Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Ultrasound-guided fine needle aspiration cytology"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Diagnostic Accuracy of Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Pancreatic Lesions
Hae Woon Baek, Min Jee Park, Ye-Young Rhee, Kyoung Bun Lee, Min A Kim, In Ae Park
J Pathol Transl Med. 2015;49(1):52-60.   Published online January 15, 2015
DOI: https://doi.org/10.4132/jptm.2014.10.26
  • 9,366 View
  • 84 Download
  • 31 Web of Science
  • 32 Crossref
AbstractAbstract PDF
Background
Endoscopic ultrasound–guided fine needle aspiration cytology (EUS-FNAC) is currently the most commonly used procedure for obtaining cytologic specimens of the pancreas. It is accurate, minimally invasive, safe and cost-effective. However, there is discrepancy between cytological and surgical diagnoses. This study was aimed at evaluating the diagnostic accuracy of EUS-FNAC of the pancreas. Methods: We performed a retrospective review of 191 cases of pancreatic lesions initially diagnosed by EUS-FNAC with subsequent histological diagnosis between 2010 and 2012 in the Department of Pathology, Seoul National University Hospital. Cytologic and surgical diagnoses were categorized into five groups: negative, benign, atypical, malignant, and insufficient for diagnosis. Subsequently, 167 cases with satisfactory yield in both surgical and cytology specimens were statistically analyzed to determine correlations with diagnosis. Results: In comparison to surgical diagnoses, cytologic diagnoses were true-positive in 103 cases (61.7%), true-negative in 28 cases (16.8%), false-positive in 9 cases (5.4%), and false-negative in 27 cases (16.1%). The diagnostic accuracy was 78.4%, sensitivity was 79.2%, and specificity was 75.7%. The positive predictive value was 92.0%, and negative predictive value was 50.9%. Conclusions: EUS-FNAC has high accuracy, sensitivity, specificity and positive predictive value. Overcoming the limitations of EUS-FNAC will make it a useful and reliable diagnostic tool for accurate evaluation of pancreatic lesions.

Citations

Citations to this article as recorded by  
  • Reporting Pancreatic FNAC using the Papanicolaou System: Still a Diagnostic Challenge
    Parul Verma, Saloni Goyal, Ruchita Tyagi, Mehar Ghuman, Ramit Mahajan, Arshneet Kaur Selhi, Harpreet Kaur, Pavneet Kaur Selhi
    Journal of Cytology.2024; 41(2): 123.     CrossRef
  • miR-6855-5p Enhances Radioresistance and Promotes Migration of Pancreatic Cancer by Inducing Epithelial-Mesenchymal Transition via Suppressing FOXA1: Potential of Plasma Exosomal miR-6855-5p as an Indicator of Radiosensitivity in Patients with Pancreatic
    Hiroki Ueda, Hidenori Takahashi, Shogo Kobayashi, Masahiko Kubo, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Junzo Shimizu, Yuichiro Doki, Hidetoshi Eguchi
    Annals of Surgical Oncology.2024;[Epub]     CrossRef
  • Preoperative treatment response prediction for pancreatic cancer by multiple microRNAs in plasma exosomes: Optimization using machine learning and network analysis
    Hiroki Ueda, Hidenori Takahashi, Ryoto Sakaniwa, Tetsuhisa Kitamura, Shogo Kobayashi, Yoshito Tomimaru, Masahiko Kubo, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Junzo Shimizu, Yuichiro Doki, Hidetoshi Eguchi
    Pancreatology.2024; 24(7): 1097.     CrossRef
  • Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration with Fine-Needle Biopsy for Solid Gastrointestinal Lesions: A Randomized Crossover Single-Center study
    Shivaraj Afzalpurkar, Vijay Kumar Rai, Nikhil Sonthalia, Gajanan Rodge, Awanesh Tewary, Mahesh Goenka
    Journal of Digestive Endoscopy.2023; 14(01): 014.     CrossRef
  • Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects
    María Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, Enrique Aranda, Antonio Rodríguez-Ariza
    Biomarker Research.2023;[Epub]     CrossRef
  • Grading pancreatic adenocarcinomas on fine needle aspiration cytology. The outstanding issues
    Mrinmay Kumar Mallik, Laila Rafiq Qadan, Asit Kumar Mohanty, Ali Alali, Kusum Kapila
    Cytopathology.2023;[Epub]     CrossRef
  • The impact of preoperative EUS-FNA for distal resectable pancreatic cancer: Is it really effective enough to take risks?
