Journal of Pathology and Translational Medicine

Original Article

Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16^INK4a Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma: Su Hyun Yoo, Eun-Mi Son, Chang Okh Sung, Kyu-Rae Kim; Korean J Pathol. 2013;47(6):549-556. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.549

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Background

Primary squamous cell carcinoma (SCC) of the upper genital tract, including the endometrium, fallopian tubes, and ovaries, is extremely rare. It must be distinguished from the mucosal extension of primary cervical SCC because determination of the primary tumor site is important for tumor staging. However, patients with SCC of the fallopian tubes or ovarian surface have often undergone prior hysterectomy with inadequate examination of the cervix, making it difficult to determine the primary site.

Methods

We compared histologic findings, p16^INK4a expression, and human papillomavirus (HPV) DNA status in four patients with primary SCC of the upper genital tract and five patients with primary cervical SCC extending to the mucosa of the upper genital tract.

Results

All five SCCs of cervical origin showed strong expression of p16^INK4a, whereas all four SCCs of the upper genital tract were negative, although one showed weak focal staining. Three of the five cervical SCCs were positive for HPV16 DNA, whereas all four primary SCCs of the upper genital tract were negative for HPV DNA.

Conclusions

Although a thorough histological examination is important, immunonegativity for p16^INK4a and negative for HPV DNA may be useful adjuncts in determining primary SCCs of the upper genital tract.

Citations

Citations to this article as recorded by

PAX8 Positivity, Abnormal p53 Expression, and p16 Negativity in a Primary Endometrial Squamous Cell Carcinoma: A Case Report and Review of the Literature
Daniela Fanni, Michele Peiretti, Valerio Mais, Elena Massa, Clara Gerosa, Francesca Ledda, Maria Luisa Fais, Gavino Faa, Stefano Angioni
International Journal of Gynecological Pathology.2022; 41(4): 431. CrossRef
Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations
Mark R. Hopkins, Doreen N. Palsgrove, Brigitte M. Ronnett, Russell Vang, Jeffrey Lin, Tricia A. Murdock
American Journal of Surgical Pathology.2022; 46(12): 1611. CrossRef
Primary squamous cell carcinoma of the endometrium—Case report with cytological characteristics in direct and indirect endometrial samples
Sanda Rajhvajn, Ana Barišić, Lada Škopljanac‐Mačina, Danijela Jurič, Vesna Mahovlić
Cytopathology.2021; 32(6): 823. CrossRef
Überraschung in der Abradatdiagnostik
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Der Pathologe.2015; 36(3): 317. CrossRef
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Eun-Jae Chung, Go-Woon Kim, Bum-Ki Cho, Sung-Jin Cho, Dae-Young Yoon, Young-Soo Rho
Annals of Surgical Oncology.2015; 22(9): 3049. CrossRef

Case Study

A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study: Da Hye Son, Su Hyun Yoo, Ho-Seok Sa, Kyung-Ja Cho; Korean J Pathol. 2013;47(2):158-162. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.158

7,105 View
55 Download
7 Crossref

Abstract PDF

Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.

Citations

Citations to this article as recorded by

A review of solitary fibrous tumours of the orbit and ocular adnexa
Cornelius René, Paolo Scollo, Dominic O’Donovan
Eye.2023; 37(5): 858. CrossRef
A giant orbital solitary fibrous tumor treated by surgical excision: a case report and literature review
Qi Zhou, Yuting Liu, Fang Wang, Yang Cao, Hongbin Lv, Xibo Zhang
Diagnostic Pathology.2023;[Epub] CrossRef
Giant cell-rich solitary fibrous tumour of the lacrimal gland with prominent angiomatoid cystic changes and an underlying NAB2ex3-STAT6ex18 fusion
Khaled A Alsaadi, Manar Alwohaib, Karen Pinto, Rola H Ali
BMJ Case Reports.2022; 15(2): e247141. CrossRef
Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review
Ancuta-Augustina Gheorghisan-Galateanu, Dana Cristina Terzea, Iulia Burcea, Roxana Dusceac, Cristina Capatina, Catalina Poiana
Diagnostic Pathology.2019;[Epub] CrossRef
Solitary Fibrous Tumor in the Lacrimal Gland Fossa: A Case Report
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
Case Reports in Ophthalmology.2016; 7(2): 398. CrossRef
Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review
Aleksandra Petrovic, Aurélie Obéric, Alexandre Moulin, Mehrad Hamedani
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Angiofibroma de células gigantes en mucosa yugal: una entidad rara en una localización infrecuente
Alejandro Rubio Fernández, María López Macías, Weimar Toro Zambrano, Mario Díaz Delgado, Alicia Hernández Amate
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