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- Fibrin-associated large B-cell lymphoma arising in an endovascular graft: first case report in Korea
- Min Gyoung Pak, Mee Sook Roh
- J Pathol Transl Med. 2024;58(2):87-90. Published online January 24, 2024
- DOI: https://doi.org/10.4132/jptm.2023.12.28
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Abstract
PDF - Fibrin-associated large B-cell lymphoma (FA-LBCL) is an extremely rare subtype of LBCL that consists of microscopic aggregates of atypical large B cells in the background of fibrin. Here, we report the first case of FA-LBCL in Korea. A 57-year-old male presented with a large amount of thrombus in the thoracic aorta during follow-up for graft replacement of the thoracoabdominal aorta 8 years prior. The removed thrombus, measuring 4.3 × 3.1 cm, histologically exhibited eosinophilic fibrinous material with several small clusters of atypical lymphoid cells at the periphery. The atypical cells were positive for CD20 by immunohistochemistry and for Epstein-Barr virus by in situ hybridization. The Ki-67 proliferation rate was 85%. The patient was still alive with no recurrence at the 7-year follow-up after thrombectomy. Although the diagnosis can be very difficult and challenging due to its paucicellular features, pathologists should be aware of FALBCL, which has likely been underestimated in routine evaluations of thrombi.
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Citations
Citations to this article as recorded by
- Acute Lower Limb Arterial Occlusion Due to Malignant Lymphoma: A Case Report
Hana Isokawa, Hiroshi Abe, Dai Ozaki, Hiroyuki Isogai, Tetsuro Miyazaki, Takashi Tokano, Tohru Minamino
Internal Medicine.2026;[Epub] CrossRef - Fibrin-associated large B-cell lymphoma arising within a hepatic cystic lesion: a case report
Zujun Qin, Yaqi Shu, Qiqi Zhu, Shunhai Jian
Frontiers in Oncology.2026;[Epub] CrossRef - Fibrin-Associated Large B-Cell Lymphoma Mimicking Pyogenic Spondylitis After Abdominal Aortic Graft Infection
Atsuya Fujita, Takashi Sono, Takayoshi Shimizu, Koichi Murata, Bungo Otsuki, Hironori Haga, Shuichi Matsuda
JBJS Case Connector.2026;[Epub] CrossRef
- Acute Lower Limb Arterial Occlusion Due to Malignant Lymphoma: A Case Report
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