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Case Study
Sclerosing Perivascular Epithelioid Cell Tumor of the Lung: A Case Report with Cytologic Findings
Ha Yeon Kim, Jin Hyuk Choi, Hye Seung Lee, Yoo Jin Choi, Aeree Kim, Han Kyeom Kim
J Pathol Transl Med. 2016;50(3):238-242.   Published online April 11, 2016
DOI: https://doi.org/10.4132/jptm.2016.02.19
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  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Benign perivascular epithelioid cell tumor (PEComa) of the lung is a rare benign neoplasm, a sclerosing variant of which is even rarer. We present a case of 51-year-old man who was diagnosed with benign sclerosing PEComa by percutaneous fine needle aspiration cytology and biopsy. The aspirate revealed a few cell clusters composed of bland-looking polygonal or spindle cells with fine granular or clear cytoplasm. Occasional fine vessel-like structures with surrounding hyalinized materials were seen. The patient later underwent wedge resection of the lung. The histopathological study of the resected specimen revealed sheets of polygonal cells with clear vacuolated cytoplasm, variably sized thin blood vessels, and densely hyalinized stroma. In immunohistochemical studies, reactivity of tumor cells for human melanoma black 45 and Melan-A further supported the diagnosis of benign sclerosing PEComa. To the best of our knowledge, this is the first case of benign sclerosing PEComa described in lung.

Citations

Citations to this article as recorded by  
  • Renal sclerosing AML/PEComa in a male - A case report and literature review
    Zoe Williams, Paul Kim, James Kovacic, Andrew Shepherd, Krishan Rasiah, Ankur Dhar, Kathleen Young
    Urology Case Reports.2026; 65: 103326.     CrossRef
  • Robotic Treatment of Adrenal Sclerosing PEComa: A Case Report with 13 Years of Follow-Up and a Literature Review
    Alessio Paladini, Raffaele La Mura, Michele Del Zingaro, Luca Lepri, Andrea Vitale, Jessica Pagnotta, Matteo Mearini, Guido Massa, Ettore Mearini, Giovanni Cochetti
    Applied Sciences.2025; 15(16): 9161.     CrossRef
  • A rare case of pulmonary perivascular epithelioid cell neoplasm
    Maolin Xu, Xiaofang Guo
    Asian Journal of Surgery.2025;[Epub]     CrossRef
  • Cytopathology of rare gastric mesenchymal neoplasms: A series of 25 cases and review of literature
    Carla Saoud, Peter B. Illei, Momin T. Siddiqui, Syed Z. Ali
    Cytopathology.2023; 34(1): 15.     CrossRef
  • Retroperitoneal Sclerosing Angiomyolipoma with Long-Term Follow up: A Case Report with Unique Clinicopathologic and Genomic Profile
    Liwei Jia, Vandana Panwar, Michelle Parmley, Elena Lucas, Ivan Pedrosa, Payal Kapur
    International Journal of Surgical Pathology.2022; 30(1): 86.     CrossRef
  • Perivascular epithelioid cell tumor of the lung: A case report and literature review
    Shaofu Yu, Shasha Zhai, Qian Gong, Xiaoping Hu, Wenjuan Yang, Liyu Liu, Yi Kong, Lin Wu, Xingxiang Pu
    Thoracic Cancer.2022; 13(17): 2542.     CrossRef
  • Cytopathology of extra-renal perivascular epithelioid cell tumor (PEComa): a series of 7 cases and review of the literature
    Sintawat Wangsiricharoen, Tatianna C. Larman, Paul E. Wakely, Momin T. Siddiqui, Syed Z. Ali
    Journal of the American Society of Cytopathology.2021; 10(2): 175.     CrossRef
  • Clear cell sugar tumour: a rare tumour of the lung
    Sarah Page, Matthew S. Yong, Alka Sinha, Pankaj Saxena
    ANZ Journal of Surgery.2020;[Epub]     CrossRef
  • Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit
    Panagiotis Paliogiannis, Giuseppe Palmieri, Francesco Tanda, Antonio Cossu
    Journal of Pathology and Translational Medicine.2017; 51(1): 7.     CrossRef

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