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Case Study
Malignant Pleural Effusion from Metastatic Prostate Cancer: A Case Report with Unusual Cytologic Findings
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
J Pathol Transl Med. 2018;52(4):257-261.   Published online June 7, 2018
DOI: https://doi.org/10.4132/jptm.2018.05.08
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AbstractAbstract PDF
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker with a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed bilateral pleural effusions of a small to moderate amount. Pigtail catheters were inserted for drainage. The pleural fluid consisted of large clusters and tightly cohesive groups of malignant cells, which however could not be ascribed to prostate cancer with certainty. We performed immunocytochemical panel studies to determine the origin of cancer metastasis. The immunostaining results were positive for prostate-specific antigen, alpha-methylacyl-coenzyme A racemase, and Nkx 3.1, consistent with prostate cancer. Pleural effusion associated with prostate cancer is rare. To our knowledge, this is the first case report in Korea to describe cytologic features of malignant pleural effusion associated with prostate cancer.

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  • EBUS-TBNA pleural biopsy reveals prostate cancer metastasis: A rare case report and review of the literature
    Fotios Sampsonas, Dimitrios Komninos, Vasilina Sotiropoulou, Matthaios Katsaras, Dimitra Gkanetsou, Ourania Papaioannou, Panagiota Tsiri, Vasiliki Tzelepi, Argyrios Tzouvelekis
    Pneumon.2024; 37(2): 1.     CrossRef
  • Cytopathological Features of Extensive Bilateral Pleural Effusions in Metastatic Prostate Cancer: Report of a Rare Case
    Hehua Huang, Caroline Yap
    Cureus.2024;[Epub]     CrossRef
  • Bilateral pleural effusion: etiology, diagnostics
    N. A. Stogova
    PULMONOLOGIYA.2022; 32(6): 885.     CrossRef
  • Rare Metastatic Prostate Cancer Mimicking Lymphoma with Malignant Pleural Effusion
    Tung Liu, En Meng, Yu-Chun Lin, Tai-Kuang Chao, Yi-Ming Chang
    Journal of Medical Sciences.2021; 42(1): 46.     CrossRef
Review
Molecular Testing of Lung Cancers
Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
J Pathol Transl Med. 2017;51(3):242-254.   Published online April 21, 2017
DOI: https://doi.org/10.4132/jptm.2017.04.10
  • 14,537 View
  • 598 Download
  • 26 Web of Science
  • 26 Crossref
AbstractAbstract PDF
Targeted therapies guided by molecular diagnostics have become a standard treatment of lung cancer. Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are currently used as the best predictive biomarkers for EGFR tyrosine kinase inhibitors and ALK inhibitors, respectively. Besides EGFR and ALK, the list of druggable genetic alterations has been growing, including ROS1 rearrangements, RET rearrangements, and MET alterations. In this situation, pathologists should carefully manage clinical samples for molecular testing and should do their best to quickly and accurately identify patients who will benefit from precision therapeutics. Here, we grouped molecular biomarkers of lung cancers into three categories—mutations, gene rearrangements, and amplifications—and propose expanded guidelines on molecular testing of lung cancers.