    Jin-Seok Park, Jae Hoon Lee, Tae Jun Song, Joune Seup Lee, Seok Jung Jo, Dong Wook Oh, Ki Byung Song, Dae Wook Hwang, Do Hyun Park, Sang Soo Lee, Song Cheol Kim, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim
    Surgical Endoscopy.2022; 36(5): 3192.     CrossRef
  • Magnetic Resonance Imaging Radiomics‐Based Nomogram From Primary Tumor for Pretreatment Prediction of Peripancreatic Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma: A Multicenter Study
    Zhenshan Shi, Chengle Ma, Xinming Huang, Dairong Cao
    Journal of Magnetic Resonance Imaging.2022; 55(3): 823.     CrossRef
  • Role of Pathologist in the Era of Image-Guided and EUS-Guided Aspirations: A 10-Year Study at a Single Tertiary Care Oncology Institute in North India
    Gurudutt Gupta, Anila Sharma, Meenakshi Kamboj, Anurag Sharma, Sunil Pasricha, Garima Durga, Anurag Mehta, Avinash Rao
    Acta Cytologica.2022; 66(3): 187.     CrossRef
  • Predicting Factors for Pancreatic Malignancy with Computed Tomography and Endoscopic Ultrasonography in Chronic Pancreatitis
    Jian-Han Lai, Keng-Han Lee, Chen-Wang Chang, Ming-Jen Chen, Ching-Chung Lin
    Diagnostics.2022; 12(4): 1004.     CrossRef
  • Phenotypic profiling of pancreatic ductal adenocarcinoma plasma-derived small extracellular vesicles for cancer diagnosis and cancer stage prediction: a proof-of-concept study
    Wei Zhang, Ling Wang, Dan Li, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Qing Dong, Erkang Wang, Yuling Wang
    Analytical Methods.2022; 14(23): 2255.     CrossRef
  • Cancer-derived small extracellular vesicles: emerging biomarkers and therapies for pancreatic ductal adenocarcinoma diagnosis/prognosis and treatment
    Wei Zhang, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Dingbin Liu, Yuling Wang
    Journal of Nanobiotechnology.2022;[Epub]     CrossRef
  • Single Cell RNA Sequencing: A New Frontier in Pancreatic Ductal Adenocarcinoma
    Maroun Bou Zerdan, Malek Shatila, Dhruv Sarwal, Youssef Bouferraa, Morgan Bou Zerdan, Sabine Allam, Merima Ramovic, Stephen Graziano
    Cancers.2022; 14(19): 4589.     CrossRef
  • Molecular Subtyping and Precision Medicine for Pancreatic Cancer
    Fieke Froeling, Raffaella Casolino, Antonio Pea, Andrew Biankin, David Chang
    Journal of Clinical Medicine.2021; 10(1): 149.     CrossRef
  • Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine
    R. Casolino, C. Braconi, G. Malleo, S. Paiella, C. Bassi, M. Milella, S.B. Dreyer, F.E.M. Froeling, D.K. Chang, A.V. Biankin, T. Golan
    Annals of Oncology.2021; 32(2): 183.     CrossRef
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Pancreatic Adenocarcinomas Revisited. A Detailed Cytological Analysis
    Mrinmay Kumar Mallik, Kusum Kapila, Asit Kumar Mohanty, Shafi Ahmed Inamdar, Ali AlAli, Abdullah Al Naseer
    Journal of Cytology.2021; 38(1): 31.     CrossRef
  • Diagnostic value of various liquid biopsy methods for pancreatic cancer
    Yuzhou Zhu, Hao Zhang, Nan Chen, Jianqi Hao, Hongyu Jin, Xuelei Ma
    Medicine.2020; 99(3): e18581.     CrossRef
