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Case Study
- TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
- Anurag Mehta, Himanshi Diwan, Divya Bansal, Manoj Gupta
- J Pathol Transl Med. 2022;56(1):53-56. Published online November 16, 2021
- DOI: https://doi.org/10.4132/jptm.2021.09.16
- 10,361 View
- 198 Download
- 7 Web of Science
- 8 Crossref
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Abstract
PDF - SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.
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Citations
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- Therapeutic misalignment averted by clonal evolutionary evidence: molecular confirmation of hepatic metastasis in SMARCA4-deficient non-small cell lung cancer initially misdiagnosed as resectable cholangiocarcinoma
Ruirui Fan, Yanyan Zhan, Junrong Yan, Jie Gao
Frontiers in Oncology.2026;[Epub] CrossRef - Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation
Yawen Zheng, Cantong Chen, Xufan Li, Zhouyang Li, Hua Li, Mingjia Tan, Danyi Zhai, Fengwu Zhang, Wenjing Lu, Zhihua Chen, Yongchao Zhao, Pengyuan Liu, Yan Lu, Xiufang Xiong, Yi Sun
Science Bulletin.2026;[Epub] CrossRef - Clinicopathological analysis of 110 cases of SMARCA4-deficient conventional non-small cell lung cancer
Huifang Li, Diming Wang, Jian Zhao, Jieting Zhao, Rongrong Song, Xianfeng Shi, Wenwen Lv, Xiaoliang Shi, Congcong Song, Xiaodong Zhu, Wei Ye
Annals of Diagnostic Pathology.2026; 85: 152708. CrossRef - SMARCA4-deficient Non–small Cell Lung Cancer on 18F-FDG PET/CT
Tao Liu, Hengshan Ji, Siyuan Jiang, Rongxin Qi, Xiaodie Zhou, Jingjing Sun, Jiang Wu
Clinical Nuclear Medicine Open.2025;[Epub] CrossRef - Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways
Jiaqin Song, Shikun Yang, Lei Xia
Frontiers in Oncology.2025;[Epub] CrossRef - One Case of Non-Small Cell Lung Cancer with SMARCA4 Deletion Was Reported
允龙 宋
Medical Diagnosis.2024; 14(01): 137. CrossRef - Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma
Lei Zhang, Ting Sun, Xiao-Ye Wu, Fa-Ming Fei, Zhen-Zhen Gao
World Journal of Clinical Cases.2022; 10(29): 10501. CrossRef - Novel germline SMARCA4 mutation in Small Cell Carcinoma of the Ovary, Hypercalcemic Type
Anurag Mehta, Himanshi Diwan, Diksha Karki, Divya Bansal, Meenakshi Kamboj, Anila Sharma, Shrinidhi Nathany, Sakshi Mattoo, Dushyant Kumar
Current Problems in Cancer: Case Reports.2022; 8: 100205. CrossRef
- Therapeutic misalignment averted by clonal evolutionary evidence: molecular confirmation of hepatic metastasis in SMARCA4-deficient non-small cell lung cancer initially misdiagnosed as resectable cholangiocarcinoma
Case Report
- Uterine Cervical Large Cell Neuroendocrine Carcinoma Concurrent with High Grade Squamous Intraepithelial Neoplasia: A Case Report.
- Yun Kyung Kang, Jae Whoan Koh
- Korean J Pathol. 2008;42(6):389-392.
- 2,451 View
- 21 Download
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Abstract
PDF
- Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare and aggressive malignancy. We report a case of uterine cervical LCNEC concurrent with high grade squamous intraepithelial neoplasia (HG-SIN). The LCNEC expressed chromogranin A and thyroid transcription factor 1 (TTF1). The HG-SIN was negative for these markers. Human papillomavirus (HPV) type 18 was positive in LCNEC whereas both type 16 and 18 were positive in HG-SIN by nested polymerase chain reaction. This case showed TTF1 positivity nonetheless diagnosed as a primary uterine cervical LCNEC confirmed by the detection of HPV genome within the tumor. It is critical to recognize LCNEC of the uterine cervix even in the small biopsy specimen because it is a distinctive clinicopathological entity with highly aggressive behavior and unfavorable outcome.
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