Citations

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    James J. Saller, Theresa A. Boyle
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  • Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing
    Jeonghyo Lee, Yeon Bi Han, Hyun Jung Kwon, Song Kook Lee, Hyojin Kim, Jin-Haeng Chung
    Journal of Pathology and Translational Medicine.2022; 56(5): 249.     CrossRef
  • Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
    Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
    Journal of Pathology and Translational Medicine.2021; 55(3): 181.     CrossRef
  • TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis
    Kyungsoo Jung, Joon-Seok Choi, Beom-Mo Koo, Yu Jin Kim, Ji-Young Song, Minjung Sung, Eun Sol Chang, Ka-Won Noh, Sungbin An, Mi-Sook Lee, Kyoung Song, Hannah Lee, Ryong Nam Kim, Young Kee Shin, Doo-Yi Oh, Yoon-La Choi
    Cancer Research and Treatment.2021; 53(1): 9.     CrossRef
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    Lukas Kalinke, Ricky Thakrar, Sam M. Janes
    Molecular Oncology.2021; 15(10): 2544.     CrossRef
  • Cost-effectiveness analyses of targeted therapy and immunotherapy for advanced non-small cell lung cancer in the United States: a systematic review
    Anthony Yu, Eva Huang, Momoka Abe, Kang An, Sun-Kyeong Park, Chanhyun Park
    Expert Review of Pharmacoeconomics & Outcomes Research.2021; 21(3): 381.     CrossRef
  • The expanding capability and clinical relevance of molecular diagnostic technology to identify and evaluate EGFR mutations in advanced/metastatic NSCLC
    Parth Shah, Jacob Sands, Nicola Normanno
    Lung Cancer.2021; 160: 118.     CrossRef
  • Testing for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets
    Mercedes L Dalurzo, Alejandro Avilés-Salas, Fernando Augusto Soares, Yingyong Hou, Yuan Li, Anna Stroganova, Büge Öz, Arif Abdillah, Hui Wan, Yoon-La Choi
    OncoTargets and Therapy.2021; Volume 14: 4671.     CrossRef
  • Treatment of Patients With Non–Small-Cell Lung Cancer Harboring Rare Oncogenic Mutations
    Melina E. Marmarelis, Corey J. Langer
    Clinical Lung Cancer.2020; 21(5): 395.     CrossRef
  • Detection of Targetable Genetic Alterations in Korean Lung Cancer Patients: A Comparison Study of Single-Gene Assays and Targeted Next-Generation Sequencing
    Eunhyang Park, Hyo Sup Shim
    Cancer Research and Treatment.2020; 52(2): 543.     CrossRef
  • High prevalence of ROS1 gene rearrangement detected by FISH in EGFR and ALK negative lung adenocarcinoma
    Yuyin Xu, Heng Chang, Lijing Wu, Xin Zhang, Ling Zhang, Jing Zhang, Yuan Li, Lei Shen, Xiaoli Zhu, Xiaoyan Zhou, Qianming Bai
    Experimental and Molecular Pathology.2020; 117: 104548.     CrossRef
  • An All-In-One Transcriptome-Based Assay to Identify Therapy-Guiding Genomic Aberrations in Nonsmall Cell Lung Cancer Patients
    Jiacong Wei, Anna A. Rybczynska, Pei Meng, Martijn Terpstra, Ali Saber, Jantine Sietzema, Wim Timens, Ed Schuuring, T. Jeroen N. Hiltermann, Harry. J.M. Groen, Anthonie van der Wekken, Anke van den Berg, Klaas Kok
    Cancers.2020; 12(10): 2843.     CrossRef
  • Immunotherapy in EGFR-Mutant and ALK-Positive Lung Cancer
    Alexander Gavralidis, Justin F. Gainor
    The Cancer Journal.2020; 26(6): 517.     CrossRef
  • Role of Immunocytochemistry in the Cytological Diagnosis of Pulmonary Tumors
    Jasna Metovic, Luisella Righi, Luisa Delsedime, Marco Volante, Mauro Papotti
    Acta Cytologica.2020; 64(1-2): 16.     CrossRef
  • Molecular Diagnostic Assays and Clinicopathologic Implications of MET Exon 14 Skipping Mutation in Non–small-cell Lung Cancer
    Eun Kyung Kim, Kyung A. Kim, Chang Young Lee, Sangwoo Kim, Sunhee Chang, Byoung Chul Cho, Hyo Sup Shim
    Clinical Lung Cancer.2019; 20(1): e123.     CrossRef
  • PD‐L1 expression in ROS1‐rearranged non‐small cell lung cancer: A study using simultaneous genotypic screening of EGFR, ALK, and ROS1
    Jongmin Lee, Chan Kwon Park, Hyoung‐Kyu Yoon, Young Jo Sa, In Sook Woo, Hyo Rim Kim, Sue Youn Kim, Tae‐Jung Kim
    Thoracic Cancer.2019; 10(1): 103.     CrossRef
  • Human Leukocyte Antigen Class I and Programmed Death-Ligand 1 Coexpression Is an Independent Poor Prognostic Factor in Adenocarcinoma of the Lung
    Yeon Bi Han, Hyun Jung Kwon, Soo Young Park, Eun-Sun Kim, Hyojin Kim, Jin-Haeng Chung
    Journal of Pathology and Translational Medicine.2019; 53(2): 86.     CrossRef
  • Molecular testing for advanced non-small cell lung cancer in Malaysia: Consensus statement from the College of Pathologists, Academy of Medicine Malaysia, the Malaysian Thoracic Society, and the Malaysian Oncological Society
    Pathmanathan Rajadurai, Phaik Leng Cheah, Soon Hin How, Chong Kin Liam, Muhammad Azrif Ahmad Annuar, Norhayati Omar, Noriah Othman, Nurhayati Mohd Marzuki, Yong Kek Pang, Ros Suzanna Ahmad Bustamam, Lye Mun Tho
    Lung Cancer.2019; 136: 65.     CrossRef
  • Somatic mutations and immune checkpoint biomarkers
    Brielle A. Parris, Eloise Shaw, Brendan Pang, Richie Soong, Kwun Fong, Ross A. Soo
    Respirology.2019; 24(3): 215.     CrossRef
  • Adverse Event Management in Patients with BRAF V600E-Mutant Non-Small Cell Lung Cancer Treated with Dabrafenib plus Trametinib
    Anna Chalmers, Laura Cannon, Wallace Akerley
    The Oncologist.2019; 24(7): 963.     CrossRef
  • Genetic and clinicopathologic characteristics of lung adenocarcinoma with tumor spread through air spaces
    Jae Seok Lee, Eun Kyung Kim, Moonsik Kim, Hyo Sup Shim
    Lung Cancer.2018; 123: 121.     CrossRef
Brief Case Reports
Mucosal Schwann Cell Hamartoma in Colorectal Mucosa: A Rare Benign Lesion That Resembles Gastrointestinal Neuroma
Jiheun Han, Yosep Chong, Tae-Jung Kim, Eun Jung Lee, Chang Suk Kang
J Pathol Transl Med. 2017;51(2):187-189.   Published online August 25, 2016
DOI: https://doi.org/10.4132/jptm.2016.07.02
  • 10,094 View
  • 203 Download
  • 6 Web of Science
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Citations