  • Factors affecting cytological results of endoscopic ultrasound guided-fine needle aspiration during learning
    Jian-Han Lai, Hsiang-Hung Lin, Ching-Chung Lin
    Diagnostic Pathology.2020;[Epub]     CrossRef
  • Comparison between Conventional Smear and Liquid-Based Preparation in Endoscopic Ultrasonography-Fine Needle Aspiration Cytology of Pancreatic Lesions
    Soo Hee Ko, Jung-Soo Pyo, Byoung Kwan Son, Hyo Young Lee, Il Whan Oh, Kwang Hyun Chung
    Diagnostics.2020; 10(5): 293.     CrossRef
  • Evaluation of Pancreatic Lesions With Endoscopic Ultrasound and Fine Needle Aspiration
    Yan Luk, Wong Hoi She, Felix Che Lok Chow, Ka Wing Ma, Simon Hing Yin Tsang, Wing Chiu Dai, Tan To Cheung, Chung Mau Lo
    Surgical Innovation.2020; 27(5): 431.     CrossRef
  • The applicability of Papanicolaou Society of Cytopathology system on reporting endoscopic ultrasound‐guided fine needle aspiration cytology specimens of pancreatic lesions in situations with limited availability of ancillary tests. Experience at a single
    Mrinmay Kumar Mallik, Laila Rafiq Qadan, Abdullah Al Naseer, Ali AlAli, Taiba Al Ansari, Shafi Ahmed Inamdar Naquib, Dilip Kumar Das, Kusum Kapila
    Cytopathology.2020; 31(6): 564.     CrossRef
  • Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer
    Marta Toledano-Fonseca, M. Teresa Cano, Elizabeth Inga, Rosa Rodríguez-Alonso, M. Auxiliadora Gómez-España, Silvia Guil-Luna, Rafael Mena-Osuna, Juan R. de la Haba-Rodríguez, Antonio Rodríguez-Ariza, Enrique Aranda
    Cancers.2020; 12(7): 1754.     CrossRef
  • Risk of malignancy in the categories of the Papanicolaou Society of Cytopathology system for reporting pancreaticobiliary cytology
    Raza S. Hoda, Elizabeth B. Finer, Ronald N. Arpin, Matthew Rosenbaum, Martha B. Pitman
    Journal of the American Society of Cytopathology.2019; 8(3): 120.     CrossRef
  • Endoscopic ultrasound guided fine‐needle aspiration vs core needle biopsy for solid pancreatic lesions: Comparison of diagnostic accuracy and procedural efficiency
    Aslam Syed, Olivia Babich, Bharat Rao, Shailendra Singh, Neil Carleton, Abhishek Gulati, Archana Kulkarni, Mrinal Garg, Katie Farah, Gursimran Kochhar, Suzanne Morrissey, Marcia Mitre, Abhijit Kulkarni, Manish Dhawan, Jan F. Silverman, Majed Pharaon, Shya
    Diagnostic Cytopathology.2019; 47(11): 1138.     CrossRef
  • Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine
    Claudio Luchini, Nicola Veronese, Alessia Nottegar, Vera Cappelletti, Maria G. Daidone, Lee Smith, Christopher Parris, Lodewijk A. A. Brosens, Maria G. Caruso, Liang Cheng, Christopher L. Wolfgang, Laura D. Wood, Michele Milella, Roberto Salvia, Aldo Scar
    Cancers.2019; 11(8): 1152.     CrossRef
  • It is necessary to exam bottom and top slide smears of EUS-FNA for pancreatic cancer
    Jong-chan Lee, Haeryoung Kim, Hyoung Woo Kim, Jongchan Lee, Kyu-hyun Paik, Jingu Kang, Jin-Hyeok Hwang, Jaihwan Kim
    Hepatobiliary & Pancreatic Diseases International.2018; 17(6): 553.     CrossRef
  • Preoperative EUS-guided FNA: effects on peritoneal recurrence and survival in patients with pancreatic cancer
