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Original Article
- MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
- Joon Im, Soo Kyung Nam, Hye Seung Lee
- J Pathol Transl Med. 2021;55(2):125-131. Published online February 19, 2021
- DOI: https://doi.org/10.4132/jptm.2021.01.17
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- 5 Web of Science
- 5 Crossref
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Abstract
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Supplementary Material - Background
MicroRNA-552 (miR-552) has been reported to correlate with the development and progression of various cancers, including colorectal cancer (CRC). This study aimed to investigate miR-552 expression in cancer tissue samples compared to normal mucosal tissue and its role as a diagnostic or prognostic marker in CRC patients.
Methods
Normal mucosal tissues and primary cancer tissues from 80 surgically resected CRC specimens were used. Quantitative real-time polymerase chain reaction was performed for miR-552 and U6 small nuclear RNA to analyze miR-552 expression and its clinicopathological significance. Immunohistochemistry for p53 and phosphatase and tension homolog (PTEN) was performed to evaluate their association with miR-552 expression.
Results
miR-552 expression was significantly higher in primary cancer tissues compared to normal mucosal tissues (p<.001). The expression level of miR552 was inversely correlated with that of PTEN (p=.068) and p53 (p=.004). Survival analysis showed that high miR-552 expression was associated with worse prognosis but this was not statistically significant (p=.255). However, patients with CRC having high miR-552 expression and loss of PTEN expression had significantly worse prognosis than others (p=.029).
Conclusions
Our results suggest that high miR-552 expression might be a potential diagnostic biomarker for CRC, and its combined analysis with PTEN expression can possibly be used as a prognostic marker. -
Citations
Citations to this article as recorded by
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World Journal of Gastrointestinal Oncology.2026;[Epub] CrossRef - MicroRNAs involved in colorectal cancer, a rapid mini-systematic review
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International Journal of Molecular Sciences.2022; 23(18): 10918. CrossRef
- Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression
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