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4 "Younghoon Kim"
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Original Articles
Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis
Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
J Pathol Transl Med. 2022;56(3):144-151.   Published online May 15, 2022
  • 2,236 View
  • 72 Download
  • 1 Citations
AbstractAbstract PDFSupplementary Material
Fusobacterium nucleatum has been identified to promote tumor progression in colorectal cancer (CRC). However, association between F. nucleatum and prognostic or clinicopathological features has been diverse among studies, which could be affected by type of biospecimen (formalin-fixed paraffin-embedded or fresh frozen [FF]).
Articles were systemically reviewed for studies that included the correlation between F. nucleatum and prognosis or clinicopathological features in CRC.
Ten articles, eight studies with survival-related features involving 3,199 patients and nine studies with clinical features involving 2,655 patients, were eligible for the meta-analysis. Overall survival, disease-free survival, and cancer-specific survival were all associated with worse prognosis in F. nucleatum–high patients (p<.05). In subgroup analysis, only studies with FF tissues retained prognostic significance with F. nucleatum. In meta-analysis of clinicopathological variables, F. nucleatum level was associated with location within colon, pT category, MLH1 hypermethylation, microsatellite instability status, and BRAF mutation regardless of type of biospecimen. However, lymph node metastasis and KRAS mutation was only associated with F. nucleatum level in FF-based studies.
In conclusion, type of biospecimen could affect the role of F. nucleatum as a biomarker associated with clinicopathological features and prognosis.


Citations to this article as recorded by  
  • Tumour Colonisation of Parvimonas micra Is Associated with Decreased Survival in Colorectal Cancer Patients
    Thyra Löwenmark, Anna Löfgren-Burström, Carl Zingmark, Ingrid Ljuslinder, Michael Dahlberg, Sofia Edin, Richard Palmqvist
    Cancers.2022; 14(23): 5937.     CrossRef
A comparative prognostic performance of definitions of Crohn-like lymphoid reaction in colorectal carcinoma
Younghoon Kim, Jeong Mo Bae, Jung Ho Kim, Nam-Yun Cho, Gyeong Hoon Kang
J Pathol Transl Med. 2021;55(1):53-59.   Published online November 27, 2020
  • 2,693 View
  • 108 Download
AbstractAbstract PDFSupplementary Material
The prognostic potential of Crohn-like lymphoid reaction (CLR) in colorectal carcinoma (CRC) has been investigated through the assessment of different criteria.
The prognostic impact of CLR was investigated in 636 CRC patients to compare methods from previously published articles. These methods included CLR measured by number of lymphoid aggregates (LAs) (CLR count), LA size greater than or equal to 1 mm (CLR size), CLR density with a cutoff value of 0.38, and subjective criteria as defined by intense CLR.
In univariate survival analysis, CLR-positive CRC as defined by the four aforementioned methods was associated with better overall survival (OS) (hazard ratio [HR], 0.463; 95% confidence interval [CI], 0.305 to 0.702; p <.001; HR, 0.656; 95% CI, 0.411 to 1.046; p=.077; HR, 0.363; 95% CI, 0.197 to 0.669; p=.001; and HR, 0.433; 95% CI, 0.271 to 0.690; p<.001, respectively) and disease-free survival (DFS) (HR, 0.411; 95% CI, 0.304 to 0.639; p<.001; HR, 0.528; 95% CI, 0.340 to 0.821; p=.004; HR, 0.382; 95% CI, 0.226 to 0.645, p=.004; and HR, 0.501; 95% CI, 0.339 to 0.741; p<.001, respectively) than CLR-negative CRC, regardless of criteria with the exception of OS for CLR density. In multivariate analysis, two objective criteria (CLR count and CLR density) and one subjective criterion (intense CLR) for defining CLR were considered independent prognostic factors of OS and DFS in CRC patients.
CLR has similar traits regardless of criteria, but CLR-positivity should be defined by objective criteria for better reproducibility and prognostic value.
Brief Case Report
Squamous Cell Carcinoma of the Seminal Vesicle from Zinner Syndrome: A Case Report and Review of Literature
Younghoon Kim, Hae Woon Baek, Eunoh Choi, Kyung Chul Moon
J Pathol Transl Med. 2015;49(1):85-88.   Published online January 15, 2015
  • 9,552 View
  • 67 Download
  • 6 Citations