    Sun Hwa Kim, Young Sik Woo, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, Joo Kyung Park, Soo Hoon Kang, Ji Won Kim, Jae Keun Park, Sung-Wook Park
    Gastrointestinal Endoscopy.2018; 88(6): 926.     CrossRef
  • Cytological characteristics of atypical cells in endoscopic ultrasound-guided fine-needle aspiration specimens obtained from the pancreas
    Shikine ESAKA, Yoko MATSUDA, Yuri HAMASHIMA, Masayuki IMAIZUMI, Hiroya KOJIMA, Yuri KISO, Hiroto SHIRAHATA, Mayumi KINOSHITA, Akemi SUZUKI, Tomio ARAI
    The Journal of the Japanese Society of Clinical Cytology.2018; 57(4): 199.     CrossRef
  • Performance measures for endoscopic retrograde cholangiopancreatography and endoscopic ultrasound: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
    Dirk Domagk, Kofi W Oppong, Lars Aabakken, Laszlo Czakó, Tibor Gyökeres, Gianpiero Manes, Peter Meier, Jan-Werner Poley, Thierry Ponchon, Andrea Tringali, Cristina Bellisario, Silvia Minozzi, Carlo Senore, Cathy Bennett, Michael Bretthauer, Cesare Hassan,
    United European Gastroenterology Journal.2018; 6(10): 1448.     CrossRef
  • Performance measures for ERCP and endoscopic ultrasound: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
    Dirk Domagk, Kofi W. Oppong, Lars Aabakken, Laszlo Czakó, Tibor Gyökeres, Gianpiero Manes, Peter Meier, Jan-Werner Poley, Thierry Ponchon, Andrea Tringali, Cristina Bellisario, Silvia Minozzi, Carlo Senore, Cathy Bennett, Michael Bretthauer, Cesare Hassan
    Endoscopy.2018; 50(11): 1116.     CrossRef
  • Imaging modalities for characterising focal pancreatic lesions
    Lawrence MJ Best, Vishal Rawji, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
    Cochrane Database of Systematic Reviews.2017;[Epub]     CrossRef
  • Percutaneous ultrasound‐guided core needle biopsy of solid pancreatic masses: Results in 250 patients
    Guven Kahriman, Nevzat Ozcan, Serap Dogan, Soner Ozmen, Kemal Deniz
    Journal of Clinical Ultrasound.2016; 44(8): 470.     CrossRef
Case Report
Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology in the Diagnosis of a Gastrointestinal Stromal Tumor of the Stomach: A Case Report.
Lucia Kim, Hyung Gil Kim, Young Chae Chu, In Suh Park, Suk Jin Choi, Jee Young Han, Sun Hee Kim, Don Haeng Lee, Joon Mee Kim
Korean J Cytopathol. 2008;19(2):178-182.
DOI: https://doi.org/10.3338/kjc.2008.19.2.178
  • 2,108 View
  • 20 Download
AbstractAbstract PDF
We report here a case of a gastrointestinal stromal tumor (GIST) in the stomach that was diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNA). A 67 year old male patient underwent regular check-ups for five years due to the presence of a submucosal tumor that was found in the fundus of the stomach incidentally. EUS-FNA was performed to evaluate the tumor, which had increased in size from 1cm to 2.8cm. A cytologic smear revealed cohesive sheets or clusters of spindle cells with elongated nuclei. Immunohistochemical staining revealed a strong positive reaction for c-kit and CD34, without any reaction for smooth muscle actin and Ki-67. Therefore, a diagnosis of GIST was made.

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP