Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Translational medical research"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives
Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong
J Pathol Transl Med. 2016;50(1):1-9.   Published online October 26, 2015
DOI: https://doi.org/10.4132/jptm.2015.09.10
  • 12,461 View
  • 153 Download
  • 20 Web of Science
  • 20 Crossref
AbstractAbstract PDF
Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease is complex in nature because it arises from multiple interactions of genetic, local environmental, and host factors, resulting in biological heterogeneity. This genetic intricacy converges on molecular characteristics reflecting the pathophysiology, tumor biology, and clinical outcome. Therefore, understanding the molecular characteristics at a genomic level is pivotal to improving the clinical care of patients with gastric cancer. A recent landmark study, The Cancer Genome Atlas (TCGA) project, showed the molecular landscape of gastric cancer through a comprehensive molecular evaluation of 295 primary gastric cancers. The proposed molecular classification divided gastric cancer into four subtypes: Epstein-Barr virus–positive, microsatellite unstable, genomic stable, and chromosomal instability. This information will be taken into account in future clinical trials and will be translated into clinical therapeutic decisions. To fully realize the clinical benefit, many challenges must be overcome. Rapid growth of high-throughput biology and functional validation of molecular targets will further deepen our knowledge of molecular dimensions of this cancer, allowing for personalized precision medicine.

Citations

Citations to this article as recorded by  
  • Advancements and challenges in gastric cancer: epidemiology, biomarkers, and therapeutic strategies
    Marina Nishimuni, Laura Carolina Lopez Claro, Maria Ignez Freitas Melro Braghiroli
    Surgical and Experimental Pathology.2024;[Epub]     CrossRef
  • Research Progress of MSI Gastric Cancer Subtypes
    成菊 马
    Advances in Clinical Medicine.2022; 12(07): 6719.     CrossRef
  • OCT4-mediated transcription confers oncogenic advantage for a subset of gastric tumors with poor clinical outcome
    Jaishree Pandian, Ponmathi Panneerpandian, Balaji T. Sekar, Karthikeyan Selvarasu, Kumaresan Ganesan
    Functional & Integrative Genomics.2022; 22(6): 1345.     CrossRef
  • Secondary Primary Cancer after Primary Gastric Cancer: Literature Review and Big Data Analysis Using the Health Insurance Review and Assessment Service (HIRA) Database of Republic of Korea
    Jeong Ho Song, Yeonkyoung Lee, Jaesung Heo, Sang-Yong Son, Hoon Hur, Sang-Uk Han
    Cancers.2022; 14(24): 6165.     CrossRef
  • Microsatellite instability: a review of what the oncologist should know
    Kai Li, Haiqing Luo, Lianfang Huang, Hui Luo, Xiao Zhu
    Cancer Cell International.2020;[Epub]     CrossRef
  • Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial
    Chul Kyu Roh, Yoon Young Choi, Seohee Choi, Won Jun Seo, Minah Cho, Eunji Jang, Taeil Son, Hyoung-Il Kim, Hyeseon Kim, Woo Jin Hyung, Yong-Min Huh, Sung Hoon Noh, Jae-Ho Cheong
    Yonsei Medical Journal.2019; 60(2): 132.     CrossRef
  • Ten Thousand Consecutive Gastrectomies for Gastric Cancer: Perspectives of a Master Surgeon
    Yoon Young Choi, Minah Cho, In Gyu Kwon, Taeil Son, Hyoung-Il Kim, Seung Ho Choi, Jae-Ho Cheong, Woo Jin Hyung
    Yonsei Medical Journal.2019; 60(3): 235.     CrossRef
  • Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
    Yujun Park, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Cancer Immunology, Immunotherapy.2019; 68(11): 1779.     CrossRef
