Uterine rhabdomyosarcoma (RMS) typically presents as a mixed epithelial and mesenchymal tumors. Pure RMSs of the female genital tract are uncommon. Spindle cell variant of RMS is a rare morphologic subtype of embryonal RMS and mostly occurs in the paratesticular region of children. Here, we present a case of uterine spindle cell RMS in a 76-year-old woman. The tumor, 20×15×7 cm in size, was highly necrotic and adherent to the colon and rectum. Tumor cells were mostly spindle-shaped, and isolated rhabdomyoblasts were scattered. Immunohistochemical stains for myoglobin and myo-D1 showed diffuse positivity for tumor cells. The patient died only of disease three months after diagnosis.

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• A rare adult case of primary uterine rhabdomyosarcoma with mixed pattern: a clinicopathological & immunohistochemical study with literature review
  Nehal K.H. Kamel, Eiman Adel Hasby
  Diagnostic Pathology.2024;[Epub]     CrossRef
• Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations
  Jennifer A. Bennett, Zehra Ordulu, Robert H. Young, Andre Pinto, Koen Van de Vijver, Eike Burandt, Pankhuri Wanjari, Rajeev Shah, Leanne de Kock, William D. Foulkes, W. Glenn McCluggage, Lauren L. Ritterhouse, Esther Oliva
  Modern Pathology.2021; 34(9): 1750.     CrossRef
• Vaginal embryonal rhabdomyosarcoma in young woman: A case report and literature review
  Lalya Issam, Laatitioui Sana, Essadi Ismail, El Omrani Abdelhamid, Khouchani Mouna
  Archives of Cancer Science and Therapy.2020; 4(1): 034.     CrossRef
• Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients
  Maha AT Elsebaie, Zeinab Elsayed
  Archives of Gynecology and Obstetrics.2018; 297(3): 559.     CrossRef
• Spindle cell sarcoma – a rare diagnosis
  SK Kathpalia, Manju Mehrotra, Pinky Jena, Archana H Deshpande
  Women's Health.2018;[Epub]     CrossRef
• Malignant mesenchymal tumors of the uterus – time to advocate a genetic classification
  Birgit Rommel, Carsten Holzmann, Jörn Bullerdiek
  Expert Review of Anticancer Therapy.2016; 16(11): 1155.     CrossRef
• Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications
  AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
  International Journal of Oncology.2016; 48(5): 1815.     CrossRef
• Primary third ventricular tumor in an 18‐year‐old man
  Tianping Yu, Mengni Zhang, Qiao Zhou, Jing Gong, Ling Nie, Xueqin Chen, Ni Chen
  Neuropathology.2015; 35(6): 599.     CrossRef
• Rhabdomyosarcoma of vulva in a young lady
  Tapesh Bhattacharyya, Firuza D. Patel, Radhika Srinivasan, Bhavana Rai, Pradeep Saha, R. Nijhawan
  Journal of Cancer Research and Therapeutics.2015; 11(3): 650.     CrossRef
• Uterine sarcoma in a 14year-old girl presenting with uterine rupture
  Jane Özcan, Özlem Dülger, Latif Küpelioğlu, Ali İhsan Gönenç, Aynur Erşahin
  Gynecologic Oncology Reports.2014; 10: 44.     CrossRef