pathol. 2009;43(4):312-316.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.4.312

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67 Download
1 Crossref

Abstract PDF

BACKGROUND
The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant lymphomas among Korean patients. METHODS: One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochemical staining for SV40 large T antigen (TAg), using an extremely sensitive, tyramide based, catalyzed signal amplification method. RESULTS: From 158 non-Hodgkin's lymphomas, including 115 diffuse large B-cell lymphomas, and 15 Hodgkin's lymphomas, none of the cases were positive for SV40 TAg. CONCLUSIONS: SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans.

Citations

Citations to this article as recorded by

No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
Minseob Eom, Jamshid Abdul-Ghafar, Sun-Mi Park, Joung Ho Han, Soon Won Hong, Kun Young Kwon, Eun Suk Ko, Lucia Kim, Wan Seop Kim, Seung Yeon Ha, Kyo Young Lee, Chang Hun Lee, Hye Kyoung Yoon, Yoo Duk Choi, Myoung Ja Chung, Soon-Hee Jung
Korean Journal of Pathology.2013; 47(2): 124. CrossRef

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