Citations to this article as recorded by  
  • Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report With a Literature Review
    Faryal Altaf, Nismat Javed, Haider Ghazanfar, Anil Dev
    Cureus.2024;[Epub]     CrossRef
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    Marissa Krizelda Santos, Kathleen Adryon Tan
    PJP.2024;[Epub]     CrossRef
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    Takeshi Okamoto, Takaaki Yoshimoto, Katsuyuki Fukuda
    BMC Gastroenterology.2021;[Epub]     CrossRef
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    The Korean Journal of Gastroenterology.2020; 76(3): 171.     CrossRef
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    Saya TAKIKAWA, Shigeo TANAKA, Masamichi KOMIYA, Masaaki SUEMITSU, Tadahiko UTSUNOMIYA, Kayo KUYAMA
    Japanese Journal of Oral and Maxillofacial Surgery.2020; 66(12): 601.     CrossRef
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    Francisco García-Molina, José Antonio Ruíz-Macia, Joaquin Sola
    Revista Española de Patología.2018; 51(1): 49.     CrossRef
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    Aoife J McCarthy, Dipti M Karamchandani, Runjan Chetty
    Journal of Clinical Pathology.2018; 71(7): 565.     CrossRef
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    JayaKrishna Chintanaboina, Kofi Clarke
    BMJ Case Reports.2018; : bcr-2018-224931.     CrossRef
Primary Neurilemmoma of the Thyroid Gland Clinically Mimicking Malignant Thyroid Nodule
Young Sub Lee, Jee Soon Kim, Arthur Minwoo Chung, Woo Chan Park, Tae-Jung Kim
J Pathol Transl Med. 2016;50(2):168-171.   Published online October 26, 2015
DOI: https://doi.org/10.4132/jptm.2015.08.26
  • 7,992 View
  • 71 Download
  • 1 Web of Science
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Necrotizing Sarcoid Granulomatosis: Possibly Veiled Disease in Endemic Area of Mycobacterial Infection
Yosep Chong, Eun Jung Lee, Chang Suk Kang, Tae-Jung Kim, Jung Sup Song, Hyosup Shim
J Pathol Transl Med. 2015;49(4):346-350.   Published online June 1, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.17
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  • 88 Download
  • 11 Web of Science
  • 12 Crossref
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Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report
Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee
Korean J Pathol. 2014;48(2):170-173.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.170
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  • 47 Download
  • 12 Crossref
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Esophageal Squamous Cell Carcinoma In Situ Overlying Leiomyoma Mimicking Invasive Cancer: A Brief Case Report
Woo Jin Oh, Eun Jung Lee, Youn Soo Lee, Tae-Jung Kim
Korean J Pathol. 2014;48(2):162-163.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.162
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Review
Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group
Hyojin Kim, Hyo Sup Shim, Lucia Kim, Tae-Jung Kim, Kun Young Kwon, Geon Kook Lee, Jin-Haeng Chung
Korean J Pathol. 2014;48(1):1-9.   Published online February 25, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.1
  • 12,855 View
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AbstractAbstract PDF

Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so accurate patient identification is crucial for successful treatment using ALK inhibitors. Furthermore, most patients with lung cancer present with advanced-stage disease at the time of diagnosis, so it is important for pathologists to detect ALK-rearranged patients while effectively maximizing small biopsy or cytology specimens. In this review, we propose a guideline recommendation for ALK testing approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

Citations

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  • Molecular Characteristics of Radon Associated Lung Cancer Highlights MET Alterations
    Gabriele Gamerith, Marcel Kloppenburg, Finn Mildner, Arno Amann, Sabine Merkelbach-Bruse, Carina Heydt, Janna Siemanowski, Reinhard Buettner, Michael Fiegl, Claudia Manzl, Georg Pall
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  • ALK Translocation in ALK-Positive Mesenchymal Tumors: Diagnostic and Therapeutic Insights
    Minsun Jung, Kyung Chul Moon, Jeongmo Bae, Tae Min Kim, Miso Kim, Yoon Kyung Jeon, Cheol Lee
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  • Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
    Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
    Journal of Pathology and Translational Medicine.2021; 55(3): 181.     CrossRef
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