  • Phosphoproteomics Enables Molecular Subtyping and Nomination of Kinase Candidates for Individual Patients of Diffuse-Type Gastric Cancer
    Mengsha Tong, Chunyu Yu, Jinwen Shi, Wenwen Huang, Sai Ge, Mingwei Liu, Lei Song, Dongdong Zhan, Xia Xia, Wanlin Liu, Jinwen Feng, Wenhao Shi, Jiafu Ji, Jing Gao, Tieliu Shi, Weimin Zhu, Chen Ding, Yi Wang, Fuchu He, Lin Shen, Tingting Li, Jun Qin
    iScience.2019; 22: 44.     CrossRef
  • Trastuzumab Specific Epitope Evaluation as a Predictive and Prognostic Biomarker in Gastric Cancer Patients
    Jiwon Koh, Soo Kyung Nam, Youn Woo Lee, Jin Won Kim, Keun-Wook Lee, Chan-Young Ock, Do-Youn Oh, Sang-Hoon Ahn, Hyung-Ho Kim, Keon-Wook Kang, Woo Ho Kim, Ho-Young Lee, Hye Seung Lee
    Biomolecules.2019; 9(12): 782.     CrossRef
  • Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier
    Sharareh Jafari, Fatemeh Nabavizadeh, Jalal Vahedian, Mehdi Shafie Ardestani, Hedayat Samandari, Ali Zare Mehrjerdi
    african journal of gastroenterology and hepatology.2019; 2(1): 28.     CrossRef
  • New therapeutic options opened by the molecular classification of gastric cancer
    Mihaela Chivu-Economescu, Lilia Matei, Laura G Necula, Denisa L Dragu, Coralia Bleotu, Carmen C Diaconu
    World Journal of Gastroenterology.2018; 24(18): 1942.     CrossRef
  • Proposed Molecular and miRNA Classification of Gastric Cancer
    Lara Alessandrini, Melissa Manchi, Valli De Re, Riccardo Dolcetti, Vincenzo Canzonieri
    International Journal of Molecular Sciences.2018; 19(6): 1683.     CrossRef
  • High serum MMP-14 predicts worse survival in gastric cancer
    Aaro Kasurinen, Taina Tervahartiala, Alli Laitinen, Arto Kokkola, Timo Sorsa, Camilla Böckelman, Caj Haglund, Dajun Deng
    PLOS ONE.2018; 13(12): e0208800.     CrossRef
  • miR-30 functions as an oncomiR in gastric cancer cells through regulation of P53-mediated mitochondrial apoptotic pathway
    Jianjun Wang, Yang Jiao, Lunmeng Cui, Lili Jiang
    Bioscience, Biotechnology, and Biochemistry.2017; 81(1): 119.     CrossRef
  • Clinicopathologic implication of meticulous pathologic examination of regional lymph nodes in gastric cancer patients
    Jiwon Koh, Hee Eun Lee, Woo Ho Kim, Hye Seung Lee, Ju-Seog Lee
    PLOS ONE.2017; 12(3): e0174814.     CrossRef
  • Perioperative chemotherapy for resectable gastric cancer – what is the evidence?
    Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
    Scandinavian Journal of Gastroenterology.2017; 52(6-7): 647.     CrossRef
  • Molecular classifications of gastric cancers: Novel insights and possible future applications
    Silvio Ken Garattini, Debora Basile, Monica Cattaneo, Valentina Fanotto, Elena Ongaro, Marta Bonotto, Francesca V Negri, Rosa Berenato, Paola Ermacora, Giovanni Gerardo Cardellino, Mariella Giovannoni, Nicoletta Pella, Mario Scartozzi, Lorenzo Antonuzzo,
    World Journal of Gastrointestinal Oncology.2017; 9(5): 194.     CrossRef
  • GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis
    Puja Khanna, Pei Jou Chua, Belinda Shu Ee Wong, Changhong Yin, Aye Aye Thike, Wei Keat Wan, Puay Hoon Tan, Gyeong Hun Baeg
    Oncotarget.2017; 8(70): 115370.     CrossRef
  • Clinicopathologic implications of immune classification by PD-L1 expression and CD8-positive tumor-infiltrating lymphocytes in stage II and III gastric cancer patients
    Jiwon Koh, Chan-Young Ock, Jin Won Kim, Soo Kyung Nam, Yoonjin Kwak, Sumi Yun, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Oncotarget.2017; 8(16): 26356.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP