Background Radiation-induced organizing hematoma (RIOH) is a sporadic form of cavernous hemangioma (CH) that occurs after cerebral radiation. RIOH lesions are distinct histologically from de novo CH; however, detailed research on this subject is lacking. In the present study, the clinical and histological features of RIOHs were evaluated based on causative lesions.
Methods The present study included 37 RIOHs confirmed by surgical excision from January 2009, to May 2020, in Yonsei Severance Hospital. All cases were divided into subgroups based on type of radiation treatment (gamma knife surgery [GKS], n = 24 vs. conventional radiation therapy [RT], n = 13) and pathology of the original lesion (arteriovenous malformation, n = 14; glioma, n = 12; metastasis, n = 4; other tumors, n = 7). The clinicopathological results were compared between the groups.
Results Clinical data of multiplicity, latency, and size and wall thickness of the original tumors and RIOHs were analyzed. The GKS group showed shorter latency (5.85 ± 4.06 years vs. 11.15 ± 8.27 years, p = .046) and thicker tumor wall (693.7 ± 565.7 μm vs. 406.9 ± 519.7 μm, p = .049) than the conventional RT group. Significant difference was not found based on original pathology.
Conclusions RIOH is more likely to occur earlier with thick tumor wall in subjects who underwent GKS than in patients who underwent conventional RT. These results indicate the clinical course of RIOH differs based on type of treatment and might help determine the duration of follow-up.
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Hemangioma of the kidney is a relatively uncommon tumor, which is most commonly located in the tip of the papilla.
This lesion is usually small and has been found incidentally at postmorten examination. About 200 cases of renal hemangioma have been reported since Virchow's original report in 1876. In renal hemangioma, cavernous hemangioma is the most common type. They can create diagnostic problem for the clinician and the radiologist. We experienced a case of renal cavernous hemangioma in the medulla of the upper pole.
The patient was a twenty-seven-year-old male who had gross hematuria and right flank pain. A nephrectomy was performed.
An ill-defined mass, 4.5x3.0x1.5 cm, was observed around the pelvis. Microscopically, the tumor mass was hemangioma of the cavernous type.