Citations to this article as recorded by  
  • Zinner syndrome: a rare diagnosis in infancy
    Joanne Michelle Oida Rose, Ravi Banthia, Zain Tamboli, Hira Lal
    BMJ Case Reports.2022; 15(5): e248558.     CrossRef
  • Classifying seminal vesicle cysts in the diagnosis and treatment of Zinner syndrome: A report of six cases and review of available literature
    Zhengwu Tan, Bing Li, Lan Zhang, Ping Han, Haitao Huang, Andrew Taylor, Xin Li
    Andrologia.2020;[Epub]     CrossRef
  • Incidental imaging findings suggesting Zinner syndrome in a young patient with pulmonary embolism: A case report
    Benedikt Hergan, Franz A. Fellner, Kaveh Akbari
    Radiology Case Reports.2020; 15(4): 437.     CrossRef
  • Ectopic ureter associated with Zinner’s syndrome in a kidney recipient: case report and literature review
    Korhan Tuncer, Gizem Kilinc, Ismail Sert, Goksever Akpinar, Cem Tugmen
    Revista da Associação Médica Brasileira.2020; 66(5): 692.     CrossRef
  • Zinner’s Syndrome: A Rare Diagnosis of Dysuria Based on Imaging
    Ahmed Ibrahimi, Abdelmoughit Hosni, Idriss Ziani, Fatima Zahra Laamrani, Hachem El Sayegh, Laila Jroundi, Lounis Benslimane, Yassine Nouini, Apul Goel
    Case Reports in Urology.2020; 2020: 1.     CrossRef
  • Primary squamous cell carcinoma of the seminal vesicle
    Lu Fang, Qian Hong, Lei Chen, Yi Wang, Liang-Kuan Bi, Dong-Dong Xie, De-Xin Yu
    Medicine.2019; 98(12): e14788.     CrossRef
Original Article
Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status
Jung Ho Kim, Jeong Mo Bae, Kyung-Ju Kim, Ye-Young Rhee, Younghoon Kim, Nam-Yun Cho, Hye Seung Lee, Mee Soo Chang, Gyeong Hoon Kang
Korean J Pathol. 2014;48(4):276-282.   Published online August 26, 2014
  • 9,961 View
  • 57 Download
  • 14 Citations
AbstractAbstract PDF

Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs.


Expression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight).


Among 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004).


Loss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.


Citations to this article as recorded by  
  • Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
    S. Raghavan, Deepak Kumar Singh, J. Rohila, A. DeSouza, R. Engineer, A. Ramaswamy, V. Ostwal, A. Saklani
    Indian Journal of Surgical Oncology.2020; 11(4): 597.     CrossRef
  • Evaluation of the Role of Circulating Tumor Cells and Microsatellite Instability Status in Predicting Outcome of Advanced CRC Patients
    Ippokratis Messaritakis, Maria Sfakianaki, Konstantinos Vogiatzoglou, Asimina Koulouridi, Chara Koutoulaki, Dimitrios Mavroudis, Maria Tzardi, Nikolaos Gouvas, John Tsiaoussis, John Souglakos
    Journal of Personalized Medicine.2020; 10(4): 235.     CrossRef
  • Is Ep-CAM Expression a Diagnostic and Prognostic Biomarker for Colorectal Cancer? A Systematic Meta-Analysis
    Susu Han, Shaoqi Zong, Qi Shi, Hongjia Li, Shanshan Liu, Wei Yang, Wen Li, Fenggang Hou
    EBioMedicine.2017; 20: 61.     CrossRef
  • Prognostic factors in sporadic colon cancer with high-level microsatellite instability
    Bo Young Oh, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Ho-Kyung Chun
    Surgery.2016; 159(5): 1372.     CrossRef
  • Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status
    Ghilsuk Yoon, Hwayoung Lee, Jae-Hoon Kim, Keun Hur, An Na Seo
    Tumor Biology.2016; 37(8): 10209.     CrossRef
  • Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis
    Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan
    BMC Cancer.2016;[Epub]     CrossRef
  • BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis
    Soo Kyung Nam, Sumi Yun, Jiwon Koh, Yoonjin Kwak, An Na Seo, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Woo Ho Kim, Hye Seung Lee, Wayne A Phillips
    PLOS ONE.2016; 11(3): e0151865.     CrossRef
  • Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells
    Bo Young Oh, So-Young Kim, Yeo Song Lee, Hye Kyung Hong, Tae Won Kim, Seok Hyung Kim, Woo Yong Lee, Yong Beom Cho
    Oncotarget.2016; 7(35): 57066.     CrossRef
  • Clinicopathologic, molecular, and prognostic implications of the loss of EPCAM expression in colorectal carcinoma
    Jung Ho Kim, Jeong Mo Bae, Young Seok Song, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
    Oncotarget.2016; 7(12): 13372.     CrossRef
  • Pathologic Factors Associated with Prognosis after Adjuvant Chemotherapy in Stage II/III Microsatellite-Unstable Colorectal Cancers
    Jung Ho Kim, Jeong Mo Bae, Hyeon Jeong Oh, Hye Seung Lee, Gyeong Hoon Kang
    Journal of Pathology and Translational Medicine.2015; 49(2): 118.     CrossRef
  • HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value
    An Na Seo, Yoonjin Kwak, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Hye Seung Lee
    Virchows Archiv.2015; 466(6): 645.     CrossRef
  • Clinical and prognostic value of MET gene copy number gain and chromosome 7 polysomy in primary colorectal cancer patients
    An Na Seo, Kyoung Un Park, Gheeyoung Choe, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
    Tumor Biology.2015; 36(12): 9813.     CrossRef
  • c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer
    Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee, Andreas Krieg
    PLOS ONE.2015; 10(10): e0139727.     CrossRef
  • Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients
    Gunjan Srivastava, Jasmeet Assi, Lawrence Kashat, Ajay Matta, Martin Chang, Paul G Walfish, Ranju Ralhan
    BMC Cancer.2014;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine